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Leukopiesis and agranulositosis 2011

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white blood cells formation

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Leukopiesis and agranulositosis 2011

  1. 1. LEUKOPOIESIS I WAYAN SUGIRITAMA http://sugiritama.blogspot.com [email_address]
  2. 2. LEUKOPOIESIS <ul><li>“ Formation and maturation of white blood cells” </li></ul><ul><li>Granulocytopoiesis </li></ul><ul><li>Agranulocytopoiesis </li></ul><ul><ul><li>Monocytopoiesis </li></ul></ul><ul><ul><li>Lymphoctye maturation </li></ul></ul>
  3. 3. NEUTROPHILS
  4. 4. EOSINOPHILS
  5. 5. BASOPHILS
  6. 6. LYMPHOCYTES
  7. 7. MONOCYTES
  8. 8. BONE MARROW : The Site of Leucopoiesis <ul><li>Vascular compartment </li></ul><ul><ul><li>Extensive network of sinusoids . </li></ul></ul><ul><li>Hemopoietic compartment </li></ul><ul><ul><li>Islands of hematopoietic cells </li></ul></ul><ul><ul><li>( Hemopoietic cells in various stage of maturation ) </li></ul></ul>
  9. 10. Leukopiesis <ul><li>Depends upon the presence of suitable microenvironment </li></ul><ul><li>Regulate by growth factors, CSF </li></ul><ul><li>Process : </li></ul><ul><ul><li>Mitosis </li></ul></ul><ul><ul><li>Differentiation </li></ul></ul>
  10. 11. GRANULOCYTOPOIESIS <ul><li>Formation of the granulocytes (neuthrophil, </li></ul><ul><li>eosinophil, and basophil ) </li></ul><ul><li>All of Granulocyte progenitor cell derive from CFC-S </li></ul><ul><li>Granulocyte Progenitor : </li></ul><ul><ul><li>CFU-Eo : eosinophil lineage </li></ul></ul><ul><ul><li>CFU-Ba : Basophil lineage </li></ul></ul><ul><ul><li>CFU-GM </li></ul></ul><ul><ul><ul><li>CF U -G : Neutrophil line </li></ul></ul></ul><ul><ul><ul><li>CFU-M : monocyte line </li></ul></ul></ul>
  11. 12. GRANULOCYTOPOIESIS <ul><li>Granulocyte maturation divide into six stages </li></ul><ul><li>Structural Changes : </li></ul><ul><ul><li>A decreased in cell size </li></ul></ul><ul><ul><li>Condensation of nuclear chromatin </li></ul></ul><ul><ul><li>Changes in nuclear shape </li></ul></ul><ul><ul><li>An accumulation of cytoplasmic granule </li></ul></ul>
  12. 13. GRANULOCYTOPOIESIS
  13. 14. MYELOBLAST (1 st )
  14. 15. PROMYELOCYTE (2 nd )
  15. 16. MYELOCYTE (neutrophil 3 rd )
  16. 17. METAMYELOCYTE (neutrophil 4 th )
  17. 18. STAB (neutrophil 5 th )
  18. 19. SEGMENTED (neutrophil 6 th )
  19. 20. Conclusion <ul><li>All of the granulocyte derive from myeloblast </li></ul><ul><li>Myelocyte is the stage when three types of granulocyte can be recognized </li></ul><ul><li>The maturation process of granulocyte characterized by : </li></ul><ul><ul><li>synthesis of azurophilic and spesific granules </li></ul></ul><ul><ul><li>Condensation of nucleus </li></ul></ul><ul><li>Mature granulocyte leave the bone marrow then enter the circulation  connective tissue </li></ul>
  20. 21. Agranulopoiesis <ul><li>Agranulocytes derive from CFC-S and CFC-Ly </li></ul><ul><li>Morphologic changes : </li></ul><ul><ul><li>Decrease in overall cell and nuclear diameter </li></ul></ul><ul><ul><li>An increase in nuclear chromatin density </li></ul></ul>
  21. 22. MONOBLAST (Monocytopoiesis) <ul><li>Large cell (15-25 ) </li></ul><ul><li>Nucleus oval </li></ul><ul><li>Cytoplasm without granule or few azurophlic granule </li></ul><ul><li>Differentiate to the Promonocyte </li></ul>
  22. 23. PROMONOCYTE (Monocytopoiesis) <ul><li>Divide twice in the course of their development into monocytes </li></ul>
  23. 24. MONOCYTE ON BONE MARROW <ul><li>Mature monocytes enter the bloodstream, circulate. </li></ul><ul><li>then enter the connective tissues, where they mature into macrophages . </li></ul>
  24. 25. MONOCYTE ON PERIPHER
  25. 26. LYMPHOPOIESIS <ul><li>CFU-Ly divides form the CFU-LyB and CFU-LyT </li></ul><ul><li>CFU-LyB migrate to “bursa-equivalent location”, divided  B lymphocytes </li></ul><ul><li>CFU-LyT undergo mitosis migrate to the Thymus  T lymphocytes </li></ul>
  26. 27. LYMPHOBLAST
  27. 28. LYMPHOCYTE ON BONE MARROW
  28. 29. LYMPHOCYTE
  29. 30. CONCLUSION <ul><li>Leucocytosis is formation of WBC, occurs in Bone Marrow </li></ul><ul><li>Granulocyte and monocyte derive from Myeloid stem cells, whereas limfocyte from Lymphoid Stem cell </li></ul><ul><li>Leucocytosis involved the series of mitosis and differentiation </li></ul><ul><li>Leucocytosis are regulated by several growth factor and Interleukin </li></ul>
  30. 31. AGRANULOCYTOSIS <ul><li>Definition ? </li></ul><ul><li>Sign and symptoms ? </li></ul><ul><li>Causes ? </li></ul><ul><li>Patophysiology ? </li></ul><ul><li>Diagnosis ? </li></ul><ul><li>Treatment ? </li></ul>
  31. 32. <ul><li>ANY QUESTION ? </li></ul>THANK YOU FOR YOUR ATTENTION

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