SlideShare a Scribd company logo
1 of 7
Download to read offline
Contact Lens and Anterior Eye (2001) 24, 34-40
© 2001 British Contact Lens Association
Review
www,nature.com/clae
AN OPTOMETRIST'S PERSONAL PERSPECTIVE OF ASPEC'I
OF REFRACTIVE SURGERY#
JenniferP. Craig*
(Received llth July 2000; in revisedform 2nd November2000)
Abs~act-- The latter part of the last century has seen significant evolution in the area of refractive surgery, such that is has become a
viable alternative to contact lenses, or spectacles, for an increasing number ofpatients. The developments ofthe principal techniques, in
this ever-expandingfield, are reviewed, and the increasing r61eof the optometrist in the pre-, intra- and post-operative management of
the refractive surgery patient is described, based upon the author's personal experience within a non-profit, refractive surgery setting. In
addition to highlighting pertinent features of the objective evaluation ofpatients, the importance ofsubjective assessment, pre- and post-
operatively, is discussed, in terms of maximising post-surgery patient satisfaction. The scope for future research in this dynamic area is
also considered. Contact Lens and Anterior Eye (2001) 24, 34-40.
KEY WORDS: refractive surgery, LASIK,PRK, outcome, satisfaction
History of Refractive Surgery
R efractive surgery has become a realistic alternative
to spectacle or contact lens correction for many
myopic individuals. The concept of permanent correc-
tion of ametropia is not new. As early as 1857, clear lens
extraction was proposed as a means of improving
unaided vision in the highly myopic, and incisional
keratotomy was introduced in 1894. However, to date,
no single technique has proved to be ideal? The desire
to overcome the limitations of each refractive technique
and, in particular, those related to the predictability of
the post-operative healing process, have ensured that
the art and science of refractive surgery continues to
evolve.
Over the last 30 years, a number of techniques have
risen and declined in favour. The 1970's saw the rise in
popularity of radial keratotomy following the work of
Fyodorov and Durnev in Russia. The Prospective
Evaluation of Radial Keratotomy (PERK) study investi-
gated the results of a wide range of attempted
corrections over 10 years follow-up.2 These are sum-
marised in Table 1. Overall the results showed that the
technique was relatively successful, but a significant
number of subjects did complain of vision fluctuating on
a diurnal basis, by as much as five lines of Snellen
acuity. The surgical technique has been refined in
recent years, producing better clinical results in terms
of uncorrected vision, however, problems such as
progressive hyperopia and predisposition to wound
ruptures following trauma have yet to be fully resolved.
Radial keratotomy remains most popular in the United
States, and the low equipment cost combined with the
~The Irving Fatt Lecture, 2000
*PhDMCOptom FAAO
simplicity of the technique will ensure that it retains a
r61e in the treatment of low myopia)
The intrastromal corneal ring or segments (Intacs~,
Keravision Inc., CA, USA) have been promoted on the
basis that they do not interfere with the visual axis and
that the procedure is reversible# However, their
insertion requires a technically challenging operation,
which involves the insertion of polymethylmethacrylate
(PMMA) segments at two-thirds the depth of the
stroma. The degree of myopia corrected by this method
is dictated by the thickness of the segments, and is
therefore limited to around -4.00 DS, similar to levels
treated with reasonable success by RK and photore-
ffactive keratectomy (PRK). However, it should be
noted that the surgery has the potential to cause
significant corneal opacity around the area of insertion
of the PMMA.
Intraocular techniques include clear lensectomy with
posterior chamber intra-ocular lens implant but, in
addition to being associated with the standard risks of
intra-ocular surgery, including a significantly increased
risk of retinal detachment, the loss of accommodation is
often unacceptable for younger individuals. Anterior
chamber intra-ocular lenses, placed in front of the
healthy crystalline lens have also been considered, in
particular the Worst iris claw lens and the Baikhoff
angle-supported lens, although there have been reports
of progressive endothelial cell loss and low grade
anterior chamber flare with such phakic intra-ocular
lenses. ~ More recently the pre-crystalline intra-ocular
'contact lens' has been developed, and the long term
results of prospective studies which are able to
determine both the success and complications, such
as the incidence of cataract formation and pupil block
glaucoma, are eagerly awaited.6
Refractive surgery from an optometric perspective
JP Craig
Table 1. Summary ofdemographicfeatures, visual outcome and significant complications ofpatients in the ProspectiveEvalutaion of
Radial Keratotomy (PERK) Study.2
35
Demographics
Visual outcome
Significant complications
Sample size
Attempted range of refractive correction
Follow-up
Post-op uncorrected vision 6/6
Post-op uncorrected vision 6/12
Loss of two or more lines of BSCVApost-op
Progressive hyperopic shift
793
-2.00 to -8.75 DS
88%at 10 years
53%
85%
3%
43%
Excimer Laser Refractive Surgery
Since the first surface-based excimer laser PRK on a
human eye in 1988, excimer laser correction of myopia
has become increasingly popular.7 Early prospective
studies showed that treatment of very high refractive
errors by PRK resulted in significant corneal haze which
reduced BSCVA in an unacceptable number of subjects
such that, by 1996, the maximum attempted correction
by PRK, in the UK, was limited to -10.00 DS or less,
with many practitioners setting an upper limit of around
- 7.00 DS. However, at lower levels of myopia, PRK has
been shown to be relatively safe and efficacious with
levels of unaided vision reported in the literature as 6/6
or greater, in between 48 and 100%of subjects, and 6/12
or greater, in between 82 and 100% of subjects, for
treatments of up to - 6.00 DS over a 6.00 mm treatment
zone. Results of a large prospective study of PRK, by
McGhee and coworkers, at Sunderland Eye Infirmary,
on 323 eyes with at least 2 years follow-up, between 1993
and 1996, concluded that PRK was very successful up to
-5.00 DS (72% at least 6/6 unaided) and moderately
successful up to -10.00 DS (89% at least 6/12
unaided). 8 Beyond this level of attempted correction,
predictability was poorer, and there was an increased
risk of severe haze and loss of best spectacle corrected
visual activity (BSCVA). Myopia was found to be
corrected more fully (actual correction up to 100% of
attempted correction) than astigmatism (around 67%
mean correction). Overall, in this prospective study,
which included attempted corrections of up to -15.00
DS, between 3 and 4%ofeyes lost two lines ofBSCVAas a
result of severe haze. The results of this study compared
well to those of similar investigations around that time.9,'°
Following the pioneering work of Barraquer in 1964
and Pureskin in 1967, the technique of excimer laser in
situ keratomileusis (LASIK) was developed and the
technique as we know it today was performed on the
first human eyes in 199071 The procedure involves
anaesthetising the eye topically. A suction ring is placed
on the eye, around the limbus, and this raises the
intraocular pressure to around 60 mmHg and immobi-
lises the eye. At this time, a microkeratome is used to
create a 160 #m flap, with a nasal or superior hinge, in
the anterior cornea. Suction is then released. Laser
ablation of the exposed stroma (of pre-programmed
depth and diameter) is performed after the flap is
reflected and whilst the patient fixates a target
coincident with the laser beam. After the ablation is
complete, the flap is returned to its original position, the
interface irrigated, and is left to settle in position without
the need for sutures. Generally, the LASIK flap adheres
securely, within 2 to 5 min, to the underlying stroma.
LASIK offers a number of advantages over PRK. It
can be used to treat higher levels of myopia (with an
upper limit of around -12.00 to -15.00 DS) without
inducing the corneal haze associated with PRK. Since
the area of epithelial disruption is minimal, there is
virtually no post-operative pain and visual rehabilitation
occurs within hours to days. However, surgically, it is a
more challenging operation and, unlike PRK, requires
sterile operating conditions due to the more surgically
invasive nature of the procedure.
Hyperopic Treatments
Treatment for hypermetropia by refractive surgery has
also become available in recent years, but results are
less well supported by long-term, longitudinal studies.
Techniques include refractive lensectomy (with intra-
ocular lens implantation) 12, PRK13, LASIK14 and more
recently, holmium laser thermal keratoplasty (LTK).15In
the latter technique, the response of the corneal tissue
to the application of the laser, at several points
concentric with the limbus, around the periphery of
the cornea, is to contract, thereby increasing central
corneal curvature, and correcting hyperopia. Overall,
hyperopic corneal refractive techniques have experi-
enced only limited success, with the best outcomes in
patients with low levels of pre-operative hyperopia
(< 4.00 DS). However, the significant risk of regression
associated with these techniques, even in small
attempted corrections, has resulted in the majority still
being considered relatively investigational. 16One of the
latest methods, with encouraging clinical results in the
treatment of hyperopia (M. McDonald, BCLA keynote
presentation, Birmingham, May 2000), is conductive or
radiofrequency keratoplasty. In this procedure, heat is
applied to the cornea with radio frequency energy,
potentially causing less damage to the surrounding
tissue than previous techniques. Results of the Phase Ill
FDA clinical trials in the US are still awaited for this new
therapy.
Prospective Study of LASIK
The author has recently been involved in a large,
prospective study of LASIK, as part of the Corneal
Diseases and Excimer Laser Research Unit at the
Contact Lens and Anterior Eye
Refractive surgery from an optometric perspective
JP Craig
36
University of Dundee in Scotland. 17 The LASIK
procedures were performed by a single surgeon
following a standardised protocol with the Chiron
Technolas 117 or 217 scanning spot excimer laser
and the Chiron Automated Corneal Shaper to create
the flap. All patients were prescribed topical steroids
and antibiotics for 2 weeks after surgery. The following
results pertain to the first 104 consecutive primary
LASIK treatments for high myopia.18 The group
comprised 67 females and 37 males with a mean age
of 39.4 years. The mean follow-up for the group was
10.2 months at the time of collecting the data. Sixteen
of the 104 subjects required retreatment due to myopic
regression, at a mean of 12 weeks following primary
treatment. The mean spherical equivalent (sph.eq.)
(+standard deviation (SD)) prior to surgery was
-9.82+4.59 DS with a range of -1.75 to -22.75
DS. The full correction was not attempted in the
highest myopes, limited by the thickness of the cornea,
which was determined, for each patient, by ultrasound
pachymetry. The current view, based upon the
experience of LASIK surgeons to date, is that a corneal
thickness of 250 #m must remain undisturbed beneath
the flap and ablation, to minimise the risk of sequelae
such as posterior keratectasia. For any given correc-
tion, decreasing the ablation zone size will decrease
the ablation depth, however, a significant risk of post-
operative glare is associated with small ablation zones.
The magnitude of correction is therefore often dictated
by the thickness of the patient's cornea, in order that
the safe thickness of 250 #m, can be retained following
