The document discusses targeted drug delivery systems. It defines targeted drug delivery as selectively delivering a drug to a preselected target site in the body. There are several approaches for targeted delivery, including passive targeting using physiological properties and active targeting using ligands. An ideal targeted delivery system would selectively deliver the drug to the target cells and tissues while avoiding other areas to minimize side effects and maximize efficacy. The document provides examples of different targeting strategies and concludes that targeted delivery can help drugs reach the desired site more effectively to reduce dose and side effects.
Video Lecture is available at https://www.youtube.com/watch?v=DXu_CLgB4q0
Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and
biological properties of drugs relevant to controlled release formulations.
Video Lecture is available at https://www.youtube.com/watch?v=DXu_CLgB4q0
Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design-controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and
biological properties of drugs relevant to controlled release formulations.
Targeted Drug Delivery System achieves maximum bioavailability thus proving to be therapeutically efficacious & with minimal side effects. This presentation won the First Prize at MSBTE sponsored State Level Technical Paper
Presentation Competition, 2017.
Targeted or site specific DDS refers to systems that place the drug at or near the receptor site or site of action.
Is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others.
The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue.
The main objective of drug targeting is to achieve a desired pharmacological response by interacting only at a selected site with out undesirable interaction at other sites; and there by minimize side effects.
Various approaches to Targeted Drug Delivery Systems (TDDS) in its formuation and evaluation in a pharmaceutical industry and research is outlined in this presentation.
Brief description of targeted drug delivery system, along with its concept and strategies for drug targeting. Advantages and disadvantages of drug targeting
Need for drug targeting.
Targeted Drug Delivery System achieves maximum bioavailability thus proving to be therapeutically efficacious & with minimal side effects. This presentation won the First Prize at MSBTE sponsored State Level Technical Paper
Presentation Competition, 2017.
Targeted or site specific DDS refers to systems that place the drug at or near the receptor site or site of action.
Is a method of delivering medication to a patient in a manner that increases the concentration of the medication in some parts of the body relative to others.
The goal of a targeted drug delivery system is to prolong, localize, target and have a protected drug interaction with the diseased tissue.
The main objective of drug targeting is to achieve a desired pharmacological response by interacting only at a selected site with out undesirable interaction at other sites; and there by minimize side effects.
Various approaches to Targeted Drug Delivery Systems (TDDS) in its formuation and evaluation in a pharmaceutical industry and research is outlined in this presentation.
Brief description of targeted drug delivery system, along with its concept and strategies for drug targeting. Advantages and disadvantages of drug targeting
Need for drug targeting.
Targeted Drug Delivery Systems:
Targeted drug delivery systems (TDDS) are a revolutionary approach in medicine that aims to deliver medications directly to diseased cells or tissues, minimizing exposure to healthy parts of the body. This strategy offers numerous advantages over traditional drug delivery methods, including:
Reduced side effects: By minimizing drug exposure to healthy tissues, TDDS can significantly reduce the risk of adverse reactions and improve patient tolerability.
Increased efficacy: Delivering drugs directly to their target site allows for higher drug concentrations at the diseased area, potentially leading to improved treatment outcomes.
Enhanced specificity: TDDS can be designed to target specific biomarkers associated with diseases, offering greater precision and personalized treatment options.
Here's a closer look at the key components and mechanisms of TDDS:
Components:
Drug: The therapeutic agent encapsulated within the delivery system.
Carrier: A biocompatible material that encapsulates and protects the drug, facilitating its transport and release. Examples include liposomes, nanoparticles, and polymers.
Targeting moiety: A molecule attached to the carrier that specifically binds to receptors on the target cells or tissues, guiding the delivery system to its designated location. Antibodies, peptides, and aptamers are commonly used targeting moieties.
Mechanisms:
Passive targeting: Utilizes the natural properties of the carrier or targeting moiety to accumulate in the target area due to factors like size, charge, or permeability.
Active targeting: Employs specific interactions between the targeting moiety and receptors on the target cells, ensuring precise delivery.
Types of TDDS:
Liposomal drug delivery: Liposomes are microscopic bubbles made of phospholipids that can encapsulate drugs and deliver them to specific cells.
