Transemulgel, a novel drug delivery system suitable for pain and inflammation related problems.

1. TRANSEMULGELS
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Prepared By:
Parul Nigam
Assistant Professor
Faculty of Pharmaceutical sciences
Rama University

2. Contents 1 • Introduction
2 • Release Profile
3 • Application of Gel on Skin
4 • Components of Gels
5 • Preparation of Gels
6 • Classification of gels
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• Gel forming Substances
8 • Advantages
9 • Disadvantages
10 • Properties of Gels
11 • Evaluation of Gels
12 • Marketed Preparation
13 • Conclusion
14 • References
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3. The USP defines gel as semisolid
system consisting of either suspension
of inorganic particles or organic
molecules within the liquid.
Gels tend to be smooth,
elegant, non greasy and
produce cooling effect and
utilize better drug release
as compared to other
semisolid formulation
Gels have better potential as a vehicle to administered drug
topically in comparison to ointment, because they are non-sticky
requires low energy during the formulation.
Introduction to Transemulgels:
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Conti….

4. Transemulgels are designed to deliver
a therapeutically effective amount of
drug across a patient’s skin
It is defined as non-solid dosage form
that produces a film after application
on the skin or any other body surface.
Gels have a higher aqueous component that
permits greater dissolution of drugs, and
also permit easier migration of the drug
through a vehicle that is essentially a
liquid, compared with the ointment or
cream bases.
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5. Fig.1 Release profile of the topical and transemulgels
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6. Application of Transemulgel
The film forming preparation can be applied to the site and can be retained for a
long time as compared to conventional semi-solid preparations.
(Fig.2) shows that gel forms almost completely transparent, fast drying film on
application.
It is a non-tacky, flexible and easily peelable film. There is an excellent adhesion
of the formed film to the skin.
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Fig.2 Formation of transparent film on human skin

7. Made up of four main components-
Component of Transemulgel
Drug
Solvent system
Volatile and Non-
volatile
Polymers
Penetration
Enhancers
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8. Preparation of Transemulgels
Weighed
polymer
Distilled
Water
After
dispersion,
sol is kept
for 24
Hours
API is
dissolved
Drug
solution
added
Homogeneous
transemulgel
obtained
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9. 1. On the basis of phase system:
Two phase system: The gel may consist of floccules of small molecules rather
than large molecules. The gel structure is not always stable in these systems.
These gels may be semi-solid on standing.
Single phase system:
2. On the basis of chemical nature:
Inorganic gel
Organic gel
Classification of gels
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3. On the basis of structure:
Physical gels: unstable at high temperature or in solvents.
Chemical gels: not tough due to uneven temperature.

10. Gel forming substances
Gel forming polymers are classified as follows:
1. Natural polymer
Proteins - Gelatin
Polysaccharides - Agar
2. Semisynthetic polymers
a. Cellulose derivatives - Methylcellulose
3. Synthetic polymers
Carbomer - Carbopol
4. Inorganic substances
Aluminium hydroxide
5. Surfactants 10

11. Dosing frequency
reduced
Equivalent
therapeutic effect
Less chance of
overdose
Suitable for old-aged, un
conscious patients
Increased patient
compliance
Advantages
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12. Disadvantages
Cause allergic
reaction
More than
10mg is not
possible
Poor
permeability of
some drugs
Itching
Possibility
of skin
irritation
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13. Desirable properties of gels
It should be inert, compatible with other additives and non-toxic.
It should be stable at storage condition.
It should be free from microbial contamination.
It should maintain all rheological properties of gel.
It should not affect biological nature of drug.
It should be washable with water and free from staining nature.
It should be convenient in handling and its application.
It should possess properties such as thixotropic, greaseless, emollient,
nonstaining etc.
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14. Evaluation of Gels
Clarity- Clarity of various formulation was determined by visual inspection under
black and white background and it was graded as follows: turbid ; clear ; very clear.
Spreadability- For the determination of spreadability, excess of sample was
applied in between two glass slides and then was compressed to uniform
thickness.
Surface pH - 2.5 gm of gel was accurately weighed and dispersed in 25ml of
distilled water. The pH of the dispersion was determined by using digital pH meter.
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15. Film flexibility- Film flexibility is evaluated on the basis of cracking and skin
fixation and this is determined by stretching the skin in 2–3 directions.
The film is rated flexible if there is no cracking or skin fixation and non-flexible if
there is cracking and skin fixation.
Drying time- For the evaluation of the drying time the formulation is applied to
the inner sides of the forearm of a volunteer.
•After a fixed time period a glass slide is placed on the film without pressure.
•If no liquid is visible on the glass slide after removal, the film is considered dry .
•If remains of the liquid are visible on the glass slide the experiment is repeated
with an increase in drying time.
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16. Marketed Preparations
Product Company
Lamisil Once Novartis Consumer Health, Australasia, Ltd
Axiron Lilly USA,
Medspray the Patch-in-a-Can MedPharm Ltd, UK
Liqui-Patch Epinamics GmbH, Germany
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17. These film forming systems are simple and offer advantages of transparency,
non-greasy, lower skin irritation, greater increased dosage flexibility,
improved patient compliance and aesthetic appearance.
Although considerable work has been done on these systems, not much data
are available on its delivery efficiency. Hence the marketed products
available are less.
Conclusion
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18. References
https://japer.in/storage/models/article/sDJwTFMMxWGpwG3ohmZS8IuCvhVg4K
JDAHSKOIQVecKA6ylMwCtauQLruPgz/formulation-and-evaluation-of-
diclofenac-transdermal-gel.pdf
https://curepharmaceutical.com/images/pdf/whitepapers/Film-forming-
transdermal-spray.pdf
https://pdfs.semanticscholar.org/49bf/4236d5da2b0fb562d0d4128dfd32da015c38.
pdf
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