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Physiology and biochemistry of epinephrine and norepinephrine
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Epinephrine and Norepinephrine.pptx
1.
Neurotransmitters – Epinephrine and Norepinephrine Dr
Zaid Azhar
2.
Epinephrine • Also known
as Adrenaline • Catecholamine, • Derived from phenylalanine and tyrosine • Molecular weight – 183g
3.
Synthesis
4.
Adrenergic Receptors
5.
Adrenergic Receptors
6.
Adrenergic Receptors
7.
Mechanism of Action
8.
Mechanism of Action
9.
Uses of Adrenaline •
Resuscitation • Management of anaphylaxis • Inotropic support in hypotension, shock, status asthmaticus
10.
Norepinepherine Catecholamine with multiple roles: •Hormone •Neurotransmitter
11.
Synthesis
12.
Functions • Stress hormone •
Fight-or-flight response • Increases heart rate • Triggers the release of glucose • Increases blood flow to skeletal muscle. • Suppress neuro-inflammation
13.
Actions • Potent action-both
a1 & b1 receptors –Little action on b2 –Causes potent vasoconstriction (α) –Lacks bronchodilating effect –↑ systolic, diastolic & MAP –Reflex bradycardia –Metabolic acidosis
14.
Comparison
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