Industrial pharmacy assignment

1. MAHARSHI
DAYANAND
UNIVERSITY
TOPIC:- Filling of Vials and
Infusion liquids.
Submitted By:-
ANUPAM
1421
BATCH A
B.Pharmacy 5th Sem.
Submitted To:-
Ms. Prerna Mam
Dr. Deepak Kaushik Sir.

2. Vials :-
 A vial (sometimes spelled phial or flacon) is a tiny
glass or plastic jar or container that is commonly
used to store medication in the form of liquids,
powders, or capsules.
 They can also be used as scientific sample
containers, such as in analytical chromatography
autosampler equipment.
 There are several sorts of vials, such as single
dosage and multi-dose vials, which are commonly
used for pharmaceuticals.
 A single dosage vial can only be used once, but a
multi-dose vial can be used several times. 2

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 Powders are reconstituted by introducing a diluent
(e.g.:- Sterile water for Injection)
 Vials are closed system
 The amount of air introduced should be equal to the
volume of fluid removed.
 An exception to this guideline is the withdrawal of
cytotoxic drugs from vials.
 Safety Note:-
 With the Exception of Cytotoxic drugs, inject an
equal amount of air into the vial with the syringe
and needle before withdrawing the medication.

4. VIAL FILLING AND
LYPOPHILLIZATION
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LIQUID FILLING
MACHINE
 Liquid Filling Machines are specialized machines
used to fill bottles, vials, ampoules and other
containers with pre determined quantity of liquids.
 These machines are easy to operate and fill precise
quantity of liquid into containers.
 Filling equipment allow adjustment of different
sized bottles without changing parts.

6. TYPES OF LIQUID
FILLING MACHINE
Volumetric Liquid Filling Machine:
▸ Volumetric Fillers: Volumetric Liquid Filling
Machines are best suited for filling liquids with
low to medium viscosity.
Vacuum Liquid Filling Machine:
▸ Vacuum Fillers: Vacuum Liquid Filling Machines
are best suited for filling liquids that are foamy
and caustic in nature.
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7. Vial
Filling
Machine
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8. INFUSION FLUID:-
▸ Intravenous fluids (abbreviated 'IV' fluids) are
liquids administered to replace water, sugar,
and salt that you may require if you are unwell
or having surgery and are unable to eat or
drink regularly. A drip is used to deliver IV
fluids directly into a vein.
▸ PVC( polyvinyl chloride) collapsible bags are
used to pack most infusion fluid. It is a part of
large volume parenteral product( 100ml-
1000ml per day)
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9. ADVANTAGES AND
DISADVANTAGES OF INFUSION
FLUID
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Advantages
 Durable and light weight.
 No air interface. The bag Collapses as it empties.
Disadvantages
 They adsorb some drugs.
 It permit high moisture penetration.
 Semi rigid polythene bags are also used for parenteral
solution(3ml), dialysis solution(5ml) and 100ml
electrolyte solution.
 The filling of infusion fluid is done by filling machine only

10. Filling of
Infusion
Fluid
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REFERENCES :-
1. Remington: The Science and Practice of Pharmacy, 20th
edition Pharmaceutical Science (RPS)
2. Theory and Practice of Industrial Pharmacy by Liberman
& Lachman
3. Pharmaceutics- The science of dosage form design by
M.EAulton,Churchill Livingstone, Latest edition
4. Introduction to Pharmaceutical Dosage Forms by H.
C.Ansel, Lea & Febiger,Philadelphia, 5 edition, 2005
5. https://www.slideshare.net/SurbhiSharma196/parentral
s-industrial-pharmacy

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