HPV integration into host epithelial cell DNA can cause overexpression of E6 and E7 oncoproteins from high-risk HPV strains. E6 degrades p53 and activates telomerase while E7 binds and deactivates RB, inactivating cell cycle controls and inducing immortalization, excessive proliferation and genomic instability. EBV infects and stimulates proliferation of B lymphocytes and epithelial cells, potentially causing cancers like Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's lymphoma. HHV-8 infection is associated with Kaposi's sarcoma through viral oncoproteins like v-cyclin, v-IRF and LANA that increase host cell proliferation and survival.