Acetyl Co A presentation

1. MADE BY :
PRIYADARSHINI PARHI
BIOCHEMISTRY ( H)

2. ACETYL CO A
• A molecule that participates in
many biochemical reactions in
protein , carbohydrate and lipid
metabolism.
• Its main function is to deliver the
acetyl group to the citric acid cycle.

4. 1.Pyruvate, the product of glycolysis is converted
to acetyl – CoA , the starting material for the citric
acid cycle, by the Pyruvate dehydrogenase
complex.
2.This reaction is called as oxidative
decarboxylation.
3.PDH complex requires 3 different enzymes :
Pyruvate dehydrogenase , dihydrolipoyl
transacetylase , dihydrolipoyl dehydrogenase
and 5 different coenzymes : CoA , TPP , FAD ,
NAD , Lipoic acid .

7.  Also known as KREBS CYCLE or TCA
 (TRICARBOXYLIC ACID ) CYCLE .
It has 8 successive reaction steps :
1.Formation of Citrate
2.Formation of Iso citrate via cis-Aconitate
3.Oxidation of Iso citrate to alpha ketoglutarate and CO2
4.Oxidation of alpha ketoglutarate to Succinyl CoA and
CO2
5.Conversion of Succinyl CoA to Succinate
6.Oxidation of Succinate to Fumarate
7.Hydration of Fumarate to Malate
8.Oxidation of Malate to Oxaloactetate

9. • The primary function is to provide energy.
• It is the final common pathway for the oxidation
of carbohydrate, lipids and protein via acetyl CoA
or intermediates of the cycle.
• Citric acid cycle is an amphibolic process i.e it
plays role in oxidation ( catabolic ) and synthetic
( anabolic ) processes. E.g Gluconeogenesis ,
Transamination, Fatty acid synthesis and
porphyrin synthesis.