The slide includes 1.Introduction to Disaster, 2.Disaster Impact and Response, 3.Relief Phase of Disaster, 4.Disaster Mitigation, 5.Disaster Preparedness 6.Personal Protection in different types of Disaster, 7.Man-made Disasters, 8. Policies concerned with disaster management 9.Worst Disasters in India 10. Organizations concerned with disaster management.
A total of 130+ slides will give a detailed idea of the disaster and its management.
DISASTER MANAGE-WPS Office-1.pptx PREPARED BY NEHA KEWATNehaKewat
Disaster nursing involves adapting professional nursing skills to meet the physical and emotional needs that arise from disasters. It aims to meet basic survival needs, identify secondary risks, assess resources and risks, promote equitable access to healthcare, empower survivors, respect diversity, and promote quality of life. Disasters are classified as natural or man-made, and the disaster management cycle includes mitigation, preparedness, response, and recovery phases before and after a disaster occurs.
The document outlines the topics that will be covered in a seminar on disaster management. The seminar will define disasters, types of disasters, epidemiology, principles and phases of disaster management. It will discuss disaster management committees, triaging, disaster nursing roles and qualities. The seminar aims to provide knowledge on disaster management that can be applied in clinical practice.
The document discusses student's knowledge on disaster medicine based on a study conducted in Albania. It provides an overview of disasters, disaster medicine, triage principles, and the disaster management cycle. The study assessed 100 medical students' familiarity with disaster medicine concepts through a questionnaire. It found that most students had little knowledge and no prior training in disaster medicine but were interested in attending relevant courses. Classroom and practical training were the preferred learning methods. The conclusions indicate a need to incorporate disaster medicine topics into medical curricula to better prepare future health professionals.
Disaster managemt and its classification (1).pptxMona22maurya
Disasters caused by human factors are called man-made disasters. They can be intentional like acts of terrorism or unintentional like industrial and technological accidents. Some major man-made disasters include the Bhopal gas tragedy, Chernobyl nuclear disaster, and wars which have caused widespread damage and loss of life. Preventing such disasters requires stricter regulations on hazardous facilities, proper siting of chemical plants away from cities, and measures to reduce human errors.
This document outlines the definition, phases, principles, and roles of nurses in disaster management. It defines disaster management as planning for and responding to disasters to minimize their impact. The phases include prevention/mitigation, preparedness, response, and recovery. Nurses play key roles in each phase, such as educating the public, responding to disasters, providing medical care, and assisting in rehabilitation. Triage is used to prioritize patient treatment based on severity of condition. The document provides an overview of the disaster management process.
Disaster management involves defining disasters and hazards, classifying disasters by scale and type, and establishing frameworks for preparedness, response, recovery and mitigation. It requires comprehensive, progressive, risk-driven, integrated and collaborative approaches. Key aspects include identifying risks, developing communication systems, coordinating response resources, educating the public, and conducting simulations. Response involves evacuation, search and rescue, medical aid, and triage. Recovery includes temporary shelters, infrastructure restoration and economic rehabilitation. Mitigation aims to permanently reduce disaster risks and impacts.
Disaster management involves mitigation, preparedness, response and recovery. A disaster is defined as an event causing damage that exceeds local capacity to respond. Disasters can be natural like earthquakes or human-caused like industrial accidents. Nurses play key roles in each phase of disaster management through community education, maintaining response plans, providing triage and medical care during events, and supporting long-term recovery through mental health services and environmental monitoring. Effective disaster management requires coordination between nurses, emergency responders, and social services to strengthen community resilience.
The slide includes 1.Introduction to Disaster, 2.Disaster Impact and Response, 3.Relief Phase of Disaster, 4.Disaster Mitigation, 5.Disaster Preparedness 6.Personal Protection in different types of Disaster, 7.Man-made Disasters, 8. Policies concerned with disaster management 9.Worst Disasters in India 10. Organizations concerned with disaster management.
A total of 130+ slides will give a detailed idea of the disaster and its management.
DISASTER MANAGE-WPS Office-1.pptx PREPARED BY NEHA KEWATNehaKewat
Disaster nursing involves adapting professional nursing skills to meet the physical and emotional needs that arise from disasters. It aims to meet basic survival needs, identify secondary risks, assess resources and risks, promote equitable access to healthcare, empower survivors, respect diversity, and promote quality of life. Disasters are classified as natural or man-made, and the disaster management cycle includes mitigation, preparedness, response, and recovery phases before and after a disaster occurs.
The document outlines the topics that will be covered in a seminar on disaster management. The seminar will define disasters, types of disasters, epidemiology, principles and phases of disaster management. It will discuss disaster management committees, triaging, disaster nursing roles and qualities. The seminar aims to provide knowledge on disaster management that can be applied in clinical practice.
The document discusses student's knowledge on disaster medicine based on a study conducted in Albania. It provides an overview of disasters, disaster medicine, triage principles, and the disaster management cycle. The study assessed 100 medical students' familiarity with disaster medicine concepts through a questionnaire. It found that most students had little knowledge and no prior training in disaster medicine but were interested in attending relevant courses. Classroom and practical training were the preferred learning methods. The conclusions indicate a need to incorporate disaster medicine topics into medical curricula to better prepare future health professionals.
