DEFINATION IMPORTANCE OF IRON ABSORPTION, DISTRIBUTION, TRANSPORT, STORAGE AND EXCRETION OF IRON. COMPOUND RELATED TO HAEMATINICS

1. HAEMATINIC
TAUFIK MULLA
ASST. PROFESSOR
DEPT. PHARMACEUTICS
SPBC COLLEGE OF PHARMACY

2. HAEMATINIC
• These are substances required in the formation of blood & are used for
treatment of anaemias. It improves the condition of the blood and also
called as haematinic agent.
• Example of Haematinic – iron , vit.B12
• These agent increase the number of erythrocytes or haemoglobin
content in blood.
• Inorganic compound used as haematinic – Ferrous sulphate, ferrous
gluconate.

3. HAEMATINIC
• Haematinic drugs available in combination with folic acid + zinc +
vit.B12. in the form of tablet, capsule, syrup and suspension.
• Marketed preparation -

4. ANAEMIA
• Decrease capacity of RBC to carry oxygen to tissue.
• Occur when balance between production and destruction of RBC is
disturbed.
• Disturbance happen because of –
• Blood cell
• Impaired RBC formation due to bone marrow depression, iron
deficiency, vit.B12 deficiency, folic acid deficiency.

5. IRON
• Iron is an essential mineral that is required for human life. Much of the
iron
• in the body is found in red blood cells.
• Distribution of iron in body:
• Haemoglobin – 66%
• Iron stores as ferritin & haemosiderin – 25%
• Myoglobin – 3%
• Parenchymal iron – 6%

6. IRON
• Daily requirement
• Adult male : 0.5-1 mg .
• Adult female : 1-2 mg.
• Infants : 60 /kg.
• Children : 25 /kg.
• Pregnancy (last 2 trimesters) : 3-5 mg.

7. ABSORPTION
• The major part of dietary iron is inorganic & in the ferric form. It needs to
be reduced to the ferrous form before absorption.
• Its absorption occurs all over in the intestine.

8. TRANSPORT, UTILIZATION, STORAGE &
EXCRETION
• Iron in transported into erythropoietic & other cells .
• Iron dissociated from the complex at the acidic pH of the intracellular
vesicles, the released iron is utilized for haemoglobin synthesis .
• Iron is stored in RE cells in liver, spleen bone marrow, also in
hepatocytes & myocytes as ferritin .
• Iron is excreted through sweat ,very little in urine, desquamated skin, in
some RBCs and in bile(all lost in faeces).

9. PREPARATION & DOSE
• Oral Iron:
• Ferrous Sulfate- Fersolate 200mg tab.
• Ferrous gluconate- Ferronicum 300mg tab,400mg/15ml.
• Ferrous fumarate- NORI-A 200mg tab.
• Colloidal ferric hydroxide-Neoferum 200mg tab, 400mg/5ml liquid,
100mg/ml drops.

10. PREPARATION & DOSE
• Parenteral Iron-
• IV ,IM.
• Iron. dextran: Imferon 2ml ampoule.
• Iron sorbitol citric acid complex- Jectofer 1.5ml ampoule.

11. ADVERSE EFFECT
• Epigastric pain
• Heartburn
• Nausea ,vomiting
• Metallic taste
• Constipation

12. DIETRY SOURCE
• RICH –
• liver, egg yolk, dry beans, dry fruits
• MEDIUM –
• meat, chicken, fish, banana, apple
• POOR –
• milk product, root vegetables

13. FERROUS SULPHATE
• Chemical formula – FeSO4.7H2O
• Molecular weight – 278
• Synonym – Green Vitriol, Iron Vitriol
• Properties –
• Color – bluish green crystal
• Odour – odourless
• Taste – metallic astringent taste
• Solubility – soluble in water and insoluble in alcohol

14. • Method of preparation –
it obtained by slight addition of iron in dil. Sulphuric acid, iron get
dissolved to form ferrous sulphate and hydrogen gas evolved. Liquid is
concentrated and cooled to get crystal.
Fe + H2SO4 FeSO4 + H2
• Assay –
assay based upon principle of oxidation – reduction reaction. By
using 0.1 N KMnO4 solution in presence of dil. Sulphuric acid. Weigh 1gm
powder and dissolved in 20 ml of dil. H2SO4. the solution is titrated
against 0.1 N KMnO4. KmnO4 self act as indicator.

15. • Uses –
• Used as haematinic
• Promote formation of Haemoglobin
• Used in treatment of anemia caused by iron deficiency
• Used to dye fabric and tanning cloth
• Used in manufacturing of ink
• Used in photography
• Also having disinfectant property
• Used as insecticide in agriculture.