Erythropoiesis is the production of RBC in the bone marrow. The red blood cell starts out as a stem cell and then goes through several differentiations to become a red blood cell.

1. Class: 1st Year B.Optometry
College: ITM IHS (Panvel)
Subject: Physiology
Topic: Erythropoiesis
Presented By: Muskaan Ansari

2. Objectives
• Erythropoiesis
 Definition
 Site of Erythropoiesis
 Process of Erythropoiesis
 Changes during Erythropoiesis
 Factors affecting
Erythropoiesis

3. Erythropoiesis
• ‘’Erythropoiesis‘’ it is the process of
formation of RBC’s

4. IN
FETAL
LIFE
MESOBLASTIC
STAGE (upto 2
months)
HEPATIC STAGE
(3-6 months)
MYELOID STAGE
(last 3 months)

5. After Birth:
• After Birth (till 20yrs)
- All bones with red bone
marrow
• In adults (after 20yrs)
- Ends of long bones like
femur, humerus
- Skull
- Vertebra
- Ribs
- Sternum
- Pelvis

6. Process of Erythropoiesis
Stem cells are pluripotential cells
capable of self-renewal.

7. FIGURE: Stem cells. L = Lymphocyte, R = Red blood cell, N = Neutrophil,
B = Basophil, E = Eosinophil, M = Monocyte, P = Platelet.

8. Proerythroblast

9. Basophilic Erythroblast

10. Polychromatophil Erythroblast

11. Orthochromatic Erythroblast

12. Reticulocyte

13. Matured
Erythrocytes

15. FACTORS CLASSIFIED INTO 3 CATEGORIES
GENERAL
FACTORS
•HYPOXIA -
ERYTHROPOEITIN
•GROWTH
INDUCERS
•VITAMINS
MATURATION
FACTORS
•Vit.B 12
•FOLIC ACID
FACTORS
NECESSARY
FOR Hb
FORMATION
• FIRST CLASS
PROTEINS
•IRON,
MANGANESE,
COPPER 
• CALCIUM, BILE
SALTS, COBALT &
NICKLE

16. References
• ESSENTIALS OF MEDICAL
PHYSIOLOGY- Book by K. SEMBULINGAM
& PREMA SEMBULINGAM
• GOOGLE SEARCH ENGINE

17. Thank You!