Disaster managemt and its classification (1).pptxMona22maurya
Disasters caused by human factors are called man-made disasters. They can be intentional like acts of terrorism or unintentional like industrial and technological accidents. Some major man-made disasters include the Bhopal gas tragedy, Chernobyl nuclear disaster, and wars which have caused widespread damage and loss of life. Preventing such disasters requires stricter regulations on hazardous facilities, proper siting of chemical plants away from cities, and measures to reduce human errors.
This document outlines the definition, phases, principles, and roles of nurses in disaster management. It defines disaster management as planning for and responding to disasters to minimize their impact. The phases include prevention/mitigation, preparedness, response, and recovery. Nurses play key roles in each phase, such as educating the public, responding to disasters, providing medical care, and assisting in rehabilitation. Triage is used to prioritize patient treatment based on severity of condition. The document provides an overview of the disaster management process.
Disaster management involves defining disasters and hazards, classifying disasters by scale and type, and establishing frameworks for preparedness, response, recovery and mitigation. It requires comprehensive, progressive, risk-driven, integrated and collaborative approaches. Key aspects include identifying risks, developing communication systems, coordinating response resources, educating the public, and conducting simulations. Response involves evacuation, search and rescue, medical aid, and triage. Recovery includes temporary shelters, infrastructure restoration and economic rehabilitation. Mitigation aims to permanently reduce disaster risks and impacts.
Disaster management involves mitigation, preparedness, response and recovery. A disaster is defined as an event causing damage that exceeds local capacity to respond. Disasters can be natural like earthquakes or human-caused like industrial accidents. Nurses play key roles in each phase of disaster management through community education, maintaining response plans, providing triage and medical care during events, and supporting long-term recovery through mental health services and environmental monitoring. Effective disaster management requires coordination between nurses, emergency responders, and social services to strengthen community resilience.
This document discusses disaster management and the nurse's role. It defines a disaster as an event that causes damage, disruption or loss on a large scale. Disaster management aims to reduce vulnerability and cope with disasters through community planning. The document outlines major natural and man-made disasters and the principles of disaster management. It describes the phases of a disaster and the roles nurses play in mitigation, preparedness, response and recovery.
The document provides an overview of the scope of disaster management. It begins with definitions of key terms like disaster, hazard, vulnerability and discusses how vulnerability and hazards can interact to cause disasters. It then covers classification of disasters, phases of disaster management including preparedness, response, recovery and mitigation. Specific aspects of medical and public health response are also summarized. The document concludes with discussing India's vulnerability to various natural disasters.
This is an emergency management. this presentation is only for study purpose. it helps to improve the knowledge at the end of session. kindly share this presentations to others.
The document defines disaster and classifies disasters as either natural or human-made, with slow or rapid onset. It discusses disaster risk management, including mitigation, preparedness, response and recovery. The effects of disasters are described as both short-term and long-term impacts on health, social issues, economics and the environment. The roles and responsibilities of primary health care facilities in disaster preparedness and management are outlined, including forming teams, stocking supplies, and establishing triage protocols to prioritize victims.
Disaster (leadership and management) ppt.KhusbuLama
The document provides information on disaster management, including definitions and types of disasters. It discusses natural disasters like floods, earthquakes and volcanic eruptions, as well as man-made disasters such as industrial accidents and warfare. The document also outlines the process of disaster planning, consequences of disasters, and management of disasters at hospitals. It details the steps hospitals should take to prepare for disasters, such as forming emergency teams, establishing triage protocols, and stocking medical supplies. The response to disasters at hospitals includes activating plans upon victim arrival and coordinating care, documentation, and evaluation after the event.
Disaster preparedness & Management for Optometry.pptxHarsh Rastogi
Any occurrence that causes damage, ecological disruption, loss of human life, deterioration of health and health services on a scale, sufficient to warrant an extraordinary response from outside the affected community or area.
The body of policy and administrative decisions and operational activities that pertain to various stages of a disaster at all levels.
An applied science which seeks, by systemic observation and analysis of disasters, to improve measures relating to prevention, emergency response, recovery and mitigation.
Encompasses all aspects of planning for, and responding to disasters, including both pre and post disaster activities.
Disaster management involves a planned, systematic approach to understanding and addressing problems caused by disasters. While disasters cannot be prevented, their impacts can be minimized through appropriate planning and preparedness. Key issues in disaster management include communication, coordination, and control. Important aspects of pre-disaster management are prediction, prevention, planning, and preparedness. During a disaster, the critical issues are immediate response, rescue, relief, and rehabilitation efforts.
This document defines key terms related to disaster management and public health, describes the causes and phases of disasters, and explains concepts of emergency management. It defines terms like crisis, disaster, hazard, vulnerability, risk, and emergency. It discusses how development can increase vulnerability to disasters and explains the five phases of a disaster: pre-emergency, impact, acute, post-emergency, and repatriation/rehabilitation. The document also outlines the public health impacts of disasters and the four phases of emergency management: mitigation, preparedness, response, and recovery.
The document discusses disaster nursing, including defining disasters and their different types, the roles and principles of nursing during disasters, and the disaster management cycle of preparedness, response, recovery, and mitigation. It also covers triage, which is used to prioritize patients and efficiently allocate limited healthcare resources during mass casualty events.
