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Platelet cell
1.
2. platelets = small plate; thrombo=clot; cytes =
cells
Platelet are smalllest blood cells, colourless,
nonnucleated, round or oval, flattened, disk-
shaped structures
Cytoplasm =Golgi apparatus , endoplamic
reticulum, few mitochondria, microvsicles,
glycogen, lysosomes
3.
4. Platelets, also called thrombocytes (thromb- + -cyte,
"blood clot cell")Platelets are produced in the bone
marrow.
Platelets are produced from very large bone marrow cells
called megakaryocytes.
As megakaryocytes develop into giant cells, that results in
the release of over 1,000 to 3000 platelets per
megakaryocyte.
Platelets have no cell nucleus.
2–3 µm in greatest diameter.
Megakaryocyte and platelet production is regulated by
thrombopoietin, a hormone in the kidneys and liver.
5. Each megakaryocyte produces between
1,000 and 3,000 platelets during its lifetime.
An average of 1011 platelets are produced
daily in a healthy adult.
average life span of circulating platelets is 8
to 9 days
In adults 1.5 -4 lakhs/mm3 of blood.
6. On a stained blood smear, platelets appear as dark purple
spots.
First, platelets attach to substances outside endothelium
Second, they change shape, turn on receptors and secrete
chemical messengers
Third, they connect to each other through receptor bridges.
platelet granules. Alpha granules contain clotting mediators such
as factor V, factor VIII, fibrinogen, fibronectin, platelet-derived
growth factor, and chemotactic agents. Delta granules, or dense
bodies, contain ADP, calcium, serotonin, which are platelet-
activating mediators. -
Platelets have d-granules that contain serotonin, adenosine
diphosphate (ADP), and Ca2
7. The main function of platelets is to contribute to hemostasis: the
process of stopping (arrest) bleeding endothelium
Phagocytosis of small particles (carbon)and (viruses)
organisms.
Storage and transport (Serotonin )of chmicals. (Heparin)
platelet provided factor 3 (platelet phospholipids ) process of
clotting blood.
Serotonin released by platelet observed immediately after
vascular injury.
Hemostatic plug is formed by platelet and is their primary
function.(stops bleeding).
Platelet have growth factor repair of the damaged vassel wall.
8. Platelet activation causes its membrane surface
to become negatively charged that negatively
charged phospholipids from the inner to the
outer platelet membrane surface.
These phospholipids then bind the tenase and
prothrombinase complexes, two of the sites of
interplay between platelets and the coagulation.
Calcium ions are essential for the binding of
these coagulation factors.
9. Symptoms of a Low Platelet Count
red, purple
a rash with small red or purple dots
nosebleeds
bleeding gums
bleeding from wounds that lasts for a prolonged period or
doesn’t stop.
heavy menstrual bleeding
blood in the stools or Gastrointestinal bleeding
blood in the urine
In more serious cases
blood in the urine
blood in the stool
bloody or very dark vomit
10. Increased Numbers Of Platelets
thaThrombocytosis
Decreased Numbers Of Platelets
Thrombocytopenia
11. aplastic anemia
a vitamin B-12 deficiency
an iron deficiency
viral infections, including HIV, Epstein-Barr virus, and
chickenpox
exposure to chemotherapy, radiation, or toxic chemicals
consuming too much alcohol or Alcohol toxicity, ethanol abuse
Leukemia
an autoimmune disorder
Pregnancy
Viral, bacterial, and rickettsial infections
Antiplatelet antibodies
12. Idiopathic thrombocytopenia (ITP), also known as immune
thrombocytopenic is the result of antibody production
against platelets.
Viral infections such as mononucleosis, hepatitis, HIV or
measles
Heparin-induced thrombocytopenia (HIT) results in low
platelets when a person who is on or received heparin
therapy develops an antibody.
Leukemia, lymphoma, or another cancer that has spread
(metastasized) to the bone marrow—people with cancers
after significantly decreased number of platelets.
Aplastic anemia—a condition in which the production of all
blood cells is significantly reduced
Long-term bleeding problems (e.g., chronic bleeding from
stomach ulcers)
Sepsis, especially that caused by a serious bacterial
infection with Gram-negative bacteria.
13. Cancer, most commonly lung, gastrointestinal, ovarian, breast or lymphoma
Anemia, in particular iron-deficiency anemia and hemolytic anemia
Inflammatory conditions such as inflammatory bowel disease (IBD) or
rheumatoid arthritis
Infectious diseases such as tuberculosis
Recovery from significant blood loss such as from trauma or major surgery
After physical activity or exertion
Recovery from excess alcohol consumption and vitamin B12 and folate
deficiency
diabetes mellitus, increased blood lipids or cholesterol levels, increased
platelet levels, and smoking.
Rheumatoid arthritis
Renal failure
Chronic pancreatitis
14. 1. Platelet counts normally increase at high
altitudes; exercise, trauma, or excitement;
and in winter.
2. Platelet counts normally decrease before
menstruation and during pregnancy.
15. avoiding contact sports
avoiding activities with a high risk of bleeding.
limiting alcohol consumption
stopping or switching medications that affect
platelets, including aspirin and ibuprofen
blood or platelet transfusions
changing medications that are causing a low
platelet count
corticosteroids to block platelet antibodies
drugs that suppress your immune system
a splenectomy, or the surgical removal of the
spleen