Bill Faloon's RAADfest 2022 Keynote Presentation slides about Age Reversal

Most slides available for review at: www.age-reversal.net
Age Reversal Update
William Faloon
October 6th 2022
RAADfest 2022

2 0 2 2
1. Research findings since last year's RAADfest.
2. What is an “optimized diet?”
3. New life extension drugs.
4. Key to super longevity!
5. Clinical trials targeting systemic regeneration.
6. “Live Forever” via transhumanism.
Advancing Towards Immortality
Regeneration
Targeted
Clinical
Trials
New
Anti
Aging
Drugs
Key to Super
Longevity

The Centenarian Surge
Total number of Americans aged 100 or older:
Year 1980: 32,000
Year 2010: 53,000
Year 2020: 92,000
Year 2060: 600,000 (projected)
https://www.prb.org/resources/u-s-population-is-growing-older/

Huge Decline in Age-Adjusted Death Rate
https://budgetmodel.wharton.upenn.edu/issues/2016/1/25/mortality-in-the-united-states-past-present-and-future
Penn Wharton Budget Model based on CDC/National Center for Health Statistics
United States Mortality Rate, 1900-2013
Death Rates Plummet

https://budgetmodel.wharton.upenn.edu/issues/2016/1/25/mortality-in-the-united-states-past-present-and-future
Significantly Fewer Deaths in 65+
Nearly 70% of Overall Improvements in Mortality
Since 1990 have been Contributed by the Elderly

https://www.prb.org/resources/u-s-population-is-growing-older/
February 19, 2020 |
Source: U.S. Census Bureau, decennial censuses and vintage 2017 population projections (2020-2060).
187% increase
Americans > age 64
1980 to 2020
U.S. Population by Age Group (millions), 1900 to 2060
Number
in
Millions
is unprecedented
in U.S. history

I am Licensed Funeral Director and Embalmer
Most of my 1970s-1980s clients (corpses)
would have LIVED with today’s technologies.

Life Expectancy in the United States in 2020
9-Year Disparity in Human Longevity

The Highest Life Expectancy?
80.7 Years in Hawaii
Aug 23, 2022 71.9 years
Higher life expectancies in California,
Utah, Minnesota and Massachusetts.
Bottom states include West
Virginia, Louisiana Alabama,
Oklahoma, and Kentucky.
https://abcnews.go.com/Health/life-expectancy-dropped-2020-us-state-due-covid/story?id=88698742

November 28, 2021
https://www.cbsnews.com/news/can-we-reset-our-biological-clocks/

A$3BillionBetonFindingtheFountainofYouth
“they believe they have glimpsed the
outline of an answer to the question of
how to reverse the process of cellular
aging. They have also recruited a star-
studded scientific cast to help them
track that answer down.”
This list includes 4 Nobel prize winners,
including the discoverer of Yamanaka
factors, Dr. Yamanaka himself.
January 22, 2022
Economist.com/science-and-technology/a-3bn-bet-on-finding-the-fountain-of-youth/21807244

HowTechBillionairesAreTryingToReverseTheAgingProcess
If They Could Turn Back Time:
Jeff Bezos and Peter
Thiel are pouring huge
sums into startups
aiming to keep us all
young – or even cheat
death. And the science
isn’t as far-fetched as
you might think.
https://www.theguardian.com/science/2022/feb/17/if-they-could-turn-back-time-how-tech-billionaires-are-trying-to-reverse-the-ageing-process
Feb. 19, 2022

 Once-faltering paws gripped objects
with renewed strength.
 Hearts and livers of rats regained
youthful vitality.
 Fuzzy memories sharpened.
 Biological age had been cut in half.
“It was as if someone had turned back time.”
April 30, 2022
“GrowingYounger:RadicalInsights IntoAgingCouldHelpUsReverse It”
April 30,2022|https://www.newscientist.com/issue/3384/

June 7
2022
https://www.technologyreview.com/2022/06/07/1053132/saudi-arabia-slow-aging-metformin/
The oil kingdom fears that its population is aging at an accelerated rate and hopes
to test drugs to reverse the problem. First up might be the diabetes drug metformin.
Saudi Arabia Plans To Spend $1 Billion A
Year Discovering Treatments To Slow Aging
of its oil wealth supportingbasic research on the biology of aging and
findingwaysto extend the number of years people live in good health
$1 BILLION A YEAR
has started a not-for-profit organization
called the Hevolution Foundation that plans to spend up to
“
”