The document provides information on disaster management. It defines disaster and differentiates between hazards and disasters. It describes different types of natural and man-made disasters and their impacts. The key principles of disaster management include prevention, preparedness, response, and recovery. The disaster management cycle involves these four phases. The document outlines the roles and responsibilities of nurses before, during, and after a disaster, which includes disaster preparedness, triage and management of casualties, and coordination of resources and staff.
Natural disasters, as well as some human-caused disasters, lead to human suffering and create needs that the victims cannot alleviate without assistance.
When any disaster strikes, a variety of international organizations offer relief to the affected country.
Each organization has different objectives, expertise, and resources to offer, and several hundred may become involved in a single major disaster.
In the event of a disaster, the government of the affected country must conduct a needs assessment to determine what emergency supplies and personnel are required.
Disaster relief operations are complex and can benefit greatly from careful planning.
Improved disaster preparedness can help save lives, reduce the suffering of survivors, and enable communities to restart normal life more quickly. As the efficiency of disaster relief operations is very dependent on the quality of the preparation,
Disasters often pose significant health threats. One of the most serious concerns after a disaster, especially a natural disaster, is sanitation.
Disruptions in water supplies and sewage systems can pose serious health risks to victims because they decrease the amount and quality of available drinking water and create difficulties in waste disposal.
Drinking water can be contaminated by breaks in sewage lines or the presence of animal cadavers in water sources.
These factors can facilitate the spread of disease after a disaster.
Providing potable drinking water to victims and adopting alternative methods of sanitation must be a priority after a disaster.
Food shortages are often an immediate health consequence of disasters. Existing food stocks may be destroyed or disruptions to distribution systems may prevent the delivery of food.
This may lead to malnutrition or death of hunger especially in populations which are particularly susceptible to malnutrition, such as children under five years of age and pregnant women.
Disaster Management in India and preventive measures .pptAnishKumar432050
Disaster management is how we deal with the human, material, economic or environmental impacts of said disaster, it is the process of how we “prepare for, respond to and learn from the effects of major failures”. Though often caused by nature, disasters can have human origins.
The National Disaster Management Authority has been constituted under the Disaster Management Act 2005, with the Prime Minister of India as its Chairman-; a Vice Chairman with the status of Cabinet Minister, and eight members with the status of Ministers of State.
This document discusses disaster management. It defines a disaster and notes that disasters can occur anywhere and at any time. There are three aspects of disaster management: preparedness, response, and mitigation. Preparedness involves evaluating risks and organizing communication systems. Response involves search and rescue, field care like triage which prioritizes patients, and relief efforts. Mitigation aims to reduce impacts through strategies like improved infrastructure and educating the public. The document outlines management strategies for different disaster types and emphasizes the importance of disaster management in minimizing impacts.
The document discusses the role of nurses in disaster nursing. It begins with defining disasters and categorizing them into natural disasters like hurricanes, floods, earthquakes, and man-made disasters like explosions, pollution, and terrorist attacks. It then outlines the phases of a disaster as pre-impact, impact, and post-impact. Key principles of disaster management are prevention, response, and recovery. The roles of nurses include assessing the community risk, developing disaster plans, implementing and evaluating those plans, and working with international aid organizations during disaster response and recovery efforts.
The document discusses key concepts related to emergency and disaster nursing including definitions of related terms, phases of disaster management, challenges to disaster planning, hospital emergency preparedness, and the role of nursing. It provides information on disasters, their effects, levels of disaster as defined by FEMA, and the national disaster risk reduction and management council in the Philippines. Details are given on hospital incident command systems, components of emergency operational plans, and initiating activation of plans.
Nurses play a key role in disaster preparedness, response, and recovery. They are often first responders who provide immediate medical care when disasters strike. Disaster nursing involves adapting nursing skills and knowledge to meet health needs with limited resources. Nurses must be competent in areas like emergency management, health promotion, and coordinating care with other providers. International standards help guide disaster nursing practice and competencies. Field hospitals can expand local healthcare capacity during disasters by providing early emergency care, follow-up treatment, and temporary medical facilities until damaged local infrastructure is repaired.
Disasters have negatively impacted human health and development since ancient times. This document discusses disaster nursing and management. It defines disasters, their classification, and their health effects. The goals of disaster nursing are to achieve the best health outcomes and meet survivors' basic needs. Disaster management involves preparing for, responding to, and recovering from emergencies through coordinated response efforts. Triage is critical to efficiently allocate limited healthcare resources to those with the most urgent needs during mass casualty events.
Everything you need to know about a disaster and their management. The slides start with an introduction of disaster their types, effects, and preventions to the initiatives taken by the government to manage reliefs and readiness.
characteristic of breast carcinomas .pptxMANJULRAJPUT1
This document summarizes the clinicopathologic characteristics and cathepsin K (CTSK) expression patterns in 45 salivary gland carcinoma (SGC) cases. The key findings are:
- CTSK expression was detected in carcinoma cells and sometimes stromal cells, but not normal salivary gland tissue. Metastatic SGC cells in lymph nodes were also CTSK-positive.
