Capsules Manufacturing Process,Capsule filling Process.

1. By ,
Mr. Nitin B.Londhe
JSPM’S Charak College of Pharmacy&
Research ,Wagholi, Pune.
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2.  capsules are tasteless & odorless.
 Masking of un-pleasant taste by enclosed in a
tasteless gelatin shell.
 Conveniently carried and Easy to handle .
 Can easily be administered orally.
 Attractive in appearance and Economical.
 More stable & have a longer shelf-life than
liquid forms.
 Compared with equivalent doses of a liquid
medication, capsules give accurate dosing.
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3.  solid dosage form
 the drug is enclosed within either a hard or soft
shell
◦ shell is typically made of gelatin
 primarily intended for oral delivery
 provide a rapid release of contents
Capsules are of 2 types
 1- Hard Gelatin Capsules
 2- Soft Gelatin Capsules
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4.  Hygroscopic drugs not suitable for filling into
capsules
 Hygroscopic drugs absorb water present in
capsule shell
 Shell very brittle & ultimately lead to crumble
into pieces.
 The concentrated solutions which require
dilution are unsuitable for capsules.
 Concentrated Solution if administered as such
lead to stomach irritation .
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5. protein, prepared from hydrolysis of collagen (animal
bones and skin)
◦ type A : pI = 7-9, pig skin
◦ type B : pI = 5, animal bones
possesses 4 essential properties
 stable when dry
 subject to microbial degradation when moist
 digested and absorbed
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6. contain 12 - 16 % moisture
typically filled with dry solids
◦ powders
◦ granules
◦ pellets
◦ tablets
also contain
◦ colorant
◦ preservatives
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SIZE VOLUME (cm3
)
000 1.37
00 0.95
0 0.68
1 0.50
2 0.37
3 0.30
4 0.21
5 0.13

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http://www.rjengineering.com/process.htm

8. operations involved
◦ rectification of empty capsules
◦ separation of caps from bodies
◦ filling capsule bodies
◦ replacing caps and ejecting filled capsules
3 basic methods for powder filling
◦ auger or screw
◦ dosator
◦ dosing disc
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9. ◦ auger
 semi-automatic operation
 filling based on volume
 need good powder flow properties
◦ dosator
 fill based on weight
 continuous operation
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10. ◦ dosing disc
 filled based on weight
 continuous operation
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11. factors which influence bioavailability
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12. Advantages
◦ tasteless and odorless
◦ swallowing is easy
◦ flexibility in formulating
◦ uniquely suitable for blinded clinical trials
◦ useful for extemporaneous compounding by
pharmacist
Disadvantages
◦ tend to be more expensive to produce than tablets
◦ not suitable for highly soluble salts
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13.  consist of a continuous gelatin shell surrounding a
liquid core
 formed, filled, and sealed in one operation
 shells are softened by addition of glycerin or
polyhydric alcohol (ex. sorbitol)
 oblong, spherical, elliptical in shape
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16. ADVANTAGES
◦ may contain liquids, suspensions, pastes
◦ rapid release of contents
◦ useful for drugs prone to oxidation
DISADVANTAGES
◦ have a greater tendency to adhere to each other
◦ more expensive
◦ increased possibility of interactions between drug
and shell
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