Polymeric nanoparticles: Nanoparticles made of biodegradable polymers can be designed to release drugs in a controlled manner at the target site.
Antibody-drug conjugates (ADCs): Antibodies are linked to cytotoxic drugs, allowing them to specifically target and kill cancer cells.
Aptamer-based drug delivery: Aptamers are short, single-stranded DNA or RNA molecules that can bind to specific targets with high affinity, guiding drug delivery.
Benefits of TDDS:
Improved treatment outcomes
Reduced side effects
Enhanced patient compliance
Personalized medicine options
Challenges of TDDS:
Complex design and development
Regulatory hurdles
Higher costs compared to traditional drugs
Future of TDDS:
Research in TDDS is rapidly advancing, with new technologies and targeting strategies emerging constantly. The future holds promise for even more precise and effective drug delivery systems, revolutionizing the treatment of various diseases.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
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Targeted drug delivery
1. TARGETED DRUG
DELIVERY SYSTEM
DEPARTMENT OF PHARMACEUTICS
AMRUTVAHINI COLLEGE OF PHARMACY
SANGAMNER MAHARASHTRA
PRESENTED BY;
MR. SHETE SHUBHAM KAILAS
F.Y.M.PHARM
1
2. CONTENTS
Introduction
Concept of drug targeting
Components used for drug targeting
Common approaches for drug targeting
Ideal properties of targeted drug delivery system
Mode of drug targeting
Conclusion
2
3. INTRODUCTION
The therapeutic response of a drug depends upon the
interaction of drug molecules with cell on cell membrane
related biological events at receptor sites in concentration
dependent manner.
It is apparent that most of disease treated by cytotoxic agents
not only demand for controlled drug delivery but also the
pattern of delivery is directed to be specified, precise and
defined at quantitative level.
Therefore, there was a need of developing such a system to
overcome the limitations related to the conventional dosage
form and improve the therapeutic efficacy of drug.
3
4. CONCEPT OF DRUG TARGETING
The concept of designing targeted drug delivery system
(TDDS) was first given by Paul Ehrlich in 1902.
An event, where a drug – carrier complex delivers a drug
exclusively to the preselected target cells in a specified
manner.
“Targeted drug delivery implies for selective and effective
localization of pharmacologically active moiety at
preselected targets in therapeutic concentration, while
restricting its access to non-target normal cellular linings,
thus minimizing toxic effects and maximizing therapeutic
index”.
4
5. 5
COMPONENTS OF DRUG TARGETING
• Specific organ or a cell
or a group of cells,
which in chronic or
acute condition need
treatment
TARGET
• Special molecules or system
essentially required for
effective transportation of
loaded drug up to the pre
selected sites.
CARRIERS
5
6. Need of Targeted Drug
Delivery System
Pharmaceutical
Reason
Low solubility
Drug instability
Pharmacokinetic
Reason
Poor absorption
Short half-life
Large Volume of
Distribution
Pharmacodynamic
Reason
Low specificity
Low therapeutic
index
6
7. APPROACHES FOR DRUG TARGETING
Controlling the distribution of drug by
incorporating it in a carrier
Altering the structure of the drug at molecular
level.
7
8. IDEAL PROPERTIES OF TDDS
Nontoxic, biocompatible and physiochemical stable in-vivo
and in-vitro.
Restrict drug distribution to target cells or tissue or organ.
Controllable and predictable rate of drug release.
Minimal drug leakage during transit.
Carrier used must be biodegradable or readily eliminated
from the body without any problem.
Its preparation should be easy or reasonably simple,
reproductive and cost effective.
8
9. ADVANTAGES
Reduced toxicity.
Bypass hepatic first pass metabolism.
Reduced dose and dosing intervals.
Enhancement of the absorption of target molecules such
as peptides and particulates.
9
10. DISADVANTAGES
Rapid clearance of targeted system.
Immune reactions against iv administered carrier system.
Diffusion and redistribution of released drug.
Drug deposition at the target site may produce toxicity
symptoms.
Difficult to maintain stability of dosage form.