- 82.2% of cases showed positive CTSK expression, with 51.1% exhibiting strong expression. Higher CTSK expression correlated with higher histologic grade, larger tumor size, positive nodal involvement, distant metastasis, and recurrence.
- CTSK expression did not significantly differ
methods used to detect cancer cells .pptxMANJULRAJPUT1
This document describes the materials and methods used in a study of salivary gland carcinomas (SGCs). It details that 45 SGC cases were selected from hospital archives, including 33 high-grade and 12 low-grade SGCs based on WHO criteria. Patient data and 3-year survival outcomes were retrieved. Normal salivary gland tissue was used as a control. Tissue samples were analyzed using immunohistochemistry for Cathepsin K expression, with staining intensity and percentage of positive cells used to calculate scores to classify expression levels.
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This document discusses disaster management and the nurse's role. It defines a disaster as an event that causes damage, disruption or loss on a large scale. Disaster management aims to reduce vulnerability and cope with disasters through community planning. The document outlines major natural and man-made disasters and the principles of disaster management. It describes the phases of a disaster and the roles nurses play in mitigation, preparedness, response and recovery.
The document provides an overview of the scope of disaster management. It begins with definitions of key terms like disaster, hazard, vulnerability and discusses how vulnerability and hazards can interact to cause disasters. It then covers classification of disasters, phases of disaster management including preparedness, response, recovery and mitigation. Specific aspects of medical and public health response are also summarized. The document concludes with discussing India's vulnerability to various natural disasters.
This is an emergency management. this presentation is only for study purpose. it helps to improve the knowledge at the end of session. kindly share this presentations to others.
The document defines disaster and classifies disasters as either natural or human-made, with slow or rapid onset. It discusses disaster risk management, including mitigation, preparedness, response and recovery. The effects of disasters are described as both short-term and long-term impacts on health, social issues, economics and the environment. The roles and responsibilities of primary health care facilities in disaster preparedness and management are outlined, including forming teams, stocking supplies, and establishing triage protocols to prioritize victims.
Disaster (leadership and management) ppt.KhusbuLama
The document provides information on disaster management, including definitions and types of disasters. It discusses natural disasters like floods, earthquakes and volcanic eruptions, as well as man-made disasters such as industrial accidents and warfare. The document also outlines the process of disaster planning, consequences of disasters, and management of disasters at hospitals. It details the steps hospitals should take to prepare for disasters, such as forming emergency teams, establishing triage protocols, and stocking medical supplies. The response to disasters at hospitals includes activating plans upon victim arrival and coordinating care, documentation, and evaluation after the event.
Disaster preparedness & Management for Optometry.pptxHarsh Rastogi
Any occurrence that causes damage, ecological disruption, loss of human life, deterioration of health and health services on a scale, sufficient to warrant an extraordinary response from outside the affected community or area.
The body of policy and administrative decisions and operational activities that pertain to various stages of a disaster at all levels.
An applied science which seeks, by systemic observation and analysis of disasters, to improve measures relating to prevention, emergency response, recovery and mitigation.
Encompasses all aspects of planning for, and responding to disasters, including both pre and post disaster activities.
Disaster management involves a planned, systematic approach to understanding and addressing problems caused by disasters. While disasters cannot be prevented, their impacts can be minimized through appropriate planning and preparedness. Key issues in disaster management include communication, coordination, and control. Important aspects of pre-disaster management are prediction, prevention, planning, and preparedness. During a disaster, the critical issues are immediate response, rescue, relief, and rehabilitation efforts.
This document defines key terms related to disaster management and public health, describes the causes and phases of disasters, and explains concepts of emergency management. It defines terms like crisis, disaster, hazard, vulnerability, risk, and emergency. It discusses how development can increase vulnerability to disasters and explains the five phases of a disaster: pre-emergency, impact, acute, post-emergency, and repatriation/rehabilitation. The document also outlines the public health impacts of disasters and the four phases of emergency management: mitigation, preparedness, response, and recovery.
The document discusses disaster nursing, including defining disasters and their different types, the roles and principles of nursing during disasters, and the disaster management cycle of preparedness, response, recovery, and mitigation. It also covers triage, which is used to prioritize patients and efficiently allocate limited healthcare resources during mass casualty events.
The document provides information on disaster management. It defines disaster and differentiates between hazards and disasters. It describes different types of natural and man-made disasters and their impacts. The key principles of disaster management include prevention, preparedness, response, and recovery. The disaster management cycle involves these four phases. The document outlines the roles and responsibilities of nurses before, during, and after a disaster, which includes disaster preparedness, triage and management of casualties, and coordination of resources and staff.
Natural disasters, as well as some human-caused disasters, lead to human suffering and create needs that the victims cannot alleviate without assistance.
When any disaster strikes, a variety of international organizations offer relief to the affected country.
Each organization has different objectives, expertise, and resources to offer, and several hundred may become involved in a single major disaster.
In the event of a disaster, the government of the affected country must conduct a needs assessment to determine what emergency supplies and personnel are required.
Disaster relief operations are complex and can benefit greatly from careful planning.
Improved disaster preparedness can help save lives, reduce the suffering of survivors, and enable communities to restart normal life more quickly. As the efficiency of disaster relief operations is very dependent on the quality of the preparation,
Disasters often pose significant health threats. One of the most serious concerns after a disaster, especially a natural disaster, is sanitation.