Scientists sequence the complete
human genome for the first time
Mar. 31, 2022
https://www.cnn.com/2022/03/31/health/first-complete-human-genome-sequence
The Human Genome Project sequenced 92% of the
human genome (2003)
Scientists struggled to decipher the remaining 8%
~100scientistteamunveilscompletehumangenome(2022)
Firsttimehumangenomehasbeensequencedinitsentirety
Fresh insights into cancer, birth defects and aging

https://www.newscientist.com/article/2335495-immortal-jellyfish-genes-identified-that-may-explain-their-long-lives/
Aug.29,2022
“By performing a DNA comparison of two
similar jellyfish species, researchers have
found the genes that could stop and
reverse ageing in immortal jellyfish…”
“…the immortal jellyfish had twice as many
copies of genes associated with DNA repair
and protection…The jellyfish also had unique
mutations that stunted cell division and
prevented telomeres – chromosomes’
protective caps – from deteriorating.”

C = Clustered
R = Regularly
I = Interspaced
S = Short
P = Palindromic
R = Repeats
CRISPR Gene Therapy

https://www.genengnews.com/t-cells/crispr-engineers-stronger-t-cells-for-immunotherapy
Aug 25, 2022
One Gene Edit Kills More Tumor Cells

Rapid Transition from Animal Findings to Clinical Trials
“CRISPR cure for High Cholesterol enters first Human Trial”
May 2021- One-time CRISPR shot lowers
LDL cholesterol by 60% in monkeys. The
base edit knocks out the PCSK9 gene, to
enable more LDL to be removed.
July 2022- Human trial launches using
nanoparticles to deliver CRISPR genetic
instructions to cells to knock out PCSK9 in
people with familial hypercholesterolemia.
Nature 2021, DOI: 10.1038/s41586-021-03534-y https://bigthink.com/health/crispr-cholesterol-gene-therapy/

“…mice with progeria that got the
gene-editing treatment lived more than
twice as long as the untreated mice.”
| Jan. 7, 2021
CRISPR Gene-Editing Treatment

CRISPR Gene-Editing Treatment
An untreated progeria mouse at 7.5
months of age, with a thin, grayish
coat, pronounced spinal curvature,
and low activity levels. Untreated
progeria mice have an average
lifespan of 7.1 months.
Three treated progeria mice at 11
months of age, with healthy
coats, no apparent spinal
curvature, and normal activity
levels. The treated progeria mice
had an average lifespan of 17
months.
CRISPR-Edited
Progeroid Mice
Unedited
Progeroid
Mouse
https://www.wsj.com/articles/crispr-gene-editing-treatment-could-point-way-to-fix-for-deadly-aging-disease-11609950054

Transcription factors turn our genes
“on” and “off ”...so, they are expressed in
the right cell, at the right time, and in the
right amount.
Key to Super Longevity

Transcription factors can enable old cells to be
reprogrammed into embryonic cells capable of
developing into all tissues of the body.
Transcription factors are proteins that help turn
specific genes "on" or "off" by binding to DNA.
Groups of transcription factors can turn
a gene on/off in specific parts of the body.
Transcription factors that are
repressors decrease transcription.
Transcription factors that are activators
boost a gene’s transcription.

The Nobel Prize in Physiology or Medicine 2012
These transcription factors are called:
“Yamanaka Factors”
Four specific genes encode transcription
factors that can convert somatic cells
into pluripotent stem cells that can
propagate indefinitely.
nobelprize.org/prizes/medicine/2012/yamanaka

February 28, 2021
 This 2021 published review and additional investigations
summarize age-reversal impact of cell reprograming.
 Human trials being investigated
 Funded by Bill Faloon and other charitable donors
“When cells were reprogrammed with a 6-factor
cocktail the (degenerative) alterations were
fully reversed and cells fully rejuvenated.”
https://www.aging-us.com/article/202712/text

March 7, 2022
Scientists
Reverse Aging in Mice

March 11, 2022
“Anti-Aging Breakthrough:
https://scitechdaily.com/anti-aging-breakthrough-cellular-rejuvenation-therapy-safely-reverses-the-aging-process-in-mice/
Cellular rejuvenation therapy safely reverses signs of
aging in mice. Credit: Salk Institute
Cellular Rejuvenation
Therapy Safely Reverses
the Aging Process in Mice”

March 9, 2022
“Newresearchbythe
SalkInstitutehasshown
cellularrejuvenation
therapysafelyreverses
signsofaginginmice.”
https://www.drugtargetreview.com/news/101826/scientists-have-shown-ageing-process-can-be-safely-and-effectively-reversed-in-mice/
“Scientists have shown aging process can
be safely and effectively reversed in mice”

https://www.dailymail.co.uk/sciencetech/article-10589031/Scientists-REVERSE-ageing-mice-using-cellular-rejuvenation-technique.html
• Experts injected mice with molecules called the Yamanaka transcription factors
• Treatment period of seven to 10 months was effective for restoring youthfulness
• The 'safe' treatment could one day help humans wind back their biological clock

March 7, 2022
https://www.salk.edu/news-release/cellular-rejuvenation-therapy-safely-reverses-signs-of-aging-in-mice/
Mar. 7, 2022
“Scientistssafelyandeffectivelyreversetheagingprocessinmiddle-aged
andelderlymicebypartiallyresettingtheircellstomoreyouthfulstates.”

