2. Pengertian HIV
Human immunodeficiency virus adalah
virus penyebab Acquired
Immunodeficiency Syndrome (AIDS).
Virus ini membawa materi genetiknya
dalam asam ribonukleat (RNA)
4. Siklus Hidup HIV
02 Penggabungan
Setelah menempel pada reseptor
di permukaan sel inang, virus
kemudian akan meleburkan diri.
Selama masa inkubasi virus,
amplop HIV dan membran sel
CD4 bergabung kemudian virus
HIV pun masuk ke dalam sel CD4.
01 Pengikatan (Penempelan)
Pada fase ini virus HIV akan
menempel pada reseptor dan
membentuk ikatan di
permukaan sel CD4.
5. Siklus Hidup HIV
04 Penyatuan (Integrasi)
Berhentinya masa inkubasi virus
HIV di dalam nukleus sel CD4
ditandai ketika HIV
menghasilkan enzim yang disebut
intergrase.
Enzim ini menggabungkan DNA
viral menjadi DNA dari sel CD4
disebut provirus.
03 Reverse Transcription
Fase reverse transcription masih
termasuk ke dalam masa inkubasi
virus HIV.
Di dalam sel CD4, HIV melepas dan
menggunakan transkriptase
terbalik.
Enzim dari HIV mengubah materi
genetik yang disebut RNA HIV
menjadi DNA HIV.
6. Siklus Hidup HIV
06 Perakitan
Rantai panjang protein HIV
menjadi ukuran protein yang lebih
kecil.
protein HIV yang baru beserta
RNA HIV pindah ke permukaan sel
merakit menjadi HIV yang belum
matang (tidak menular).
05 Replikasi
Begitu bersatu dengan DNA sel
CD4 dan mulai aktif bereplikasi.
HIV mulai menggunakan CD4
untuk menghasilkan rantai
panjang protein HIV.
Rantai panjang protein HIV
bertugas untuk membentuk
virus HIV lainnya.
7. Siklus Hidup HIV
07 Bertunas
Protein HIV yang lebih kecil
(belum matang) berkombinasi
untuk membentuk HIV yang
matang.
9. Type dari HIV
1. HIV-1
Ditemukan di seluruh dunia
2. HIV-2
Jarang ditemukan di tempat lain selain di
Afrika Barat.
Lebih sulit menular
Infeksi HIV-2 jauh lebih lambat berubah
menjadi AIDS dibandingkan HIV-1.
10. Klasifikasi Klinis Infeksi HIV menurut
WHO
1. Stadium 1 (asimtomatis)
Asimtomatis
Limfadenopati generalisata
2. Stadium 2 (ringan)
Penurunan berat badan < 10%
Manifestasi mukokutaneus minor: dermatitis seboroik, prurigo,
onikomikosis, ulkus oral rekurens, keilitis angularis, erupsi popular
pruritik
Infeksi herpers zoster dalam 5 tahun terakhir
Infeksi saluran napas atas berulang: sinusitis, tonsillitis, faringitis,
otitis media
11. Klasifikasi Klinis Infeksi HIV menurut
WHO
3. Stadium 3
•Berat badan menurun > 10%
•Diare kronis yang tidak diketahui
•penyebabnya > 1 bulan
•Demam tanpa sebab yang jelas > 1 bulan
•Kandidiasis oral
•TB paru dalam 1 tahun terakhir
4. Stadium 4
•BB turun 10% + diare kronik > 1 bulan atau
demam > 1 bulan
•Pneumocystis carinii pneumonia
•Toxoplasmosis otak
•Cryptococcosis extrapulmonari
•Citomegalovirus (CMV) pada organ selain liver,
spleen
12. 1. Infeksi primer atau sindrom akut
gejala yang muncul mirip dengan gejala
penyakit flu berlangsung hingga beberapa
minggu. Meliputi:
Demam hingga menggigil.
Muncul ruam di kulit.
Muntah.
Nyeri pada sendi dan otot.
Pembengkakan kelenjar getah bening.
Sakit kepala.
Sakit perut.
Sakit tenggorokan dan sariawan.
Efek Terhadap Sistem
Imun
13. 2. Fase Laten
Berlangsung hingga beberapa tahun atau
dekade
Gejalanya meliputi :
Berat badan turun.
Berkeringat di malam hari.
Demam.
Diare.
Mual dan muntah.
Herpes zoster
Pembengkakan kelenjar getah bening.
Sakit kepala.
Tubuh terasa lemah.
Efek Terhadap Sistem
Imun
14. 3. Fase Infeksi Kronis (AIDS)
Ketika penderita memasuki tahap ini, sistem
kekebalan tubuh sudah rusak parah.
Gejalanya meliputi :
Berat badan turun tanpa diketahui sebabnya.
Berkeringat di malam hari.
Bercak putih di lidah, mulut, kelamin, dan
anus.
Bintik ungu pada kulit yang tidak bisa hilang.
