The document discusses drug interactions, defining them as interactions between drugs, foods, chemicals, laboratory tests, or diseases. It identifies the main types of interactions as drug-drug, food-drug, chemical-drug, drug laboratory test, and drug disease. The document also outlines the factors that can contribute to drug interactions, such as multiple drug therapy, multiple prescribers, the pharmacological effects and diseases of the patient. It describes the mechanisms of drug interactions as pharmaceutical, pharmacokinetic involving absorption, distribution, metabolism and excretion, and pharmacodynamic involving direct and indirect interactions. Finally, it notes interactions can be minor, moderate or major in their effects on the patient.

1. DRUG INTERACTIONS
Presented by : Khevana Joshi and Dhruv Kadia
Guided by : Prof. Kaushika Patel

2. INTRODUCTION:
Definition
Types of drug interaction
 Drug – Drug interaction
 Food drug interaction
 Chemical drug interaction
 Drug laboratory test interaction
 Drug disease interaction

3. FACTOR CONTRIBUTING TO DRUG
INTERACTION:
Multiple drug therapy
Multiple prescribers
Multiple pharmacological effects of drug
Multiple diseases/ predisposing illness
Poor patient compliance
Advancing age of patient
Drug related factor

4. MECHANISM OF DRUG INTERACTION:
Pharmaceutical interaction
Pharmacokinetic interaction
I. Absorption interaction
II. Distribution interaction
III. Metabolism interaction
IV. Excretion interaction

5. MECHANISM OF DRUG INTERACTION
(cont.):
Pharmacodynamic interaction
I. Direct interaction
II. Indirect interaction

6. REDUCING THE RISK OF DRUG
INTERACTION:
Major – life threatening
Moderate – deterioration of patient’s status
Minor – little effect

7. Thank you
FOR LISTENING US
Reference: Biopharmaceutics and
pharmacokinetics D.M. Brahmankar
pg no. 224-234