• Partial cell reprogramming in live (in vivo) mice
• OSKM (“Yamanaka”) transcription factors used
• Longeradministrationdemonstrateduniquebenefits
• No toxicity or increase in cancer detected
Partial Cell Reprogramming Safe
https://www.nature.com/articles/s43587-022-00183-2

• Long-termcell reprogrammingresults in “younger”skin age.
• Skin cells divide more rapidly.
• Lower inflammation and reduced senescent-associated
secretory phenotypes in treated animals.
• No data collected on lifespan, exercise, memory, or muscle.
Cell Rejuvenation in Live Mice

March 7, 2022
“In both the kidneys
and skin, the
epigenetics of treated
animals more closely
resembled epigenetic
patterns seen in
younger animals.”
“…theyfoundthatthemice,inmanyways,resembledyoungeranimals.”

Human Skin Cells Rejuvenated By 30
Years With New Aging-Reversal Method
When applied to skin cells of three donors aged 38, 53, and
53,theresearchersfoundthattheirmethodwoundbackthe
fibroblasts’ epigenetic clock by about 30 years.
Reprogrammed cells produced more collagen & migrated
to wound areas faster than untreated fibroblasts. Pointing
to significant reversal of age-related functional decline.
A new method of utilizing Yamanaka factors called
“maturation phase transient reprogramming”
(MPTR) now allows for significant age reversal
“without loss of cell identity.”
April 8th, 2022 | elifesciences.org/articles/71624

> 2006: cell reprogramming demonstrates cellular rejuvenation.
> 2011: Rejuvenation induced in very old human cells (in vitro)
> 2022: 100% of Human Genome sequenced.
> 2022: Aging partially reversed in live mice (in vivo)
> 2022: Research underway to rejuvenate old humans.
Prior biology doctrine: Cell aging irreversible…rejuvenation not possible.
Cellular Reprogramming
--> Rewriting the Rules of Biology | https://pubmed.ncbi.nlm.nih.gov/33627519

Step 1: Remove old cells from circulating blood.
Step 2: Use transcription factors to transform the autologous
old cells back to youthful structure/function.
Step 3:
Human project initiated in 2022:
Reinfuse the reprogrammed autologous stem cells
to induce systemic regeneration.
Research using Autologous
Stem Cells + Transcription Factors
Pilot studies are evaluating safety and regenerative efficacy

Clinical Trials Center in Florida

Anti-Aging Clinical Trials
Building 200, Suite 205
13940 US Hwy 441
The Villages, FL 32159
Betterhumans.org

• $100,000 approx. monthly expenditure
Betterhumans.org
• Funded by tax deductible donations
• Stocked with expensive "kits",
primers, reagents, assays, etc.
• Five scientists working 6-7 days a week
Biomedical Lab in Central Florida
A 501(c)(3) non-
profit organization.
Donations are
tax deductible!

Betterhumans DNA/RNA/DNA Methylation Sequencing Room

Betterhumans Mass Spectrometry Room

Health and Longevity Biomarker Assay Facility

Full Time Scientists Who Work at Betterhumans to Find Ways to Reverse Aging

Construction of New Research Facility in Texas
Betterhumans new
facility will be a
28,000 sq. ft
Age Reversal Vivarium
and Diagnostic Lab.
Pictured is the construction
of four of the six planned
20’ by 40’ lab rooms.

Senolytics Update
October 6, 2022

Senescent cells accumulate with normal aging and:
Removing Senescent Cells Confers Healthy Longevity

Senolytics are compounds
that selectively destroy
senescent cells.

Aug. 24th, 2022
272 papers for
2021 alone
“Senolytics”
Publications increase
from near zero in 2013
to 850 by mid-2022.
https://pubmed.ncbi.nlm.nih.gov/?term=senolytic

Current Experimental Dasatinib Dose Schedule
Afterreviewingcontraindicationswithyourdoctor,considerthefollowing ONCEmonthly:
Repeat each month. Do not take rapamycin week you take senolytic.
Rapamycin may impede senolysis. Register for updates at: age-reversal.net
Day One: Dasatinib 100 mg
Theaflavins 275 mg
Quercetin 25 mg (bioavailable)
Fisetin 56 mg (bioavailable)
Day Two: Repeat Day One doses unless
dasatinib side effects manifest.