Disruptions in water supplies and sewage systems can pose serious health risks to victims because they decrease the amount and quality of available drinking water and create difficulties in waste disposal.
Drinking water can be contaminated by breaks in sewage lines or the presence of animal cadavers in water sources.
These factors can facilitate the spread of disease after a disaster.
Providing potable drinking water to victims and adopting alternative methods of sanitation must be a priority after a disaster.
Food shortages are often an immediate health consequence of disasters. Existing food stocks may be destroyed or disruptions to distribution systems may prevent the delivery of food.
This may lead to malnutrition or death of hunger especially in populations which are particularly susceptible to malnutrition, such as children under five years of age and pregnant women.
Disaster Management in India and preventive measures .pptAnishKumar432050
Disaster management is how we deal with the human, material, economic or environmental impacts of said disaster, it is the process of how we “prepare for, respond to and learn from the effects of major failures”. Though often caused by nature, disasters can have human origins.
The National Disaster Management Authority has been constituted under the Disaster Management Act 2005, with the Prime Minister of India as its Chairman-; a Vice Chairman with the status of Cabinet Minister, and eight members with the status of Ministers of State.
This document discusses disaster management. It defines a disaster and notes that disasters can occur anywhere and at any time. There are three aspects of disaster management: preparedness, response, and mitigation. Preparedness involves evaluating risks and organizing communication systems. Response involves search and rescue, field care like triage which prioritizes patients, and relief efforts. Mitigation aims to reduce impacts through strategies like improved infrastructure and educating the public. The document outlines management strategies for different disaster types and emphasizes the importance of disaster management in minimizing impacts.
The document discusses the role of nurses in disaster nursing. It begins with defining disasters and categorizing them into natural disasters like hurricanes, floods, earthquakes, and man-made disasters like explosions, pollution, and terrorist attacks. It then outlines the phases of a disaster as pre-impact, impact, and post-impact. Key principles of disaster management are prevention, response, and recovery. The roles of nurses include assessing the community risk, developing disaster plans, implementing and evaluating those plans, and working with international aid organizations during disaster response and recovery efforts.
The document discusses key concepts related to emergency and disaster nursing including definitions of related terms, phases of disaster management, challenges to disaster planning, hospital emergency preparedness, and the role of nursing. It provides information on disasters, their effects, levels of disaster as defined by FEMA, and the national disaster risk reduction and management council in the Philippines. Details are given on hospital incident command systems, components of emergency operational plans, and initiating activation of plans.
Nurses play a key role in disaster preparedness, response, and recovery. They are often first responders who provide immediate medical care when disasters strike. Disaster nursing involves adapting nursing skills and knowledge to meet health needs with limited resources. Nurses must be competent in areas like emergency management, health promotion, and coordinating care with other providers. International standards help guide disaster nursing practice and competencies. Field hospitals can expand local healthcare capacity during disasters by providing early emergency care, follow-up treatment, and temporary medical facilities until damaged local infrastructure is repaired.
Disasters have negatively impacted human health and development since ancient times. This document discusses disaster nursing and management. It defines disasters, their classification, and their health effects. The goals of disaster nursing are to achieve the best health outcomes and meet survivors' basic needs. Disaster management involves preparing for, responding to, and recovering from emergencies through coordinated response efforts. Triage is critical to efficiently allocate limited healthcare resources to those with the most urgent needs during mass casualty events.
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characteristic of breast carcinomas .pptxMANJULRAJPUT1
This document summarizes the clinicopathologic characteristics and cathepsin K (CTSK) expression patterns in 45 salivary gland carcinoma (SGC) cases. The key findings are:
- CTSK expression was detected in carcinoma cells and sometimes stromal cells, but not normal salivary gland tissue. Metastatic SGC cells in lymph nodes were also CTSK-positive.
- 82.2% of cases showed positive CTSK expression, with 51.1% exhibiting strong expression. Higher CTSK expression correlated with higher histologic grade, larger tumor size, positive nodal involvement, distant metastasis, and recurrence.
- CTSK expression did not significantly differ
methods used to detect cancer cells .pptxMANJULRAJPUT1
This document describes the materials and methods used in a study of salivary gland carcinomas (SGCs). It details that 45 SGC cases were selected from hospital archives, including 33 high-grade and 12 low-grade SGCs based on WHO criteria. Patient data and 3-year survival outcomes were retrieved. Normal salivary gland tissue was used as a control. Tissue samples were analyzed using immunohistochemistry for Cathepsin K expression, with staining intensity and percentage of positive cells used to calculate scores to classify expression levels.
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Salivary gland carcinomas (SGCs) are a diverse group of tumors that are difficult to classify and treat due to their varying clinical characteristics, morphologies, and unexpected prognoses. Mucoepidermoid carcinoma and adenoid cystic carcinoma are the most common SGCs. Certain factors like histology, patient age, metastasis, and local invasion influence the prognosis of malignant salivary gland tumors. Generally, children have better prognoses than adults for SGCs. Distant metastasis is a major cause of death for SGC patients.
