3 different types of obesity & 4 Medicines usually prescribed are described here.

1. Types of Obesity
& Dietary Pills
Guided By:
Dr. Raghavendra Hegde Katte
Dept. of Molecular Biology
Presented By:
Inchara R
7th Semester
Molecular Biology
08/12/2020
1

2. CONTENTS
• Introduction
• BMI
• Types of Obesity
• Treatment
– Dietary Pills
• Conclusion
• References
• Acknowledgement
2

3. INTRODUCTION
3

4. Body Mass Index
• The most widely used method to gauge obesity
is body mass index (BMI).
Eq 1: Formula to calculate
BMI
4

5. Fig 1: BMI & Nutritional State 5

6. Fig 2: BMI Chart
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7. Types of Obesity
• Obesity can be classified into 2 types:
1. Physical obesity
2. Pathological Obesity
1. Physical Obesity
This is based on distribution of the fats in the body i.e.,
purely based on the appearance of a person.
Types: (A) Android Obesity
(B) Gynoid Obesity
7

8. Fig 3: Apple and Pear shaped
Obesity 8

9. 2. Pathological Obesity
This is based on the structure of the fat tissue.
Types: (A) Hyperplastic type.
(B) Hypertrophic type.
Fig 4: Central & Peripheral Obesity 9

10. • Based on causes obesity can be further classified into 2
types.
a) Endogenous obesity - Obesity resulting from internal
conditions.
b) Exogenous Obesity - Overfeeding or gluttony with less
physical activity.
10

11. Treatment of Obesity
Fig 5: Pyramid of interventions in
the management of obesity 11

12. Dietary Pills
• There are 3 different mechanisms used to classify
pharmacological treatment of obesity.
a. Drugs that reduce appetite & food intake.
b. Drugs that increase energy expenditure.
c. Drugs that effect metabolism and nutrition
partitioning.
12

13. Orlistat
Naltrexone-
Bupropion
Lorcaserin Sibutramine
13

14. 1. Orlistat
Fig 6: Molecular
Structure of Orlistat
Fig 7: Xenical
(Orlistat Capsules)
14

15. Fig 8: Mechanism of action of
Orlistat 15

16. 2. Naltrexone-Bupropion
Fig 9: Molecular Structure
of Naltrexone-Bupropion
Fig 10: Contrave
(Naltrexone-Bupropion
Capsules)
16

17. Fig 11: Mechanism of action of
Naltrexone-Bupropion 17

18. 3. Lorcaserin
Fig 12: Molecular
Structure of Lorcaserin
Fig 13: Belviq
(Lorcaserin Capsules)
18

19. Fig 14: Mechanism of action of
Lorcaserin 19

20. 4. Sibutramine
Fig 15: Molecular
Structure of Sibutramine
Fig 16: Sibutril/leptos
(Sibutramine Capsules)
20

21. Fig 17: Mechanism of action of
Sibutramine 21

22. CONCLUSION
22

23. REFERENCES
• Chatterjea M. N. & Rana Shinde. 2012. Textbook of
Medical Biochemistry, 8th edition, Jaypee Brothers
Medical Publishers (P) Ltd, New Delhi, India, 894pp.
• George A. Bray, Claude Bouchard &. James W. P. T.
2004. Handbook of Obesity Clinical Applications, 2nd
edition, Marcel Dekker, inc., New York, USA, 414pp.
• Harsh Mohan. 2010. Textbook of Pathology, 6th
edition, Jaypee Brothers Medical Publishers (P) Ltd,
New Delhi, India, 949pp.
• Robert H. Glew & Miriam D. Rosenthal. 2007. Clinical
Studies in Medical Biochemistry, 3rd edition, Oxford
University Press, New York, USA, 387pp. 23

24. • https://pubmed.ncbi.nlm.nih.gov/28245771/
• https://www.sciencedirect.com/science/article/pii/S1043661
814000449
• https://go.drugbank.com/drugs/DB01083
• https://www.ncbi.nlm.nih.gov/books/Definitions,
Classification, and Epidemiology of Obesity/NBK279167/
• https://www.alfadoc.co.uk/weight-loss/xenical/
• https://www.semanticscholar.org/paper/Review-Paper%3A-
Current-Strategies-in-the-Development-
Elangbam/033190e774f9a8d9902fb69b4a0f01b6d9149c03
• https://youtu.be/B1xJhtROIw8
• https://youtu.be/eTCOi2Nslfs
• https://slideplayer.com/slide/ antiobesitydrugs-
170215131630/
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25. ACKNOWLEDGEMENT
I would like to thank the Dept. of Molecular Biology
for providing this opportunity to present this
seminar.
I would also like to thank my guide Dr. Raghavendra
Hegde Katte for his valuable guidance.
Thank you one and all.
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26. 26

27. 4. Phentermine
Fig 15: Molecular Structure
of Phentermine
Fig 16: Lamaira
(Phentermine Capsules)
27