Oct.13,2021
Highly selective marker of cellular
senescence present on membranes
of senescent cells targets specific
delivery of senolytic drugs into
senescent cells.
nature
“Non-senescent cells were not affected by either antibody,
confirming the specificity of the treatment. …”
A Vaccine to Eliminate Senescent Cells!

A Vaccine Eliminates Senescent Cells
https://www.longevity.technology/a-vaccine-for-aging-that-eliminates-senescent-cells
Dec. 13, 2021

Senolytics described in new book.
https://medium.com/@bdajess/drug-that-increases-human-lifespan-to-200-years-is-in-the-works-edb3a1a64af1
“A fascinating look at how scientists
are working to help doctors treat the
aging process itself, helping us all to
lead longer, healthier lives.”
— Sanjay Gupta, MD
“I don’t think there is any kind of
absolute cap on how long we can live.”
— Dr. Andrew Steel
British Computational Biologist

Intermittent Fasting Update
16
hours
fasted
8
hours
fed

https://www.nejm.org/doi/full/10.1056/NEJMra1905136
EffectsofIntermittentFasting onHealth, Aging, andDisease
Dec. 26, 2019
Abdominal fat
Blood pressure
Stress resistance
Glucose regulation
Human benefits of intermittent fasting:
Heart rate
Endurance
Cognition
Inflammation
IMPROVEMENTS IN ALL THESE KEY MARKERS AND MORE

Intermittent Fasting Can Help
Manage Metabolic Disease
Sep.22,2021
Eating calories within a consistent window of 8-10 hours is powerful
strategy to prevent-manage chronic diseases.
Endocr Rev, bnab027,| https://doi.org/10.1210/endrev/bnab027
Sept. 22, 2021
Funded by National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Aging, National Cancer
Institute, Larry l. Hillblom Foundation, Wu Tsai Human Performance Alliance, U.S. Department of Defense and Federal
Emergency Management Agency; September 22, 2021
Intermittent fasting can improve sleep and quality of life as well as
reduce the risk of obesity, diabetes, heart disease.
Genes, hormones & metabolism rise/fall at different times of the day.
(Eating randomly makes us prone to diseases.)

Front. Nutr., 18 October 2021 | https://doi.org/10.3389/fnut.2021.669325
Oct. 18, 2021
 Body weight
 Fat mass
 Body mass index
 Blood pressure
 Waist circumference
 Fasting glucose
 Total Cholesterol
 Fasting insulin
 Triglycerides
 Insulin resistance
Compared to controls, intermittent fasting groups decreased:

University of Illinois-Chicago
researchers say intermittent
fasting can produce clinically
significant weight loss,
reductions in inflammation,
blood pressure, and cholesterol.
https://medicalxpress.com/news/2021-10-intermittent-fasting-worksfor-weight-loss.html
“Research review shows intermittent fasting works…”
Oct. 12, 2021

Scientific Reports | (2020) 10:18341 | https://doi.org/10.1038/s41598-020-73767-w
“Intermittent fasting from dawn to sunset for 4 consecutive weeks induces
anticancer serum proteome response & improves metabolic syndrome”
• 7.25 pounds of weight loss
• 8.8 mmHg reduction in blood pressure
• Significant increase in tumor suppressor/anticancer proteins
• Significant decrease in several tumor promoter/pro-cancer proteins
• Increasing a protein called calreticulin (by around 16 times)
• Calreticulin enhances IgG response to a SARS-CoV spike protein
natureresearch
No eating/drinking between dawn & dusk…14-15 hours a day:
Oct. 27, 2020

https://cancerdiscovery.aacrjournals.org/content/12/1/90
Cancer patients took up a five-day, plant-based, calorie-restricted (low-carb/protein) diet.
It resulted in reduced median plasma glucose concentration
by 18.6%, serum insulin by 50.7% and serum IGF-1 by 30.3%.
The reduced plasma glucose, insulin and IGF-1 was found
to be crucial to down-regulating immunosuppressive
myeloid cells and enhancing intra-tumor T cell cytotoxicity.
“…our results provide first evidence that five-day FMD
produces systemic immunological effects that are
associated with the activation of several antitumor
immune programs at the tumor level in human cancers.”