ablation. The mean (+ SD) preoperative cylinder was
-1.46+1.37 DC. At 1 year post-LASIK, the mean
refractive error (sph.eq.) was -1.3+3.0 DS and the
mean cyclinder was -0.7+0.7 DC. This was influ-
enced largely by the extreme myopes within the group.
The group was therefore divided into three groups;
moderate myopes, high myopes and extreme myopes
(Table 2) and the mean refractive error (sph.eq.) for
each group across the 12-month follow-up period was
then assessed separately. It showed that the residual
refractive error was greatest, across all the time points,
for the extremely myopic group. This is reflected by
the tabulated results which show the percentage of
subjects within each group who achieved an unaided
vision of 6/6 or better, 6/12 or better, or < 6/12. The
apparently poorer results, in the extreme myopes, is
due largely to the limitations on attempted correction
dictated by corneal thickness, described above.
LASIK Complications
The complication rate was low in this series of patients.
Intra-operatively, there were three microkeratome-re-
lated complications: two thin flaps and one button-hole
in the flap. None of these patients experienced any
adverse outcome as a result of these imperfect flaps and
achieved good levels of unaided vision, while retaining
their pre-operative BSCVA, post-LASIK. Thin flaps or
button-hole flaps (in which the flap is doughnut-shaped
with a central portion still attached to the main body of
the cornea) can occur if suction is inadequate, and the
cornea is not located in the ideal plane before the
microkeratome is activated. The intraocular pressure is
checked by applanation tonometry prior to creating the
flap to minimise the risk of such complications, but they
can also occur in cases of sudden patient movement or
severe blepharospasm. In the event of a thin, incomplete
or button-hole flap being apparent following the excur-
sion of the microkeratome, the flap is left in place
without being lifted, and the partial corneal flap allowed
to heal in position without performing the ablation.
Following successful healing in around 3 months, the
LASIK procedure may be attempted again, with the
creation of an entirely new flap.
Post-operatively, the flap was displaced in two cases
within an hour of the operation, once, on removal of the
speculum used to hold the eyelids apart during the
operation, and once by the patient who vigorously
chewed on a toffee immediately post-operatively, dislod-
ging the flap! One further flap displacement occurred
around 12 h after surgery, when the patient instilled
their prescribed topical medication and struck the flap
with the bottle tip. In all cases, the patients were
brought back to theatre, and the flap was rehydrated
and repositioned without adverse sequelae. Overall, 97%
of the group of 104 LASIK patients maintained or gained
lines of BSCVA at final flow-up. Two patients lost one
line of BSCVA (2%) and only one subject, two lines of
BSCVA (1%). In this latter patient, the loss in vision was
in fact attributable to the onset of cataract which was
subsequently removed, resulting in a final BSCVA two
fines better than initial BSCVA.
However, although results, such as these, following
LASIK surgery are encouraging in terms of speed of
Table 2. Percentageofpatients achieving 6/6 or better,6/12 or better,orpoor than 6/12 vision, unaided,following a primary LASIK
treatment.
Percentage ofpatients achieving the given levelof vision
unaided post-primary LASIK
Refractive range, Mean refraction
Myopicgroup Sample size pre-op(Sph. eq.) (Sph.eq.) 6/6 6/12 <6/12
Moderate 32 <- 8D - 4.96 DS 74% 97% 3%
High 33 - 8 to - 12 DS - 8.80 DS 50% 78% 22%
Extreme 39 >- 12 DS - 14.76 DS 4% 30% 70%
Contact Lens and Anterior Eye
Refractive surgery from an optometric perspective
JP Craig
recovery and unaided vision, the technique, like any
surgical procedure is not free from serious complica-
tions (Table 3).19-24Indeed, some complications appear
unique to LASII~ One patient, who was not part of the
prospective study, experienced a severe non-infective
inflammation, known as diffuse lamellar keratitis or
'Sands of the Sahara'. The aefiology of this interesting
phenomenon is unknown, but may be related to a
reaction to debris from the surgical procedure, for
example, from the microkeratome or laser plume. The
condition presents with a sand-storm appearance of the
cornea, at the level of the flap interface.25 Vision is
reduced as a result. In the majority of patients, intensive
topical steroids, for a short period of time, reduce the
inflammation and vision is restored to its full potential.
Subjective Assessment in Refractive Surgery
Clearly, success of refractive surgery cannot be mea-
sured in objective terms, such as BSCVA and residual
refractive error, alone, but must, at least in part, be
assessed subjectively. A - 12.00 DS patient who under-
goes LASIKwith an attempted correction of - 10.00 DS
may be extremely happy with a residual refractive error
of -2.00 DS and unaided vision of less than 6/12,
allowing them to be less dependent on their spectacles
and to wear more cosmetically-appealing spectacles.
Conversely, a myopic patient who has surgery for - 2.50
DS and who emerges with a residual refractive error of
plano with a - 0.50 D cylinder and vision of 6/6 unaided,
may consider that, because they feel the need to wear a
spectacle correction for driving at night, their result is
disappointing. Patient satisfaction is therefore a vital
indicator of refractive surgery success. The fact that
refractive procedures are elective surgery on essentially
healthy eyes, albeit ametropic ones, makes subjective
success all the more important. A study was therefore
conducted at the Corneal Diseases and Excimer Laser
Research Unit at the University of Dundee, to establish
the functional and satisfaction outcomes of the patients
who underwent LASIKfor high myopia.26
An anonymous 34-question, visual analogue ques-
tionnaire, which was adapted from a questionnaire that
the authors had used previously to assess satisfaction
following PRK, was posted, simultaneously, to 48
consecutive patients who had undergone primary
LASIK surgery at the Unit. This corresponded to 76
treated eyes. The response rate from the group of 28
male and 20 female subjects, with a mean age of 40.2
years, was 100%. The mean pre-operative myopia
(sph.eq.) (±SD) was -10.7+4.4 DS. In eight eyes of
seven subjects, the intended refractive end point was
greater than - 3.00 DS or the preoperative BSCVA was
less than 6/18. Of the remaining 68 eyes, 77% achieved
6/12 or better unaided vision and 32% achieved 6/6 or
better unaided vision following a primary LASIK
treatment.
The questionnaire incorporated questions about
preoperative visual function and about postoperative
status, in terms of functionalityand satisfaction. Patients
were requested to record answers to questions on a
visual analogue scale; a horizontal line anchored at each
end by two adjectival descriptors, upon which the
subject could place a mark at the point which best
represented their opinion. For example, in asking the
patient how they rated their unaided vision pre-
operatively, the line would be anchored by a descriptor
such as 'very poor' at one end and 'very good' at the
other end. For ease of analysis, the lines were
subsequently divided into four equal categories corre-
sponding to responses of 'very positive', 'positive',
'negative' and 'very negative' for each question.
All subjects considered their preoperative unaided
vision to be poor, with 92%rating it 'very poor'. Only 34%
of subjects had rarely, or never, worn contact lenses,
and approximately equal numbers of subjects were
wearing spectacles and contact lenses prior to surgery.
Despite being a predominantly presbyopic group, the
majority of subjects reported an improvement in the
ability to undertake near tasks unaided, following
surgery. Only 4% noted a subjective deterioration in
reading in daylight, and 9% in artificial light. The
majority of subjects reported an improvement in their
ability to watch television, drive in daylight or view a
cinema screen without correction, however a number
were aware of visual difficulties when driving at night
(9%). None of the patients with difficulties had a central
ablation zone of less than 5.0 mm and, in all cases, the
centration of the zone was within 0.5 mm of the virtual
37
Table 3. Reported complications ofLASIK surgery,z9-24
Complications ofLASIK surgery
Intra-operative Post-operative
Thin/incomplete flap
Button-holeflap
Free/macerated flap
Full-thicknesscorneal cut
Minor corneal bleeding
Epithelial abrasion
Inadequate sucfion/IOP elevation
Primary over or under-correction
Decentred ablation
Subconjunctivalhaemorrhage
Severelywrinkled/dislodged flap
Interface debris
Punctate epithelialkeratopathy
Diffuselamellarkeratitis
Interface haze
Infectiouskeratitis
Regression of refractiveeffect
Epithelialingro~_h
Progressive keratolysis (focalmelt)
Corneal ectasia
Contact Lens and Anterior Eye
Refractive surgery from an optometric perspective
JP Craig
38
pupil centre. In terms of satisfaction post-operatively, all
patients felt that they had fully understood the
procedure prior to surgery, and all except one was very
happy with their speed of visual recovery following
surgery. This patient was awaiting retreatment for
myopic regression and, ultimately, was delighted with
their result. Ninety-four per cent of subjects felt that
they had achieved the goals for which they had
undergone the surgery and all but one subject felt that
their quality of life had improved. It is noteworthy that
two of the three subjects (including the dissatisfied
patient mentioned above) who did not feel that their
goals had been realised were awaiting retreatment and
both recorded their unaided visual outcome as 'excel-
lent' on a four point scale: poor, average, good, or
excellent, following an enhancement procedure.
Thus, overall, this study reported a very high level of
functional improvement, a perceived improvement in
quality of life, and consistently high levels of post-
operative satisfaction, across a range of visual function
parameters. Given that more than 31% of the eyes did
not achieve 6/12 or better unaided, this may be
considered surprising. The high levels of satisfaction
reported in this anonymous study are believed to be due
in part to the extensive preoperative counselling and
written information given to subjects, which helps to set
realistic expectations of the surgery. Indeed, the
preoperative counselling in the Unit has been refined
on the basis of an extensive study determining the
reasons why patients seek LASIK treatment. It has been
established, from a previous study which compared
psychological aspects of patients attending an optometry
practice for a contact lens assessment to those consult-
ing a laser unit for an excimer laser PRK assessment,
that patients seeking PRK cannot be considered
conspicuously neurotic, nor driven to refractive surgery
because of low self-esteemY It is therefore important
that the eye-care professional understands the reasons
for patients seeking LASIK, in order to be able to best
counsel patients, prior to surgery. In a further study at
the University of Dundee, 21 cards, each printed with a
potential reason for choosing to undergo LASIK for
myopia, together with three blank cards for subjects to
include any additional motives, were posted to 71
patients (detailed in Table 4) who had undergone
myopic LASIK.28These choices were ranked by each
patient, in order of personal importance, and were
returned for analysis.
Table 4. Characteristics of patients enrolled in study to
investigate reasonsfor seeking LASIK treatment for myopia.
Patient characteristics and responses
18 males, 37 females
41.7+ 9.3 years
-9.26_+4.58 DS
Gender
Mean age (+ standard deviation)
Mean pre-operative refraction
