Nutrigenomics mod1

WELCOME
I am honored by your choice to trust me as your health
educator and I thank you for being here and giving me the
opportunity to live out my passion of facilitating improved
health for everyone.
Bhagavati Harris – (772) 713-5371
www.SevenStreamstoWellness.com
Seven Streams to Wellness

NUTRI~GENOMICS +
Blueprints for Disease Prevention & Vitality
It is my intention to share healthful wisdom with you,
that you didn't even know was critical to your vibrant longevity.

CONGRATULATIONS FOR
CHOOSING HEALTH
http://mmg-233-2014-genetics-
genomics.wikia.com/wiki/

4
3 PART PRESENTATION INCLUDES:
Nutri~Genomics Basics.
 Part One we will learn about Healing Your Gut with your
Microbiome.
 Part Two we will learn about Methylation and Managing
Your Genes.
 Part Three of Nutri~Genomics, you are NOT a victim of your genes.
Learning How to Feed Your Genes.

NUTRI~GENOMICS
By Following Me Through These Foundational Blueprints You Will
LEARN HOW TO:
1. Encourage Vibrant Health at Any Age
2. Improve Your Immune System
 Nurture Your Gut Health
3. Improve Mental Clarity
4. Increase Energy And Vitality
5. Develop Tools for Disease Prevention

Which one of those bullet points is most
important to you?

Before We Continue,
Allow Me to Cover a Few General Definitions:
1. Microbiome: Module 1 will explain the microbiome ~ The bacteria (bugs) in our gut.
We can NOT heal the gut without the help of a healthy microbiome.
2. Methylation is similar to a computer’s software program. Every cell in our body is regulated
by this process called methylation. Methylation is one of the primary dictates of how our genes
behave. Many diseased states ~ mind & body ~ are a result of poor methylation.. Methylation
will be explained in Module 2.
3. Broadly speaking, Nutri~genomics is the science of how to feed & nurture your genes
for optimal health. Nutri~genomics will be explained in Module 3.

OUR HEALING PROCESS BEGINS WITH THE GUT
Before this presentations is over, you will learn of
5 PRIMARY PROTECTORS FOR YOUR GUT

MODULE 1
GUT MICROBIOME

http://www.economist.com/node/21560559
YOU ARE JUST 10% HUMAN
AROUND 90% OF THE GENES IN OUR BODIES BELONG TO BUGS
A HUMAN CONSISTS OF 23,000 GENES ~ THE BACTERIA WITHIN US HAVE MILLIONS OF GENES
For every one of the cells that make up the vessel that you call your body, there are nine
impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and
skin, but also bacteria and fungi. You are more ‘them’ than you are ‘you’.

DISGUSTING, ISN’T IT?
We are surely too sophisticated, too hygienic, too evolved to be colonized
in this way. Shouldn’t we have shunned microbes, like we did fur and
tails, when we left the forests?
Doesn’t modern medicine have the tools to help us evict them so that we
can live cleaner, more healthy, independent lives?
NO!
WE CAN NOT THRIVE WITHOUT BUGS!
Unlike the coral reefs, or the rainforests, we have not YET
thought to protect them, let alone to cherish them.

“We construct our beliefs, mostly unconsciously, and
thereafter they hold us captive. They can help us focus and
make us more effective, but sadly, they also limit us: They
blind us to possibility and subject us to fog, fear, and doubt.”
Rapid Visualization: by Kurt Hands
In your wildest imagination, what would you have
your gut microbes do for you?

THE HYGIENE HYPOTHESIS
Being too clean is destructive to good health.
The hygiene hypothesis proposes that as a result of modern
public health practices, individuals living in the
industrialized world experience a relative deficiency in
immune stimulation by microbes, rendering them vulnerable
to the development of allergic hypersensitivities and their
associated diseases.
Prescott S, Fiocchi A. Avoidance or exposure to foods in prevention and treatment of food allergy? Curr Opin Allergy Clin Immunol 2010,10:258–66

It’s Important to Know That There Are
Good Guys, And There Are Bad Guys.
The bad guys promote most all diseases.