September 2022
Pilot studies are evaluating safety and regenerative efficacy
“Exceptional tumor responses to fasting-mimicking
diet combined with standard anticancer therapies…”
Five of 101 patients enrolled with advanced, poor prognosis solid neoplasms:
1extensivestagesmallcelllungcancer;
1metastaticpancreaticadenocarcinoma;
1 metastatic colorectal cancer;
2metastatictriple-negativebreastcancer
Achievedcompleteandlong-lasting
tumorresponses whentreatedwith
combination cyclicfasting mimicking
dietandstandard systemic treatments.
https://pubmed.ncbi.nlm.nih.gov/35810555/

Prevention Magazine
> Intermittent Fasting
> Metformin
> DNA methylation tests
> Sirtuin activation
> Young plasma transfer
> Senolytic drugs
RAADfest presented all these
findings' years ago.
September 2021
favorably describes:
(Prevention Magazine initially hostile to anti-aging medicine)

Radical Interventions are Going Mainstream
AtthecheckoutcounterofWholeFoods,amagazine
displays what we’ve been advocating for years.
August 22, 2022
More of what you learn at RAADfest is going mainstream.

60%
(in middle-aged mice)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814615/

“In middle-aged mice, just 3 months of high-dose rapamycin
treatment was sufficient to increase life expectancy up to 60%.
When taken late in life, rapamycin increases lifespan by 9-14%
[155], despite the dosage being suboptimal. This possibly equates
to more than 7 years of human life.”

IncreasedFidelityofProteinSynthesisExtendsLifespan
The paper’s authors emphasize that the baseline
rate of error in protein synthesis can be hundreds of
thousands of times more then the DNA mutation
rate. Making it a major neglected aspect of aging.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(21)00417-4
“We show that anti-aging drugs such as rapamycin,
Torin1, and trametinib reduce translation errors,
and that rapamycin extends further organismal
longevity in RPS23 hyper-accuracy mutants. This
implies a unified mode of action for diverse
pharmacological anti-aging therapies.”
November 2,2021

Rapamycin Human Study
Receives $485,000 Funding
 Randomized, placebo-controlled trial into the safety/efficacy of rapamycin in
reducing clinical measures of aging in an older adult population.
 Two differing doses: 5 mg or 10 mg of rapamycin one time a week or placebo.
 Primary Outcome Measure: Changes in visceral fat as measured by (DXA) scan.
 Secondary Outcomes: Range of clinical measures, e.g. bone density, blood tests, etc.
 > 50 people enrolled at $360 each (original cost before donations was $1,200).
March 5th, 2022
Sponsor: AgelessRx Collaborator: University of California, Los Angeles
Principal investigators: James Watson, M.D. and Sajad Zalzala, M.D.
https://www.agelessrx.com/pearl
Toenrolllogonto:

Effect of Rapamycin to Improve
Cardiac Function in Frail Older Adults
 To see if rapamycin will improve heart's ability to pump by improving oxygen consumption.
 Pilot, proof-of-concept study. Patients 60 years or older with invasively proven heart failure.
 Subjects with hsCRP levels ≥2mg/L will undergo treatment with open label rapamycin.
 Efficacy outcomes will be measured at baseline and at 6 months.
 Safety will be assessed by remote video monitoring.
 Rapamycin levels (≤ 4ng/mL) measured twice-a-month first month/ then monthly for 5 months.
April 2022
Principal investigator: Mandeep Singh------------Sponsor: Mayo Clinic
https://clinicaltrials.gov/ct2/show/NCT04996719

“The Rapamycin Human Longevity Open Registry is a worldwide
initiative to collect data on individuals using rapamycin for
longevity through a series of online surveys in order to build the
largest and most comprehensive global collection of information
on this topic to date. It is the first online patient-driven registry
for rapamycin usage, with individuals taking the drug driving the
collection of data.”
www.Rapamycin.io
>> <<
To Help Enhance Research Efforts VISIT:

“Our goal is to assess the impact of rapamycin
use on healthy people and disseminate these
findings for the benefit of everyone.”
- Dr. Matt Kaeberlein, Dr. Jonathan An and Dr. Alan Green
This research has been funded by an Impetus Grant
University of Washington Rapamycin Study https://rapamycinstudy.org/

SurgingRapamycinScientificInterest
1720 Rapamycin or Rapalog Studies Listed On
ClinicalTrials.gov
https://www.rapamycin.news/t/rapamycin-searches-on-google-up-900-this-year/874
As of July 2022:
• Rapamycin Google searches up 900%
this year compared to all last year.
• 203 published rapamycin/title studies
• 114 published sirolimus/title studies

-
VIA PARABIOSIS
Young blood circulated
into old animals enables
system wide benefits…
But no reversal of
immune senescence
January 15, 2015
https://www.nature.com/articles/517426a
-
-