(+ standard deviation)
Response rate to questionnaire 77.5%
Contact Lens and Anterior Eye
Reasons for Seeldng LASIK
The reasons ranked within the top five by each patient
were considered to be representative of their main
reasons for undergoing LASIK for myopia. As might be
expected, primary motives included the desire to
improve unaided social vision (for example, being able
to get about in daily living, without spectacle or contact
lens correction) and the desire to be free from
spectacles or contact lenses. Surprisingly, however,
another very important factor (ranked within the top five
reasons by 65% of respondents) was intolerance to
spectacles or contact lenses. Almost 70% of subjects
recorded one of these three reasons as their main
motive for undergoing this treatment. The inconveni-
ence of spectacle or contact lenses, and the desire to
improve unaided vision for sports and leisure activities,
were also ranked highly.
Another interesting finding, reflecting, perhaps, the
mean magnitude of refractive error treated by LASIK in
the current group, was the relative unimportance of
cosmesis, or self-confidence. Patients with such high
levels of myopia, are warned that they are likely to be
left with a residual refractive error which may necessi-
tate continued spectacle or contact lens wear, albeit, of
lower power. Those patients, for whom cosmetic
appearance is the sole motive, are often discouraged
from undergoing surgery, for fear of their expectations
not being realised. This is supported by the finding that
the individuals with lower preoperative refractive errors
(~<10.00 DS) considered freedom from spectacles to be
significantly more important than did those with higher
refractive error (>10.00 DS) (P<0.05). Males, unex-
pectedly, were found to be significantly more keen to be
free from spectacles or contact lenses than females,
whilst higher intolerance levels to these modes of
refractive correction were claimed by females (P< 0.05
in both cases). The reason for the latter finding is
unknown, but might reflect a possible higher incidence
of contact lens-induced dry eye reported by females
than by males, in the clinical setting. The results of this
study have helped the individuals involved in the pre-
operative counselling of prospective LASIK patients, to
establish most effectively the individual patient's incen-
tives for undergoing surgery. With this knowledge,
more realistic expectations can be set, and patient
satisfaction can be maximised. It should be noted that
approximately 50% of patients attending the Corneal
Diseases and Excimer Laser Research Unit in Dundee
were advised against undergoing refractive surgery, not
only as a result of unsuitability for the technique, but
more often as a result of high patient expectations which
could not realistically be guaranteed.
Scope for Research
Although subjective aspects of refractive surgery out-
come have been a primary research interest for the
author, many aspects of refractive surgery, beyond
visual acuity, lend themselves to objective analyses.
New generation 3-D slit-scanning topographers such as
Refractive surgery from an optometric perspective
JP Craig
the Orbscan, non-invasively provide the user with a full-
cornea pachymetry map, based on the difference
between anterior and posterior corneal heights. This
has clear benefits over the current gold standard,
ultrasound pachymetry, which requires topical anaes-
thesia and direct contact of the probe with the corneal
epithelium. In a large study of topography, a comparison
between these methods of establishing central corneal
thickness was undertaken. Central corneal thickness
was compared in a group of 101 normal eyes and in a
group of 30 eyes post-LASIK, and it was found that the
Orbscan tended to overestimate, on average, for the
normal eyes, but underestimate, on average in the post-
LASIK eyes compared to ultrasound pachymetry.29 It
was also associated with significant variability such that
the results from the two techniques cannot be con-
sidered clinically interchangeable. The higher variability
experienced in the post-LASIK eyes is believed to be
related to altered corneal composition in the region of
the LASIK flap interface affecting calculations which
assume constant refractive index for the cornea.
It is an unfortunate consequence of the high profile of
refractive surgery in the media that the exciting
phototherapeufic options of excimer laser techniques
have been overshadowed. The author has been involved
in a number of studies using PTK to treat superficial
corneal disease, particularly recurrent corneal erosions
and superficial corneal opacity, in addition to therapeutic
refractive techniques for iatrogenic refractive errors. In
particular, LASIK seems to have an important r61e in
dealing with post-corneal transplantation ametropia
where, as a general rule, up to 10% of individuals post-
graft might benefit greatly from LASIK correction of
ametropia not readily corrected by contact lenses? ° In
comparison with incisional techniques which are cur-
rently used to treat post-transplantation astigmatism,
LASIK appears equally successful, but has the added
benefit of being able to treat the myopia, such that the
spherical equivalent can be reduced to as near zero as
possible. Therefore, although more technically difficult
than LASIK on previously unoperated corneas, this
success, in combination with the rapid rehabilitation and
absence of the haze associated with comparable correc-
tions by PRK, will ensure a r61e for LASIK in this area of
transplantation surgery for the foreseeable future.
Conclusion
In conclusion, refractive surgery today cannot be 16
considered an unconditional panacea for the permanent
correction of ametropia. For the outcome to be
17
optimised, the risks and benefits of the ever-changing
face of refractive surgery must be fully assessed. This
requires a highly professional and motivated team, 18
within which the r61e of the optometrist is increasingly
expanding. 19
Acknowledgements
Dr JP Craig was supported, in part, by an unrestricted
grant from the Speed-Pollock Memorial Research Trust.
Individuals are acknowledged for their contribution to
the work by citation in the reference section. I would
like to thank Professor CNJ McGhee, PhD, FRCOphth
for assistance in preparing the manuscript.
Address for Correspondence
Dr JP Craig, Discipline of Ophthalmology, University of
Auckland, Private Bag 92019, Auckland 1001, New
Zealand. E-mail: jp.craig@auctdand.ac.nz
REFERENCES
20
Brahma, A. and McGhee, C.NJ. Surgical correction of refractive
errors. J. Royal Soc. Med., 93, 118-123 (2000).
Waxing III G.O., Lynn, M.J. and McDonnell, P.J. Results of the
Prospective Evaluation of Radial Keratotomy (PERK) study ten
years after surgery. Arch. Ophthalmol., 112, 1298-1308 (1994).
Rowsey, J.J. and Morley, W.A. Surgical correction of moderate
myopia:which method should you choose? I. Radialkeratotomy
will alwayshave a place. Surv. OphthalmoL, 43, 147-156 (1998).
Twa,M.D.,Karpecld,P.M.,King,B.J.,Linn,S.H.,Duffle, D.S.and
Schanzlin, D.J. One-yearresults from the phase IIIinvestigationof
the KeraVisionlntacs.J. Am. Optom. Assoc., 70, 515-524 (1999).
Menezo,J.L.,Avino,J.A.,Cisneros,/kI., Rodriguez-Salvador,V.and
Martinez-Costa, R. Iris claw phakic intraocular lens for high
myopia.J. Refract. Surg., 13, 545-555 (1997).
Arne, J.L. and Lesueur, L.C.Phakic posterior chamber lenses for
high myopia: functional and anatomical outcomes, jr. Cataract
Refract. Surg., 26, 369-374 (2000).
Steinert, ILKand Bafna,S. Surgicalcorrectionofmoderatemyopia:
which method should you choose? II. PRK and LASIKare the
treatments ofchoice. Surv. OphthalmoL, 43, 157-179 (1998).
McGhee, C.N.J. The assessment and surgical treatment of refractive
errors: utilising photo-ablative surgical techniques. PhD Thesis.
Universityof Dundee, pp. 107-152 (1999).
Gartry, D.S., Kerr Muir, M.G. and Marshall, J. Excimer laser
photoreffactive keratectomy. 18-monthfollow-up.Ophthalmology,
99, 1209-1219 (1992).
Hamberg-Nystrom,H.,Fagerholm,P., Sjoholm,C.andTengroth, B.
Photorefractive keratectomy for 1.5 to 8 dioptres of myopia,f
Refract. Surg., 11,265-267 (1995).
Pallikaris, I.G., Paptzanaki, M.E., Siganos, D.S. and Tsilimbaris,
M.K.Acornealflaptechniqueforlaser in situkeratornileusis.Arch.
Ophthalmol., 109, 1699-1702 (1991).
Fink, A.M., Gore, C. and Rosen, E.S. Refractivelensectomy for
hyperopia. Ophthalmology 107, 1540-1548 (2000).
O'Brart,D.P.,Stephenson,C.G.,Baldwin,H., Illafi,L.and Marshall,
J. Hyperopicphotorefractivekeratectomy with the erodible mask
and axicon system: two year follow-up,f Cataract Refract. Surg.,
26, 524-535 (2000).
Arbelaez, M.C. and Knorz, M.C. Laser in situ keratomileusis for
hyperopia and hyperopic astigmatism,f Refract. Surg., 15, 406-
414 (1999).
Geerling,G., Koop,N., Brinkmann,I~,Tnngier,A.,Wirbelauer,C.,
Birngruber, R. and Laqua, H. Continuous-wave diode laser
thermokeratoplasty:first clinicalexperience in blind human eyes.
J. Cataract Refract. Surg., 25, 32-40 (1999).
Eggink, C./L, Bardak, Y., Cuypers, M.H. and Deutman, /LF.
Treaanent of hyoperopia with contact Ho: YAG laser thermal
keratoplasty.J. Refract. Surg., 15, 16-22 (1999).
Craig, J.P., Brown, A.D. and McGhee, C.N.J. Laser in situ
keratomileuisis (LASIK):An optumetrisfs perspective. Optician,
215, June 19, 34-38 (1998).
McGhee, C.N.J. The assessment and surgical treatment of refractive
errors: utilising photo-ablative surgical techniques. PhD Thesis.
Universityof Dundee, pp.218-251 (1999).
Holland, S.P., Srivannaboon, S. and Reinstein, D.Z. Avoiding
serious complicationsof laser assisted in situ keratomileusis and
photorefractive keratectomy. Ophthalmology, 107, 640-652
(2000).
Tham, V.M. and Maloney, 1LK.Microkeratome complicationsof
laser in situ keratomileusis.Ophthalmology, 107, 920-940 (2000).
39
Contact Lens and Anterior Eye
Refractive surgery from an optometric perspective
JP Craig
40
21 Gimbel, H.V., Penno, E.E., van Westenbrugge, J./k, Ferensowicz,
M. and Furlong, M.T. Incidence and management of intraoperafive
and early postoperative complications in 1000 consecutive laser in
situ keratomileusis cases. Ophthalmology, 105, 1839-1847 (1998).
22 Stulfing, I~D., Carr, J.D., Thompson, K.P., Waring III, G.O., Wiley,
W.M. and Walker, J.G. Complications oflaser in situ keratomileusis
for the correction of myopia. Ophthalmology, 106, 13-20 (1999).
23 Lam, D.S., Leung,/LT., Wu, J.T., Cheng, A.C., Fan, D.S., Rao, S.t{_,
Talamo, J.H. and Barraquer, C. Management of severe flap
wrinkling or dislodgement after laser in situ keratomileusis. ].
Cataract Refract. Surg., 25, 1441-1447 (1999).
24 Casfillo, /k, Diaz-Valle, D., Gufierrez, A.K, Toledano, N. and
Romero, F. Peripheral melt offlap after laser in situ keratomileusis.
J. Refract. Surg., 14, 61-63 (1998).
25 Smith, RJ. and Maioney, R.IC Diffuse lamellar keratitis. A new
syndrome in lameUar refractive surgery. Ophthalmology, 105,
1721-1726 (1998).
26 McGhee, C.N.J., Craig, J.P., Sachdev, N., Weed, tCH. and Brown,
/LD. Functional, psychological, and satisfaction outcomes of laser
in situ keratomileusis for high myopia. J. Cataract Refract. Surg.,
26, 497-509 (2000).
27 Kidd, B., Stark, C. and McGhee, C.N.J. Screening for psychiatric
distress and low self-esteem in patients presenting for excimer
laser surgery for myopia. J. Refract. Surg., 13, 40-44 (1997).
2s Craig, J.P., Khan-Lira, D. and McGhee, C.N.J. Reasons for seeking
excimer LASIK treatment for myopia. Optom. Vis. Sci., 76, 18
(1999).
29 Craig, J.P., Chakrabarti, H.S., Brahma, A., Keller, P.I~ and McGhee,
C.NJ. Comparison of ultrasound and slit-scanningtechniques for
determining corneal thickness. Optom. Vis. Sci., 76, 168 (1999).
30 Koay, P.Y.P., McGhee, C.N.J., Weed, I~H. and Craig, J.P. Laser in
situ keratomileusis for ametropia after penetrating keratoplasty. ].
Refract. Surg., 16, 140-147 (2000).
Contact Lens and Anterior Eye