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This document discusses two types of antibodies - polyclonal and monoclonal - used for antigen retrieval. It also provides recipes for making different antigen retrieval buffers, including TRIS-EDTA buffer at pH 9.0, EDTA buffer at pH 8.0, and Citrate buffer at pH 6.0. Finally, it mentions a Tris buffered saline solution for washing at pH 7.4 and lists some advantages and disadvantages of antigen retrieval.
This document discusses the expression of CD44 in minimal change nephrotic syndrome (MCNS) and focal segmental glomerulosclerosis (FSGS) and its association with clinical and histopathological prognostic factors. It finds that CD44 positivity correlates with lower estimated GFR and higher serum creatinine, both poor prognostic signs. It also associates CD44 positivity with segmental sclerosis and tubular atrophy/interstitial fibrosis. While CD44 positivity makes it a sensitive marker for FSGS, it is also detected in some cases of MCNS, suggesting a continuum between the two.
This document describes a study comparing primary focal segmental glomerulosclerosis (FSGS) and minimal change nephrotic syndrome (MCNS). The study included 30 patients with biopsy-proven MCNS and 30 with FSGS. Histological and immunohistochemical analysis was performed on biopsy samples to examine differences between the two conditions. Immunohistochemical staining for CD44 was evaluated as a potential marker to distinguish FSGS from MCNS, as CD44 marks activated parietal epithelial cells that may be present in FSGS but not MCNS. The results were analyzed to compare demographic, clinical, laboratory, histopathological and immunohistochemical findings between MCNS and FSGS.
Immunohistochemistry is a technique that uses antibodies to identify antigens in cells and tissues. It works by binding antibodies, which are highly specific serum proteins, to antigens in the tissue. This binding is then identified either directly by labeling the antibody or through a secondary labeling method. It is used to study antigen expression, antigen status of cells, and antigen location in tissues. Antibodies are produced against antigens, which are molecules that induce antibody formation. There are two main types of antibodies used: polyclonal antibodies which are a heterogeneous mixture, and monoclonal antibodies which are a homogeneous population against a single epitope. Labels like enzymes, metals, fluorescent dyes or radioisotopes are used to identify the antigen-antibody complex
This document provides information on common antibody markers used in immunohistochemistry, including their typical applications and staining characteristics. It lists several antibodies and their targets, such as Bcl-2 for follicular lymphoma staining cytoplasm, CD3 for T-cells staining membrane, and CD68 staining monocyte/macrophage lineage cells with diffuse or granular cytoplasmic staining. Finally, it provides a brief overview of the purposes of tissue fixation in immunohistochemistry.
The immunohistochemistry protocol involves sectioning tissue samples onto slides, deparaffinizing the slides using xylene and ethanol, performing antigen retrieval in a retrieval buffer in a decloaking chamber, blocking peroxidase activity and washing in TBS buffer, incubating with primary and secondary antibodies, staining with hematoxylin and DAB chromogen, dehydrating and mounting the slides for microscopic examination.
This document discusses tissue preparation for immunohistochemistry (IHC). It covers the following key points:
1. Formalin-fixed paraffin-embedded tissue is most commonly used for IHC due to its preservation of tissue architecture during routine histology. However, some antigens do not survive this process so frozen sections are also used.
2. Proper fixation is important to prevent elution, degradation, and modification of antigens while preserving tissue structure. Formalin is the preferred fixative.
3. Paraffin wax embedding allows sectioning of tissue for staining but can mask some antigens, so antigen retrieval methods like heat-induced epitope retrieval are used to uncover hidden sites.
The document discusses several immunohistochemistry (IHC) methods: direct method, indirect method, polymer chain two step indirect technique, PAP method, ABC method, and LSAB method. The polymer chain two step indirect technique uses an unlabeled primary antibody followed by a secondary antibody conjugated to an enzyme-labeled polymer chain with many enzyme and antibody molecules attached, providing great sensitivity without using biotin. This technique is now commonly used in diagnostic applications due to being quick, reliable, reproducible and offering high sensitivity.
HTLV-1 is a retrovirus that infects T-cells and can cause adult T-cell leukemia/lymphoma (ATLL). It is endemic in parts of Japan, the Caribbean, South America, and Africa. Worldwide, 15 to 20 million people are infected. HTLV-1 is transmitted sexually, through blood products, or breastfeeding. Only 3-5% of those infected develop leukemia, typically after a long latent period of 40-60 years. The virus has tropism for CD4+ T-cells and the TAX and HBZ viral proteins interact with host cell genes and pathways to stimulate proliferation and inhibit tumor suppression, eventually leading to monoclonal proliferation and leukemia.
HTLV-1 is a retrovirus that infects T-cells and can cause adult T-cell leukemia/lymphoma (ATLL). It is endemic in parts of Japan, the Caribbean, South America, and Africa. Worldwide, 15 to 20 million people are infected. HTLV-1 is transmitted sexually, through blood products, or breastfeeding. Only 3-5% of those infected develop leukemia, typically after a long latent period of 40-60 years. The virus has tropism for CD4+ T-cells and the TAX and HBZ viral proteins interact with host cell genes and pathways to stimulate proliferation and inhibit tumor suppression, eventually leading to monoclonal proliferation and leukemia.
