Newer drug delivery devices described in detail. Includes devices used for drug delivery exogenously or by implantation.

1. 1
Drug Delivery
Devices
Dr. Saurabh Patil
JR-1
Guide: Dr. Shruti Bhide
March 30, 2019

2. 2
Outline
1.Definition
2.Need
3.Devices
4.Development
5.Regulatory Scenario
6.Future Perspectives

3. 3
Drug Delivery Devices

4. 5
Drug Delivery Systems
vs
Drug Delivery Devices

5. 6
Drug Delivery Systems
vs
Drug Delivery Devices
engineered technologies
for the targeted delivery and/or controlled
release of
therapeutic agents
“
”

6. 7
Drug Delivery Systems
vs
Drug Delivery Devices
engineered technologies
for the targeted delivery and/or controlled
release of
therapeutic agents
formulation or a device
that enables the introduction of
a therapeutic substance
in the body
“
”
“
”

7. 8
Drug Delivery Systems
vs
Drug Delivery Devices
Medical
Devices

8. 9
Drug Delivery Systems
vs
Drug Delivery Devices
Medical
Devices
Drug
Delivery
Systems

9. 10
Drug Delivery Systems
vs
Drug Delivery Devices
Medical
Devices
Drug
Delivery
Systems

10. 11
Drug Delivery Systems
vs
Drug Delivery Devices
Medical
Devices
Drug
Delivery
Systems
Pumps
Syringes
Anesthesia
Machine
Stoma bag
Glucometer
Sphygmomanometer
Ventilator
Liposome
Nanoparticle
Erythrosome
Formulations
Carriers
Monoclonal
antibody
Biodegradable films

11. 12
Drug Delivery Systems
vs
Drug Delivery Devices
Medical
Devices
Drug
Delivery
Systems
Pumps
Syringes
Anesthesia
Machine
Stoma bag
Glucometer
Sphygmomanometer
Ventilator
Liposome
Nanoparticle
Erythrosome
Formulations
Carriers
Monoclonal
antibody
Biodegradable films
Drug
Delivery
Devices

12. 13
Need

13. 14
Need

14. 15
Need
First pass metabolism

15. 16
Need

16. 17
Need
Enzymatic Degradation

17. 18
Need
₹₹₹
Costly / Small quantities

18. 19
Need
₹₹₹
Targeted Delivery

19. 20
Need
Ease / efficiency of administration

20. 21
Need
Immediate reconstitution

21. 22
Need
Disability

22. 23
Device

23. 24
Device

24. 25
Device

25. 26
Device

26. 27
Device

27. 28
Problem Statement

28. 29
Nasal Spray

29. 37
Nasal Spray
Oxymetazoline Nasal congestion
Fluticasone Nasal congestion
Influenza Vaccine Flu
Fentanyl Pain
Esketamine Depression

30. 38
Problem Statement

31. 39
Transdermal Patch

32. 40
Transdermal Patch

33. 41
Transdermal Patch

34. 42
Transdermal Patch

35. 44
Transdermal Patch
Clonidine Hypertension
Nicotine Smoking Cessation
Fentanyl Pain
Selegiline Parkinson's disease
Rivastigmine Parkinson's disease and Alzheimer’s disease
Methylphenidate Attention Deficit Hyperactivity Disorder
Vitamin D Osteoporosis
Buprenorphine Smoking Cessation
Nitroglycerine Angina
Scopolamine Motion sickeness
Cannabinoids Pain
Estradiol Hormone replacement therapy

36. 46
Transdermal Implant

37. 47
Transdermal Implant

38. 48
Transdermal Implant

39. 49
Transdermal Implant
Testosterone Hormone Replacement Therapy
Itraconazole Systemic Fungal Infections
Estradiol Hormone Replacement Therapy
Repaglinide Diabetes Mellitus

40. 50
Problem Statement

41. 51
Wearable Pump

42. 52
Wearable Pump

43. 53
Wearable Pump
Insulin Diabetes Mellitus
Epinephrine Allergic Reaction / Anaphylaxis

44. 54
Problem Statement

45. 55
Drug eluting stent

46. 56
Drug eluting stent

47. 57
Drug eluting stent
Sirolimus
Tacrolimus
Everolimus
Leflunomide
Prednisolone
Dexamethasone
Interferon r-1b
Mycophenolic acid
Mizoribine
Cyclosporine
Coronary Stenting

