This document provides information about different types of tablets and the formulation process. It discusses:
1) The definition and advantages/disadvantages of tablets. 2) Various types of tablets including those ingested orally, used in the oral cavity, administered by other routes, and used to prepare solutions. 3) Excipients commonly used in tablets and their functions. 4) The formulation process including pulverization, granulation, compression, and coating. 5) Details on wet and dry granulation methods and tablet coating techniques.
This document discusses tablets as a type of solid oral dosage form used for drug delivery. It defines tablets as compressed powders or granules containing medicinal ingredients. The document outlines the advantages of tablets such as ease of administration and accurate dosing. It also discusses different types of tablets including compressed, enteric coated, and chewable tablets. The document provides details on the manufacturing process for compressed tablets including preparation of granules, compression, and coating. It also lists common excipients used in tablet formulations such as diluents, binding agents, and disintegrating agents.
DEFINITION
Capsules are solid preparations with hard and soft shells of various shapes and capacities, usually containing a single dose of active ingredients.
A detailed study on tablets, its classification, excipients, tablet granulation, methods of granulation, compression machines, equipment tooling and the problems that occur during the tablet manufacturing process. This presentation is based on the PCI syllabus for bpharm students of fifth semester.
The document discusses sterile formulations and parenteral products. It covers key topics like routes of parenteral administration, pre-formulation of sterile products, physicochemical properties, general requirements, and sterility testing. The different routes discussed are subcutaneous, intramuscular, intravenous, and others. Ideal properties of sterile dosage forms include sterility, isotonicity, being pyrogen-free and particle-free. The document also differentiates between small volume parenterals and large volume parenterals.
The presentation deals with a detailed study of soft gelatin capsules. this involves the production of soft gelatin capsule based on the importance of base adsorption factor and minim/gram factor. also quality control studies was also elaborated.
This document discusses sterile dosage forms and parenteral preparations. It defines sterile products as dosage forms that are free of microorganisms. Sterile products include parenteral, ophthalmic, and irrigating preparations. Parenteral preparations include injections and are sterile, pyrogen-free solutions or suspensions intended for administration outside the intestinal tract. Ideal sterile preparations must be sterile, pyrogen-free, clear, stable, and meet other stringent requirements. The document discusses various types of sterile preparations and their formulation considerations including vehicles, preservatives, buffers, and other excipients.
This document discusses tablet coating, which involves covering tablet surfaces with a polymeric film to provide benefits like masking taste, protecting drugs, and controlling drug release. It describes the main types of tablet coating - sugar coating, film coating, enteric coating, vacuum film coating, electrostatic coating, and dip coating. For each coating type, it outlines the basic process and materials used. The document also explains the need for tablet coating and lists the ideal characteristics of coating materials.
Parenterals are sterile solutions or suspensions of drugs administered through routes other than the gastrointestinal tract. This document discusses various aspects of parenterals including their routes of administration, requirements for stability and sterility, and types such as small volume parenterals and large volume parenterals. It provides details on the production of water for injection and various parenteral vehicles, formulations, and examples.
This document discusses tablets as a type of solid oral dosage form used for drug delivery. It defines tablets as compressed powders or granules containing medicinal ingredients. The document outlines the advantages of tablets such as ease of administration and accurate dosing. It also discusses different types of tablets including compressed, enteric coated, and chewable tablets. The document provides details on the manufacturing process for compressed tablets including preparation of granules, compression, and coating. It also lists common excipients used in tablet formulations such as diluents, binding agents, and disintegrating agents.
DEFINITION
Capsules are solid preparations with hard and soft shells of various shapes and capacities, usually containing a single dose of active ingredients.
A detailed study on tablets, its classification, excipients, tablet granulation, methods of granulation, compression machines, equipment tooling and the problems that occur during the tablet manufacturing process. This presentation is based on the PCI syllabus for bpharm students of fifth semester.
The document discusses sterile formulations and parenteral products. It covers key topics like routes of parenteral administration, pre-formulation of sterile products, physicochemical properties, general requirements, and sterility testing. The different routes discussed are subcutaneous, intramuscular, intravenous, and others. Ideal properties of sterile dosage forms include sterility, isotonicity, being pyrogen-free and particle-free. The document also differentiates between small volume parenterals and large volume parenterals.
The presentation deals with a detailed study of soft gelatin capsules. this involves the production of soft gelatin capsule based on the importance of base adsorption factor and minim/gram factor. also quality control studies was also elaborated.
This document discusses sterile dosage forms and parenteral preparations. It defines sterile products as dosage forms that are free of microorganisms. Sterile products include parenteral, ophthalmic, and irrigating preparations. Parenteral preparations include injections and are sterile, pyrogen-free solutions or suspensions intended for administration outside the intestinal tract. Ideal sterile preparations must be sterile, pyrogen-free, clear, stable, and meet other stringent requirements. The document discusses various types of sterile preparations and their formulation considerations including vehicles, preservatives, buffers, and other excipients.
This document discusses tablet coating, which involves covering tablet surfaces with a polymeric film to provide benefits like masking taste, protecting drugs, and controlling drug release. It describes the main types of tablet coating - sugar coating, film coating, enteric coating, vacuum film coating, electrostatic coating, and dip coating. For each coating type, it outlines the basic process and materials used. The document also explains the need for tablet coating and lists the ideal characteristics of coating materials.
