G6PD deficiency is a genetic disorder classified into 5 classes based on enzyme activity level, ranging from severe deficiency with less than 10% activity to increased enzyme activity. Management involves avoiding oxidative stressors that can trigger hemolysis like fava beans, certain drugs, and chemicals. For acute hemolysis episodes, treatment may include blood transfusions. The main approach is preventing oxidative stressors that can cause red blood cell breakdown in those with the condition.

1. 1
G6PD DEFICIENCYPROBLEM BASED LEARNING (PBL)
PREPARED BY: MUHAMMAD ARIFF B. MAHDZUB
BACHELOR MEDICINE AND SURGERY (MBBS)
UNIVERSITY COLLEGE SHAHPUTRA, KUANTAN

2. CLASSIFICATION OF G6PD DEFICIENCY
Class 1 : Severe deficiency ( < 10% activity ).
Associated with chronic nonspherocytic hemolytic
anemia.
Class 2 : Severely deficiency. 1-10% residual activity.
associated with acute hemolytic anemia.
Class 3 : Moderately deficient. 10-60% residual
activity . Hemolysis with stressors only.
Class 4 : Normal activity. Non-deficent variant.
Class 5 : Increased enzyme activity.

3. MANAGEMENT OF G6PD DEFICIENCY
Since G6PD deficiency is a genetic disorder, there is no
cure but the main treatment is avoidance of oxidative
stressors.
G6PD deficiency is prevented by avoiding fava beans,
oxidant drug, oxidant chemicals and other stressors.
In the acute phase of hemolysis, blood transfusions
might be necessary.