Red blood cell production

1. Erythropoiesis
1.DEFINITION
2.CHARACTERISTICS
3.STAGES
PRINCE REHMAN
BS(HON) PATHOLOGY
GANDHARA UNI PESH

2. 1.Defination
THE FORMATION OF RED BLOOD CELL IN NORMAL BONE MARROW IS CALLED
ERYTHROPOIESIS.
• PRONORMOBLAST IS THE FIRST IDENTICAL CELL OF ERYTHROID SERIES.
2.CHARACTERISTICS
1.DECREASE IN CELL SIZE
2.HEMOGLUBINIZATION
3.DIS APPEAR OF NUCLEUS

3. 3.STAGES
FOLLOWING 6 STAGES…
1.PRONORMOBLAST
2.BASOPHALIC NORMOBLAST
3.POLYCHROMATIC NORMOBLAST
4.ORTHROCHROMATIC NORMOBLAST
5.RETICULOCYTES
6.RBC

4. 1.Pronormoblast
SHAPE: LARGE ROUND CELL
SIZE : 12-20 MICRO METER
NUCLEUS: LARGE ROUND HAVE NUCLEI
CYTOPLASM: SMALL DEEP BLUE IN COLOR.
IT MATURE INTO BASOPHILIC NOR…

5. 2.Basophalic normoblast
SHAPE: LARGE ROUND CELL
SIZE : 10-16 MICRO METER
NUCLEUS: LAGRE AND NO NUCLEI
CYTOPLASM: BLUE IN COLOR
IT MATURE INTO POLYCHROMATIC NORMOBLAST

6. 3.Polychromatic Normoblast
SHAPE : ROUND SHAPED CELL
SIZE : 8-14 MICRO METER
NUCLEUS : OCCUPY SMALL PLACE BECOM BLUE
CYTOPLASM : REDISH IN COLOR
HB FORMATION TAKE PLACE
IT MATURE INTO ORTHROCHROMATIC NORMOBLAST

7. 4.Orthrochromatic normoblast
SHAPE: ROUND CELL
SIZE: 8-10 MICRO METER
NUCLEUS: TOO SMALL AND DIS APPEAR
CYTOPLASM: ACIDOPHILIC DUE TO HB

8. 5.Reticulocyte
IT IS ALSO CALLED IMMATURE RBC
SHAPE : ROUND SHAPE CELL
SIZE : SLIGHTLY LARGER THAN RBC
NUCLEUS: NO NUCLEUS
CYTOPLASM: CONTAIN BASOPHILIC MATERIAL (DNA,RNA) CALLED RETICULUM
STAIN : SUPRA VIOLET STAIN
IT MATURE INTO RBC IN 4 DAYS

9. 6.RBC
SHAPE : BI CONCAVE DISK
SIZE : 7.2 – 7.4 MICRO METER
NUCLEUS: ABSENT
CYTOPLASM: PINK CYTOPLASM DUE TO HB
LIFE SPAN : 90- 120 DAYS