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PRESENTED BY JAIDEN MALIK
TOPICAL ROUTE
“A way to deliver medication that
is applied onto a partical part of
body ,topically skin to treat
various aliment.”
qeg :Lotion, gel patches and
powder mainly formulated as
cream and ointment
§ skin is ideal for drug
administration
§ It priduce both local and
systemic effect
MECHANISM
Transdermal administration:
-Dilver drug to blood stream via
adsorption through the skin via a
patch or skin
- Skin present a barrier to ready
adsorption
-Adsorption occur slowly
-Therapeutic effect last for 24
hours up to 1 week
-Chemical in the patch
-Across membrane of the skin
ADVANTAGES OF ROUTE OF ADMINISTRATION
ØAvoidence at first pass metabolism.
ØConvenient and easy to apply.
ØAchievement of efficacy with lower total daily dosage of drug by
continous drug input.
ØAvoid fiucation drug level inter and intra patient variation.
Øprovide suitability for self medication.
Disadvantages of topical administration
ØDrug having high molecular weight and poorly liquid soluble are not
absorbed via skin or mucous membrane .
ØPossibility of local skin irriation at the site of administration .
ØContact dermatitis due to some drug or excipient may denature the
drug .
ØEnzyme in the epidermis may denature the drug .
ØPresence of bacteria on the skin may also causes toxicity which
reduce effectiveness.
THANKYOU

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TOPICAL ROUTE FOR DRUG ADMINISTRATION.pdf

  • 2. TOPICAL ROUTE “A way to deliver medication that is applied onto a partical part of body ,topically skin to treat various aliment.” qeg :Lotion, gel patches and powder mainly formulated as cream and ointment § skin is ideal for drug administration § It priduce both local and systemic effect
  • 3. MECHANISM Transdermal administration: -Dilver drug to blood stream via adsorption through the skin via a patch or skin - Skin present a barrier to ready adsorption -Adsorption occur slowly -Therapeutic effect last for 24 hours up to 1 week -Chemical in the patch -Across membrane of the skin
  • 4. ADVANTAGES OF ROUTE OF ADMINISTRATION ØAvoidence at first pass metabolism. ØConvenient and easy to apply. ØAchievement of efficacy with lower total daily dosage of drug by continous drug input. ØAvoid fiucation drug level inter and intra patient variation. Øprovide suitability for self medication.
  • 5. Disadvantages of topical administration ØDrug having high molecular weight and poorly liquid soluble are not absorbed via skin or mucous membrane . ØPossibility of local skin irriation at the site of administration . ØContact dermatitis due to some drug or excipient may denature the drug . ØEnzyme in the epidermis may denature the drug . ØPresence of bacteria on the skin may also causes toxicity which reduce effectiveness.
  • 6.