More Related Content

Similar to An Optometrist S Personal Perspective Of Aspects Of Refractive Surgery

Intacs, Corneal inserts for treatment of keratoconus and ectasia
Intacs, Corneal inserts for treatment of keratoconus and ectasiaIntacs, Corneal inserts for treatment of keratoconus and ectasia
Intacs, Corneal inserts for treatment of keratoconus and ectasiaMichael Duplessie
 
October 2017 laser and its applications
October 2017  laser and its applicationsOctober 2017  laser and its applications
October 2017 laser and its applicationsVinitkumar MJ
 
FR and the astigmatism after penetrating keratoplasty
FR and the astigmatism after penetrating keratoplastyFR and the astigmatism after penetrating keratoplasty
FR and the astigmatism after penetrating keratoplastyFerrara Ophthalmics
 
LASIK Surgery is Safe in the Long-Term
LASIK Surgery is Safe in the Long-TermLASIK Surgery is Safe in the Long-Term
LASIK Surgery is Safe in the Long-TermLondon Vision Clinic
 
Using real time feedback during cataract surgery to improve refractive outcomes
Using real time feedback during cataract surgery to improve refractive outcomesUsing real time feedback during cataract surgery to improve refractive outcomes
Using real time feedback during cataract surgery to improve refractive outcomesSM2 Strategic
 
Using real time feedback during cataract surgery to improve refractive outcom...
Using real time feedback during cataract surgery to improve refractive outcom...Using real time feedback during cataract surgery to improve refractive outcom...
Using real time feedback during cataract surgery to improve refractive outcom...SM2 Strategic
 
Laser Eye Surgery Guide for Canadians
Laser Eye Surgery Guide for CanadiansLaser Eye Surgery Guide for Canadians
Laser Eye Surgery Guide for CanadiansOlympia Benefits Inc.
 
Ferrara ICRS in Mild Keratoconus
Ferrara ICRS in Mild KeratoconusFerrara ICRS in Mild Keratoconus
Ferrara ICRS in Mild KeratoconusFerrara Ophthalmics
 
PENETRATING KERATOPLASTY - Cmmmmopy.pptx
PENETRATING KERATOPLASTY - Cmmmmopy.pptxPENETRATING KERATOPLASTY - Cmmmmopy.pptx
PENETRATING KERATOPLASTY - Cmmmmopy.pptxHarshika Malik
 
Case report on post lasik ecstasia
Case report on post lasik ecstasiaCase report on post lasik ecstasia
Case report on post lasik ecstasiaMeenakshi Jha
 
Scleral buckling for rhegmatogenous retinal detachment
Scleral buckling for rhegmatogenous retinal detachmentScleral buckling for rhegmatogenous retinal detachment
Scleral buckling for rhegmatogenous retinal detachmentreboca smith
 
Femtosecond laser assistedcataractsurgery
Femtosecond laser assistedcataractsurgeryFemtosecond laser assistedcataractsurgery
Femtosecond laser assistedcataractsurgerysolinskyeyecare
 
320º Intra Corneal Ring Segment - Ferrara Ring™
320º Intra Corneal Ring Segment - Ferrara Ring™320º Intra Corneal Ring Segment - Ferrara Ring™
320º Intra Corneal Ring Segment - Ferrara Ring™Ferrara Ophthalmics
 

Similar to An Optometrist S Personal Perspective Of Aspects Of Refractive Surgery (20)

Intacs, Corneal inserts for treatment of keratoconus and ectasia
Intacs, Corneal inserts for treatment of keratoconus and ectasiaIntacs, Corneal inserts for treatment of keratoconus and ectasia
Intacs, Corneal inserts for treatment of keratoconus and ectasia
 
October 2017 laser and its applications
October 2017  laser and its applicationsOctober 2017  laser and its applications
October 2017 laser and its applications
 
320º Six Month Follow up
320º Six Month Follow up320º Six Month Follow up
320º Six Month Follow up
 
Kamra
KamraKamra
Kamra
 
FR and the astigmatism after penetrating keratoplasty
FR and the astigmatism after penetrating keratoplastyFR and the astigmatism after penetrating keratoplasty
FR and the astigmatism after penetrating keratoplasty
 
LASIK Surgery is Safe in the Long-Term
LASIK Surgery is Safe in the Long-TermLASIK Surgery is Safe in the Long-Term
LASIK Surgery is Safe in the Long-Term
 
Using real time feedback during cataract surgery to improve refractive outcomes
Using real time feedback during cataract surgery to improve refractive outcomesUsing real time feedback during cataract surgery to improve refractive outcomes
Using real time feedback during cataract surgery to improve refractive outcomes
 
Using real time feedback during cataract surgery to improve refractive outcom...
Using real time feedback during cataract surgery to improve refractive outcom...Using real time feedback during cataract surgery to improve refractive outcom...
Using real time feedback during cataract surgery to improve refractive outcom...
 
Laser Eye Surgery Guide for Canadians
Laser Eye Surgery Guide for CanadiansLaser Eye Surgery Guide for Canadians
Laser Eye Surgery Guide for Canadians
 
Ferrara ICRS in Mild Keratoconus
Ferrara ICRS in Mild KeratoconusFerrara ICRS in Mild Keratoconus
Ferrara ICRS in Mild Keratoconus
 
Pdt of armd
Pdt of armdPdt of armd
Pdt of armd
 
PENETRATING KERATOPLASTY - Cmmmmopy.pptx
PENETRATING KERATOPLASTY - Cmmmmopy.pptxPENETRATING KERATOPLASTY - Cmmmmopy.pptx
PENETRATING KERATOPLASTY - Cmmmmopy.pptx
 
13 influence of corneal volume
13 influence of corneal volume13 influence of corneal volume
13 influence of corneal volume
 
09 clinical outcomes _ 210º
09 clinical outcomes _ 210º09 clinical outcomes _ 210º
09 clinical outcomes _ 210º
 
Case report on post lasik ecstasia
Case report on post lasik ecstasiaCase report on post lasik ecstasia
Case report on post lasik ecstasia
 
09 long term-follow-up
09 long term-follow-up09 long term-follow-up
09 long term-follow-up
 
Scleral buckling for rhegmatogenous retinal detachment
Scleral buckling for rhegmatogenous retinal detachmentScleral buckling for rhegmatogenous retinal detachment
Scleral buckling for rhegmatogenous retinal detachment
 
12 large case series
12 large case series12 large case series
12 large case series
 
Femtosecond laser assistedcataractsurgery
Femtosecond laser assistedcataractsurgeryFemtosecond laser assistedcataractsurgery
Femtosecond laser assistedcataractsurgery
 
320º Intra Corneal Ring Segment - Ferrara Ring™
320º Intra Corneal Ring Segment - Ferrara Ring™320º Intra Corneal Ring Segment - Ferrara Ring™
320º Intra Corneal Ring Segment - Ferrara Ring™
 

More from Erin Taylor

Looking For Genuine Online Essay Help We Help You
Looking For Genuine Online Essay Help We Help YouLooking For Genuine Online Essay Help We Help You
Looking For Genuine Online Essay Help We Help YouErin Taylor
 
Essay Editing Services Essay Writing Service
Essay Editing Services Essay Writing ServiceEssay Editing Services Essay Writing Service
Essay Editing Services Essay Writing ServiceErin Taylor
 
Depaul University Admissions Essay DePau
Depaul University Admissions Essay DePauDepaul University Admissions Essay DePau
Depaul University Admissions Essay DePauErin Taylor
 
Writing Your College Essay More CavsConnect
Writing Your College Essay More CavsConnectWriting Your College Essay More CavsConnect
Writing Your College Essay More CavsConnectErin Taylor
 
How To Quote Plays In Mla - How To Cite A Play Line Citation Guide
How To Quote Plays In Mla - How To Cite A Play Line Citation GuideHow To Quote Plays In Mla - How To Cite A Play Line Citation Guide
How To Quote Plays In Mla - How To Cite A Play Line Citation GuideErin Taylor
 
Essay Self Help Is The Best Help Essay Help Best Web
Essay Self Help Is The Best Help  Essay Help Best WebEssay Self Help Is The Best Help  Essay Help Best Web
Essay Self Help Is The Best Help Essay Help Best WebErin Taylor
 
Writing Research Paper Ppt. Online assignment writing service.
Writing Research Paper Ppt. Online assignment writing service.Writing Research Paper Ppt. Online assignment writing service.
Writing Research Paper Ppt. Online assignment writing service.Erin Taylor
 
ReMarkableS Redesigned E-Paper Tablet Is More Powerful And More Papery ...
ReMarkableS Redesigned E-Paper Tablet Is More Powerful And More Papery ...ReMarkableS Redesigned E-Paper Tablet Is More Powerful And More Papery ...
ReMarkableS Redesigned E-Paper Tablet Is More Powerful And More Papery ...Erin Taylor
 
Help Me Write My Research Paper - College Homewor
Help Me Write My Research Paper - College HomeworHelp Me Write My Research Paper - College Homewor
Help Me Write My Research Paper - College HomeworErin Taylor
 
Sample Argumentative Essay With Outline. Online assignment writing service.
Sample Argumentative Essay With Outline. Online assignment writing service.Sample Argumentative Essay With Outline. Online assignment writing service.
Sample Argumentative Essay With Outline. Online assignment writing service.Erin Taylor
 
FCE Exam Writing Samples And Essay Examples - My
FCE Exam Writing Samples And Essay Examples - MyFCE Exam Writing Samples And Essay Examples - My
FCE Exam Writing Samples And Essay Examples - MyErin Taylor
 
Informal Discussssion Research Paper Example ~ 022 Essay Example What ...
Informal Discussssion Research Paper Example ~ 022 Essay Example What ...Informal Discussssion Research Paper Example ~ 022 Essay Example What ...
Informal Discussssion Research Paper Example ~ 022 Essay Example What ...Erin Taylor
 
How To Write An Essay In 5 Easy Steps Teaching Writi
How To Write An Essay In 5 Easy Steps  Teaching WritiHow To Write An Essay In 5 Easy Steps  Teaching Writi
How To Write An Essay In 5 Easy Steps Teaching WritiErin Taylor
 
007 Writing Good College Entrance Essays Online E
007 Writing Good College Entrance Essays Online E007 Writing Good College Entrance Essays Online E
007 Writing Good College Entrance Essays Online EErin Taylor
 
CHEAP ESSAY WRITING SER. Online assignment writing service.
CHEAP ESSAY WRITING SER. Online assignment writing service.CHEAP ESSAY WRITING SER. Online assignment writing service.
CHEAP ESSAY WRITING SER. Online assignment writing service.Erin Taylor
 
A Website That Writes Essays For You. The 5 Be
A Website That Writes Essays For You. The 5 BeA Website That Writes Essays For You. The 5 Be
A Website That Writes Essays For You. The 5 BeErin Taylor
 
Top 10 Majors At Baruch College - OneClass Blog
Top 10 Majors At Baruch College - OneClass BlogTop 10 Majors At Baruch College - OneClass Blog
Top 10 Majors At Baruch College - OneClass BlogErin Taylor
 
