Death and the maiden: predictions from multiple working hypotheses for the evolution of senescence

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Roy Moger-Reischer

Moger-Reischer RZ (2018) Indiana University Evolution Discussion Group. Bloomington, IN. Contributed talk.

Science

Death and the maiden: evaluating working
hypotheses for the evolution of senescence
Roy Z Moger-Reischer
rzmogerr@indiana.edu

Acknowledgements
• Jay Lennon, Brent Lehmkuhl,
Megan Behringer, Ken Locey,
Daniel Schwartz, Jordan Bird,
Will Shoemaker, Nathan
Wisnoski, Venus Kuo, Emmi
Mueller
• Danni Boylan, Betsy Snider,
Derek Hocker, Kelsey McKenzie,
JD French
• Farrah Bashey-Visser, Matt
Hahn, Leonie Moyle
• Katie Beidler, Ashwini Ramesh
• Daniel Schwab, Logan Cole,
Kevin Webster, Allan
Drummond, Jake McKinlay,
Megan Behringer, Soni Lacefield,
Brian Kennedy, Mark McCormick
• Curt Lively

log(lx) x
No senescenceSenescence
Evolution of senescence
• Background theory
• In the wild
• Laboratory experiments

log(lx)
x
No senescenceSenescence
Senescence is a problem for evolutionary biology.

log(lx)
x
No senescenceSenescence
Life-history theory
Senescence is a problem for evolutionary biology.

log(lx)
x
No senescenceSenescence
Life-history theory

Senescence
Q
Programmed aging:
Demographic stability theory

Senescence
Q
Programmed aging:
Demographic stability theory
Life-history theory

log(lx) x
No senescenceSenescence
Senescence is a problem for
evolutionary biology.
• Background theory
• In the wild
• Fitness costs of senescence;
reproductive senescence
• Red Maiden and molecular data
• Laboratory experiments

Senescence
π
Programmed aging:
Red Maiden theory

log(lx) x
No senescenceSenescence
Senescence is a problem for
evolutionary biology.
• Background theory
• In the wild
• Laboratory experiments

Mutant lifespan
Rateofadaptationtoacetate
Programmed aging:
Red Maiden theory

• Dietary restriction is a big deal in aging research.
• Dietary restriction suppresses senescence.
Evolution experiment #2

Dietary restriction and disposable
soma theory
Reproduction
Survival

Reproduction
Survival
Dietary restriction and disposable
soma theory

Dietary restriction
effect
Reproduction
Survival
Dietary restriction and disposable
soma theory

x
log(lx)
Demographic stability theory
Disposable soma theory
(assuming allocation tradeoffs)

log(lx) x
No senescenceSenescence
Senescence is a problem for evolutionary biology.
• Background theory
• Classical evolutionary ecology
• Challenges to dogma
• In the wild
• Fitness costs of senescence
• Molecular data
• Laboratory experiments
• Saccharomyces cerevisiae
• Lifespan mutants
• Dietary restriction

Death and the maiden: predictions from multiple working hypotheses for the evolution of senescence

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Death and the maiden: predictions from multiple working hypotheses for the evolution of senescence

1. Death and the maiden: evaluating working hypotheses for the evolution of senescence Roy Z Moger-Reischer rzmogerr@indiana.edu

2. Acknowledgements • Jay Lennon, Brent Lehmkuhl, Megan Behringer, Ken Locey, Daniel Schwartz, Jordan Bird, Will Shoemaker, Nathan Wisnoski, Venus Kuo, Emmi Mueller • Danni Boylan, Betsy Snider, Derek Hocker, Kelsey McKenzie, JD French • Farrah Bashey-Visser, Matt Hahn, Leonie Moyle • Katie Beidler, Ashwini Ramesh • Daniel Schwab, Logan Cole, Kevin Webster, Allan Drummond, Jake McKinlay, Megan Behringer, Soni Lacefield, Brian Kennedy, Mark McCormick • Curt Lively

3. log(lx) x No senescenceSenescence Evolution of senescence • Background theory • In the wild • Laboratory experiments

4. log(lx) x No senescenceSenescence Senescence is a problem for evolutionary biology.

5. log(lx) x No senescenceSenescence Life-history theory Senescence is a problem for evolutionary biology.

6. log(lx) x No senescenceSenescence Life-history theory

7. Senescence Q Life-history theory

8. Programmed aging theory

9. Senescence Q Programmed aging: Demographic stability theory

10. Senescence Q Programmed aging: Demographic stability theory Life-history theory

11. q0 x log(lx)

12. q0 x log(lx)

13. log(lx) x No senescenceSenescence Senescence is a problem for evolutionary biology. • Background theory • In the wild • Fitness costs of senescence; reproductive senescence • Red Maiden and molecular data • Laboratory experiments

14. log(lx) x No senescenceSenescence Senescence is a problem for evolutionary biology. • Background theory • In the wild • Fitness costs of senescence; reproductive senescence • Red Maiden and molecular data • Laboratory experiments

15. Senescence π Programmed aging: Red Maiden theory

16. Senescence π Programmed aging: Red Maiden theory

17. log(lx) x No senescenceSenescence Senescence is a problem for evolutionary biology. • Background theory • In the wild • Laboratory experiments

18. Mutant lifespan Rateofadaptationtoacetate Programmed aging: Red Maiden theory

19. • Dietary restriction is a big deal in aging research. • Dietary restriction suppresses senescence. Evolution experiment #2

20. x log(lx) Demographic stability theory

21. Dietary restriction and disposable soma theory Reproduction Survival

22. Reproduction Survival Dietary restriction and disposable soma theory

23. Dietary restriction effect Reproduction Survival Dietary restriction and disposable soma theory

24. x log(lx) Demographic stability theory Disposable soma theory (assuming allocation tradeoffs)

25. log(lx) x No senescenceSenescence Senescence is a problem for evolutionary biology. • Background theory • Classical evolutionary ecology • Challenges to dogma • In the wild • Fitness costs of senescence • Molecular data • Laboratory experiments • Saccharomyces cerevisiae • Lifespan mutants • Dietary restriction

Death and the maiden: predictions from multiple working hypotheses for the evolution of senescence

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