Immune
Gut Inflammation
Poor Pathogen Fighting
Food Sensitivities
Detoxification
Decreased Detoxification
Digestion
Leaky Gut
Dysbiosis
Less Nutrient Absorption
Nutrient Deficiencies
Neurology
Brain Inflammation
Opiates
Microbial toxins
Neurotransmitters
DISEASE BEGINS IN THE GUT,
WITH THE BAD GUYS.

UNHEALTHY GUT MICROBIOME EQUALS:
1. Toxic Emotions
2. Fungal Infections
3. Foggy Brain
4. Depression
5. Lack of Energy
6. Weight Gain
7. Loss of Sex Drive
8. Hormone Imbalance
9. DISEASED STATE
Tid Bit: The microbiome also helps to
control the clock in our gut.
If we do not have healthy gut bacteria,
you will not be sleeping well.

Gut Flora Influenced By
1. Diet, Genes, Exercise, Environment & Thoughts

INFLUENTIAL FACTORS CONTINUED
 Natural Birth vs. Caesarean Section.
 The bacteria we acquire at birth educates our immune system and
makes us less “allergic” to our environment and foods.
 70 – 80% of our immune system is in our GALT – the lymph
tissue in the gut.
 Breast Feeding.
 Long Term Anti-biotic Usage.
 City or Rural Living.
 Over Concern with Clean.
 Bacteria communicate with each other, to the gut wall, and to the
brain in our head.
 GALT= Gut associated lymph tissue
Food sensitivities are the first sign that the gut biome is out of balance. Bhagavati Harris – (772) 713-5371

NATURAL BIRTH
A Baptism of Healthy Bugs
Babies delivered Naturally are dominated by Lactobacillus, Prevotella, and
Atopobium. These babies are healthily inoculated by the mother’s vaginal
canal as they are being birthed.
Babies delivered by Caesarian section have a less than healthy microbiota.
These babies have microbiota similar to the maternal skin community like
Staphylococcus.
Dr. David Perlmutter at the Bucks Institute:
“Being Born by C-Section Doubles the Risk of Autism”.
http://www.drperlmutter.com/dr-perlmutter-dr-bredesen-buck-
institute/?utm_source=newletter&utm_medium=email&utm_campaign=Buck_Livestream_Vid7_5_2015&utm_source=DrPerlmutter.com+Newsletter&utm_campaign
=704561ae18-Buck_Livestream_Vid7_5_2015&utm_medium=email&utm_term=0_3e059546f6-704561ae18-99110709&mc_cid=704561ae18&mc_eid=c0e3bc4739

DISEASE PREVENTION
The microbiota plays many roles in shaping your health, including
protection against pathogens, metabolism, detoxification,
and immune and nervous system development (6).
A number of modern chronic diseases are associated with a disruption of the microbiota,
such as (5). allergies, autoimmunity, skin conditions, inflammatory bowel
disease, thyroid conditions, diabetes, obesity, and others
(5) http://www.nature.com/cmi/journal/v8/n2/full/cmi201067a.html
(6)http://www.ncbi.nlm.nih.gov/pubmed/19491241

Bugs that assist our psychological well~being:
Lactobacillus spp. and Bifidobacterium spp.
They produce GABA. GABA is an important neurotransmitter for
general calm.
WHICH BUGS HELP US?

The Bug, Bacillus spp., Produce Dopamine for
Drive and That “Feel Good” Sense.
JF Cryan - 2012, Nature review Neuroscience

Bifidobacteria spp. can increase the
concentration of tryptophan in blood
plasma (the precursor of serotonin) so act
as an anti-depresent. Which was tested by
Desbonnet L in 2008 by infecting Germ
Free mice with specific pathogen.
viz. Bifidobacterium infantis and let them take the swim test forcefully.
Desbonnet L, Journal of psychiatric research, 2008
ANTI~DEPRESSANTS BUGS

BUGS EVEN MODULATE OUR THOUGHTS.
And you thought it was YOU
who chose those doughnuts to eat!

