A study was done by National Malaria Elimination Program of Bangladesh . Draft analysis was done by Md Mosiqure Rahaman- the Epidemiologist by using EPI info
4. Objective of the Study
General Objective: To generate the evidence for decision
making on the need for G6PD testing in the treatment of
malaria
Specific Objective:
• To determine the status of G6PD among the population living
in malaria risk areas of Bangladesh
• To categorize the status of G6PD among the population
living in malaria risk areas of Bangladesh
• To assess the socio demographic feature among the risk
population
Dr.Rahaman
5. Sample Size & Method
A cross-sectional study with 600 samples were under-taken to estimate
the population prevalence of G6PDd in 3 malaria endemic districts of
Bangladesh using CareStart™ G6PD Biosensor. Hemoglobin level of each
patient will be measured by portable hemoglobin meter.
In each district, 2 high endemic upazilas were selected from each district
based on the district health records in coordination with Brac .Then 1
unions were randomly selected from each upazila. A sampling frame
will be prepared from HHs list and 100 HH were selected randomly from
each union. Among the HHs sample were collected following the
inclusion and exclusion criteria. Each upazila team will comprise 1
medical technologist, 1 data collector and 1 field staff supervised by
Research Assistant. Each team collected data from 10 respondents each
day and data collection will be completed by 25 days. Data will be
analyzed in Epi info and the result will be plotted according to WHO
classification of G6PD deficiency. Analysis done by EPI-Info software
Dr.Rahaman
21. Relationship between Hb level & G6PD
Dr.Rahaman
G6PD Status Pearson Correlation 1 -.208**
Sig. (2-tailed) 0.000
N 607 607
Hb level(gm/dl) Pearson Correlation -.208** 1
Sig. (2-tailed) 0.000
N 607 607
**. Correlation is significant at
the 0.01 level (2-tailed).
25. Summery of Result
• Around 20.76% of sampled population in the 3 malaria high
burden districts are very severe to moderate level of G6PD
deficiency according to WHO classification
• Significant geographical variation exists among the 3
districts where Bandarban the district with highest malaria
prevalence have also the highest burden of deficiencies
• Variation also exists between male and females and also
among bengalis and non-bengalies
• 80% sampled population are normal or enhanced level of
deficiencies
• Hemoglobin level negatively co-related with G6PD status
• Highest deficiencies observed among the age group of 5-
25Years of age
Dr.Rahaman
26. Recommendations
• Include of G6PD testing in national malaria treatment guideline
• Determine level of the health care system where G6PD testing and PQ
administration should be Introducing/expanding a G6PD testing system
at country level
• Develop plan for pilot implementation and progressive scale-up.
• Cross-checking the result of this study by using qualitative method
• Behaviour change communication for demand creation among health
care providers and patients
• Pharmacovigilance to strengthen monitoring of Primaquin
administration in combination with other Acute Hemolytic Anaemia-
inducing medicines in G6PD-deficient patient
Dr.Rahaman