Parenterals are sterile solutions or suspensions of drugs administered through routes other than the gastrointestinal tract. This document discusses various aspects of parenterals including their routes of administration, requirements for stability and sterility, and types such as small volume parenterals and large volume parenterals. It provides details on the production of water for injection and various parenteral vehicles, formulations, and examples.
This document provides information about tablets, including their definition, advantages, types, and manufacturing process. It begins with definitions of tablets from pharmacopoeias and discusses how they are the most popular dosage form, comprising 70% of pharmaceutical preparations. It describes various types of tablets including compressed, sugar-coated, film-coated, enteric-coated, and effervescent tablets. The document outlines the tablet manufacturing process using tableting machines and discusses characteristics and specifications of compressed tablets.
This document evaluates different tests performed on capsules, including stability, invariability, disintegration, dissolution, and moisture permeation tests. Stability tests evaluate the integrity of the capsule shell and determine shelf life by testing shell integrity and storage conditions. Invariability tests ensure uniform weight and drug content across capsules using weight variation and content uniformity tests. Disintegration and dissolution tests measure how quickly the capsule shell breaks down and releases its drug in water or simulated gastric fluid. Moisture permeation testing verifies the suitability of packaging for preventing moisture from affecting capsules.
Tablets are the most popular dosage form, comprising 70% of pharmaceutical preparations. Tablets can be produced in various types including compressed, sugar-coated, film-coated, gelatin-coated, enteric-coated, effervescent, chewable, and orally disintegrating tablets. Quality standards for tablets include specifications for weight, content uniformity, thickness, hardness, friability, and disintegration time. Proper control of these factors during manufacturing is necessary to ensure consistent and reliable dosing of the active pharmaceutical ingredient.
The document summarizes key aspects of the Drug and Cosmetic Act and Rules in India, including:
- The Acts and Rules regulate the import, manufacture, distribution and sale of drugs and cosmetics in India.
- Important definitions are provided for terms like "drug", "cosmetic", "manufacture" and others.
- Drugs and cosmetics can be deemed "misbranded", "adulterated" or "spurious" if they do not meet certain standards.
- The Rules contain 18 parts and 26 schedules providing detailed requirements and guidelines for drugs and cosmetics.
- Key agencies like the Drugs Technical Advisory Board help administer the Acts and
This document discusses tablet coating processes. There are three main types of coatings: sugar coating, film coating, and enteric coating. Sugar coating involves applying a sucrose solution to tablets to make them easier to swallow. Film coating deposits a thin polymer film around tablet cores. Enteric coatings are designed to pass through the stomach and dissolve in the intestines. Tablet coating is done in pans or fluidized beds to evenly apply coatings and dry the tablets. Coatings are used to mask tastes, protect medications, and control drug release.
The document discusses parenteral products and their administration. It defines parenteral as referring to administration by injection rather than orally, bypassing the gastrointestinal tract. It then discusses the advantages and disadvantages of the parenteral route, including faster systemic delivery but also risks of infection. The document outlines various routes of parenteral injection and provides details on procedures like subcutaneous, intramuscular, and intravenous injection. It also discusses formulation, processing, and quality testing of parenteral products.
This document provides an overview of tablet formulation and manufacturing. It discusses the definition and advantages of tablets as a popular dosage form. It describes different types of tablets including compressed, enteric coated, and chewable tablets. The document outlines the manufacturing process for compressed tablets including preparation of granules through wet and dry granulation. It also discusses common excipients used in tablet formulations such as diluents, binders, and lubricants. Finally, it provides information on tablet coating techniques and quality evaluation tests for tablets.
Direct compression is the most advanced technology. It involves only blending and compression. Thus offering advantage particularly in terms of speedy production. Because it requires fewer unit operations, less machinery, reduced number of personnel and considerably less processing time along with increased product stability.
Capsules are solid dosage forms that contain a drug enclosed within a hard or soft soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules, which consist of two pieces that are joined, and soft gelatin capsules, which have a soft, one-piece shell. Capsules offer benefits like being tasteless, odorless, and easy to administer, and allow for flexible dosing. However, some drugs are not suitable for capsules due to stability issues. Capsules are manufactured through various processes depending on the type, including dipping, spinning, drying, filling, and sealing. They must pass quality tests like weight variation and content uniformity testing.
This document discusses soft gelatin capsules. Soft gelatin capsules have soft, gelatin shells that contain liquid or semisolid fill materials. They are formed, filled, and sealed in a single operation using either a droplet or pressing method. Soft gelatin capsules offer advantages over hard capsules like improved bioavailability and enhanced stability. The shells are made of gelatin, plasticizers, preservatives, colors and flavors. Soft gelatin capsules can be used orally or for other routes of administration.
The document discusses different granulation techniques used in pharmaceutical manufacturing. It describes granulation as a size enlargement process used to improve properties like flowability and compressibility of powders for tablet making. The key granulation methods covered are wet granulation, dry granulation, and direct compression. Wet granulation involves using a liquid to form granules and allows for a wide range of excipients. Dry granulation uses pressure rather than liquid. Direct compression can be used for materials with good compression properties. Modern techniques like steam granulation are also briefly mentioned.
Granules are agglomerates of powder particles that are larger in size, ranging from 0.2 to 4.0 mm. They are formed through a process called granulation where primary powder particles adhere together. Granules have better flow properties and compressibility compared to powders. They are often used as an intermediate step in tablet production since granules flow more evenly into tablet dies compared to powders. Granules can be prepared through wet or dry granulation methods.
