PHARMACY PRACTICE BY KHUSBOO DEBNATH. CLASSIFICATION OF ADVERSE DRUG REACTION. definition ,adverse drug reaction, adverse drug effect, classification, side effect, application.

1. Classification Of Adverse
Drug Reaction
Name: Khusboo Debnath
Class: B.pharm 7th sem
Reg no. 1803268039
Subject: Pharmacy Practice
Teacher: Sujit Kumar Martha Sir
Jeypore College of Pharmacy 1

2. Definitions :-
Adverse Effect:
It is defined as ‘any undesirable or unintended
consequences of drug administration’. It is a broad
term, includes all kinds of noxious effect--trivial,
serious or even fatal.
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3. Adverse Drug Reaction:-
It is defined as any noxious and unwanted
effect of drug that occurs at doses given to
human being for prophylaxis, diagnosis or
treatment.
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4. Adverse Drug Event:-
Adverse Drug Event is an injury
resulting from medical intervention
related to a drug.
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5. Classification Of Adverse Drug Reaction:-
It has been classified in many ways but the most commonly
encountered ADR types are:
1.Predictable (Type A or Augmented) reactions:- These are based on
the pharmacological properties of the drug,which means that they
are augmented but qualitatively normal response to the drug
include side effects, toxic effects and consequences of drug
withdrawal.
• They are more common,dose related and mostly preventable and
reversible.
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6. Side effects:-
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7. 2. Unpredictable (Type B or Bizarre) reactions:- These are
based on peculiarities of the patient and not on drug’s
known action, include allergy and idiosyncrasy.
• They are less common,often non-dose related, generally
more serious and require withdrawal of the drug.
• Some of these reactions can be predicted and prevented
if their genetic basis is known and suitable test to
characterize the individual’s phenotype is performed.
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8. Allergic Drug Reaction:-
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9. • Alphabetical Classification Of ADR:
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10. Severity of adverse drug reactions has been
graded as :
1. Minor:No therapy, antidote or prolongation of hospitalization is
required.
2. Moderate: Requires change in drug therapy, specific treatment
or prolongs hospital stay by atleast one day.
3. Severe: Potentially life-threatening, causes permanent damage
or requires intensive medical treatment.
4. Lethal: Directly or Indirectly contributes to death of the
patient.
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11. • References:-
• 1.Ritter, J.M., Lewis, L.D., Mant, T.GK. & Ferro, A. (2008).
Adverse Drug Reactions. A Textbook of Clinical Pharmacology
and Therapeutics (Fifth Edition, PP 62-70). Hodder Arnold.
http://www.hoddereducation.com.
• 2.Whittlesea, C. & Hodson, K. (2019). Adverse Drug Reactions.
Clinical Pharmacy and Therapeutics (Sixth Edition, PP 66-80).
Elsevier Limited.
• 3.Tripathi, K.D. (2013). Adverse Drug Effects. Essentials of
Medical Pharmacology (Seventh Edition, PP 82-91). Jaypee
Brothers Medical Publishers (P) Ltd. 11