› Older partners paired with young
rats lived for four-to-five months
longer than controls.
› This life span extension is the
equivalent of 10-12 human years.
› Source: New York Academy of Sciences, (1972 Nov) Vol. 34, No. 7, pp. 582-7.
› in 1972 researchers at the University of California
studied the life spans of old–young circulatory
connected rat pairs.

https://www.newscientist.com/article/2112829-blood-from-human-teens-rejuvenates-body-and-brains-of-old-mice/
Mice treated with young human
plasma appeared to have created
more new cells in their brain.
November 15, 2016
“Young human plasma
treatment can increase
neurogenesis.”

https://www.newscientist.com/article/2311876-we-may-now-know-why-young-blood-can-have-rejuvenating-effects/
Packages of RNA and proteins that bud off
from cells have reversed some signs of
aging in mice, and they may account for
the rejuvenating effects of young blood.
March10,2022
“…itreversedseveralsignsofaging,
includingboostingmusclestrength
andhairgrowthandimproving
coordinationandendurance.”

https://doi.org/10.1016/j.stem.2022.04.017
Heterochronic Parabiosis Induces Stem Cell Revitalization
and Systemic Rejuvenation Across Aged Tissues
June 2nd, 2022
Research Highlights:
Youthful hematopoietic stem cell
function restored.
“Rejuvenatingfactors”identified in youngblood.
Immune senescence of lymphocytes mitigated.

Shortage of Regulatory Immune
Cells Implicated in Sepsis Mortality
Feb. 15, 2022
In a mouse model, sepsis was associated with
significant depletion of hematopoietic stem and
progenitor cells (HSPCs) and mortality within 5–7 days.
HSPC infusion restored HSPC levels and saw an
increase in myeloid-derived suppressor cells and a
dampening of systemic inflammation thought to
cause the 50-60% overall survival improvement.
Sepsis accounts for 1 in 5 deaths worldwide and is a
common final pathway for many disease processes
such as cancer, diabetes, and cardiovascular disease.
elifesciences.org/articles/74561

September 02, 2022 | https://doi.org/10.1111/acel.13696
September 2nd, 2022

“Umbilical cord plasma concentrate has beneficial effects on
DNA methylation GrimAge and human clinical biomarkers”
Human Study
• Each injection equivalent to 100 mL
umbilical cord plasma infusion.
September 02, 2022 | https://doi.org/10.1111/acel.13696
• 18 human participants average age 74 years.
• Safety-efficacy evaluated with blood tests +
GrimAge® epigenetic clock.
• Weekly injection of umbilical cord plasma
concentrate into muscle for 10 weeks.
(Fourumbilicalcordsusedtoproduceeachweeklyinjection.)

• GrimAge®: -0.78yearsyounger(predictorofdeathrisk)
• 30% of 90 biomarkers changed
beneficially, zero negatively
• No significant side effects
• Kidney function: 7% improvement
measured by eGFR (+ 5)
• Phenotypic Age Score biomarkers such as RDW
and MCV improved, reducing predicted age
September 2nd, 2022 https://onlinelibrary.wiley.com/doi/10.1111/acel.13696

Clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-021-01112-7
Academic.oup.com/biomedgerontology/article/76/5/741/5992253
“DNAm GrimAge is a strong predictor
of mortality independent of genetic
influences among female twin pairs.” 1
“GrimAge Outperforms Other Epigenetic
Clocks in the Prediction of Age-Related
Clinical Phenotypes and All-Cause Mortality.”2
2021 findings corroboratedata published 2019-2020
1.
2.
NewStudiesDemonstratePredictivePowerofEpigeneticClocks

https://www.lyfspn.com/#Pilot
In the Bay Area, Lyfspn has
initiated a plasmapheresis
human clinical trial that aims to
demonstrate the rejuvenation
and lifespan improving potential
that was previously shown in
animal models.
DobriKiprov,M.D.,H.P.(ASCP),Co-founderofLyfspn
https://longevity.technology/news/be-part-of-bringing-plasmapheresis-to-trial/

Buck Institute for Research on Aging
https://www.buckinstitute.org/
“The Buck is a collective
of the world’s top
scientists in the field of
aging who are sharing
their methods and
expertise to find ways to
help everyone lead fuller,
healthier lives by ending
age-related disease.”