Capsules are solid dosage forms that enclose one or more active ingredients within a soluble shell, typically made of gelatin. There are two main types: hard-shelled capsules containing dry powders, and soft-shelled capsules used for oils. Capsules are manufactured through a process involving dipping pins in gelatin solutions to form the shells, drying, stripping from the pins, trimming, joining the cap and body portions, and polishing. Various sizes of empty capsules are commercially available. Capsules offer benefits like ease of swallowing and unit dosing but require specialized filling equipment for industrial production.
pellets can be defined as multi particulate system or multiunit system
They are spherical particulates manufactured by agglomeration of the powder granules containing drug substance and excipients.
Pellets can be prepared by a special technique called Pelletization.
This technique is referred to an agglomeration process that convert fine powder or granules of bulk drug or excipient in to small , free flowing , spherical or semi spherical pellets .
Multi particular drug delivery system especially suitable for achieving controlled delay released oral formulation with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.
Multi particulate drug delivery system are mainly oral dosage form consisting of a multiplicity of small discrete units each exhibiting some desire characteristics.
This document discusses common manufacturing defects that can occur during tablet production such as picking and sticking, capping and lamination, mottling, double impression, poor mixing, poor flow, weight variation, and hardness variation. For each defect, the document provides the reason for why the defect occurs and recommendations for how to correct the issue, such as using properly designed punches, adequate drying, uniform granule size distribution, and controlling punch movement. The overall goal of the document is to outline typical tablet defects, their causes, and methods for prevention.
The document summarizes procedures for evaluating ophthalmic drug preparations. It discusses that evaluation includes sterility testing, clarity testing, leak testing, and testing for metal particles in ointments. It also describes that drug product quality tests assess attributes like identification, potency, purity, sterility and particulate matter, while performance tests evaluate drug release. Key quality tests discussed are identification, assay, pH, osmolarity, bacterial endotoxins, and uniformity of dosage units. Specific tests covered include viscosity and drop size.
The document discusses the evaluation and testing of tablets. It describes non-official tests like general appearance, organoleptic properties, size and shape, hardness, and friability. It also describes official tests like weight variation, content uniformity, dissolution, and disintegration. It discusses different types of tablets like compressed and molded tablets. It provides details on evaluating the appearance, hardness, friability and other properties of tablets and describes tests like weight variation, content uniformity, and dissolution used to ensure tablets meet specifications.
The document discusses parenterals, which are sterile preparations intended for administration through layers of skin or mucous membranes. It defines parenterals and outlines their advantages like 100% bioavailability and ability to administer to unconscious patients. The document also discusses the various routes of parenteral administration, types of parenterals like powders, solutions, and emulsions. It describes the formulation, layout, and quality control testing of parenterals. Specifically, it provides details on the areas involved in parenteral production, types of small and large volume parenterals, and common quality tests like leaker, clarity, pyrogenic, sterility, and content uniformity testing.
The document describes three main methods for manufacturing tablets: wet granulation, dry granulation, and direct compression. Wet granulation involves using a liquid such as water to form granules, then drying the granules. It produces tablets with good mechanical properties but requires multiple steps. Dry granulation uses compaction without liquid to form granules. Direct compression compresses powder directly without a granulation step, making it faster but requiring special excipients. Each method has advantages and disadvantages related to processing steps, equipment needs, stability concerns, and tablet properties.
Tablet excipients serve several important functions in tablet manufacturing including improving properties like flow, stability, and bioavailability. Common excipients include diluents, binders, disintegrants, and lubricants. Tablets can be classified based on their route of administration, drug delivery system, and manufacturing method. Key types include compressed, enteric coated, chewable, sublingual, and effervescent tablets. Excipients allow tablets to be designed for rapid or delayed drug release depending on the therapeutic need.
This document provides an overview of tablets, including their history, types, ingredients, manufacturing processes, and evaluation. It begins with an introduction to tablets, noting they were first patented in 1843 and now represent over 2/3 of dosage forms. The main types of tablets discussed are compressed, multiple compressed (layered, compressed coated), sugar coated, film coated, and chewable tablets. Ingredients like drugs, diluents, binders, lubricants and disintegrants are explained. Tablet production methods like wet granulation, dry granulation and direct compression are covered. Common processing problems and methods of evaluation like weight variation, content uniformity and hardness testing are also summarized.
Tablet, Tablet as a dosage form, tablet as a solid unit dosage form, tablet t...RajkumarKumawat11
Tablet, Tablet as a dosage form, tablet as a solid unit dosage form, tablet topic for pharma student, presentation of tablet, tablet by raj kumar kumawat
This document provides information about tablets, including their definition, advantages, types, and manufacturing process. It begins with definitions of tablets from pharmacopoeias and discusses how they are the most popular dosage form, comprising 70% of pharmaceutical preparations. It describes various types of tablets including compressed, sugar-coated, film-coated, enteric-coated, and effervescent tablets. The document outlines the tablet manufacturing process using tableting machines and discusses characteristics and specifications of compressed tablets.
This document evaluates different tests performed on capsules, including stability, invariability, disintegration, dissolution, and moisture permeation tests. Stability tests evaluate the integrity of the capsule shell and determine shelf life by testing shell integrity and storage conditions. Invariability tests ensure uniform weight and drug content across capsules using weight variation and content uniformity tests. Disintegration and dissolution tests measure how quickly the capsule shell breaks down and releases its drug in water or simulated gastric fluid. Moisture permeation testing verifies the suitability of packaging for preventing moisture from affecting capsules.
