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1. FTIR
Presented by:
Jacob Thon Bior
M. Pharm 1st year
Dep’t Of Pharmaceutical Chemistry.
KLE College of Pharmacy, Belagavi.
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Department Of Pharmaceutical Chemistry,KLE CollegeOf
Pharmacy, Belgavi.

2. CONTENT:
Introduction
Principle
Instrumentation and working
Application
References
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Department Of Pharmaceutical Chemistry,KLE CollegeOf
Pharmacy, Belgavi.

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Pharmacy, Belgavi.
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Pharmacy, Belgavi.
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5. Principle:
In FTIR analysis, Infrared light from the light source passing
through a Michelson interferometer along the optical path.
The Michelson interferometer comprises a beam splitter, moving
mirror and fixed mirror.
The light beam split into two by the beam splitter is reflected from
the moving mirror and fixed mirror, before being recombined by
beam splitter.
As the moving mirror makes reciprocating movement the optical
path different to the fixed mirror changed such that the path
difference change with time. The light beam are combined in
Michelson interferometer to produce interference light. The
intensity of the interference is recorded in an Interferogram with
optical path difference recorded along the horizontal axis.
Department Of Pharmaceutical Chemistry,KLE CollegeOf
Pharmacy, Belgavi.
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Pharmacy, Belgavi.

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Pharmacy, Belgavi.

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Pharmacy, Belgavi.

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Pharmacy, Belgavi.

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Pharmacy, Belgavi.

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Pharmacy, Belgavi.

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Department Of Pharmaceutical Chemistry,KLE CollegeOf
Pharmacy, Belgavi.

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Pharmacy, Belgavi.
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Pharmacy, Belgavi.
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15. Applications:
Identification of organic compounds since compounds will not have same
IR Spectrum( by measuring absorptions).
Qualitative determination of functional group predicted by present/absence
of absorption bands.
Quantitative analysis: by measuring intensity of absorption bands using
Beer-Lambert law.
Identification of impurities in drugs sample by giving additional peaks
compare to the pure compounds.
Department Of Pharmaceutical Chemistry,KLE CollegeOf
Pharmacy, Belgavi.
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16. Referencs:
FTIR Spectroscopy by Jorge.E. Perez and Richard T. Meyer
Introduction to Fourier Transform Infrared Spectrometry by
Thermo Nicolet Corporation.
Instrumental methods of chemical analysis by Gurdeep R.
Chatwal & Sham K. Anand
Department Of Pharmaceutical Chemistry,KLE CollegeOf
Pharmacy, Belgavi.
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