An antigen is a molecule that induces antibody formation and contains antibody binding sites known as epitopes. Antibodies, also called immunoglobulins, are serum proteins found in blood and tissues that recognize and bind to specific antigens. The basic unit of an antibody is a monomer composed of two heavy and two light chains that can assemble into multimeric structures. IgG is the most common antibody type used for immunohistochemistry and binds specifically to antigen epitopes through highly targeted antibody binding sites.
The Epstein-Barr virus (EBV) is a double-stranded DNA virus that infects human B-lymphocytes and epithelial cells. EBV has been implicated in several human cancers such as Burkitt lymphoma, nasopharyngeal carcinoma, post-transplant lymphoproliferative disease, and Hodgkin lymphoma. EBV is transmitted orally through saliva and can also spread through blood or transplanted organs. It evades the immune system and causes cells to proliferate uncontrollably, leading to cancer development. Diagnosis involves antibody testing for EBV, while prevention focuses on avoiding contact with saliva and maintaining clean conditions.
HPV is a small, non-enveloped virus with double-stranded DNA and an icosahedral capsid containing two structural proteins, L1 and L2. High risk HPV types 16 and 18 can cause cervical cancer by integrating their DNA into host cells and overexpressing the E6 and E7 oncoproteins, which inactivate tumor suppressors and promote cell cycle progression. HPV is transmitted through skin-to-skin contact and causes genital warts, cervical cancer, and other anogenital cancers but often has no visible symptoms for years.
HPV integration into host epithelial cell DNA can cause overexpression of E6 and E7 oncoproteins from high-risk HPV strains. E6 degrades p53 and activates telomerase while E7 binds and deactivates RB, inactivating cell cycle controls and inducing immortalization, excessive proliferation and genomic instability. EBV infects and stimulates proliferation of B lymphocytes and epithelial cells, potentially causing cancers like Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's lymphoma. HHV-8 infection is associated with Kaposi's sarcoma through overexpression of latency proteins like v-cyclin and LANA that increase host cell proliferation and survival.
HPV integration into host epithelial cell DNA can cause overexpression of E6 and E7 oncoproteins from high-risk HPV strains. E6 degrades p53 and activates telomerase while E7 binds and deactivates RB, inactivating cell cycle controls and inducing immortalization, excessive proliferation and genomic instability. EBV infects and stimulates proliferation of B lymphocytes and epithelial cells, potentially causing cancers like Burkitt's lymphoma, nasopharyngeal carcinoma, and Hodgkin's lymphoma. HHV-8 infection is associated with Kaposi's sarcoma through viral oncoproteins like v-cyclin, v-IRF and LANA that increase host cell proliferation and survival.
Chronic inflammation is a prolonged inflammatory response that can last for weeks or months. It can occur following acute inflammation that does not fully resolve, from recurrent acute inflammatory attacks, or beginning as chronic from the start. Chronic inflammation involves lymphocytes, plasma cells, macrophages and sometimes foreign body or Langhans giant cells. It can cause fibrosis, calcification, and elevated markers like ESR. Diseases marked by granulomatous inflammation include tuberculosis, leprosy, syphilis, cat scratch disease, sarcoidosis, and Crohn's disease.
This document summarizes different viruses that are associated with cancer development in humans and other hosts. It discusses RNA and DNA oncogenic viruses, including acute and slow transforming retroviruses, papillomaviruses, herpesviruses, adenoviruses, poxyviruses, and hepadnaviruses. Some of the key viruses and cancers mentioned are human papillomavirus causing cervical, genital, and head/neck cancers; Epstein-Barr virus linked to lymphomas and nasopharyngeal carcinoma; hepatitis B and C viruses associated with hepatocellular carcinoma; and human T-cell lymphotropic virus type 1 related to adult T-cell leukemia/lymphoma.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Cell Therapy Expansion and Challenges in Autoimmune DiseaseHealth Advances
There is increasing confidence that cell therapies will soon play a role in the treatment of autoimmune disorders, but the extent of this impact remains to be seen. Early readouts on autologous CAR-Ts in lupus are encouraging, but manufacturing and cost limitations are likely to restrict access to highly refractory patients. Allogeneic CAR-Ts have the potential to broaden access to earlier lines of treatment due to their inherent cost benefits, however they will need to demonstrate comparable or improved efficacy to established modalities.
In addition to infrastructure and capacity constraints, CAR-Ts face a very different risk-benefit dynamic in autoimmune compared to oncology, highlighting the need for tolerable therapies with low adverse event risk. CAR-NK and Treg-based therapies are also being developed in certain autoimmune disorders and may demonstrate favorable safety profiles. Several novel non-cell therapies such as bispecific antibodies, nanobodies, and RNAi drugs, may also offer future alternative competitive solutions with variable value propositions.
Widespread adoption of cell therapies will not only require strong efficacy and safety data, but also adapted pricing and access strategies. At oncology-based price points, CAR-Ts are unlikely to achieve broad market access in autoimmune disorders, with eligible patient populations that are potentially orders of magnitude greater than the number of currently addressable cancer patients. Developers have made strides towards reducing cell therapy COGS while improving manufacturing efficiency, but payors will inevitably restrict access until more sustainable pricing is achieved.