Tablets are the most popular dosage form, comprising 70% of pharmaceutical preparations. Tablets can be produced in various types including compressed, sugar-coated, film-coated, gelatin-coated, enteric-coated, effervescent, chewable, and orally disintegrating tablets. Quality standards for tablets include specifications for weight, content uniformity, thickness, hardness, friability, and disintegration time. Proper control of these factors during manufacturing is necessary to ensure consistent and reliable dosing of the active pharmaceutical ingredient.
The document summarizes key aspects of the Drug and Cosmetic Act and Rules in India, including:
- The Acts and Rules regulate the import, manufacture, distribution and sale of drugs and cosmetics in India.
- Important definitions are provided for terms like "drug", "cosmetic", "manufacture" and others.
- Drugs and cosmetics can be deemed "misbranded", "adulterated" or "spurious" if they do not meet certain standards.
- The Rules contain 18 parts and 26 schedules providing detailed requirements and guidelines for drugs and cosmetics.
- Key agencies like the Drugs Technical Advisory Board help administer the Acts and
This document discusses tablet coating processes. There are three main types of coatings: sugar coating, film coating, and enteric coating. Sugar coating involves applying a sucrose solution to tablets to make them easier to swallow. Film coating deposits a thin polymer film around tablet cores. Enteric coatings are designed to pass through the stomach and dissolve in the intestines. Tablet coating is done in pans or fluidized beds to evenly apply coatings and dry the tablets. Coatings are used to mask tastes, protect medications, and control drug release.
The document discusses parenteral products and their administration. It defines parenteral as referring to administration by injection rather than orally, bypassing the gastrointestinal tract. It then discusses the advantages and disadvantages of the parenteral route, including faster systemic delivery but also risks of infection. The document outlines various routes of parenteral injection and provides details on procedures like subcutaneous, intramuscular, and intravenous injection. It also discusses formulation, processing, and quality testing of parenteral products.
This document provides an overview of tablet formulation and manufacturing. It discusses the definition and advantages of tablets as a popular dosage form. It describes different types of tablets including compressed, enteric coated, and chewable tablets. The document outlines the manufacturing process for compressed tablets including preparation of granules through wet and dry granulation. It also discusses common excipients used in tablet formulations such as diluents, binders, and lubricants. Finally, it provides information on tablet coating techniques and quality evaluation tests for tablets.
Direct compression is the most advanced technology. It involves only blending and compression. Thus offering advantage particularly in terms of speedy production. Because it requires fewer unit operations, less machinery, reduced number of personnel and considerably less processing time along with increased product stability.
Capsules are solid dosage forms that contain a drug enclosed within a hard or soft soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules, which consist of two pieces that are joined, and soft gelatin capsules, which have a soft, one-piece shell. Capsules offer benefits like being tasteless, odorless, and easy to administer, and allow for flexible dosing. However, some drugs are not suitable for capsules due to stability issues. Capsules are manufactured through various processes depending on the type, including dipping, spinning, drying, filling, and sealing. They must pass quality tests like weight variation and content uniformity testing.
This document discusses soft gelatin capsules. Soft gelatin capsules have soft, gelatin shells that contain liquid or semisolid fill materials. They are formed, filled, and sealed in a single operation using either a droplet or pressing method. Soft gelatin capsules offer advantages over hard capsules like improved bioavailability and enhanced stability. The shells are made of gelatin, plasticizers, preservatives, colors and flavors. Soft gelatin capsules can be used orally or for other routes of administration.
The document discusses different granulation techniques used in pharmaceutical manufacturing. It describes granulation as a size enlargement process used to improve properties like flowability and compressibility of powders for tablet making. The key granulation methods covered are wet granulation, dry granulation, and direct compression. Wet granulation involves using a liquid to form granules and allows for a wide range of excipients. Dry granulation uses pressure rather than liquid. Direct compression can be used for materials with good compression properties. Modern techniques like steam granulation are also briefly mentioned.
Granules are agglomerates of powder particles that are larger in size, ranging from 0.2 to 4.0 mm. They are formed through a process called granulation where primary powder particles adhere together. Granules have better flow properties and compressibility compared to powders. They are often used as an intermediate step in tablet production since granules flow more evenly into tablet dies compared to powders. Granules can be prepared through wet or dry granulation methods.
Capsules are solid dosage forms that enclose one or more active ingredients within a soluble shell, typically made of gelatin. There are two main types: hard-shelled capsules containing dry powders, and soft-shelled capsules used for oils. Capsules are manufactured through a process involving dipping pins in gelatin solutions to form the shells, drying, stripping from the pins, trimming, joining the cap and body portions, and polishing. Various sizes of empty capsules are commercially available. Capsules offer benefits like ease of swallowing and unit dosing but require specialized filling equipment for industrial production.
pellets can be defined as multi particulate system or multiunit system
They are spherical particulates manufactured by agglomeration of the powder granules containing drug substance and excipients.
Pellets can be prepared by a special technique called Pelletization.
This technique is referred to an agglomeration process that convert fine powder or granules of bulk drug or excipient in to small , free flowing , spherical or semi spherical pellets .
Multi particular drug delivery system especially suitable for achieving controlled delay released oral formulation with low risk of dose dumping, flexibility of blending to attain different release patterns as well as reproducible and short gastric residence time.
Multi particulate drug delivery system are mainly oral dosage form consisting of a multiplicity of small discrete units each exhibiting some desire characteristics.
