Here i made a presentation on the topic GLYCOLYSIS. I Demonstrated the ten steps of Glycolysis in a few word and flow chart so that you can easily learn about it.

1. Glycolysis
Rahman R Hillol
KGHS,Dhaka.

2. What is Glycolysis
Glycolysis (from the Greek glykos, meaning sweet, and
lysis, meaning splitting) involves the breakdown of
glucose, a simple sugar. This process can occur in the
presence or absence of oxygen, that is, under aerobic
or anaerobic conditions.

3. History of Glycolysis
During the 1930s, the efforts of several German
biochemists, including Gustav Embden, Otto Meyerhof,
and Jacob Parnas, determined that glycolysis involves
10 steps, each one catalyzed by a different enzyme.

4. Concept of Glycolysis
Glycolysis

5. Step 1
Glucose is phosphorylated by ATP. Glucose-6-phosphate
is more easily trapped in the cell compared to glucose.
ATP
ADP
Hexokinase
Glucose
Glucose-6-Phosphate

6. Step 2
The structure of glucose-6-phosphate is rearranged to
fructose-6-phosphate.
Phosphogluco
isomerase
Glucose-6-Phosphate
Fructose-6-phosphate

7. Step 3
Fructose-6-phosphate is phosphorylated
to make fructose-1,6-bisphosphate.
ATP
ADP
Phosphofructo
kinase
Fructose-6-phosphate
Fructose-1,6-bisphosphate

8. 4. Fructose-1,6-bisphosphate is cleaved into
dihydroxyacetone phosphate and
Dihydroxyacetone
phosphate
glyceraldehyde-3-phosphate.
5.
Di-hydroxyl-acetone phosphate is
somerized to glyceraldehyde-3-phosphate.
4.
5.
Isomerase
Aldolase
Fructose-1,6-bisphosphate
Glyceraldehyde-3phosphate (x2)

9. 6.
Glyceraldehyde-3-phosphate is oxidized to 1,3bisphosphoglycerate. NADH is produced. In 1,3-bisphospho-glycerate,the phosphate group in the upper left
is destabilized, meaning that the bond will break in a
highly exergonic reaction.
Unstable Phosphate
Bond
2NADH
2 NAD+
Glyceraldehyde-3phosphate (x2)
+2H+
Glyceraldehyde-3phosphate
dehydrogenase
1,3-bisphosphoglycerate (x2)

10. 7.
A phosphate is removed from 1,3-bis-phospho-glycerate
to form 3-phosphor-glycerate. The removed phosphate is
transferred to ADP to make ATP via substrate-level
phosphorylation.
Unstable Phosphate
Bond
2ATP
2ADP
Phosphoglycero–
kinase
1,3-bisphosphoglycerate (x2)
3-phosphoglycerate(x2)

11. 8.
The phosphate group in 3 phosphoglycerate
is moved to a new location, creating 2phosphoglycerate
Phosphoglycero–
mutase
3-phosphoglycerate(x2)
2-phosphoglycerate(x2)

12. 9.
A water molecule is removed from 2-phosphor-glycerate to
form phosphor-enol-pyruvate. In phosphor-enol-pyruvate,
the phosphate group is destabilized, meaning that the bond
will break in a highly exergonic reaction.
Unstable phosphate
bond
Enolase
2-phosphoglycerate(x2)
Phosphoenolpyruvate(x2)

13. 10.
A phosphate is removed from phosphor-enol-pyruvate
to form pyruvate. The removed phosphate is transferred
to ADP to make ATP via substrate-level phosphorylation.
Unstable phosphate
bond
2ADP
2ATP
Pyruvate Kinase
Phosphoenolpyruvate(x2)
pyruvate(x2)

14. :p
Thanks God!
It’s over at last!!