Industrial pharmacy assignment

1. MAHARSHI DAYANAND
UNIVERSITY
DEPT. OF PHARMACEUTICAL
SCIENCES
Assignment of Industrial Pharmacy on :
Formulation of eye lotions.
Submitted to : DR. DEEPAK
MS. PRERNA
Submitted by : Amit
B.Pharm , Vth sem.
1417

2. INTRODUCTION
 Ophthalmic preparations (eye preparations) are sterile,
liquid, semisolid, or solid preparations that may contain one
or more active pharmaceutical ingredient(s) intended for
application to the conjunctiva, the conjunctival sac or the
eyelids.
 The most commonly employed ophthalmic dosage forms
are solutions, suspensions, and ointments.
 But these preparations when instilled into the eye are
rapidly drained away from the ocular cavity due to tear flow
and lachrymal nasal drainage.
 The newest dosage forms for ophthalmic drug delivery are:
gels, gel-forming solutions, ocular inserts, intravitreal
injections and implants.

3. TYPES OF OPTHALMIC PREPRATIONS
 1.Eye drpos
 2.Eye ointments
 3.Eye lotions
Eye drops- Eye drops are
sterile water and oily solutions,
emulsions, or suspensions of one
or more active ingredients meant
for instillation into eye with
suitable dropper.

4. Eye ointment – Ophthalmic
ointments are sterile, greasy, semi-
solid preparations that are applied to
the conjunctiva or the eyelids.
 The drug enters the eye through
the cornea by simple diffusion.
 For ex- soft paraffin, liquid paraffin
and wool fat.
Eye lotions – Eye lotions are
sterile aqueous solutions applied to
an eye bath for washing of the eyes.
 The large volume of fluid to flow
quickly over the eye.

5. CRITERIA FOR SELECTION OF A DRUG FOR
OPHTHALMIC USE
1. The drug must be bio-chemically and pharmacologically
potent.
2. The drug must be non toxic to both ocular and systemic
tissues.
3. The drug must be sufficiently stable that neither significant
loss in potency from diminished availability nor little increase
in toxicity from byproducts of degradation arises.
4. The drug can be either targetable to tissues and location of
primary disease state etiology or to sites responsible for
symptomatic response.
5. The drug must be sufficiently compatible with the dosage
form, and with the tissues exposed to it, to achieve an
effective pharmaco-kinetic tissue profile

6. EYE LOTIONS
 Eye lotion are the sterile aqueous solutions used
for washing of the eyes.
 The eye lotions are supplied in concentrated form
and are required to be diluted with warm water
immediately before use.
 They are usually applied with a clean eye-bath or
sterilized fabric dressing and a large volume of
solutions is allowed to flow quickly over the eye.
 Eye lotions should be isotonic and free from foreign
particles to avoid irritation to the eye.
 They are required to be prepared fresh and should
not be stored for more than two days as the lotion
may get contaminated.

7. FORMULATION OF EYE LOTION
 Eye lotions are simple solution. They are iso-osmotic with
tears because they cause much greater dilution of the
lachrymal fluid and hence are more likely to cause
discomfort if not adjusted.
 The eye lotion should be sterile because the large volume
is used to irritation from the eye.
 While removing the irritation from the eye, it become more
susceptible to infection. The eye lotions are sterilized by
autoclaving or by passing through bacteria proof filters.
 Sodium chloride eye lotion and sodium bicarbonate eye
lotion are commonly used to remove foreign substance
from the eye.

8. METHOD OF PREPARATION
To prepare and submit 1000 ml of sodium
chloride eye lotion B.P.C
Sodium chloride – 9gm
Purified water to produce - 1000ml
Procedure –
1. Dissolve sodium chloride in purified water
and
2. Made the final volume by adding more of
purified water.
3. Filter through sintered glass filter grade 4.

9. 4. The eye lotion is transfer to the bottle.
5. Close and sealed the bottle.
6. Sterilize it by autoclaving.
Container –
1. Amber coloured screw capped fluted
bottles are used to pack eye lotion.
2. The container is labelled “For external use
only”.

10. REFERENCES :-
 https://www.slideshare.net/shubhrajit/opthal
mic-preparation
 A textbook of Industrial pharmacy, Pvee
Prakashan pg no. 170-177.
 A textbook of Industrial pharmacy, Nirali
Prakashan pg no. 6.1 .
 https://www.ncbi.nlm.nih.gov/pmc/articles/P
MC4289909/