48. 58
Problem Statement

49. 59
Ocular Inserts
L O
R

50. 60
Ocular Inserts

51. 61
Ocular Inserts

52. 62
Ocular Inserts

53. 63
Ocular Inserts

54. 64
Ocular Inserts

55. 65
Ocular Inserts - Retisert
Fluocinolone Chronic Noninfectious Uveitis
Ganciclovir Cytomegalovirus (CMV) Infection
Pilocarpine Glaucoma
Ciprofloxacin Conjunctivitis
Moxifloxacin Conjunctivitis
Cellulose Xerosis / Dryness of eyes

56. 66
Punctal Plugs

57. 67
Punctal Plugs
Travoprost Glaucoma

58. 68
Problem Statement

59. 69
Intracochlear diffuser

60. 70
Intracochlear diffuser

61. 71
Intracochlear diffuser
Neurotrophic factors Chemotherapy induced SNHL
Antibiotics Intracochlear infections

62. 72
E-cigarettes

63. 73
E-cigarettes

64. 74
E-cigarettes
Liquid Tetrahydrocannabinol
(THC)
Chemotherapy induced Pain
Nicotine Smoking Cessation

65. 79
Problem Statement

66. 80
Inhalers

67. 81
Inhalers
Metered
Dose
Inhaler

68. 82
Inhalers
Metered
Dose
Inhaler
Autohaler

69. 83
Inhalers
Metered
Dose
Inhaler
Diskhaler
Autohaler

70. 84
Inhalers
Metered
Dose
Inhaler
Autohaler
Diskhaler
Turbuhaler

71. 85
Inhalers

72. 86
Inhalers

73. 87
Problem Statement

74. 88
Uniject

75. 89
Uniject

76. 90
Uniject
Vaccines Tetanus
Oxytocin Postpartum Hemorrhage
Medroxyprogesterone
(DMPA-SC)
Contraception

77. 91
Problem Statement

78. 92
Jet injector

79. 93
Jet injector

80. 94
Jet injector
Vaccine
Smallpox
Influenza
Gene therapy Various

81. 95
Problem Statement

82. 96
Autoinjector

83. 97
Autoinjector

84. 98
Autoinjector
Darbapoetin alfa Chronic Kidney Disease
Epinephrine
Anaphylaxis
Nerve Agent Antidote
Interferon beta-1a Multiple Sclerosis

85. 99
Vaginal Ring

86. 10
0
Vaginal Ring

87. 101
Vaginal Ring
Etonogestrel
Ethinyl estradiol
Contraception

88. 102
Vaginal Sponge

89. 103
Vaginal Sponge
Nonoxynol-9
Benzalkonium chloride
Sodium Cholate
Lactic acid preparations
Spermicidal

90. 10
4
Problem Statement

91. 105
Ommaya Reservoir

92. 10
6
Ommaya Reservoir

93. 107
Ommaya Reservoir

94. 10
8
Ommaya Reservoir

95. 10
9
Ommaya Reservoir

96. 110
Ommaya Reservoir

97. 111
Ommaya Reservoir
Temozolomide
Carmustine
Lomustine
Cisplatin
Carboplatin
Etoposide
Irinotecan
Chemotherapy

98. 112
Intrathecal pump

99. 113
Intrathecal pump

100. 114
Intrathecal pump
Baclofen Spastic pain
Opioids Postoperative Pain

101. 115
Intrauterine devices

102. 116
Intrauterine devices
Levonergestrel
Progestogen
Contraception

103. 117
Intraperitoneal nebulizer

104. 118
Intraperitoneal nebulizer

105. 119
Intraperitoneal nebulizer
Ropivacaine Postoperative analgesia
Chemotherapeutic agents Intraperitoneal carcinomatosis

106. 120
Nanoneedle

107. 121
Nanoneedle

108. 122
Nanoneedle

109. 123
Infusion Pump

110. 124
Infusion Pump

111. 133
Development

112. 134
Development

113. 135
Development

114. 136
Development

115. 137
Regulatory Scenario
Not specific for medical devices Specific for medical devices
Nil 5 Step Process
No specific guidelines Device undergoes Clinical Trials
Closest term is
“medicated devices”
Includes all devices used for
medical purposes

116. 138
Future perspectives
Micro-Electro-Mechanical
Systems

117. 139
Future perspectives
Internet of
Things

118. 14
0
Future perspectives
Microfluidics

119. 141
Future perspectives
3D Printing

120. 142
Open House