Molecular Psychiatry (2016) 21, 738-748;
doi:10.1038/mp.2016.50
Is the secret to human
intelligence &
psychological wellness
lurking in our guts?
Recent studies suggest
that it might.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037020/
26
It has been proven that children who show the largest
diversity with regard to their bacterial population are those
who are least affected by asthma and allergic rhinitis.
BUGS HAVE A CORRELATION with ASTHMA

http://www.holisticprimarycare.net/topics/topics-a-g/functional-medicine/1630-welcome-to-the-microbiome-holistic-medicine-s-new-
frontier.html?tmpl=component&print=1&layout=default&page=
BUGS PLAY A ROLE IN CANCER
"Gut microbiome analysis has the potential to be a new
tool to noninvasively screen for colorectal cancer," said
Dr. Schloss.
COLOGUARD
Investigators are just beginning to explore the potential impact of the microbiome on cancer risk. It is reasonable to expect that it would play a role, at least in cancers of the gastrointestinal tract.
This summer, University of Michigan researchers reported that analysis of the microbiome is more effective in predicting the presence of precancerous adenomatous polyps and invasive colorectal tumors than fecal occult blood testing.
Dr. Patrick Schloss and colleagues at the University's Department of Microbiology & Immunology analyzed stool samples from 90 people: 30 healthy individuals, 30 patients with precancerous adenomatous polyps, and 30 patients with
invasive colorectal cancer. They found that the composition of the gut microbiome was distinct for individuals in the three groups.
Using this information, they then clarified microbiome signatures for each group, and found that people with precancerous or cancerous lesions had marked depletions in a number of commensals found in the gut of the normal cancer-free
subjects.
Dr. Schloss' team then developed a risk assessment tool based on the microbiome data, and found that by looking for the "signature" microbial changes, they obtained a 4.5-fold improvement in the detection of adenomatous polyps, and a
5.4-fold improvement in the detection of invasive colorectal cancer (Zackular JP, et al. Cancer Prev Res; epub ahead of print)

Do Microbes Play
a Role in Your Fitness?

Our Primary Energy Maker – Mitochondria – Were
Derived From Microbes.
Mitochondria are known as the powerhouses of the cell. They
are organelles that act like a digestive system which takes in
nutrients, breaks them down, and creates energy rich
molecules for the cell. The biochemical processes of the cell are
known as cellular respiration.
Mitochondria were once microbes.
(8) http://www.ncbi.nlm.nih.gov/pubmed/12694174

BUGS INFLUENCE OUR METABOLISM
Friendly bugs are required for the thorough metabolism of
proteins, fats, carbohydrates and micronutrients.
Humans do not have ALL of the required enzymes for this to
happen efficiently, whereas, our healthy bugs do.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144392/

Obesity (2009) 17, 1906–1915. doi:10.1038/oby.2009.112
Large-scale alterations of the gut microbiota and its microbiome (gene content) are associated
with obesity and are responsive to weight loss. Gut microbes can impact host metabolism via
signaling pathways in the gut, with effects on inflammation, insulin resistance, and deposition
of energy in fat stores.
Restoration of the gut microbiota to a healthy state may ameliorate the conditions associated
with obesity and help maintain a healthy weight.
A CALORIE IN IS NOT JUST A CALORIE IN
Obesity and the Human Microbiome

Bad bugs feed on stress hormones – growing 10,000%.
They interpret our stress as us being weak,
and then feed on us.

Bad bugs eat your micronutrients and excrete toxins.
Good bugs eat your toxins and excrete vitamins.
33

What Harms The Good Bugs?
1. Antibiotics are like dropping a bomb and
some microbes never recover.
2. Stress
3. Acid Blocking Drugs.
4. NSAIDs
5. High SUGAR diet ~ High FAT diet.
6. Birth control pills.
7. Bio~identical hormones.
8. GMO’s
9. Chlorine, fluorine, chloramine, bromine,
etc.
We Are Slowly Killing Ourselves

GMO: A Brief History of Glyphosate
Glyphosate is the active ingredient in the herbicide,
Roundup®.
Monsanto assures us that glyphosate is practically nontoxic
to humans because
• Disrupts shikimate pathway which our cells don’t have.