10
12. PASSIVE TARGETING
•In Passive targeting, we make use of and modify the
physiochemical properties of the drug carrier complex, so
that it escapes body defence system and accumulate in the
target tissue.
•Passive process utilises the natural course of bio distribution
of the carrier system, through which it eventually accumulate
into the organ compartment of body.
•It refers to the system that targets the systemic circulation
i.e., targeting occurs because of body’s natural response to
the physiochemical characteristic of the drug or drug-carrier
system.
12
13. Few examples of passive targeting
1. The colloids which are taken up by the reticulo-endothelial
system (RES) can be ideal vector for passive targeting of drugs
to RES predominant compartments.
2.In case of cancer treatment the drug carrier complex can be
targeted to the tumour site by employing the Enhanced
permeability retention (EPS) effect.
3.Passive targeting may also be directed to lymphoid organs,
as these organs are finely structured and nanoparticles may
easily penetrate into lymphatic vessels.
13
14. ACTIVE TARGETING
•This type of targeting exploits modification or manipulation
of drug carrier . Natural distribution pattern of the drug
carrier composites is enhanced using the chemical,
biological and physical means.
•The ease of the binding of the drug-carrier to target cells
through the use of ligands or engineered homing devices
(antibodies, peptides, sugar &vitamins) to increase
localization of the drug and target specific delivery of drug
is referred to as active targeting.
•There are three levels of active targeting –
• first order (organ compartmentalization),
•second order (cellular targeting) and
•third order (intracellular targeting).
14
15. • Restricted distribution of drug carrier system to the capillary bed of
a predetermined target site, organ.
• Ex- Compartmental targeting in lymphatic, peritoneal cavity plural
cavity, cerebral ventricles etc.
FIRST
ORDER
• When the drug delivery system releases the drug into a
particular cell within an organ or tissue, it is called cellular
targeting.
• Ex- Selective drug delivery to kuppfer cells in the liver.
SECOND
ORDER
• When the delivery system can enter specific cells and leave the
drug intracellular, then it is called third order or sub cellular
targeting process.
• Ex- Receptor based ligand mediated entry of a drug complex into
a cell by endocytosis.
THIRD
ORDER
15
17. INVERSE TARGETING
•It is based on avoiding passive uptake of colloidal carriers by RES.
•It can be achieved by supressing the function of RES by pre-
injection of a large amount of blank colloidal carriers or
macromolecules like dextran sulphate.
•Alternative strategies include modification of size, surface
charges, composition, surface rigidity & hydrophilicity
characteristics of carriers for desirable biofate.
•For example- In 1985, Hansrami, reported that phospholipid
microsphere emulsified with polaxmer 338 (hydrophillic non-
ionic surfactant) showed the lowest RES uptake.
17
18. DUAL TARGETING
•This approach employs carrier molecules which
have their own intrinsic antiviral effect thus
synergies the antiviral effect of the loaded active
drug.
•Major advantage of the dual targeting is - virus
replication process can be attacked at multiple
points, excluding the possibilities of resistant viral
stain development.
18
19. COMBINATION TARGETING
The idea of combination targeting was
proposed in 1998, by Petit and Gombtz. It can be
given as site specific targeting for delivery of
protein and peptides.
These targeting systems are equipped with
carriers, polymers and homing devices of
molecular specificity that could provide a direct
approach to target site.
Modification of polymer with natural polymers
may alter their physical characteristics and favour
targeting the specific compartments, organs or
tissue within the vasculature.
19
20. CONCLUSION
•Targeted delivery assist the drug molecule to reach
preferably to the desired site.
• Reduction in dose and side effects of the drug.
•Particulate drug carriers get accumulated in the liver
cells due to their smaller size than blood capillaries.
•Among particulate drug carriers, liposomes are potential
•mode of delivery for the treatment of intracellular
infections
•Microparticles serve as future mode of delivery for oral
route especially proteins.
20
21. REFERENCE
“Targeted and Controlled drug delivery (Novel
carrier systems)”, S P Vyas and R K Khar, CBS
Publishers, page no: 40-67.
“Progress in Controlled and Novel drug delivery
Systems”, N K Jain, CBS publishers, page no: 365-
369.
21