NANOPARTICLES : AN OVERVIEW BY : BHAVESH DADHEECH

1. NANOPARTICLES :
AN OVERVIEW
Submitted By:
BHAVESH DADHEECH
B. PHARMA PART-IV
(2018-2019)

2. PRESENTATION FOCUS
 INTRODUCTION
 IDEAL PROPERTIES OF NANOPARTICLES
 ADVANTAGES
 CLASSFICATION OF NANOPARTICLES
 METHODS OF PREPARATION
 POLYMER USED IN PREPARATION
 APPLICATION
 CONCULSION

3. INTRODUCTION
The prefix nano comes from the ancient Greek
vavoc through the Latin nanus meaning very small.
Nanoparticles are defined as particulate
dispersions or solid particles with a size in the range
of 1nm-100nm.
The drug dissolved, entrapped, encapsulated or
attached to a nanoparticle matrix.
.

4. NANOPARTICLES
 NANOCAPSULES : The nanocapsules are system in which the
drug is confined to a cavity surrounded by a unique polymer
membrane.
 NANOSPHERES : The nanospheres are matrix systems in
which the drug is physically and uniformly dispersed.

5. IDEAL PROPERTIES OF NANOPARTICLES
NECESSARY FOR DRUG DELIVERY
 Stable in blood
 Nontoxic
 Non-thrombogenic
 Non inflammatory
 Non-immunogenic
 Biodegradable

6. APPLICATION
 Nanoparticles in Ocular Delivery
 Nanoparticles for Brain Delivery
 Nanoparticles in Drug Delivery System
 Nanoparticles in Contraception
 Nanoparticles in Cardiac Treatment
 Adjuvant effect for Vaccines
 Nanoparticles in Inflammation

7. CLASSSIFICATION OF NANOPARTICLES
 1) On the basis of Dimension
 a) In One Dimensin (thin surface coating)
 b) In Two Dimension
 Carbon Nanotubes
 c) In Three Dimension
 Fullerenes (Carbon 60)
 2)On the basis of containig Metal
 a) QD unmodified
 b) QD modified
 c) Micelle
 d) Gold-Particles
 3) Novel Nanoparticles System
 a) SLN(solid lipid nanoparticles)
 b) CPP(co polymerized peptide nanoparticles)

8. METHODS OF PREPARATION OF NANOPATICLES
 1) Amphiphillic macromolecules cross linking
 a. Heat cross linking
 b. Chemical cross linking
 2) Polymerization based methods
 a. Dispersion Polymerization
 b. Emulsion Polymerization
 c. Interfacial Complexation
 d. Interfacial Condensation polymerization
 3) Polymer Precipitation Methods
 a. Salting out
 b. Solvent Evaporation / Extraction

9. POLYMER USED IN PREPARATION
 NATURAL HYDROPHILIC POLYMER
 PROTEINS POLYSACCHARIDES
 Gelatin Alginates
 Albumin Dextran
 Lectins Chitosan
 Legumin Agarose
 Vicilin Pullulan

10. ADVANTAGES
 Targeted Drug Delivery
 CR and SR of active drug can be achived
 Provide better patients compliances
 Capable of being stored the product upto 1 year
 Metal nanoparticles important in DNA detection
 LIMITATIONS
 The polymer of natural origin used in preparation of nanoparticles are suffer
some disadvantages
 Batch to batch variations
 Conditional biodegrability

11. CONCLUSION
 • The main goal of this review was to describle the
different preparation technique available for
production of polymeric nanoparticles.
 Nanoparticels is a vital part of novel drug delivery
systems .
 • The drug-loded nanospehere or nanocapsules
now can be produced by simple,safe and
reproducible techniques available.
 • The limitation like one particulae process or
technique is not suitable to all drugs,post prepartive
steps, such as purifaction and preservation .

12. THANK YOU