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HAEMATINIC AGENT-1.pptx
- 1. APOLLO COLLAGE OF PHARMACY ANJORA PHARMACOLOGY GUIDED BY MR. HARI PRASAD SONWANI PRESENTED BY DUSHYANT KUMAR JAYPRAKASH SAHU NITIN DESHMUKH UDAY SATNAMI
- 3. s HAEMATINICS HAEMATINICS ARE COMPOUNDS REQUIRED IN THE FORMATION OF BLOOD AND ARE USED TO THE TREATMENT OF ANAEMIAS. HAEMATINICS INCLUDE: 1. IRON. 2. VITAMIN B12. 3. FOLIC ACID. 4.
- 4. CLASSIFICATION HEAMATINICS IRON MATURATION FACTORS ADJUVANT HAEMATINICS ORAL IRON PARENTERAL IRON Ferrous sulfate Ferrous fumarate Ferrous gluconate Ferrous succinate Ferrous aminoate Ferric ammonium Citrate Ferric hydroxy Polymaltose Carbonyl iron Iron-cal.complex Iron-dextran Iron-sorbitol- citric acid Ferrous sucrose Ferric carboxy- maltose Vitamin B12 Cyanocobalamin Hydroxocobalamin Methyl cobalamin Folic acid: Folinic acid (leucovorin, Citrovorum factor) Copper Pyridoxine Riboflavin
- 5. IRON IRON IS ESSENTIAL FOR HEMOGLOBIN PRODUCTION .TOTAL BODY IRONS ABOUT 2.5 TO 5 GRAMS, TWO-THIRD OF WHICH IS PRESENT IN HEMOGLOBIN. EACH MOLECULES OF HEMOGLOBIN HAS 4 IRON CONTAINING RESIDUES. ALSO PRESENT IN MYOGLOBIN , THE CYTOCHROMES AND OTHER ENZYMES.
- 6. DAILY REQUIREMENTS OF IRON • ADULT MALE. - 0.5-1 MG • ADULT FEMALE - 1-2 MG • PREGNANCY AND LACTATION - 3-5 MG
- 7. DIETARY SOURCES OF IRON FOOD ITEMS THAT ARE RICH IN IRON ARE : 1. LIVER 2. EGG YOLK 3. MEAT 4. FISH, CHICKEN 5. SPINACH 6. DRY FRUIT 7. WHEAT AND APPLE
- 8. FUNCTIONS OF IRON • PRIMARY COMPONENT IN RED BLOOD CELLS • CELL GROWTH AND DIVISION • OXYGEN TRANSPORT • DNA SYNTHESIS
- 9. DEFICIENCY • IRON DEFICIENCY ANAMEIA • BLOOD LOSS • LACK OF RED BLOOD CELLS PRODUCTION • HIGH RATE OF RED BLOOD CELLS DISTRUCTIONS
- 11. DRUGS NAME ORAL – ZINCOFER – XT IV – IRON SUCROSE
- 12. USE OF IRON • IRON DEFICIENCY ANAEMIA • IRON IS GIVEN IN CONDITION WITH • INCREASED IRON REQUIREMENT AS IN PREGNANCY
- 13. VITAMIN B12 • VITAMIN B12 (CYNOCOBALAMIN) IS SYNTHESIZED BY MICROORGENISM. • THE DIETARY SOURCES OF B12 ARE : 1. FISH 2. EGG YOLK 3. MEAT 4. CHEESE • VIT B12 OCCURS AS WATER SOLUBLE,THERMOSTABLE RED CRYSTALS.
- 14. DAILY REQUIREMENT • PREGNANCY – 1-3 MG • LACTATION – 3-5 MG
- 15. FUNCTIONSOF VITAMIN B12 • MAINTAIN HEALTHY NERVES CELLS • HELPS IN THE PRODUCTION OF DNA RNA • HELP MAKE RED BLOOD CELLS
- 16. DEFICIENCY • VITAMIN B12 DEFICIENCY MAY BE DUE TO • ADDISONIAN PERNICIOUS ANAEMIA • GASTRECTOMY • CHRONIC • GASTRITIS
- 18. DRUGS NAME • ORAL – NEROBION FORTE NUROKIND • IV - NUROKIND PLUS RENERVE PLUS
- 19. USE • VITAMIN B12 DEFECIENCY • TREATMENT OF MEGALOBLASTIC ANAEMIADUE TO B12 DEFICIENCY • PERNICIOUS ANAEMIA • NEUROPATHIES: • NEUROPATHIES THROUGHT TO BE DUE TO B12 DEFICENCY LIKE TROPICAL NEUROPATHY RESPOND TO VITAMIN B12 BUT THE MECHANISM IS NOT CLEAR.
- 20. FOLIC ACID • FOLIC ACID IS PTEROYLGLUTAMIC ACID. • IT WAS FIRST ISOLATED FROM SPINACH AND, THEREFORE, NAME AS FOLIC ACID
- 21. DIETARY SOURCE • GREEN VEGETABLES • LIVER • YEAST • MILK • SOME FRUITS
- 22. DAILY REQUIREMENT • AN ADULT IS <0.1 MG BUT DIETARY ALLOWANCE OF 0.2 MG/DAY IS RECOMMENDED • DURING PREGNANCY,LACTATION OR ANY CONDITION OF HIGH METABOLIC ACTIVITY, 0.8 MG/DAY IS CONSIDERED APPROPRIATE
- 23. FUNCTIONS OF FOLIC ACID • SYNTHESIS OF DNA • NORMAL MATURATION OF RBC AND WBC • SYNTHESIS OF PURINE AND PYRIMIDINE
- 24. DEFICINCY • FOLATE DEFICIENCY • CLINICAL MANIFESTATION 1.MEGALOBLASTIC ANAEMIA 2.GLOSSITISS 3.DIARRHOEA AND 4.WEAKNESS
- 25. DRUGS NAME • ORAL – FOLVITE FERORIL-XT
- 26. USES • MEGALOBLASTIC ANAEMIA • PREGNANCY • LACTATION • INFANCY
- 27. REFERENCE • TRIPATHI, K.D.(2018). ESSENTIALS OF MEDICAL PHARMECOLOGY (8TH ED.).JAYPEE BROTHERS MEDICAL • MEDICAL PHARMECOLOGY PADMAJA UDAYKUMAR PUBLISHERS: CBS PUBLISHERS & DISTRIBUTERS ,NEW DELHI, FOURTH EDITION 2013 • KAEWN, W. (2015)LIPPINCOTT ILLUSTRATED REVIEWS PHARMECOLOGY. 6TH EDITION, EOLTERS KLUWER, ALPHEN AAN DEN RIJN, 456-457. • TARA V SHANBHAG & SMITA SHENOY ; PHARMECOLOGY FOR MEDICAL GRADUATES, 5TH EDITION ; ELSEVIER.
- 28. THANK YOU