Including SMEDS &SNEDS

1.  Solid-lipid
nanoparticle
 Nano structure lipid
carrier
 Nanosuspension
 SMEDS/SNEDS
Presented by
Mr.Khillare Khillare
Madhav
B.Pharm Final year
Under the Guidenance
Ms.Tiwari S.Madam

2.  SOLID LIPID NANOPARTICLE
 NANOSTRUCTURE LIPID CARRIER
 NANOSUSPENSION
 SMEDS/SNEDS

3. INTRODUCTION
Solid lipid nanoparticle posses a solid
lipid core matrix that can solubilize liphophilic
molecule.
A solid lipid nanoparticle is typically spherical
with an avarage diameter between 10 to 1000
nm
SLN offer unique properties such as small size,
large surface area, high drug loading

4. Control and / or target drug release.
• Excellent biocompatibility.
• Easy to scale up and sterilize.
• Enhanced bioavailability
• Chemical protection of labile incorporated compounds.
• Improve stability of pharmaceutics.
Disadvantages of SLN
• Particle growth.
• Unpredictable gelation tendency.
• Unexpected dynamics of polymeric transitions

5. • Possibility of controlled drug release.
• Increased drug stability.
• High drug pay load.
• No bio-toxicity of the carrier.
• Avoidance of organic solvents.
• Incorporation of lipophilic and hydrophilic
drugs.
Preparation of solid lipid nanoparticles
SLNs are prepared from lipid, emulsifier
and water/solvent by using different methods

6.  A. Hot homogenization
 B. Cold homogenization
2. Ultrasonication/high speed homogenization
A. Probe ultrasonication
B. Bath ultrasonication
3. Solvent evaporation method
4. Solvent emulsification-diffusion method
5.Supercritical fluid method
6. Microemulsion based method
7. Spray drying method
8. Double emulsion method
9. Precipitation technique
10. Film-ultrasound dispersion

7. LIPID MATRIX - Beeswax Behenic acid
Caprilic /capric triglyceride
Cholesterol Steric acid
Solid paraffin
EMULSIFIERS - Phosphatidyl choline 95%
Soy & Egg lecithin
Poloxamer 407,188,
Cremophor EL, Polysorbate 80
CO-EMULSIFIER Tyloxopol ,Butanol, Sodium oleate
CRYOPROTECTANTS Trehalose, Glucose,Mannose,

8.  1.PARTICLE SIZE-
 2. Influence of the ingredients on product
quality
 3.Influence of the lipids
 4.Influence of the emulsifiers
APPLICATION OF SLN.
1.SLN as potential new adjuvant for vaccines
2. Solid lipid nanoparticles in cancer
chemotherapy
3.Solid lipid nanoparticles for delivering
peptides and proteins

9. 5. Solid lipid nanoparticles for parasitic
diseases
6. Solid lipid nanoparticles for ultrasonic drug
and gene delivery
7. SLN applications for improved delivery of
antiretroviral drugs to the brain
8. SLN applied to the treatent of malaria
9.Targeted delivery of solid lipid nanoparticles
for the treatment of lung disease
10. Solid lipid nanoparticles in tuberculosis
disease

10.  Nanostructured lipid carriers (NLCs) is being
explored present a relatively new type of
colloidal drug delivery system that consists of
solid lipid and liquid lipid, and offers the
advantage of improved drug loading capacity
and release properties .
 NLCs have the usual particle diameter ranging
10–1000 nm.

11. • Better physical stability
• Increased dispersability in an aqueous
medium
• High entrapment of lipophilic drugs and
hydrophilicdrugs
• Controlled particle size
• An advanced and efficient carrier system in
particular for substances
• Increase of skin occlusion
• Extended release of the drug

12. Three Types of Excipients used Nanostructure Lipid Carrier
 Lipid
 Water
 Emulsifier
1.Lipid-Both solid and liquid lipids are included in NLCs for
constructing the inner cores. The solid lipids commonly used
for NLCs include fatty acids (e.g. stearic acid), triglycerides (e.g.
tristearin), steroids (e.g. cholesterol), and waxes (e.g. cetyl
palmitate)
2.Emulsifiers-The emulsifiers have been used to stabilize the
lipid dispersions. Most of the investigations employ hydrophilic
emulsifiers such as Pluronic F68 (poloxamer 188), polysorbates
(Tween), polyvinyl alcohol, and sodium deoxycholate .
Lipophilic or amphiphilic emulsifiers such as Span 80