Offshore
AgeReversalResearch
Nassau, Bahamas
(and other countries)
Updates onoffshorestudy options at:
www.age-reversal.net
Nassau

Age Reversal Clinical Project - Bahamas

age-reversal.net
For Offshore Clinical Research Updates:

Daily Deaths of Americans > age 64:
https://www.cdc.gov/nchs/fastats/older-american-health.htm
6,800 Human Lives Lost

Experimental Human Age Reversal Interventions
Urgent Need to Rapidly Accelerate Clinical Trials

Bridging the Longevity Gap
Urgent Need to Reform Clinical Trial Regulations

 England approves metformin:1957
 FDA approves metformin: 1994
 37-year delay caused millions of
American deaths.
 65 years later most people don’t
know metformin is anti-aging drug.
Regulatory Barriers Must be Abolished!
Deadly Delays…Urgent Need for Reform

1906-2022 = 116 Years of Needless Deaths

Petition FDA-Congress to
Amend Clinical Trial Constraints
age-reversal.net/FDA

Life Extension® versus the FDA

FDA Surrenders in 1996
This was the first time the FDA has been
forced to give up on a criminal prosecution.
https://www.lifeextension.com/magazine/1996/9/freedom
By February 1996, Federal Judge Daniel
Hurley dismissed all 56 criminal charges
against Saul Kent and William Faloon.
This victory goes beyond winning in court.
The FDA's defeat is a victory for everyone
who cherishes freedom in healthcare.

Free updated chapters available at LifeExtension.com

Lyndon Johnson Prematurely
Died Due to Technology Delay
•First heart attack age 46 (1955)
•Suffered chronic angina pain
•Resigned re-election age 59 (1968)
•Dead age 64 years (1973)
(Treatments to reverse coronary blockage lacking)

Alive Because of Biomedical Technology
Bill Clinton
Coronary Bypass Age 58
In 2004
Coronary Stent Age 63
In 2010
George W. Bush
in 2013
Dick Cheney
Coronary Bypass Age 47
In 1988
in 2000
Ventricular Assist Age 69
in 2010
Heart Transplant Age 71
in 2012
Age 76 Today Age 81 Today
Age 76 Today

Age-reversal science
is rapidly advancing.
We are in similar
predicament as
LBJ in 1955-1973.
Good News:

Age-standardized death rate
rate from heart disease per
100,000 people dropped:
Huge Reduction in Heart Disease Deaths
From: 520 in 1969
To: 167 in 2014
68% decline over 45 years

“Declining Risk of Sudden Death in Heart Failure." New England
Journal of Medicine. 2017;377(1):41-51.
Clinical trials spanning 1995 to 2014 show:
44% decline of sudden death
in heart failure patients
Sharp Decline in Heart Failure Death Rates
Leading cause of age-related death
markedly reduced in just 19 years!

Heart Failure Deaths Surge in Young Adults
Mortalitywithheartfailure involvementin
Americansaged15-44yearsincreaseby: 33.8%
Journal of the American Medical Association
https://jamanetwork.com/journals/jamacardiology/article-abstract/2794437
July 27, 2022
2012-2019

Front page Wall Street Journal: January 15, 2020
Obesity epidemic
causing heart
disease rates to
soar higher,
especially in those
under age 65

https://vividmaps.com/obesity-united-states/

Combat Excess
Body Fat with:
Diet
+
Drugs

“Overweight people lost 35 to 52 pounds
on newly approved diabetes drug…”
June 7, 2022
https://www.cnn.com/2022/06/06/health/weight-loss-drug-diabetes-wellness/index.html
 “Almost 40% of individuals lost a quarter
of their body weight…
 The middle range of weight loss for
people in this new study was 49 pounds…
 It'stherangeofweightlossthatwetypically
thinkonlypossible through surgery.”

Tirzepatide Once Weekly for the Treatment of Obesity
https://www.nejm.org/doi/full/10.1056/NEJMoa2206038
June 4, 2022
In a 72-week obesity trial, 50% of participants
in the 10-mg and 15-mg tirzepatide groups had:
 Weight loss in non-diabeticswas 15% - still substantial
 A reduction in body weight of 20% or more, as
compared with 3% in the placebo group.
 Improvements in all cardiometabolic measures.

First Oral Version:
Rybelsus
First Approved: 2019
Subcutaneous Injectable Versions:
Byetta, Lyxumia, Victoza, Trulicity & Mounjaro
Approved GLP-1 Agonists
(7 mg or 14 mg tablets)

Glucagon-like peptide-1
(GLP-1) agonist drugs
function via multiple
mechanisms to:
 Reduce body fat.
 Improve cardiovascular
risk factors.
 Combatmetabolicdisorders
like type II diabetes &
fatty liver disease
GLP-1 Agonist Drugs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6484915/figure/f1-jomes-26-155/