This document discusses common manufacturing defects that can occur during tablet production such as picking and sticking, capping and lamination, mottling, double impression, poor mixing, poor flow, weight variation, and hardness variation. For each defect, the document provides the reason for why the defect occurs and recommendations for how to correct the issue, such as using properly designed punches, adequate drying, uniform granule size distribution, and controlling punch movement. The overall goal of the document is to outline typical tablet defects, their causes, and methods for prevention.
The document summarizes procedures for evaluating ophthalmic drug preparations. It discusses that evaluation includes sterility testing, clarity testing, leak testing, and testing for metal particles in ointments. It also describes that drug product quality tests assess attributes like identification, potency, purity, sterility and particulate matter, while performance tests evaluate drug release. Key quality tests discussed are identification, assay, pH, osmolarity, bacterial endotoxins, and uniformity of dosage units. Specific tests covered include viscosity and drop size.
The document discusses the evaluation and testing of tablets. It describes non-official tests like general appearance, organoleptic properties, size and shape, hardness, and friability. It also describes official tests like weight variation, content uniformity, dissolution, and disintegration. It discusses different types of tablets like compressed and molded tablets. It provides details on evaluating the appearance, hardness, friability and other properties of tablets and describes tests like weight variation, content uniformity, and dissolution used to ensure tablets meet specifications.
The document discusses parenterals, which are sterile preparations intended for administration through layers of skin or mucous membranes. It defines parenterals and outlines their advantages like 100% bioavailability and ability to administer to unconscious patients. The document also discusses the various routes of parenteral administration, types of parenterals like powders, solutions, and emulsions. It describes the formulation, layout, and quality control testing of parenterals. Specifically, it provides details on the areas involved in parenteral production, types of small and large volume parenterals, and common quality tests like leaker, clarity, pyrogenic, sterility, and content uniformity testing.
The document describes three main methods for manufacturing tablets: wet granulation, dry granulation, and direct compression. Wet granulation involves using a liquid such as water to form granules, then drying the granules. It produces tablets with good mechanical properties but requires multiple steps. Dry granulation uses compaction without liquid to form granules. Direct compression compresses powder directly without a granulation step, making it faster but requiring special excipients. Each method has advantages and disadvantages related to processing steps, equipment needs, stability concerns, and tablet properties.
Tablet excipients serve several important functions in tablet manufacturing including improving properties like flow, stability, and bioavailability. Common excipients include diluents, binders, disintegrants, and lubricants. Tablets can be classified based on their route of administration, drug delivery system, and manufacturing method. Key types include compressed, enteric coated, chewable, sublingual, and effervescent tablets. Excipients allow tablets to be designed for rapid or delayed drug release depending on the therapeutic need.
This document provides an overview of tablets, including their history, types, ingredients, manufacturing processes, and evaluation. It begins with an introduction to tablets, noting they were first patented in 1843 and now represent over 2/3 of dosage forms. The main types of tablets discussed are compressed, multiple compressed (layered, compressed coated), sugar coated, film coated, and chewable tablets. Ingredients like drugs, diluents, binders, lubricants and disintegrants are explained. Tablet production methods like wet granulation, dry granulation and direct compression are covered. Common processing problems and methods of evaluation like weight variation, content uniformity and hardness testing are also summarized.
Tablet, Tablet as a dosage form, tablet as a solid unit dosage form, tablet t...RajkumarKumawat11
Tablet, Tablet as a dosage form, tablet as a solid unit dosage form, tablet topic for pharma student, presentation of tablet, tablet by raj kumar kumawat
This document provides information on tablet formulation and manufacturing. It defines what a tablet is and lists some key advantages such as stability, portability, accuracy of dosing, and low cost. It then describes different types of tablets including those ingested orally, used in the oral cavity, administered via other routes, and those used to prepare solutions. The document discusses excipients commonly used in tablet formulations and provides details on granule preparation methods, compression of granules into tablets, and potential defects that can occur during tablet manufacturing.
This document discusses tablets as a solid oral dosage form. It defines tablets and describes their advantages such as precise dosing, low cost, and stability. The document outlines common tablet ingredients like diluents, binders, disintegrants, and lubricants. It also discusses different types of tablets based on route of administration and describes various tableting methods including wet and dry granulation and compression. The document provides a detailed overview of the key components and processes involved in manufacturing tablets.
This document discusses tablets as a dosage form for delivering medications. It defines tablets and outlines their advantages such as precise dosing, low cost, and stability. Various types of tablets are described based on where they are administered and how they release the drug. The key ingredients used in tablets called excipients are explained. Granulation techniques for tablet manufacturing like wet and dry granulation are summarized. The document also covers tablet processing problems that can occur and ways to control the manufacturing process.
Tablets are solid oral dosage forms made by compressing powders containing active pharmaceutical ingredients and excipients. Tablets offer advantages like precise dosing, low cost, stability, and ease of production and administration. Tablet production involves blending powders, granulation to improve flow and compression properties, lubrication, and compression using tablet presses to form the final tablets. Tablet properties, types, ingredients, manufacturing processes, and equipment are described in detail in the document.
This document provides an overview of tablets, including:
- Tablets are compressed solid dosage forms that are usually circular in shape and may be flat or curved. They are the most popular dosage form.
- Advantages of tablets include being easy to administer and dispense, more stable, light and compact, and economical. Disadvantages include difficulty formulating some drugs and increased costs from coating.