Is Glyphosate Toxic?
However, our gut bacteria DO have this pathway
• We depend upon them to supply us with essential amino acids
(among many other things).
Other ingredients in Roundup greatly increase
glyphosate’s toxic effects
Insidious effects of glyphosate accumulate over time.
• Most studies are too short to detect damage.

Main Toxic Effects of Glyphosate*
Kills beneficial gut bacteria and allows pathogens to overgrow.
Interferes with function of cytochrome P450 (CYP) enzymes.
Chelates important minerals (iron, cobalt, manganese, etc.)
Interferes with synthesis of aromatic amino acids and
methionine.
• Leads to shortages in critical neurotransmitters and folate.
Disrupts sulfate synthesis and sulfate transport.
*Samsel and Seneff, Entropy 2013, 15, 1416-1463 Bhagavati Harris – (772) 713-5371

http://people.csail.mit.edu/seneff/
How Might Glyphosate Cause Obesity?
 Glyphosate Disrupts liver’s ability to detox pervasive
organic pollutants.
 Excess abdominal fat becomes a site where these toxins
can be sequestered. TOXIC Storage
 Gut microbes convert sugar to fat where the toxins can
be safely stored.

GMO phone app: EWG.org

GMO INCREASES LEAKY GUT

LEAKY GUT & IMMUNITY

ENZYMES, METABOLISM &
HYDROCHLORIC ACID (HCL)
Feeding Your Genes to Protect Your Gut
http://buy-vitamins-minerals.com/enzymes/

5 PRIMARY PROTECTORS FOR THE GUT
THE NECESSARY GUT DEFENSE SYSTEM
1. Tight Junction Cells
2. Microbiome
3. Mucus
4. SIgA Secratory Antibodies
(G.U.L.T 70% of immune system)
5. Acid
LEAKY GUT = PRELUDE TO AUTOIMMUNE DISEASE
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886850/

Multiple research studies have linked gluten to the condition known as intestinal permeability – AKA – Leaky Gut Syndrome. One of the leading gluten
sensitivity researchers in the world, is the head of research at the University of Maryland Celiac Research Center, and he is responsible for discovering the
gluten/leaky gut connection.
Dr. Alessio Fasano,
&
ZONULIN
See more at:
https://www.glutenfreesociety.org/gluten-free-society-blog/
dr-fasano-on-leaky-gut-syndrome-and-gluten-sensitivity/#
sthash.FtTLkxNJ.dpuf
THE EXPERT ON LEAKY GUT
http://www.icnr.org/articles/lgs.html

LETS BEGIN HEALING THE
GUT
A Habitat for an Extraordinary Community of Microbes.

WHAT CAN BE DONE TO HELP HEAL
YOUR GUT?

GO ORGANIC!
https://www.ewg.org/foodnews/?gclid=CjwKEAiAxKrFBRD
m25f60OegtwwSJABgEC-
ZbfEzhhGkZk85A9TMNu3NNunojBjkCJf-
GYW1pZmvvhoCBhHw_wcB

ADJUST FOOD INTAKE
Reduce or Avoid:
 Sugars: Artificial sweeteners, highly processed sugars, cane sugar.
 Goods high in mold or fungus: Dried fruits, melons, peanuts, mushrooms, corn
and rye.
 Bakers yeast including bread and other products such as pretzels.
 Vinegar Ferments: Ketchup, mustard, Worcestershire sauce, pickles.
 Certain Fruits: Bottled fruit juice and dried fruit.
 Hot dogs, salami, processed lunch meats.
Add:
 Lacto-fermented foods: *SCD yogurt, raw cultured veggies, apple cider vinegar.
 Alkalizing veggies.
 Coconut oil.
 Antifungal foods & spices – Found in Mod 3 of “Nutri~Genomics”.
*Information on SCD (Specific Carbohydrate Diet) can be found at: http://www.breakingtheviciouscycle.info/home/

ELIMINATE OR CUT DOWN ON GLUTEN
ELIMINATE OR CUT
DOWN ON HIGHLY
PROCESSED FOODS.