Despite these headwinds, industry leaders and investors remain confident that cell therapies are poised to address significant unmet need in patients suffering from autoimmune disorders. However, the extent of this impact on the treatment landscape remains to be seen, as the industry rapidly approaches an inflection point.
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Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
2. “Humans are good at creating
disasters, and throughout history
we’ve rarely been afraid to prove it”.
3. DEFINITION :
•Man-made disasters are the threats
having an element of human intent,
negligence, or error ; or involving a
failure of a human-made system.
•Human causation may be accidental
or intentional
4. TYPES OF MAN MADE DISASTERS
• Sudden disasters : such as Chernobyl disaster and Bhopal
gas tragedy,
Insidious disasters : Chemical and radiation exposure,
global warming
5. SOCIOLOGICAL HAZARDS
• Terrorism : The primary objective of a terrorism is to create widespread fear.
• E.g. : On 11 September 2001 the World Trade Centre in New York City was
destroyed by crashing American airlines and killed 2,752.
6. WORST DISASTERS IN INDIA
Bhopal Gas Tragedy :1984
• Worlds worst man made disaster in which methyl isocyanate gas
was leaked at Union Carbide Pesticide Plant
• More than 20,000 people have been killed till date
• Today, in Bhopal 1,20,000 people are suffering from chronic diseases
like Emphysema, Cancer etc.
7. INDIA’S VULNERABILITY TO DISASTERS :
• 57% land is vulnerable to earthquakes. Of these, 12% is vulnerable to severe earthquakes.
• 68% land is vulnerable to drought.
• 12% land is vulnerable to floods.
• 8% land is vulnerable to cyclones.
• Apart from natural disasters, some cities in India are also vulnerable to chemical and industrial disasters and man-made disasters.
• Northern mountain region prone to land slides, snow–storms , earthquakes
• Eastern coastal area prone to severe floods ,cyclones
• Western desert prone to draughts
9. WHO WILL WORK ?
• Usually military force, police, BSF, volunteers from other region.
• Disaster management is a specialised training & is provided by
local, state, federal and private organizations.
• Undergraduate and Graduate degrees in disaster management or
a related field are provided. (Disaster Management Institute, Bhopal, M.P and Disaster
Mitigation Institute, Ahmadabad, Gujarat).
• Certified Emergency Manager (CEM) the most important degree.
The National Emergency Management Association and the
International Association of Emergency Managers are two examples
of these professional organizations.
10. PRINCIPLES OF DISASTER MANAGEMENT
• Comprehensive – disaster managers consider and take into account all hazards,
all phases, and all impacts relevant to disasters.
• Progressive – anticipate future disasters and take preventive and preparatory
measures
• Risk-driven – use sound risk management principles (hazard identification, risk
analysis, and impact analysis) in assigning priorities and resources.
• Integrated – ensure unity of effort among all levels of government and all
elements of a community.
11. CONTD...
• Collaborative – create and sustain broad and sincere relationships among
individuals and organizations .
• Coordinated – synchronize the activities to achieve a common purpose.
• Flexible – use creative and innovative approaches in solving disaster challenges.
• Professional – value a science and knowledge-based approach for continuous
improvement.
14. ORGANIZATIONS IN INDIA :
FOR INFORMATION ON DISASTERS DIAL TOLL FREE No.
1070
Log on to http://www.ndmindia.nic.in
15. VOLUNTEERS :
THEY FORM AN IMPORTANT NON-PROFESSIONAL SUPPORTING TEAM IN DISASTER
MANAGEMENT.
16. IMPACT & RESPONSE :
• Greatest need for emergency care is in 1st few hours after the impact.
• The management of mass casualties are divided into :
Search and Rescue
First Aid
Field care
Triage
Tagging
17. SEARCH AND RESCUE & FIRST-AID :
• For search and rescue the team should be organised and
work as one. Even with a good team the search may be a
small fraction in major disasters.
• The immediate help is usually obtained from the uninjured
survivors.
18. FIELD CARE :
• The injured people are brought to nearest health care immediately by available means of
transport and people converge into health facilities.
• The hospitals must get ready to deal with mass input of injured with new priorities for bed
availability and surgical services.
• Provision for food, shelter should be done.
• A centre to respond for the enquiries from patient’s relatives and friends.
• Priority is given to :
a. victims identification and
b. adequate mortuary space.
19. TRIAGE :
• It consists of rapidly classifying the injured on the basis of the severity of their
injuries and their likelyhood of their survival with prompt medical intervention.
• The principle of “First come, first serve” is NOT FOLLOWED.
• High priority is given to those whose immediate or long term prognosis can be
changed dramatically with simple intensive care.
• It is the only approach that can provide maximum benefit to large population in a
major disaster.
20. COLOUR CODING IN A TRIAGE :
Internationally
accepted four
colour coding
system :
• Red – High priority
treatment or
transfer.
• Yellow – Medium
priority.
• Green –
Ambulatory
patients.
• Black – Dead or
Moribound
patients.
Triage should be carried out
at the site of the disaster.
Local health workers should
be taught the principles of
triage as a part of disaster
training.
People with minor injuries
should be treated in their
homes to avoid social
dislocation and drain the
resources which are needed
by severely injured person.
All persons should be
tagged with details – name,
age, place of origin, triage,
initial diagnosis and