- The document describes different types of tablets based on how they are administered, manufactured, and used. It also covers tablet ingredients, manufacturing processes, coating methods, and potential defects.
The document discusses tablets, including their definition, types, formulation, methods of preparation, defects, and quality control tests. Tablets are solid dosage forms that contain medicinal substances and may be compressed or molded. They are classified based on how they are administered or where they act, such as oral, chewable, sublingual, etc. Tablet formulation involves active ingredients and excipients like diluents, binders, lubricants, and disintegrants. Tablets are prepared by wet granulation, dry granulation, or direct compression methods. Quality control tests evaluate properties like weight variation, hardness, friability, disintegration time, and drug content uniformity.
This includes detail study of the tablet dosage form. Different types of tablets and method of preparation. It will surely help you to understand the topic with the easy language. And it is also helpful as exam point of view.
This document discusses different types of tablets and the tablet manufacturing process. It begins by defining what a tablet is and listing some key advantages such as precise dosing, low cost, and stability. It then describes different types of tablets including compressed, coated, chewable, and those for different routes of administration. The document outlines common excipients used in tablets and their functions. It explains the importance of granulation and describes different granulation methods including dry, wet, and direct compression. The wet granulation process is outlined in detail including mixing, granulation, and drying steps.
This document provides an overview of tablets as a drug delivery system. It discusses the definition, advantages, and disadvantages of tablets. It describes different types of tablets including compressed, enteric coated, and chewable tablets. The document outlines the main excipients used in tablet formulations and the manufacturing process, which typically involves granulation and compression. It also discusses tablet coating methods and common defects in tablets. The document serves as a comprehensive guide to the fundamentals of tablet design and production.
This document provides an overview of tablets as a drug delivery system. It discusses the definition and advantages of tablets. It describes different types of tablets including compressed, enteric coated, and chewable tablets. The document outlines the manufacturing process for compressed tablets including granulation, compression, and coating. It also discusses common excipients used in tablet formulations and methods for evaluating tablet quality.
this presentation discusses about; Dosage forms
Tablet dosage forms
Desirable properties of tablets
Classification of tablets
Types of tablets
Tablet ingredients
Tablet manufacturing methods
Major equipments used for wet granulation
Evaluation of tablets
Tableting problems and their remedies
This document provides information about tablets, including their formulation, design, manufacturing, types, advantages, and excipients. Tablets are solid oral dosage forms made by compressing powder mixtures into various shapes. They have advantages like precise dosing and ease of production. The document discusses different granulation and compression methods used in tablet manufacturing. It also describes common excipients like diluents, binders, disintegrants, lubricants and their functions in tablets.
Here are the answers to your questions:
1) Scored or grooved tablets
2) Disintegrants
3) Friabulator
4-6) Wet granulation, dry granulation, direct compression
7) Microencapsulation
The document discusses pharmaceutical powders, including their advantages and disadvantages as a dosage form. It defines powders as intimate mixtures of dry, finely divided drugs and chemicals that can be used internally or externally. The document outlines different types of powders like bulk powders, simple powders, compound powders, and effervescent granules. It also describes methods of preparing powders, including particle size reduction, homogeneous mixing, packaging, and addressing special issues like volatile, hygroscopic, or efflorescent ingredients. Quality control testing of powders is also summarized.
Pharmaceutical Solid and Semi-solid Dosage FormBenozir Shuvo
The document discusses various aspects of solid and semi-solid dosage forms including tablets, capsules, and semi-solid forms like ointments, creams, gels, and suppositories. It describes the tablet manufacturing process including direct compression, dry granulation, and wet granulation methods. It also discusses capsule manufacturing, coating processes, evaluation tests and advantages of semi-solid dosage forms.
This document provides information about tablets, including their definition, advantages, disadvantages and types. It discusses the main components of tablets, including active ingredients and excipients. It describes different types of tablets based on their route of administration and production process. The purposes and examples of various excipients like diluents, binders, disintegrants, lubricants and coloring agents are outlined. Granulation is introduced as a process to prevent segregation and improve flow of powder mixtures that are then compressed into tablets.
This document provides information about tablet formulation and manufacturing. It discusses the different types of tablets, advantages and disadvantages of tablets, granulation process, tablet excipients including diluents, binders, disintegrants, lubricants and glidants. The key points covered are:
1) Tablets are solid oral dosage forms made by compressing powder mixtures into various shapes and sizes. They have advantages like precise dosing, stability and low cost of production.
2) Granulation is used to improve powder flow and compressibility. It can be done by wet or dry methods. Common excipients added to tablets include diluents, binders, disintegrants and lubricants which aid in tablet
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Formulation of Different Types of Tablets Summary.pdf
1. HEMVATI NANDAN BAHUGUNA GARHWAL UNIVERSITY
A Central University (Srinagar Garhwal)
Formulation of Different Types of Tablets Summary
B.Pharm VIIIth Semester
Sudhir Priyadarshi
Roll No : 17134518057
To Head Of Department
Proof. Dr. Abdul Faruk
(Batch : 2017–2021)
Submitted By : Submitted To :
2. Contents :
-
-
Tablets
Advantages of Tablets
Disadvantages of Tablets
- Types of Tablets
Tablets ingested Orally
Tablets used Orally
Tablets administrated by other routes
Tablets used to prepare solutions
Excipients and its Types
Diluents
Binder
Disintegrants
Lubricant and Glidents
Coloring Agents
Flavouring and Sweatness
- Formulation of Tablets
Pulverization and mixing
Granulation
- Wet Granulation
- Dry Granulation
Tablet Compression
Tablet Coating
Film coating
3. -
Tablets :
With Reference to USP, Tablets are compressed solid dosage form containing
Drug with or without vehicle.
