MAGNETIC MICROSPHERE

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  • Hai Dipak kumar dash
    This is NAGESH VANKADARA persuing M.pharmacy(pharmaceutics) really nice ppt n u know i am doing my project on this magnetic microspheres itself n i had completed preparation of magnetite in our lab n else wanna do microspheres n i just got a doubt of preparation methods Phase seperation emulsion polymerisation - the oil quantity is not mentioned clearly n u get me know abt it if u can u can msg me as u go thru this urgently.09399936268 .Meanwhile i am gng for another method
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MAGNETIC MICROSPHERE

  1. 1. DIPAK Kumar DASH<br />HIMALAYAN PHARMACY INSTITUTE,SIKKIM<br />M.PHARM <br />PHARMACEUTICS<br />
  2. 2. MAGNETIC MICROSPHERE<br />
  3. 3. INTRODUCTION<br /><ul><li>Microsphere are small in soluble spherical particle consisting of polymer matrix.
  4. 4. Particles size ranges from 50nm to 2mm
  5. 5. Magnetic microsphere use for drug targeting.</li></li></ul><li>4<br />
  6. 6. MAGNETIC MICROSPHERE<br /><ul><li>Magnetic microspheres are supramolecular particles that are small enough to circulate through capillaries without producing embolic occlusion but are (ferromagnetic) to be captured in micro vessels.
  7. 7. dragged in to the adjacent tissues by magnetic fields of 0.5-0.8 tesla (T) </li></li></ul><li>CONCEPT<br /><ul><li>The use of magnetic force for site-specific drug delivery by using albumin microspheres containing magnetite appears to be a promising strategy.
  8. 8. Significant improvements in response can be incorporated and obtained with magnetic albumin microspheres delivery system compared with conventional and nonmagnetic microspheres drug regimens.</li></li></ul><li>HISTORY OF MAGNETIC GUIDANCE<br /><ul><li>Tyle 1988
  9. 9. Earliest use of magnet for selective delivery of clinical agents involved treatment of arterial thrombosis by use of carbonyl iron.</li></li></ul><li>
  10. 10. MAGNETIC MICROSPHERE<br />9<br />
  11. 11. MAGNETITE<br /><ul><li>Magnetite a ferromagnetic materials when incorporated in to microspheres makes them magnetically responsive so that they can be concentrated to the desired site by applying </li></ul>some magnetic field.<br /><ul><li>Fe3O4</li></li></ul><li>
  12. 12. Alternating magnetic field<br />Ferromagnetic<br />microspheres<br />(20-30 mm)<br />Microsphere<br />Artery<br />Catheter<br />Tumor<br />Alternating magnetic field<br />12<br />
  13. 13. PREPARATION<br />There is mainly 2 method of microsphere preparation.<br />Phase separation emulsion polymerisation.<br />Continuous solvent evaporation.<br />
  14. 14. PHASE SEPARATION EMULSION POLYMERISATION <br />ALBUMIN+DRUG+MAGNETITE+VEGETABLE OIL<br /> SOLUTION<br />HEAT<br />SUSPENSION SEPARATED FROM OIL STORE AT 40C<br />
  15. 15. CONTINUOUS SOLVENT EVAPORATION<br />VOLATILE ORGANIC SOLVENT+POLYMER+DRUG+MAGNETITE<br />STIRRING<br />CENTRIFUGED AND MICROSPHERE SEPARATED AND STORED<br />
  16. 16. ANALYSIS OF MOVEMENT<br />16<br />
  17. 17. ADVANTAGES<br /><ul><li>It allows high local concentration of therapeutic agents.
  18. 18. Controlled drug release within target tissue for intervals of 30 min to 30 hour, as desired
  19. 19. Avoidance of drug toxicity
  20. 20. Adaptable to any part of the body</li></li></ul><li>Advance of magnetic microsphere<br />18<br />
  21. 21. <ul><li>Magnetic targeting is an expensive aspect.
  22. 22. Technical approach , manufacturing and quality control should be highly specialized.
  23. 23. Its needs specialized magnet for targeting & advance technique for monitoring.
  24. 24. Trained personnel to perform procedures. </li></ul>DISADVANTAGES<br />19<br />
  25. 25. APLICATION<br /><ul><li>It is use for drug targeting.
  26. 26. Magnetic fluid hyperthermia.
  27. 27. High throughput DNA isolation.
  28. 28. Improvement in drug release.</li></li></ul><li>
  29. 29. REFERENCES<br />Y.W. Chien, Concepts and system design for the rate-controlled drug delivery, Drug and pharmaceutical sciences, Marcel Dekker Inc. York, 2nd Edn. 50 (1992): pp. 1-139.<br />S.P. Vyas & R.K. Khar, Targeted and Controlled Drug Delivery.1st edn, CBS publisher & distributor New Delhi.<br />H.A. Lieberman, M.R. Martin & G.S. Banker, Pharmaceutical dosage forms: Disperse Systems vol-2.<br />American journal of pharmaceutical sciences.<br />www.dogpile.com<br />www.pubmed.com<br />

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