Help Me Write My College Essays. Online assignment writing service.
Help Me Write My College Essays. Online assignment writing service.Help Me Write My College Essays. Online assignment writing service.
Help Me Write My College Essays. Online assignment writing service.Erin Taylor
 
How To Write An Autobiography Essay Tel
How To Write An Autobiography Essay  TelHow To Write An Autobiography Essay  Tel
How To Write An Autobiography Essay TelErin Taylor
 
Self Evaluation Examples Business Mentor
Self Evaluation Examples  Business MentorSelf Evaluation Examples  Business Mentor
Self Evaluation Examples Business MentorErin Taylor
 

More from Erin Taylor (20)

Looking For Genuine Online Essay Help We Help You
Looking For Genuine Online Essay Help We Help YouLooking For Genuine Online Essay Help We Help You
Looking For Genuine Online Essay Help We Help You
 
Essay Editing Services Essay Writing Service
Essay Editing Services Essay Writing ServiceEssay Editing Services Essay Writing Service
Essay Editing Services Essay Writing Service
 
Depaul University Admissions Essay DePau
Depaul University Admissions Essay DePauDepaul University Admissions Essay DePau
Depaul University Admissions Essay DePau
 
Writing Your College Essay More CavsConnect
Writing Your College Essay More CavsConnectWriting Your College Essay More CavsConnect
Writing Your College Essay More CavsConnect
 
How To Quote Plays In Mla - How To Cite A Play Line Citation Guide
How To Quote Plays In Mla - How To Cite A Play Line Citation GuideHow To Quote Plays In Mla - How To Cite A Play Line Citation Guide
How To Quote Plays In Mla - How To Cite A Play Line Citation Guide
 
Essay Self Help Is The Best Help Essay Help Best Web
Essay Self Help Is The Best Help  Essay Help Best WebEssay Self Help Is The Best Help  Essay Help Best Web
Essay Self Help Is The Best Help Essay Help Best Web
 
Writing Research Paper Ppt. Online assignment writing service.
Writing Research Paper Ppt. Online assignment writing service.Writing Research Paper Ppt. Online assignment writing service.
Writing Research Paper Ppt. Online assignment writing service.
 
ReMarkableS Redesigned E-Paper Tablet Is More Powerful And More Papery ...
ReMarkableS Redesigned E-Paper Tablet Is More Powerful And More Papery ...ReMarkableS Redesigned E-Paper Tablet Is More Powerful And More Papery ...
ReMarkableS Redesigned E-Paper Tablet Is More Powerful And More Papery ...
 
Help Me Write My Research Paper - College Homewor
Help Me Write My Research Paper - College HomeworHelp Me Write My Research Paper - College Homewor
Help Me Write My Research Paper - College Homewor
 
Sample Argumentative Essay With Outline. Online assignment writing service.
Sample Argumentative Essay With Outline. Online assignment writing service.Sample Argumentative Essay With Outline. Online assignment writing service.
Sample Argumentative Essay With Outline. Online assignment writing service.
 
FCE Exam Writing Samples And Essay Examples - My
FCE Exam Writing Samples And Essay Examples - MyFCE Exam Writing Samples And Essay Examples - My
FCE Exam Writing Samples And Essay Examples - My
 
Informal Discussssion Research Paper Example ~ 022 Essay Example What ...
Informal Discussssion Research Paper Example ~ 022 Essay Example What ...Informal Discussssion Research Paper Example ~ 022 Essay Example What ...
Informal Discussssion Research Paper Example ~ 022 Essay Example What ...
 
How To Write An Essay In 5 Easy Steps Teaching Writi
How To Write An Essay In 5 Easy Steps  Teaching WritiHow To Write An Essay In 5 Easy Steps  Teaching Writi
How To Write An Essay In 5 Easy Steps Teaching Writi
 
007 Writing Good College Entrance Essays Online E
007 Writing Good College Entrance Essays Online E007 Writing Good College Entrance Essays Online E
007 Writing Good College Entrance Essays Online E
 
CHEAP ESSAY WRITING SER. Online assignment writing service.
CHEAP ESSAY WRITING SER. Online assignment writing service.CHEAP ESSAY WRITING SER. Online assignment writing service.
CHEAP ESSAY WRITING SER. Online assignment writing service.
 
A Website That Writes Essays For You. The 5 Be
A Website That Writes Essays For You. The 5 BeA Website That Writes Essays For You. The 5 Be
A Website That Writes Essays For You. The 5 Be
 
Top 10 Majors At Baruch College - OneClass Blog
Top 10 Majors At Baruch College - OneClass BlogTop 10 Majors At Baruch College - OneClass Blog
Top 10 Majors At Baruch College - OneClass Blog
 
Help Me Write My College Essays. Online assignment writing service.
Help Me Write My College Essays. Online assignment writing service.Help Me Write My College Essays. Online assignment writing service.
Help Me Write My College Essays. Online assignment writing service.
 
How To Write An Autobiography Essay Tel
How To Write An Autobiography Essay  TelHow To Write An Autobiography Essay  Tel
How To Write An Autobiography Essay Tel
 
Self Evaluation Examples Business Mentor
Self Evaluation Examples  Business MentorSelf Evaluation Examples  Business Mentor
Self Evaluation Examples Business Mentor
 

Recently uploaded

Earth Day Presentation wow hello nice great
Earth Day Presentation wow hello nice greatEarth Day Presentation wow hello nice great
Earth Day Presentation wow hello nice greatYousafMalik24
 
Presiding Officer Training module 2024 lok sabha elections
Presiding Officer Training module 2024 lok sabha electionsPresiding Officer Training module 2024 lok sabha elections
Presiding Officer Training module 2024 lok sabha electionsanshu789521
 
Roles & Responsibilities in Pharmacovigilance
Roles & Responsibilities in PharmacovigilanceRoles & Responsibilities in Pharmacovigilance
Roles & Responsibilities in PharmacovigilanceSamikshaHamane
 
Painted Grey Ware.pptx, PGW Culture of India
Painted Grey Ware.pptx, PGW Culture of IndiaPainted Grey Ware.pptx, PGW Culture of India
Painted Grey Ware.pptx, PGW Culture of IndiaVirag Sontakke
 
Employee wellbeing at the workplace.pptx
Employee wellbeing at the workplace.pptxEmployee wellbeing at the workplace.pptx
Employee wellbeing at the workplace.pptxNirmalaLoungPoorunde1
 
How to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptxHow to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptxmanuelaromero2013
 
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...Marc Dusseiller Dusjagr
 
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxPOINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxSayali Powar
 
Interactive Powerpoint_How to Master effective communication
Interactive Powerpoint_How to Master effective communicationInteractive Powerpoint_How to Master effective communication
Interactive Powerpoint_How to Master effective communicationnomboosow
 
Pharmacognosy Flower 3. Compositae 2023.pdf
Pharmacognosy Flower 3. Compositae 2023.pdfPharmacognosy Flower 3. Compositae 2023.pdf
Pharmacognosy Flower 3. Compositae 2023.pdfMahmoud M. Sallam
 
Alper Gobel In Media Res Media Component
Alper Gobel In Media Res Media ComponentAlper Gobel In Media Res Media Component
Alper Gobel In Media Res Media ComponentInMediaRes1
 
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions  for the students and aspirants of Chemistry12th.pptxOrganic Name Reactions  for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptxVS Mahajan Coaching Centre
 
History Class XII Ch. 3 Kinship, Caste and Class (1).pptx
History Class XII Ch. 3 Kinship, Caste and Class (1).pptxHistory Class XII Ch. 3 Kinship, Caste and Class (1).pptx
History Class XII Ch. 3 Kinship, Caste and Class (1).pptxsocialsciencegdgrohi
 
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdfEnzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdfSumit Tiwari
 
Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)eniolaolutunde
 
Hierarchy of management that covers different levels of management
Hierarchy of management that covers different levels of managementHierarchy of management that covers different levels of management
Hierarchy of management that covers different levels of managementmkooblal
 
भारत-रोम व्यापार.pptx, Indo-Roman Trade,
भारत-रोम व्यापार.pptx, Indo-Roman Trade,भारत-रोम व्यापार.pptx, Indo-Roman Trade,
भारत-रोम व्यापार.pptx, Indo-Roman Trade,Virag Sontakke
 
Meghan Sutherland In Media Res Media Component
Meghan Sutherland In Media Res Media ComponentMeghan Sutherland In Media Res Media Component
Meghan Sutherland In Media Res Media ComponentInMediaRes1
 
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdfFraming an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdfUjwalaBharambe
 

Recently uploaded (20)

Earth Day Presentation wow hello nice great
Earth Day Presentation wow hello nice greatEarth Day Presentation wow hello nice great
Earth Day Presentation wow hello nice great
 
Presiding Officer Training module 2024 lok sabha elections
Presiding Officer Training module 2024 lok sabha electionsPresiding Officer Training module 2024 lok sabha elections
Presiding Officer Training module 2024 lok sabha elections
 
Roles & Responsibilities in Pharmacovigilance
Roles & Responsibilities in PharmacovigilanceRoles & Responsibilities in Pharmacovigilance
Roles & Responsibilities in Pharmacovigilance
 
Model Call Girl in Bikash Puri Delhi reach out to us at 🔝9953056974🔝
Model Call Girl in Bikash Puri  Delhi reach out to us at 🔝9953056974🔝Model Call Girl in Bikash Puri  Delhi reach out to us at 🔝9953056974🔝
Model Call Girl in Bikash Puri Delhi reach out to us at 🔝9953056974🔝
 
Painted Grey Ware.pptx, PGW Culture of India
Painted Grey Ware.pptx, PGW Culture of IndiaPainted Grey Ware.pptx, PGW Culture of India
Painted Grey Ware.pptx, PGW Culture of India
 
Employee wellbeing at the workplace.pptx
Employee wellbeing at the workplace.pptxEmployee wellbeing at the workplace.pptx
Employee wellbeing at the workplace.pptx
 
How to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptxHow to Make a Pirate ship Primary Education.pptx
How to Make a Pirate ship Primary Education.pptx
 
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
“Oh GOSH! Reflecting on Hackteria's Collaborative Practices in a Global Do-It...
 