- With Reference to IP, Tablets are solid unit dosage form prepared by
compressing a Drug or a Mixture of Drug with or without vehicle.
-
-
Disadvantages of tablets :
- Hard To Swallowing case of Children and Unconscious patient.
Tablets with slow dissolution property and poor wetting are difficult to
Formulate.
- Disagreeable Taste with bad odour or oxygen sensitive Drug require
Encapsulation Coating, In such cases Capsules are recommended.
Due to amorphous Nature and Low Density property some Drugs
oppose Compaction.
4. Types of Tablets :
1. Tablets Ingested Orally
- Compressed Tablets : These tablets are begin by Compression
without Coating. They are made from powdered, granular or
crystalline material, With or without Vehicle.e.g: Aspirin, Paracetamol.
-
-
-
-
Advantages of tablets :
They can be carried easily, swallowed easily and also aesthetic in look.
Disagreeable taste can be cover up by sugar coating.
Simple to take when fraction dose required.
Tablets are produced on a large scale, hence economical.
5. - Multiple Compressed Tablets : These are compressed Tablets made more
than One compression cycle, These Tablets formed by compressing
additional Tablet Granulation on a prior compressed Granulation.
- Sustained action Tablets: These are the Tablets which release the Drug at
a Desired Time with Extend effect after oral administration. E.g.
Diclofenac SR Tablets.
6. - Sugar Coated Tablets: Tablets containing sugar coating to cover up bitter
Taste of drug.
- Enteric Coated Tablets: These are the Tablets to by-pass the stomach
and breakdown in the intestine only.
- Film coated Tablets: These tablets are film coated by polymers.
E.g.. Hydroxy propyl cellulose, hydroxyl propyl methyl cellulose and ethyl
Cellulose (Protect drug from atmospheric effects).
7. -
Tablets used in oral cavity:
Buccal Tablets: These Tablets placed in check side where they
dissolve Slowly absorbed in buccal cavity without passing alimentary
canal
E.g. progesterone tablets.
- Chewable tablets: These Tablets chewed and broken down between
teeth Before ingestion (for children) e.g. Antacid tablets, Digiene etc.
8. Lozenges Tablets: These tablets intent to perform local effect in mouth
or throat(for sore throat or coughing in cold)e.g. Vicks, lozenges,
Strepsils etc.
Sublingual tablets: These tablets placed under tongue where they
dissolve quickly And absorbed directly without passing GIT e.g.
Nitroglycerin.
9. -
Tablets administrated by other routes:
Implantation Tablets: These Tablets introduced subcutaneously by
minor surgery And slowly absorbed.
.
- Dental cones: These tablets are compressed tablets for placement on the
empty Sockets after tooth removal.(also having Anti Bacterial property).
10. -
Tablets used to prepare solution:
Effervescent Tablets: These Tablets containing sodium bicarbonate,
citric acid and tartaric acid which respond in regard of water release
carbon dioxide and Effervescence leading to decompose of
Tablet(ranitidine).
- Vaginal Tablets: These tablets intent to dissolve slowly in vaginal
cavity typically Ovid or peer shaped which can be inserted easily
11. Hypodermic Tablets: These are soft, easily soluble Tablets used for
the preparation of solution to be injected.
Dispensing Tablets: These Tablets Keep suitable quantity of potent drug
that can be converted into powder and integrate into liquids e.g. mild
silver potentiate, bichloride of mercury merbromin, and quaternary
ammonium compounds.
12. -
-
-
-
-
-
-
Excipient / Tablet ingredients:
Diluent
Binder and adhesive
Disintegrants
Lubricants and Glidants.
Colouring agents.
Flavouring agents.
Sweetening agents.
Tablet Triturates: These are powders moulded into tablets,
containing potent substance mixed with lactose, sucrose and
dextrose etc.
13. Binders and adhesive:
These agents used to Enhance cohesive properties to powdered material.
E.g. starch paste, liq. Glucose, Sucrose soln., Gelatin soln., Cellulose soln.
(Hydroxy propyl methyl cellulose), (poly vinyl pyrollidone).
Diluents:
These are used to make bulk of Tablets when drug is insufficient to produce
Bulk.
E.g. Lactose-anhydrous and spray dried lactose,
Directly compressed starch,
Calcium sulphate dihydrate,
Mannitol and sorbitol dextrose, sucrose.
-
-
Function of Excipients:
- It impart weight, accuracy and volume.
- It Enhance Solubility.
- It Increase Stability.
It Enhances Bioavailability.
To alter Drug Release.
14. Lubricant and Glidants:
These are used to prevent adhesion of tablets materials to the surface of dies
and Punches and smoothes ejection of tablets from the die cavity e.g. Stearic
acid, magnesium stearate .
While, Glidants are designed to encourage flow of granules or powder material
by decreasing the friction between particles. E.g. Corn starch 5-10% conc. Talc
5% conc.
Coloring agent:
It makes aesthetic look to the tablets and also helps to identify the product
during Preparation .(colorant acquired in form of dyes and lakes).
Disintegrants:
It is a substance added to tablet to ease its disintegration after
administration
In the GIT e.g. Starch, clays, cellulose, gums and cross-linked polymers
etc.
