This document discusses prostaglandin biosynthesis and therapeutic uses of prostaglandin analogues. It describes several prostaglandin analogues including misoprostol, gemeprostol, alprostadil, epoprostenol, latanoprost, carboprost, and dinoprostone. It details their clinical uses such as preventing NSAID-induced ulcers, therapeutic abortion, labor induction, maintaining ductus arteriosus patency in neonates, treating pulmonary hypertension, reducing intraocular pressure, postpartum hemorrhage, and termination or induction of pregnancy. The document also notes some adverse effects and contraindications of the prostaglandin analogues.

1. PROSTAGLANDIN BIOSYNTHESIS &
THERAPEUTIC USES OF PROSTAGLANDIN
ANALOGUES
Dr. Jannatul Ferdoush
Assistant Professor
Department Of Pharmacology

2. PROSTAGLANDIN BIOSYNTHESIS

3. PROSTAGLANDIN ANALOGUES
Prostaglandin E1: Misoprostol (oral, Intravaginal)
Gemeprostol
Alprostadil (IV, Intraurethral, Intracavernosal route)
Prostagladin I2: Epoprostenol (IV)
Prostaglandin F2 α : Latanoprost (Opthalmic)
Carboprost (IM)
 Prostaglandin E2 : Dinoprostone (Intravaginal )

4. MISOPROSTOL (PROSTAGLANDIN E1)
 Clinical use:
NSAID induced pectic ulcer
Therapeutic abortion
Induction of labour
 NSAID induce gastric ulcer occur mainly due to decrease in
PG synthesis.
 It cause ripening & softening & dilatation of cervix.
 It binds to myometrial cells to cause strong contraction ,
leading to expulsion of product of conception.

5. ALPROSTADIL (PROSTAGLANDIN E1)
 Use:
To maintain patency ductus arteriosus
 The ductus arteriosus in neonate is highly sensitive to
PG E1. Maintence of patent ductus arteriosus is important
for neonate with congenital heart disease.

6. EPOPROSTENOL (PROSTAGLADIN I2)
 Use: Pulmonary hypertension.
 It work by relaxing the blood vessels
↓
increasing the supply of blood to the lung
↓
reducing work load of the heart.

7. LATANOPROST ( PROSTAGLANDIN F2 Α )
 Use:open angle glucoma
 it reduce intraocular pressure by increasing
the removal aqueous humor from the eye.

8. CARBOPROST: PROSTAGLANDIN F2
CARBOPROST: Prostaglandin F2 α
 Use: PPH
Its use for it oxytocic action.
.

9. DINOPROSTONE (PROSTAGLANDIN E2)
 Use: Termination of pregnancy
Induction of labour
PPH
 Act directly on myometrium to induce contraction
Relaxation of cervix.

10. cont’d
 Adverse effect:
Abdominal cramp ,nausea, vomiting
Diarrhoea
Bronchospasm
priapism
 Contraindication: pregnancy

11. THANK YOU