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptxPOINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
POINT- BIOCHEMISTRY SEM 2 ENZYMES UNIT 5.pptx
 
Interactive Powerpoint_How to Master effective communication
Interactive Powerpoint_How to Master effective communicationInteractive Powerpoint_How to Master effective communication
Interactive Powerpoint_How to Master effective communication
 
Pharmacognosy Flower 3. Compositae 2023.pdf
Pharmacognosy Flower 3. Compositae 2023.pdfPharmacognosy Flower 3. Compositae 2023.pdf
Pharmacognosy Flower 3. Compositae 2023.pdf
 
Alper Gobel In Media Res Media Component
Alper Gobel In Media Res Media ComponentAlper Gobel In Media Res Media Component
Alper Gobel In Media Res Media Component
 
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions  for the students and aspirants of Chemistry12th.pptxOrganic Name Reactions  for the students and aspirants of Chemistry12th.pptx
Organic Name Reactions for the students and aspirants of Chemistry12th.pptx
 
History Class XII Ch. 3 Kinship, Caste and Class (1).pptx
History Class XII Ch. 3 Kinship, Caste and Class (1).pptxHistory Class XII Ch. 3 Kinship, Caste and Class (1).pptx
History Class XII Ch. 3 Kinship, Caste and Class (1).pptx
 
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdfEnzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
Enzyme, Pharmaceutical Aids, Miscellaneous Last Part of Chapter no 5th.pdf
 
Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)Software Engineering Methodologies (overview)
Software Engineering Methodologies (overview)
 
Hierarchy of management that covers different levels of management
Hierarchy of management that covers different levels of managementHierarchy of management that covers different levels of management
Hierarchy of management that covers different levels of management
 
भारत-रोम व्यापार.pptx, Indo-Roman Trade,
भारत-रोम व्यापार.pptx, Indo-Roman Trade,भारत-रोम व्यापार.pptx, Indo-Roman Trade,
भारत-रोम व्यापार.pptx, Indo-Roman Trade,
 
Meghan Sutherland In Media Res Media Component
Meghan Sutherland In Media Res Media ComponentMeghan Sutherland In Media Res Media Component
Meghan Sutherland In Media Res Media Component
 
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdfFraming an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
Framing an Appropriate Research Question 6b9b26d93da94caf993c038d9efcdedb.pdf
 

