Stimuler enhance immune system

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AMASCO
DONGSUN IND. CO. LTD
BIO RESOURCE INTERNATIONAL CO

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- -ecdysone -
 Major ecdysis hormone of insect and crustacean
Main Ingredient

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WHAT
is
ECDYSONE ?

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Ecdysone is
• Major molting hormone
• A sort of steroid hormone
• Made from cholesterol
• Secreted from Y-organ

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Ecdysis Mechanism
• Brain neurosecretory hormone
• Y-organ(Ecdysone)
• Synthesis of chitin/protein
• Molting

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Sequence
of Events
in Molting

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Structure
-ecdysone
-ecdysone

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Difference
-ecdysone :
prohormone
-ecdysone :
active form

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Conversion Mechanism
Cytochrome P450
(metabolic enzyme)
-ecdysone -ecdysone

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Multi-process by enzymes
Ecdysone Biosynthesis

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• Cholesterol
• Oxygen(hydroxylation)
• Vitamin C
• Disease
• Stress(ex, temperature)
• Toxic material(ex, antibiotics, fenarimol)
• Nutrition factor
Ecdysone Biosynthesis Factor

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Concept
of
STIMULER

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 Shrimp cannot produce the cholesterol that is the precursor
of ecdysis hormone owing to lack of squalene oxidocyclase
 So, cholesterol must be supplied through the shrimp feed
 Cholesterol is changed to ecdysis hormone through multi-
process in associated with enzymes
 But, this multi-process are inhibited by many kinds of stress
 In conclusion, direct supply of phyto-ecdysone is better than
supply of cholesterol
Increase the growth rate by direct supply
of
Phyto-ecdysis hormone

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TRIAL

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• National Fisheries University
Department of Applied Aquabiology
• Supervisor : Dr. Toshiaki ITAMI
• Trial period : 2002. 6 ~ 2002. 10
• Shrimp species : kuruma Shrimp

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Increase of 5%
5.5
6
6.5
7
7.5
Average
body
weight(g)
0 10 18 25 32
Days after feeding
STIMULER(0.1%) Control
Changes of Average Body Weight

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Increase of 29%
0
0.2
0.4
0.6
0.8
1
1.2
1.4
1.6
Average
weight
gain(g)
0 10 18 25 32
Days after feeding
STIMULER(0.1%) Control
Changes of Weight Gain

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Control 0.1% STIMULER
Survival rate(%) 90 100
No. survival/No. tested 27/30 30/30
Survival Rates

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Specification
&
Dosage

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Achyranthes sp. extract
………….……… more than 5%
Stimuler 1kg in 1M/T feed