13. INGREDIENTS MATERIALS
SOLID LIPID Tristerin,stearic acid ,cetyl palmitate, cholesterol,
precirol,softisan,geliol
LIQUID LIPID Medium chain triglycerides,paraffin oil, 2-octyl
dodecanol
Oleic acid, squalene, isopropyl myristate, vitamin,
HYDROPHILIC EMULSIFIER Pluronic F68 (paloxamer188), tween 20,
tween40,tween60,
Polyvinyl alcohol,solutol,,trahalose, sodium
deoxycholate,
Sodium glycocholate, sodium oleat,polyglycerol
methyl distearate.
LIPOPHILIC EMULSIFIER Myverol, span 20,40,60
AMPHIPHILIC EMULSIFIER Egg lecithin,soya lecithin, phospatidylcholine,
phosphadylethanolamines
water used in all experiments was purified by reverse osmosis.

14.  1 High pressure homogenization
 2. Microemulsion technique
 3. Solvent emulsification-evaporation
technique
 3. Solvent emulsification-evaporation
technique
 5. Phase inversion temperature (PIT) method
 6. Melting dispersion method
 7.High Shear Homogenization or
Ultrasonication Technique
 8.Solvent injection (or solvent displacement)
technique

15.  Oral drug delivery system
 Topical drug delivery system
 Parentral drug delivery system
 Brain drug delivery system
 Pulmonary drug delivery system
 Cardiovascular treatment
 Intranasal drug delivery system
 Ocular drug delivery system
 Cancer chemotherapy
 Parasitic treatment
 Cosmetic application

16. Phrmaceutical nanosuspension finely colloid
biphasic dispersed and solid drug particle in
aqueous vehicle size below 1um without any
matrix material stabilised surfactant and
polymer
 Advantages of Nanosuspensions
 Can be applied for the poorly water soluble
drugs.
 Can be given by any route.
 Reduced tissue irritation in case of
subcutaneous/intramuscular administration.
 Rapid dissolution and tissue targeting can be
achieved by IV route of administration.

17.  The absorption from absorption window of the drugs can be
increased, due to reduction in the particle size.
 Higher bioavailability and more consistent dosing in case of
ocular administration and inhalation delivery.
 Drugs with high log P value can be formulated as
nanosuspensions to increase the bioavailability of such
drugs.
 Improvement in biological performance due to high
dissolution rate and saturation solubility of the drug.
 Ease of manufacture and little batch-to-batch variation.
 Long term physical stability (Due to absence of Ostwald
ripening).
 Nanosuspensions can be incorporated in tablets, pellets,
hydrogel and suppositories are suitable for various routes of
administration.
 Increasing the amorphous fraction in the particles, leading
to a potential change in the crystalline structure and higher
solubility.
 Possibility of surface-modification of nanosuspension for
site specific delivery

18.   Physical stability, sedimentation and
compaction can causes problems.
  It is bulky sufficient care must be taken during
handling and transport.
  Uniform and accurate dose cannot be achieved
unless suspension are in proper dose
PREPARATION OF NANOSUSPENSIONS
1)High pressure homogenization
2)Homogenisation in nonaqueous media
(nanopure)
3)Nanoedge
4)Lipid emulsion/microemulsion template
5)Media milling

19. 1)Stabilizer –Cellulosics, Poloxamers, Polysorbates,
Lecithin and Povidones.
2)Organic solvents-Partially water-miscible organic
solvents like glycols can be used as the internal phase
of the microemulsion when the nanosuspensions are
to be produced using a microemulsion as a template.
3)Surfactants -Surfactants are incorporated to improve
the dispersion by reducing the interfacial tension. They
also act as wetting or deflocculating agents e.g.
Tweens and Spans - widely used surfactants.
4)Co-surfactants-Transcutol, glycofurol, ethanol and
iso-propanol

20. 1)Oral Drug Delivery:
2)Parentral Drug Delivery:
3)Pulmonary Drug Delivery
4)Occular Drug Delivery
5)Targeted Drug Delivery
6)Mucoadhesion Of Nanoparticle