nanoparticle by shubham singh GLA university

1. NANOPARTICLE
Presented by:-
Shubham singh
(M.pharm)

2. 1. INTRODUCTION
2. ADVANTAGE
3. METHOD OF PREPARATION
4. EVALUATION
5. APPLICATIONS
2

3. INTRODUCTION
» DEFINITION:
» Nanoparticles are subnanosized colloidal drug delivery systems
» particle size ranges from 10-1000 nm in diameter.
» They are composed of synthetic or
semi synthetic polymers carrying drugs or
proteinaceous substances, i.e. antigen(s).
» Drugs are entrapped in the polymer matrix particulates or solid
solutions or may be bound to particle surface by physical
adsorption or in chemical form.

4. » Reduction in the frequency of the dosages
taken by the patient
» More uniform effect of thedrug
» Reduction of drug SideEffects
» Reduced fluctuation in circulating druglevels
» Avoids hepatic first passmetabolism

5. A : Cross Linking Methods
» 1) By Cross-linking of Amphiphilic Macromolecules
» 2) By Crosslinking in W/O Emulsion
» 3) By Emulsion chemical dehydration
» 4) By Phase Separation
» 5) By pH lnduced Aggregation
B : Polymerization Methods
» 1) Emulsion polymerization
» 2) Solvent evaporation method

6. Solvent Evaporation Method

7. PARAMETER METHOD
1) Particle size
spectroscopy
- Photon correlation
- Laser defractometry
- Scanning electron
microscopy
- Gel Chromatography2) Molecular weight
3) Charge determination
- Zeta potentiometer

8. 4) Density - Helium compression
pynometry
5) Crystallinity - X-ray diffraction &
Differential scanning
Calorimetry,
Thermogravimetry
6) Hydrophobicity - Hydrophobic
interaction,
Chromatography
7) Surface element analysis - X-ray, photon
electron

9. 1) Widely used in case of Cancer Therapy.
2) In lntracellular Targeting
3) Used for Prolonged Systemic Circulation.
4) As a Vaccine Adjuvant.
5) In Case of Ocular delivery.
6) Used in DNA Delivery.
7) It is used in case of Oligonucleotide delivery.
8) Enzyme immunoassays
9) Radio-imaging.
10) Tocross BBB.

10. » Targetted and controlled drug delivery by S.P. VYAS and
R.K. KHAR
» Jain N.K. “Advances in controlled and novel Drug Delivery”,
CBS publisher & Distributers, Edition 1st 2001, Pg. 408
» Nanotechnology in drug delivery - A Review, Indian Drugs,
Issue 11,november 2011.
» http://en.wikipedia.org/wiki/Nanoparticle
» http://www.pharmainfo.net/reviews/nanoparticles-review

11. 31