An Optometrist S Personal Perspective Of Aspects Of Refractive Surgery

  • 1. Contact Lens and Anterior Eye (2001) 24, 34-40 © 2001 British Contact Lens Association Review www,nature.com/clae AN OPTOMETRIST'S PERSONAL PERSPECTIVE OF ASPEC'I OF REFRACTIVE SURGERY# JenniferP. Craig* (Received llth July 2000; in revisedform 2nd November2000) Abs~act-- The latter part of the last century has seen significant evolution in the area of refractive surgery, such that is has become a viable alternative to contact lenses, or spectacles, for an increasing number ofpatients. The developments ofthe principal techniques, in this ever-expandingfield, are reviewed, and the increasing r61eof the optometrist in the pre-, intra- and post-operative management of the refractive surgery patient is described, based upon the author's personal experience within a non-profit, refractive surgery setting. In addition to highlighting pertinent features of the objective evaluation ofpatients, the importance ofsubjective assessment, pre- and post- operatively, is discussed, in terms of maximising post-surgery patient satisfaction. The scope for future research in this dynamic area is also considered. Contact Lens and Anterior Eye (2001) 24, 34-40. KEY WORDS: refractive surgery, LASIK,PRK, outcome, satisfaction History of Refractive Surgery R efractive surgery has become a realistic alternative to spectacle or contact lens correction for many myopic individuals. The concept of permanent correc- tion of ametropia is not new. As early as 1857, clear lens extraction was proposed as a means of improving unaided vision in the highly myopic, and incisional keratotomy was introduced in 1894. However, to date, no single technique has proved to be ideal? The desire to overcome the limitations of each refractive technique and, in particular, those related to the predictability of the post-operative healing process, have ensured that the art and science of refractive surgery continues to evolve. Over the last 30 years, a number of techniques have risen and declined in favour. The 1970's saw the rise in popularity of radial keratotomy following the work of Fyodorov and Durnev in Russia. The Prospective Evaluation of Radial Keratotomy (PERK) study investi- gated the results of a wide range of attempted corrections over 10 years follow-up.2 These are sum- marised in Table 1. Overall the results showed that the technique was relatively successful, but a significant number of subjects did complain of vision fluctuating on a diurnal basis, by as much as five lines of Snellen acuity. The surgical technique has been refined in recent years, producing better clinical results in terms of uncorrected vision, however, problems such as progressive hyperopia and predisposition to wound ruptures following trauma have yet to be fully resolved. Radial keratotomy remains most popular in the United States, and the low equipment cost combined with the ~The Irving Fatt Lecture, 2000 *PhDMCOptom FAAO simplicity of the technique will ensure that it retains a r61e in the treatment of low myopia) The intrastromal corneal ring or segments (Intacs~, Keravision Inc., CA, USA) have been promoted on the basis that they do not interfere with the visual axis and that the procedure is reversible# However, their insertion requires a technically challenging operation, which involves the insertion of polymethylmethacrylate (PMMA) segments at two-thirds the depth of the stroma. The degree of myopia corrected by this method is dictated by the thickness of the segments, and is therefore limited to around -4.00 DS, similar to levels treated with reasonable success by RK and photore- ffactive keratectomy (PRK). However, it should be noted that the surgery has the potential to cause significant corneal opacity around the area of insertion of the PMMA. Intraocular techniques include clear lensectomy with posterior chamber intra-ocular lens implant but, in addition to being associated with the standard risks of intra-ocular surgery, including a significantly increased risk of retinal detachment, the loss of accommodation is often unacceptable for younger individuals. Anterior chamber intra-ocular lenses, placed in front of the healthy crystalline lens have also been considered, in particular the Worst iris claw lens and the Baikhoff angle-supported lens, although there have been reports of progressive endothelial cell loss and low grade anterior chamber flare with such phakic intra-ocular lenses. ~ More recently the pre-crystalline intra-ocular 'contact lens' has been developed, and the long term results of prospective studies which are able to determine both the success and complications, such as the incidence of cataract formation and pupil block glaucoma, are eagerly awaited.6
  • 2. Refractive surgery from an optometric perspective JP Craig Table 1. Summary ofdemographicfeatures, visual outcome and significant complications ofpatients in the ProspectiveEvalutaion of Radial Keratotomy (PERK) Study.2 35 Demographics Visual outcome Significant complications Sample size Attempted range of refractive correction Follow-up Post-op uncorrected vision 6/6 Post-op uncorrected vision 6/12 Loss of two or more lines of BSCVApost-op Progressive hyperopic shift 793 -2.00 to -8.75 DS 88%at 10 years 53% 85% 3% 43% Excimer Laser Refractive Surgery Since the first surface-based excimer laser PRK on a human eye in 1988, excimer laser correction of myopia has become increasingly popular.7 Early prospective studies showed that treatment of very high refractive errors by PRK resulted in significant corneal haze which reduced BSCVA in an unacceptable number of subjects such that, by 1996, the maximum attempted correction by PRK, in the UK, was limited to -10.00 DS or less, with many practitioners setting an upper limit of around - 7.00 DS. However, at lower levels of myopia, PRK has been shown to be relatively safe and efficacious with levels of unaided vision reported in the literature as 6/6 or greater, in between 48 and 100%of subjects, and 6/12 or greater, in between 82 and 100% of subjects, for treatments of up to - 6.00 DS over a 6.00 mm treatment zone. Results of a large prospective study of PRK, by McGhee and coworkers, at Sunderland Eye Infirmary, on 323 eyes with at least 2 years follow-up, between 1993 and 1996, concluded that PRK was very successful up to -5.00 DS (72% at least 6/6 unaided) and moderately successful up to -10.00 DS (89% at least 6/12 unaided). 8 Beyond this level of attempted correction, predictability was poorer, and there was an increased risk of severe haze and loss of best spectacle corrected visual activity (BSCVA). Myopia was found to be corrected more fully (actual correction up to 100% of attempted correction) than astigmatism (around 67% mean correction). Overall, in this prospective study, which included attempted corrections of up to -15.00 DS, between 3 and 4%ofeyes lost two lines ofBSCVAas a result of severe haze. The results of this study compared well to those of similar investigations around that time.9,'° Following the pioneering work of Barraquer in 1964 and Pureskin in 1967, the technique of excimer laser in situ keratomileusis (LASIK) was developed and the technique as we know it today was performed on the first human eyes in 199071 The procedure involves anaesthetising the eye topically. A suction ring is placed on the eye, around the limbus, and this raises the intraocular pressure to around 60 mmHg and immobi- lises the eye. At this time, a microkeratome is used to create a 160 #m flap, with a nasal or superior hinge, in the anterior cornea. Suction is then released. Laser ablation of the exposed stroma (of pre-programmed depth and diameter) is performed after the flap is reflected and whilst the patient fixates a target coincident with the laser beam. After the ablation is complete, the flap is returned to its original position, the interface irrigated, and is left to settle in position without the need for sutures. Generally, the LASIK flap adheres securely, within 2 to 5 min, to the underlying stroma. LASIK offers a number of advantages over PRK. It can be used to treat higher levels of myopia (with an upper limit of around -12.00 to -15.00 DS) without inducing the corneal haze associated with PRK. Since the area of epithelial disruption is minimal, there is virtually no post-operative pain and visual rehabilitation occurs within hours to days. However, surgically, it is a more challenging operation and, unlike PRK, requires sterile operating conditions due to the more surgically invasive nature of the procedure. Hyperopic Treatments Treatment for hypermetropia by refractive surgery has also become available in recent years, but results are less well supported by long-term, longitudinal studies. Techniques include refractive lensectomy (with intra- ocular lens implantation) 12, PRK13, LASIK14 and more recently, holmium laser thermal keratoplasty (LTK).15In the latter technique, the response of the corneal tissue to the application of the laser, at several points concentric with the limbus, around the periphery of the cornea, is to contract, thereby increasing central corneal curvature, and correcting hyperopia. Overall, hyperopic corneal refractive techniques have experi- enced only limited success, with the best outcomes in patients with low levels of pre-operative hyperopia (< 4.00 DS). However, the significant risk of regression associated with these techniques, even in small attempted corrections, has resulted in the majority still being considered relatively investigational. 16One of the latest methods, with encouraging clinical results in the treatment of hyperopia (M. McDonald, BCLA keynote presentation, Birmingham, May 2000), is conductive or radiofrequency keratoplasty. In this procedure, heat is applied to the cornea with radio frequency energy, potentially causing less damage to the surrounding tissue than previous techniques. Results of the Phase Ill FDA clinical trials in the US are still awaited for this new therapy. Prospective Study of LASIK The author has recently been involved in a large, prospective study of LASIK, as part of the Corneal Diseases and Excimer Laser Research Unit at the Contact Lens and Anterior Eye
  • 3. Refractive surgery from an optometric perspective JP Craig 36 University of Dundee in Scotland. 17 The LASIK procedures were performed by a single surgeon following a standardised protocol with the Chiron Technolas 117 or 217 scanning spot excimer laser and the Chiron Automated Corneal Shaper to create the flap. All patients were prescribed topical steroids and antibiotics for 2 weeks after surgery. The following results pertain to the first 104 consecutive primary LASIK treatments for high myopia.18 The group comprised 67 females and 37 males with a mean age of 39.4 years. The mean follow-up for the group was 10.2 months at the time of collecting the data. Sixteen of the 104 subjects required retreatment due to myopic regression, at a mean of 12 weeks following primary treatment. The mean spherical equivalent (sph.eq.) (+standard deviation (SD)) prior to surgery was -9.82+4.59 DS with a range of -1.75 to -22.75 DS. The full correction was not attempted in the highest myopes, limited by the thickness of the cornea, which was determined, for each patient, by ultrasound pachymetry. The current view, based upon the experience of LASIK surgeons to date, is that a corneal thickness of 250 #m must remain undisturbed beneath the flap and ablation, to minimise the risk of sequelae such as posterior keratectasia. For any given correc- tion, decreasing the ablation zone size will decrease the ablation depth, however, a significant risk of post- operative glare is associated with small ablation zones. The magnitude of correction is therefore often dictated by the thickness of the patient's cornea, in order that the safe thickness of 250 #m, can be retained following ablation. The mean (+ SD) preoperative cylinder was -1.46+1.37 DC. At 1 year post-LASIK, the mean refractive error (sph.eq.) was -1.3+3.0 DS and the mean cyclinder was -0.7+0.7 DC. This was influ- enced largely by the extreme myopes within the group. The group was therefore divided into three groups; moderate myopes, high myopes and extreme myopes (Table 2) and the mean refractive error (sph.eq.) for each group across the 12-month follow-up period was then assessed separately. It showed that the residual refractive error was greatest, across all the time points, for the extremely myopic group. This is reflected by the tabulated results which show the percentage of subjects within each group who achieved an unaided vision of 6/6 or better, 6/12 or better, or < 6/12. The apparently poorer results, in the extreme myopes, is due largely to the limitations on attempted correction dictated by corneal thickness, described above. LASIK Complications The complication rate was low in this series of patients. Intra-operatively, there were three microkeratome-re- lated complications: two thin flaps and one button-hole in the flap. None of these patients experienced any adverse outcome as a result of these imperfect flaps and achieved good levels of unaided vision, while retaining their pre-operative BSCVA, post-LASIK. Thin flaps or button-hole flaps (in which the flap is doughnut-shaped with a central portion still attached to the main body of the cornea) can occur if suction is inadequate, and the cornea is not located in the ideal plane before the microkeratome is activated. The intraocular pressure is checked by applanation tonometry prior to creating the flap to minimise the risk of such complications, but they can also occur in cases of sudden patient movement or severe blepharospasm. In the event of a thin, incomplete or button-hole flap being apparent following the excur- sion of the microkeratome, the flap is left in place without being lifted, and the partial corneal flap allowed to heal in position without performing the ablation. Following successful healing in around 3 months, the LASIK procedure may be attempted again, with the creation of an entirely new flap. Post-operatively, the flap was displaced in two cases within an hour of the operation, once, on removal of the speculum used to hold the eyelids apart during the operation, and once by the patient who vigorously chewed on a toffee immediately post-operatively, dislod- ging the flap! One further flap displacement occurred around 12 h after surgery, when the patient instilled their prescribed topical medication and struck the flap with the bottle tip. In all cases, the patients were brought back to theatre, and the flap was rehydrated and repositioned without adverse sequelae. Overall, 97% of the group of 104 LASIK patients maintained or gained lines of BSCVA at final flow-up. Two patients lost one line of BSCVA (2%) and only one subject, two lines of BSCVA (1%). In this latter patient, the loss in vision was in fact attributable to the onset of cataract which was subsequently removed, resulting in a final BSCVA two fines better than initial BSCVA. However, although results, such as these, following LASIK surgery are encouraging in terms of speed of Table 2. Percentageofpatients achieving 6/6 or better,6/12 or better,orpoor than 6/12 vision, unaided,following a primary LASIK treatment. Percentage ofpatients achieving the given levelof vision unaided post-primary LASIK Refractive range, Mean refraction Myopicgroup Sample size pre-op(Sph. eq.) (Sph.eq.) 6/6 6/12 <6/12 Moderate 32 <- 8D - 4.96 DS 74% 97% 3% High 33 - 8 to - 12 DS - 8.80 DS 50% 78% 22% Extreme 39 >- 12 DS - 14.76 DS 4% 30% 70% Contact Lens and Anterior Eye
