Blood cells and hematopoesis


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the structure of and formation blood cells, erythrocyte,leucocyte,neutrophil,basophil,eosinophil,lymphocyte T,lymphocyte B, hematopoiesis, erythropoiesis,leucopoiesis,granulocytopoiesis,agranulocytopoiesis,lymphopoiesis

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Blood cells and hematopoesis

  2. 2. COMPONENT OF THE BLOOD<br />Blood is specialized connective tissue<br />Composed by :<br /><ul><li>Formed elements
  3. 3. Fluid component , Plasma (the extracellular(matrix)</li></li></ul><li>FORMED ELEMENTS OF BLOOD<br />Formed elements : cells and cell fragments (platelets)<br />The cells of blood :<br /><ul><li>red blood cells (RBC)
  4. 4. white blood cells (WBCs, leukocytes). </li></li></ul><li>NEUTROPHILS <br /><ul><li>60-70% of total leucocytes
  5. 5. 9-12 µm in diameter
  6. 6. Multilobe nucleus
  7. 7. Female : drum stick/Barr Body
  8. 8. Granules :
  9. 9. Small spesific granules
  10. 10. Azurophilic granules (Lysosomes)
  11. 11. Tertiary granules (gelatine and cathepsins)
  12. 12. Function :
  13. 13. Phagocytes</li></li></ul><li>EOSINOPHILS<br />4% of total leucocyte<br />10 - 14 µm in diameter<br />Bilobed nucleus<br />Many large spesific granules stained by eosin<br />Function :<br /><ul><li>Eliminate antibody-antigen complexes
  14. 14. Destroy parasitic worms</li></li></ul><li>BASOPHILS<br /><1% of total leucocyte<br />8-10 µm in diameter<br />S-shape nucleus (irregular lobes) <br />Large spesific granules obscured the nucleus<br />Granules (dark blue) contain heparin & histamin<br />Surface receptor (Ig E receptors)<br />Function :<br />As initiator of inflamatory process<br />
  15. 15. LYMPHOCYTES <br />20%-25% of total leucocyte <br />8-10 µm in diameter<br />Round nucleus with slight indented, occupies most of the cell<br />Contain few azurophilic granules<br />
  16. 16. MONOCYTES <br />Largest circulating blood cells<br />3-8% ot total leucocyte <br />Large, acentric, kidney- shape nucleus<br />numerous azurophlic granules<br />Migrate to the connective tissue  MACROPHAGES (phagocytose antigens and as APC)<br />
  17. 17. PLATELETS<br />250.000-400.000 platelets/mm3<br />2 to 4 µm in diameter<br />Display peripheral clear region (hyalomere ) and central darker region (granulomere)<br /> receptor molecules (glycocalyx) on plasmalemma<br />Function : Blood clott<br />
  18. 18. HEMATOPOIESIS<br />Mature blood cells have a relatively short life span<br />Must be continusly replaced by stem cells<br />Stem cells produce in HEMATOPOIETIC ORGAN<br />
  19. 19. PRENATAL HEMOPOIESIS<br />Subdivide into four phases :<br />Mesoblastic : <br />begin after 2 weeks after conception at yolk sac<br />Mesenchymal cells aggregate into blood islands<br />Hepatic<br />Begins at 6 weeks until end of gestation<br />Nucleated erythrocyte<br />Appear of leucocyte (8th week)<br />Splenic<br />Begin at second trimester until end of gestation<br />Myeloid<br />Begin at the end of second trimester<br />Hemopoiesis at bone marrow<br />
  20. 20. POSTNATAL HEMOPOIESIS<br />Hemopoiesis almost exclusively in BONE MARROW<br />Stem cells undergo <br />multiple cells divisions<br /> and differentiation<br />Replace the cells that leave the blood stream, die or destroy<br />
  21. 21. BONE MARROW<br />A gelatinous, vascular connective tissue located in medulary cavity of long bones <br />Responsible for hemopoiesis<br />Structure :<br />Vascular compartment<br />Extensive network of sinusoids , arteries and veins form the<br />Hemopoietic compartment<br />Islands of hematopoietic cells <br />Hemopoietic cells in various stage of maturation <br />
  22. 22. HEMOPOIETIC GROWTH FACTORSTable 10-6 Gartner colour text histology<br />Regulated the hemopoiesis<br />Produce by spesific cells<br />Acts on spesific stem cells, progenitor cells, and precursor cells<br />The route to deliver growth factor :<br />Via blood stream<br />Secrete near the hemopoietic cells<br />Direct cell-cell contact<br />Induced rapid mitosis or and differentiation<br />Most ot them are glycoproteins<br />
  23. 23. HEMATOPOIESIS<br />
  24. 24. ERYTHROPOIESIS<br />Formation of red blood cells<br />Generates 2.5 x 10 11 erythrocytes /day<br />By two types of unipotential progenitor cell<br />BFU-E<br />CFU-E<br />Regulate by : erythropoietin<br />
  25. 25. PROERYTHROBLAST<br />.<br />
  26. 26. NORMOBLAST<br />.<br />
  27. 27. RETICULOCYTE<br />
  28. 28. ERYTHROCYTE<br />Biconcave-shape disk<br />Without nuclei and organelles<br />Have soluble enzymes <br />Filled with Hemoglobin (Hb)<br />Average life span of erythrocyte : 120 days<br />
  29. 29. GRANULOCYTOPOIESIS<br />Formation of the granulocytes (neuthrophil, eosinophil, and basophil<br />CFU-Eo : eosinophil lineage<br />CFU-Ba : Basophil lineage<br />CFU-GM<br />CFH-G : Neutrophil line<br />CFU-M : monocyte line<br />Influence by G-CSF, GM-CSF<br />
  31. 31. EOSINOPHYL STAB<br />
  32. 32. NEUTROPHYL STAB<br />
  33. 33. BASOPHIL (BONE MARROW)<br />
  34. 34. MONOCYTOPOIESIS<br />
  35. 35. PROMONOCYTE<br />
  36. 36. PLATELET FORMATION<br />CFU-Meg, gives rise the Megakaryoblast<br />Megakaryoblast differentiate  Megakaryocytes (single lobulated nucleus)<br />Megakaryocytes protrude  clusters of proplatelets  platelets<br />
  37. 37. MEGAKARYOCYTE<br />
  38. 38. LYMPHOPOIESIS<br />CFU-Ly divides form the CFU-LyB and CFU-LyT<br />CFU-LyB migrate to “bursa-equivalent location”, divided  B lymphocytes <br />CFU-LyT undergo mitosis migrate to the Thymus  T lymphocytes<br />
  39. 39. LYMPHOBLAST<br />
  40. 40. LEARNING TASKS<br />Expain the composition of the blood!<br />Explain the structure of formed elements of blood!<br />How to differentiate the blood cells from a blood-smear? <br />Explain the classification and function of leucocyte !<br />Explain the maturation of lymphocyte!<br />What blood cell would be in abundance during an active parasitic infection? Explain your answer!<br />Eplain the structure and function of platelets!<br />What blood cell in bone marrow is the earliest recognizable stage of the red blood cell line?<br />Describe the structure of erythrocyte if lack of this nutrient: vitamin B12 and iron during the erythrocytopoiesis<br />
  41. 41. I WAYAN SUGIRITAMA<br /><br /><br />