1. Reduce TWO unhealthy foods ~ Such as Glutens, Heavily
Processed Foods, Sugars and Unhealthy Fats, &/or GMOs.
2. Add 1-3 fermented foods to your menu, in order to introduce
healthy bugs to your gut. Homemade Yogurt; Homemade Kefir;
Homemade Fermented Veggies. You can find a few instructional
videos at:
 http://www.breakingtheviciouscycle.info/knowledge_base/detail/scd-yoghurt/
 Or, simply purchase LIVE, ORGANIC store bought premade ferments.
2 SUGGESTED ACTION STEPS

CHANGE THE QUALITY OF FATS & OILS IN YOUR DIET
Use:
 Extra Virgin Coconut Oil
 Extra Virgin Olive Oil
 Grape-Seed Oil
Skip These:

AVOID HEAVILY PROCESSED & TRANS- FATS
If Your food can go bad, it’s good for you.
If it can’t go bad, it’s bad for yoU.
The majority of trans
fats are artificial
fats created by
adding hydrogen to
liquid vegetable oil
to make it into a solid.

ADD PROBIOTICS
WHAT ARE THEY & WHAT DO THEY DO?
Probiotic products contain helpful, viable bacteria and/or yeasts that
assist in balancing the levels of indigenous microorganisms in the
human body.
Probiotics are available in varied
forms such as yogurt and other culture
milk foods, capsules, tablets, beverages,
and powders.

ADD FERMENTED COCONUT WATER
& MILK KEFIR.
ADD SCD YOGURT TO YOUR DIET.
Information on SCD (Specific Carbohydrate Diet) can be found at:
http://www.breakingtheviciouscycle.info/home/
BodyEcology.com

PROBIOTICS &
Atmosphere Within The Gut
Is your gut like the desert, or is it like luscious fertile soil?
We must nurture the atmosphere within the gut in order for
the probiotics to take hold. Bhagavati Harris – (772) 713-5371

FEED YOUR BUGS ~ PREBIOTICS
Fiber exclusively feeds bacteria = Prebiotics
Insoluble Fiber: Aids in motility and prevents
constipation.

Soluble Fiber: Slows so you feel fuller longer.
FEED YOUR BUGS ~ more PREBIOTICS

“We construct our beliefs, mostly unconsciously, and
thereafter they hold us captive. They can help us focus and
make us more effective, but sadly, they also limit us: they
blind us to possibility and subject us to fog, fear, and doubt”
Rapid Visualization: by Kurt Hands
In your wildest imagination, what would you have
your gut microbes do for you?

TAKE HOME TOOLS
1. The KEY to a healthy gut microbiome is to eat a diet rich in color, fiber,
protein, *SCD Yogurt, Kefir and fermented foods to foster the growth of
the good guys.
2. Stop eating heavily processed foods.
3. Supplementing with a variety of Pro-Biotics helps establish and maintain
the healthy population of gut bacteria. VSL#3 – non prescription has been
found by Consumerlab.com, to have one of the highest number of healthy
bacteria.
*Information on SCD (Specific Carbohydrate Diet) can be found at:
http://www.breakingtheviciouscycle.info/home/

EXCELLENT GUT HEALTH RESOURCES

YOUR ARE HERE! Bhagavati Harris – (772) 713-5371

62
I am honored by your choice to trust me as your health educator
and I thank you for giving me the opportunity to live out my
passion of facilitating improved health for everyone.

MODULE 2
METHYLATION ~ Managing Your Genes

Nutrigenomics mod1

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