Demam yang berlangsung lebih dari 10 hari.
Diare kronis.
Gangguan saraf, seperti sulit berkonsentrasi
atau hilang ingatan.
Infeksi jamur di mulut, tenggorokan, atau
vagina.
Efek Terhadap Sistem
Imun
15. Infeksi Oportunistik
Infeksi oportunistik adalah infeksi akibat virus, bakteri,
jamur, atau parasit yang terjadi pada orang dengan sistem
kekebalan tubuh yang lemah.
Pasien yang mengalami infeksi oportunistik artinya
kemungkinan besar stadium infeksi HIV yang diderita sudah
lanjut pada tahap akhir yaitu AIDS (Acquired Immune
Deficiency Syndrome).
16. Manifestasi Klinis
Berikut adalah beberapa infeksi oportunistik yang dapat terjadi pada
pengidap HIV/AIDS.
1. Candidiasis
Disebabkan oleh jamur Candida.
Gejala : bercak putih di lidah atau tenggorokan.
2. Infeksi paru (pneumocystis)
Gejala : batuk, demam, dan kesulitan bernapas
Dapat menyebar ke kulit, tulang, atau saluran kemih.
Bila ke otak : pembengkakan otak (meningitis).
3. Tuberkulosis
Gejala : batuk, kelelahan, penurunan berat badan, demam, dan
berkeringat di malam hari.
Sulit diobati pada penderita HIV dibanding pada orang sehat.
17. Manifestasi Klinis
4. Herpes simplex
virus penyebab penyakit kelamin herpes.
Ditandai : kutil kelamin dan sariawan di daerah mulut dan
bibir.
5. Salmonella septicemia
gejala : mual, muntah-muntah, dan diare
infeksi ini dapat berkembang menjadi septikemia.
6. Toksoplasmosis
disebabkan oleh parasit Toxoplasma gondii.
dapat menginfeksi : mata, paru, jantung, hati dan otak.
7. Infeksi pencernaan
menyebabkan berat badan turun drastis.
19. Pencegahan Infeksi Oportunistik
Terapkan gaya hidup sehat.
Cuci dan masak makanan dengan baik.
Hindari mengonsumsi susu, daging, dan telur yang mentah atau kurang
matang.
Gunakan sarung tangan untuk mengambil kotoran hewan peliharaan, dan
jauhkan kucing dari dalam ruangan agar tidak membawa kuman yang dapat
membahayakan Anda.
Hindari berbagi penggunaan sikat gigi atau handuk dengan orang lain.
Hindari menelan atau meminum air yang langsung berasal dari kolam, danau,
atau sungai.
Ikuti program vaksinasi yang diwajibkan dan dianjurkan oleh pemerintah
untuk menjaga kekebalan tubuh.
Bagi wanita, lakukan pemeriksaan panggul dan pap smear untuk mendeteksi
kanker atau infeksi.
20. Terapi Untuk
HIV
1. Terapi Antiretroviral
Tujuannya untuk menekan
jumlah virus.
2. Terapi Informasi
Pertolongan pertama untuk
mengobati ketakutan terhadap
hal yang tak diketahui.
3. Terapi Spiritual
perbaikan kekebalan tubuh
akibat keadaan psikis yang baik
melalui jalur saraf.
mengembalikan fungsi psikis dan
sosial seseorang.
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You can simply impress
your audience and add
a unique zing and
appeal to your
Presentations. Easy to
change colors, photos
and Text.
Content Here
You can simply impress
your audience and add
a unique zing and
appeal to your
Presentations. Easy to
change colors, photos
and Text.
Content Here
You can simply impress
your audience and add
a unique zing and
appeal to your
Presentations. Easy to
change colors, photos
and Text.
Content Here
You can simply impress
your audience and add
a unique zing and
appeal to your
Presentations. Easy to
change colors, photos
and Text.
54. Infographic Style
Get a modern PowerPoint
Presentation that is
beautifully designed.
Contents
Get a modern PowerPoint
Presentation that is
beautifully designed.
Contents
Get a modern PowerPoint
Presentation that is
beautifully designed.
Contents
Get a modern PowerPoint
Presentation that is
beautifully designed.
Contents
Get a modern PowerPoint
Presentation that is
beautifully designed.
Contents
Get a modern PowerPoint
Presentation that is
beautifully designed.
Contents
06 05 04 03 02 01
55. Infographic Style
Your Text Here Your Text Here Your Text Here Your Text Here
Simple PowerPoint
Presentation
Simple PowerPoint
Presentation
Simple PowerPoint
Presentation
Simple PowerPoint
Presentation
You can simply impress
your audience and add a
unique zing and appeal to
your Presentations.
You can simply impress
your audience and add a
unique zing and appeal to
your Presentations.
You can simply impress
your audience and add a
unique zing and appeal to
your Presentations.
You can imply impress
your audience and add a
unique zing and appeal to
your Presentations.
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