15. -
-
-
-
Formulation of Tablets:
1. Pulverization and mixing :in this different solid / powder
materials are reduced to same particle size, with the help of cutter
mill, Hammer Mill, Roller Mill and Fluid energy mill etc.
2. Granulation: In this the pulverized particles are made to cleave
to form large multi-Particle substance.(Range 0.2 to 4 mm.)
Objective of Granulation:
Enhance flow of powder.
To produce dust free formulation and steady mixture.
To improve compaction.
To avoid powder segregation.
Flavoring And Sweetness:
These are indented to chewable tablets or other tablets dissolve
in mouth.
e.g. Mannitol, Saccharin, Cyclamate, Asparmate
16. Step III: Mixing is done by using any one blender.
- Double cone blender - Planetary Mixer
- Ribbon Blender - V-blender
Step II: Weighing must be done in the clean area with suitable air
flow system to Avoid cross-contamination.
Step I: Milling of the drugs and vehicle, in this process active
ingredients and vehicle are milled To obtain homogeneity in the
final granulation.
1. Wet Granulation:
There are two types of Granulation:
17. Objective of wet Screening
- It Gain particle contact point.
- It Gain surface area to facilitate drying.
Step IV: Wet Massing: In this addition of binder soln. to Granules.
Method I Method II
Drug + Diluent Drug +Diluent
Dry Binder Is Added Binder solution is added
Blended Uniformly
Suitable Solvent is added to trigger the dry blender
Blended in sigma-mixer or planetary mixer till suitable
Wet mass is formed.
18. Step VII : Dry Screening:
In this granules are passed through mesh screen .
(Mesh size plays an important role)
-
It can be done by :
Tray dryers (24 hrs of drying)
- Fluid bed dryer(30 min of drying)
Step VI: Drying:
- It is carried out at 60 degree C ,Depending on
Thermo labile nature of drug.
- It is required for removal of solvent.
19. I.
II.
II. Dry Granulation:
This method follows in a situation when
Effective dose of drug is too high for direct compaction.
Drug is heat sensitive/Moisture sensitive or both.
Steps :
Milling > Weighing > Screening > Blending > Slugging > Granulation (dry)
> Lubrication > Compaction.
Step VIII: Lubrication of Granules:
In this lubricant is added as a fine powder and blended very gently
using Tumbling Action to maintain the uniform size granules.
Tablet Diameter Mesh Size
3/16” #20
3.5/16-5/16” #16
5.5/16-6.5/16” #14
20. Tablets Compression:
By tablet compression it can reduce the volume by applying
pressure re-arrangement
Die, resulting a closer packing structure, reduce space and inter
particulate friction
Gains.
-
-
-
Advantages of dry granulation over wet granulation:
No use of moisture.
Involves less steps and less time.
Less steps equals to less working space and energy.
-
-
Here, Slugging
Slug signify to inadequate tablets or may be compacted mass of
powdered material. And it is done for imparting cohesiveness to
ingredients.
It is done by :
High Capacity Heavy Duty Tablet Press
Chilsonator Roller Compactor.
21. 1.
2.
3.
Tablet machine output is controlled by three basics
No. of tooling sets.
No. of compression station.
Rotational speed of press.
However, Rotary press are designed for fast and economical
production of all kind of Tablets.
-
-
Advantages are as follows:
Much more faster than any other process.
Minimum number of steps required.
- Modifying diluents, binders etc are available in market which
ensure spherical shape.
- To modify flow property.
It is done by direct compression method:
Milling> weighing> sieving> Blending> Compression.
22. -
-
-
-
-
-
Tablet Coating:
Reason Behind Tablet Coating are
For cover up taste, color and odor of drug and make aesthetic
look.
Provide Physical handling.
Gives chemical protection from environment.
Control release of drug from tablet.
TYPES OF COATING:
1. Sugar coating
Sealing:
To prevent moisture enter into tablet core.
To strengthen the tablet core.
E.g. Alcoholic sol. Of shellac, Alcoholic sol. Of cellulose acetate
phthalate,
Alcoholic sol. of poly vinyl acetate phthalate.
23. -Polishing:
To bring the desired luster on the surface .
E.g. mixture of waxes (bees wax, carnauba wax, candella wax etc
-Printing:
For identify Sugar coating tables.
-Smoothing:
To cover and fill in the defect in the tablet surface occurred by sub-
coating step.
-Color coating:
To give an fine and uniform color .
-Sub-coating:
To round the edge and building up tablet size.
50%-100% weight increased by tablet.
24. - Pan-spray method:
In this method coating directly sprayed over Tablets from nozzles and
hot air passed
Through Tablets bed to dry it.
-
-
-
Film Coating:
It adds 2% to 5% of weight, Its complex process in which use of
thin (20-200 µm)
Polymer-based coatings to an suitable substrate under conditions.
Types of film coating
Pan-pour method.
Pan-spray method
Fluidized bed process.
- Pan-pour method:
In this viscosity materials directly added into the Rotating pan
moving with the
Tablets.
25. - Enteric materials:
Cellulose acetate phthalate
Acryl polymers
Poly vinyl acetate phthalate
Hydroxy propyl methyl cellulose phthalate.
- Non enteric materials:
Hydroxy propyl methyl cellulose
Ethyl cellulose
Poly pyrrilodone
Enteric coating:
It is done by three process:
1. Pan-pour tablets.
2. Pan-spray method.
3. Fluidized bed process.
- Fluidized bed process:
It is used for coating of tablets and capsules etc.