  • 4. Refractive surgery from an optometric perspective JP Craig recovery and unaided vision, the technique, like any surgical procedure is not free from serious complica- tions (Table 3).19-24Indeed, some complications appear unique to LASII~ One patient, who was not part of the prospective study, experienced a severe non-infective inflammation, known as diffuse lamellar keratitis or 'Sands of the Sahara'. The aefiology of this interesting phenomenon is unknown, but may be related to a reaction to debris from the surgical procedure, for example, from the microkeratome or laser plume. The condition presents with a sand-storm appearance of the cornea, at the level of the flap interface.25 Vision is reduced as a result. In the majority of patients, intensive topical steroids, for a short period of time, reduce the inflammation and vision is restored to its full potential. Subjective Assessment in Refractive Surgery Clearly, success of refractive surgery cannot be mea- sured in objective terms, such as BSCVA and residual refractive error, alone, but must, at least in part, be assessed subjectively. A - 12.00 DS patient who under- goes LASIKwith an attempted correction of - 10.00 DS may be extremely happy with a residual refractive error of -2.00 DS and unaided vision of less than 6/12, allowing them to be less dependent on their spectacles and to wear more cosmetically-appealing spectacles. Conversely, a myopic patient who has surgery for - 2.50 DS and who emerges with a residual refractive error of plano with a - 0.50 D cylinder and vision of 6/6 unaided, may consider that, because they feel the need to wear a spectacle correction for driving at night, their result is disappointing. Patient satisfaction is therefore a vital indicator of refractive surgery success. The fact that refractive procedures are elective surgery on essentially healthy eyes, albeit ametropic ones, makes subjective success all the more important. A study was therefore conducted at the Corneal Diseases and Excimer Laser Research Unit at the University of Dundee, to establish the functional and satisfaction outcomes of the patients who underwent LASIKfor high myopia.26 An anonymous 34-question, visual analogue ques- tionnaire, which was adapted from a questionnaire that the authors had used previously to assess satisfaction following PRK, was posted, simultaneously, to 48 consecutive patients who had undergone primary LASIK surgery at the Unit. This corresponded to 76 treated eyes. The response rate from the group of 28 male and 20 female subjects, with a mean age of 40.2 years, was 100%. The mean pre-operative myopia (sph.eq.) (±SD) was -10.7+4.4 DS. In eight eyes of seven subjects, the intended refractive end point was greater than - 3.00 DS or the preoperative BSCVA was less than 6/18. Of the remaining 68 eyes, 77% achieved 6/12 or better unaided vision and 32% achieved 6/6 or better unaided vision following a primary LASIK treatment. The questionnaire incorporated questions about preoperative visual function and about postoperative status, in terms of functionalityand satisfaction. Patients were requested to record answers to questions on a visual analogue scale; a horizontal line anchored at each end by two adjectival descriptors, upon which the subject could place a mark at the point which best represented their opinion. For example, in asking the patient how they rated their unaided vision pre- operatively, the line would be anchored by a descriptor such as 'very poor' at one end and 'very good' at the other end. For ease of analysis, the lines were subsequently divided into four equal categories corre- sponding to responses of 'very positive', 'positive', 'negative' and 'very negative' for each question. All subjects considered their preoperative unaided vision to be poor, with 92%rating it 'very poor'. Only 34% of subjects had rarely, or never, worn contact lenses, and approximately equal numbers of subjects were wearing spectacles and contact lenses prior to surgery. Despite being a predominantly presbyopic group, the majority of subjects reported an improvement in the ability to undertake near tasks unaided, following surgery. Only 4% noted a subjective deterioration in reading in daylight, and 9% in artificial light. The majority of subjects reported an improvement in their ability to watch television, drive in daylight or view a cinema screen without correction, however a number were aware of visual difficulties when driving at night (9%). None of the patients with difficulties had a central ablation zone of less than 5.0 mm and, in all cases, the centration of the zone was within 0.5 mm of the virtual 37 Table 3. Reported complications ofLASIK surgery,z9-24 Complications ofLASIK surgery Intra-operative Post-operative Thin/incomplete flap Button-holeflap Free/macerated flap Full-thicknesscorneal cut Minor corneal bleeding Epithelial abrasion Inadequate sucfion/IOP elevation Primary over or under-correction Decentred ablation Subconjunctivalhaemorrhage Severelywrinkled/dislodged flap Interface debris Punctate epithelialkeratopathy Diffuselamellarkeratitis Interface haze Infectiouskeratitis Regression of refractiveeffect Epithelialingro~_h Progressive keratolysis (focalmelt) Corneal ectasia Contact Lens and Anterior Eye
  • 5. Refractive surgery from an optometric perspective JP Craig 38 pupil centre. In terms of satisfaction post-operatively, all patients felt that they had fully understood the procedure prior to surgery, and all except one was very happy with their speed of visual recovery following surgery. This patient was awaiting retreatment for myopic regression and, ultimately, was delighted with their result. Ninety-four per cent of subjects felt that they had achieved the goals for which they had undergone the surgery and all but one subject felt that their quality of life had improved. It is noteworthy that two of the three subjects (including the dissatisfied patient mentioned above) who did not feel that their goals had been realised were awaiting retreatment and both recorded their unaided visual outcome as 'excel- lent' on a four point scale: poor, average, good, or excellent, following an enhancement procedure. Thus, overall, this study reported a very high level of functional improvement, a perceived improvement in quality of life, and consistently high levels of post- operative satisfaction, across a range of visual function parameters. Given that more than 31% of the eyes did not achieve 6/12 or better unaided, this may be considered surprising. The high levels of satisfaction reported in this anonymous study are believed to be due in part to the extensive preoperative counselling and written information given to subjects, which helps to set realistic expectations of the surgery. Indeed, the preoperative counselling in the Unit has been refined on the basis of an extensive study determining the reasons why patients seek LASIK treatment. It has been established, from a previous study which compared psychological aspects of patients attending an optometry practice for a contact lens assessment to those consult- ing a laser unit for an excimer laser PRK assessment, that patients seeking PRK cannot be considered conspicuously neurotic, nor driven to refractive surgery because of low self-esteemY It is therefore important that the eye-care professional understands the reasons for patients seeking LASIK, in order to be able to best counsel patients, prior to surgery. In a further study at the University of Dundee, 21 cards, each printed with a potential reason for choosing to undergo LASIK for myopia, together with three blank cards for subjects to include any additional motives, were posted to 71 patients (detailed in Table 4) who had undergone myopic LASIK.28These choices were ranked by each patient, in order of personal importance, and were returned for analysis. Table 4. Characteristics of patients enrolled in study to investigate reasonsfor seeking LASIK treatment for myopia. Patient characteristics and responses 18 males, 37 females 41.7+ 9.3 years -9.26_+4.58 DS Gender Mean age (+ standard deviation) Mean pre-operative refraction (+ standard deviation) Response rate to questionnaire 77.5% Contact Lens and Anterior Eye Reasons for Seeldng LASIK The reasons ranked within the top five by each patient were considered to be representative of their main reasons for undergoing LASIK for myopia. As might be expected, primary motives included the desire to improve unaided social vision (for example, being able to get about in daily living, without spectacle or contact lens correction) and the desire to be free from spectacles or contact lenses. Surprisingly, however, another very important factor (ranked within the top five reasons by 65% of respondents) was intolerance to spectacles or contact lenses. Almost 70% of subjects recorded one of these three reasons as their main motive for undergoing this treatment. The inconveni- ence of spectacle or contact lenses, and the desire to improve unaided vision for sports and leisure activities, were also ranked highly. Another interesting finding, reflecting, perhaps, the mean magnitude of refractive error treated by LASIK in the current group, was the relative unimportance of cosmesis, or self-confidence. Patients with such high levels of myopia, are warned that they are likely to be left with a residual refractive error which may necessi- tate continued spectacle or contact lens wear, albeit, of lower power. Those patients, for whom cosmetic appearance is the sole motive, are often discouraged from undergoing surgery, for fear of their expectations not being realised. This is supported by the finding that the individuals with lower preoperative refractive errors (~<10.00 DS) considered freedom from spectacles to be significantly more important than did those with higher refractive error (>10.00 DS) (P<0.05). Males, unex- pectedly, were found to be significantly more keen to be free from spectacles or contact lenses than females, whilst higher intolerance levels to these modes of refractive correction were claimed by females (P< 0.05 in both cases). The reason for the latter finding is unknown, but might reflect a possible higher incidence of contact lens-induced dry eye reported by females than by males, in the clinical setting. The results of this study have helped the individuals involved in the pre- operative counselling of prospective LASIK patients, to establish most effectively the individual patient's incen- tives for undergoing surgery. With this knowledge, more realistic expectations can be set, and patient satisfaction can be maximised. It should be noted that approximately 50% of patients attending the Corneal Diseases and Excimer Laser Research Unit in Dundee were advised against undergoing refractive surgery, not only as a result of unsuitability for the technique, but more often as a result of high patient expectations which could not realistically be guaranteed. Scope for Research Although subjective aspects of refractive surgery out- come have been a primary research interest for the author, many aspects of refractive surgery, beyond visual acuity, lend themselves to objective analyses. New generation 3-D slit-scanning topographers such as
  • 6. Refractive surgery from an optometric perspective JP Craig the Orbscan, non-invasively provide the user with a full- cornea pachymetry map, based on the difference between anterior and posterior corneal heights. This has clear benefits over the current gold standard, ultrasound pachymetry, which requires topical anaes- thesia and direct contact of the probe with the corneal epithelium. In a large study of topography, a comparison between these methods of establishing central corneal thickness was undertaken. Central corneal thickness was compared in a group of 101 normal eyes and in a group of 30 eyes post-LASIK, and it was found that the Orbscan tended to overestimate, on average, for the normal eyes, but underestimate, on average in the post- LASIK eyes compared to ultrasound pachymetry.29 It was also associated with significant variability such that the results from the two techniques cannot be con- sidered clinically interchangeable. The higher variability experienced in the post-LASIK eyes is believed to be related to altered corneal composition in the region of the LASIK flap interface affecting calculations which assume constant refractive index for the cornea. It is an unfortunate consequence of the high profile of refractive surgery in the media that the exciting phototherapeufic options of excimer laser techniques have been overshadowed. The author has been involved in a number of studies using PTK to treat superficial corneal disease, particularly recurrent corneal erosions and superficial corneal opacity, in addition to therapeutic refractive techniques for iatrogenic refractive errors. In particular, LASIK seems to have an important r61e in dealing with post-corneal transplantation ametropia where, as a general rule, up to 10% of individuals post- graft might benefit greatly from LASIK correction of ametropia not readily corrected by contact lenses? ° In comparison with incisional techniques which are cur- rently used to treat post-transplantation astigmatism, LASIK appears equally successful, but has the added benefit of being able to treat the myopia, such that the spherical equivalent can be reduced to as near zero as possible. Therefore, although more technically difficult than LASIK on previously unoperated corneas, this success, in combination with the rapid rehabilitation and absence of the haze associated with comparable correc- tions by PRK, will ensure a r61e for LASIK in this area of transplantation surgery for the foreseeable future. Conclusion In conclusion, refractive surgery today cannot be 16 considered an unconditional panacea for the permanent correction of ametropia. For the outcome to be 17 optimised, the risks and benefits of the ever-changing face of refractive surgery must be fully assessed. This requires a highly professional and motivated team, 18 within which the r61e of the optometrist is increasingly expanding. 19 Acknowledgements Dr JP Craig was supported, in part, by an unrestricted grant from the Speed-Pollock Memorial Research Trust. Individuals are acknowledged for their contribution to the work by citation in the reference section. I would like to thank Professor CNJ McGhee, PhD, FRCOphth for assistance in preparing the manuscript. Address for Correspondence Dr JP Craig, Discipline of Ophthalmology, University of Auckland, Private Bag 92019, Auckland 1001, New Zealand. E-mail: jp.craig@auctdand.ac.nz REFERENCES 20 Brahma, A. and McGhee, C.NJ. Surgical correction of refractive errors. J. Royal Soc. Med., 93, 118-123 (2000). Waxing III G.O., Lynn, M.J. and McDonnell, P.J. Results of the Prospective Evaluation of Radial Keratotomy (PERK) study ten years after surgery. Arch. Ophthalmol., 112, 1298-1308 (1994). Rowsey, J.J. and Morley, W.A. Surgical correction of moderate myopia:which method should you choose? I. Radialkeratotomy will alwayshave a place. Surv. OphthalmoL, 43, 147-156 (1998). Twa,M.D.,Karpecld,P.M.,King,B.J.,Linn,S.H.,Duffle, D.S.and Schanzlin, D.J. One-yearresults from the phase IIIinvestigationof the KeraVisionlntacs.J. Am. Optom. Assoc., 70, 515-524 (1999). Menezo,J.L.,Avino,J.A.,Cisneros,/kI., Rodriguez-Salvador,V.and Martinez-Costa, R. Iris claw phakic intraocular lens for high myopia.J. Refract. Surg., 13, 545-555 (1997). Arne, J.L. and Lesueur, L.C.Phakic posterior chamber lenses for high myopia: functional and anatomical outcomes, jr. Cataract Refract. Surg., 26, 369-374 (2000). Steinert, ILKand Bafna,S. Surgicalcorrectionofmoderatemyopia: which method should you choose? II. PRK and LASIKare the treatments ofchoice. Surv. OphthalmoL, 43, 157-179 (1998). McGhee, C.N.J. The assessment and surgical treatment of refractive errors: utilising photo-ablative surgical techniques. PhD Thesis. Universityof Dundee, pp. 107-152 (1999). Gartry, D.S., Kerr Muir, M.G. and Marshall, J. Excimer laser photoreffactive keratectomy. 18-monthfollow-up.Ophthalmology, 99, 1209-1219 (1992). Hamberg-Nystrom,H.,Fagerholm,P., Sjoholm,C.andTengroth, B. Photorefractive keratectomy for 1.5 to 8 dioptres of myopia,f Refract. Surg., 11,265-267 (1995). Pallikaris, I.G., Paptzanaki, M.E., Siganos, D.S. and Tsilimbaris, M.K.Acornealflaptechniqueforlaser in situkeratornileusis.Arch. Ophthalmol., 109, 1699-1702 (1991). Fink, A.M., Gore, C. and Rosen, E.S. Refractivelensectomy for hyperopia. Ophthalmology 107, 1540-1548 (2000). O'Brart,D.P.,Stephenson,C.G.,Baldwin,H., Illafi,L.and Marshall, J. Hyperopicphotorefractivekeratectomy with the erodible mask and axicon system: two year follow-up,f Cataract Refract. Surg., 26, 524-535 (2000). Arbelaez, M.C. and Knorz, M.C. Laser in situ keratomileusis for hyperopia and hyperopic astigmatism,f Refract. Surg., 15, 406- 414 (1999). Geerling,G., Koop,N., Brinkmann,I~,Tnngier,A.,Wirbelauer,C., Birngruber, R. and Laqua, H. Continuous-wave diode laser thermokeratoplasty:first clinicalexperience in blind human eyes. J. Cataract Refract. Surg., 25, 32-40 (1999). Eggink, C./L, Bardak, Y., Cuypers, M.H. and Deutman, /LF. Treaanent of hyoperopia with contact Ho: YAG laser thermal keratoplasty.J. Refract. Surg., 15, 16-22 (1999). Craig, J.P., Brown, A.D. and McGhee, C.N.J. Laser in situ keratomileuisis (LASIK):An optumetrisfs perspective. Optician, 215, June 19, 34-38 (1998). McGhee, C.N.J. The assessment and surgical treatment of refractive errors: utilising photo-ablative surgical techniques. PhD Thesis. Universityof Dundee, pp.218-251 (1999). Holland, S.P., Srivannaboon, S. and Reinstein, D.Z. Avoiding serious complicationsof laser assisted in situ keratomileusis and photorefractive keratectomy. Ophthalmology, 107, 640-652 (2000). Tham, V.M. and Maloney, 1LK.Microkeratome complicationsof laser in situ keratomileusis.Ophthalmology, 107, 920-940 (2000). 39 Contact Lens and Anterior Eye
  • 7. Refractive surgery from an optometric perspective JP Craig 40 21 Gimbel, H.V., Penno, E.E., van Westenbrugge, J./k, Ferensowicz, M. and Furlong, M.T. Incidence and management of intraoperafive and early postoperative complications in 1000 consecutive laser in situ keratomileusis cases. Ophthalmology, 105, 1839-1847 (1998). 22 Stulfing, I~D., Carr, J.D., Thompson, K.P., Waring III, G.O., Wiley, W.M. and Walker, J.G. Complications oflaser in situ keratomileusis for the correction of myopia. Ophthalmology, 106, 13-20 (1999). 23 Lam, D.S., Leung,/LT., Wu, J.T., Cheng, A.C., Fan, D.S., Rao, S.t{_, Talamo, J.H. and Barraquer, C. Management of severe flap wrinkling or dislodgement after laser in situ keratomileusis. ]. Cataract Refract. Surg., 25, 1441-1447 (1999). 24 Casfillo, /k, Diaz-Valle, D., Gufierrez, A.K, Toledano, N. and Romero, F. Peripheral melt offlap after laser in situ keratomileusis. J. Refract. Surg., 14, 61-63 (1998). 25 Smith, RJ. and Maioney, R.IC Diffuse lamellar keratitis. A new syndrome in lameUar refractive surgery. Ophthalmology, 105, 1721-1726 (1998). 26 McGhee, C.N.J., Craig, J.P., Sachdev, N., Weed, tCH. and Brown, /LD. Functional, psychological, and satisfaction outcomes of laser in situ keratomileusis for high myopia. J. Cataract Refract. Surg., 26, 497-509 (2000). 27 Kidd, B., Stark, C. and McGhee, C.N.J. Screening for psychiatric distress and low self-esteem in patients presenting for excimer laser surgery for myopia. J. Refract. Surg., 13, 40-44 (1997). 2s Craig, J.P., Khan-Lira, D. and McGhee, C.N.J. Reasons for seeking excimer LASIK treatment for myopia. Optom. Vis. Sci., 76, 18 (1999). 29 Craig, J.P., Chakrabarti, H.S., Brahma, A., Keller, P.I~ and McGhee, C.NJ. Comparison of ultrasound and slit-scanningtechniques for determining corneal thickness. Optom. Vis. Sci., 76, 168 (1999). 30 Koay, P.Y.P., McGhee, C.N.J., Weed, I~H. and Craig, J.P. Laser in situ keratomileusis for ametropia after penetrating keratoplasty. ]. Refract. Surg., 16, 140-147 (2000). Contact Lens and Anterior Eye