Oneweekeachmonth,modestlow–carb,verylow–proteindiet:
June 5, 2022 | https://doi.org/10.1210/clinem/dgac197
Effects of Six-Month Periodic Fasting in Patients
With Type 2 Diabetes & Diabetic Nephropathy
 22 pounds of weight loss
 1.4% decrease in A1C
 59% improved insulin sensitivity
 67% of people
ADietPlanof:
Day1 ≈1100calories
Days2–5≈ 700calories
Day6≈Normalintake
22 pounds of weight loss
1.4% decrease in A1C
59% improved insulin sensitivity
67% of people reduced diabeticdrug dose
Resulted in:

“Changing your diet could add up
to 13 years to your life…”
Feb. 9, 2022
https://www.cnn.com/2022/02/08/health/longer-life-diet-wellness/index.html

https://doi.org/10.1371/journal.pmed.1003889
“When changing from a typical
Western to an optimized diet,
the largest gains in LE could be
made by eating more legumes,
whole grains, and nuts, as well
as eating less red meat and
processed meat, with gradual
reduction in effect with
increasing age.”
Key Finding
Components of an Optimized Diet
Feb. 8, 2022
Some Legume Choices

Feb. 08, 2022 | https://doi.org/10.1371/journal.pmed.1003889
Legumes
Whole Grains
Nuts
Red Meat
Processed Meat
Sweetened Drinks
Refined Grains
Eggs
Fish
Fruit
Vegetables
Life expectancy gains in order of significance
Optimized Diet = 10 to 13 more years at age 20
Feb. 8, 2022
Switching to an optimal diet from
age 20 years onward is modeled
to increase life expectancy by:
13.0 years for men
10.7 years for women

Legumes
Whole Grains
Nuts
Red Meat
Processed Meat
Sweetened Drinks
Refined Grains
Eggs
Fish
Fruit
Vegetables
8.8 years for men
8.0 years for women
Optimized Diet = 8-year lifespan increase at age 60
Feb. 8, 2022

Legumes
Whole Grains
Nuts
Red Meat
Processed Meat
Sweetened Drinks
Refined Grains
Eggs
Fish
Fruit
Vegetables
Optimized Diet = 2.6-3.9 more years at age 80
Feb. 8, 2022
2.7 to 3.9 years for men
2.6 to 3.4 years for women

•Chickpeas
•Peanuts
•Black beans
•Green peas
•Lima beans
https://www.webmd.com/food-recipes/health-benefits-legumes
•Kidney beans
•Black-eyed peas
•Navy beans
•Pinto beans
•Lentils
Legumes — a class of vegetables that
includes beans, peas and lentils:

Foods to Reduce or Avoid
Re
 Red meat
 Overcooked meats
 Butter
 Processed red meat (hot dogs, bacon)
 Cured ham (nitrite/nitrite preserved meats)
 Most frozen meals
 Soda, desserts, candy
 Most processed foods
 Sugars
 Refined grains (white bread/white grain pasta)
 Excess salt
https://www.foodnetwork.com/healthy/articles/what-foods-are-not-allowed-on-mediterranean-diet

August 1st, 2022
28% faster rate of global cognitive decline
25% faster rate of executive function decline
(56% of calories consumed in U.S. come from ultra processed foods.)
People who ate the most ultra processed foods
compared to those who ate the least had a:
https://www.cnn.com/2022/08/01/health/ultraprocessed-food-dementia-study-wellness/index.html
https://www.nbcnews.com/health/health-news/highly-processed-food-linked-faster-cognitive-decline-rcna40999

Jun. 30, 2021
https://www.ahajournals.org/doi/10.1161/JAHA.120.019158
Mediterranean Diet Reduces
Risk of Sudden Cardiac Death
Study of 21,000 people over 9.8 years reveals:
Diet high in fried foods, organ meats and processed
meats regularly had a 46% higher risk of sudden
cardiac death compared to those with least adherence.
Those who most closely followed the traditional
Mediterranean diet had a 26% lower risk of sudden
cardiac death than those with the least adherence.
Mediterranean diet defined as high in vegetables and whole
grains, low intake of meat, high intake of marine omega-3s.

“Will We Ever Cheat Death and Become Immortal With Mind Uploading?”
“…scientists,researchers, andtechcompaniesareworkingtowardsmakingminduploadingareality.”
December 7th,2021
https://interestingengineering.com/science/cheating-death-and-becoming-immortal-with-mind-uploading

Result is super-intelligencethat advances
our abilities to incomprehensive levels.
Ray Kurzweil’s Exit Plan to Immortality
• Survive until year 2045.
• Singularity enables neocortex to merge
with cloud-based artificial intelligence.
• Neocortex/AI enters limitless self-
improvement cycles.

“Synchronized pairs of laser pulses
drive the fastest logic gates ever
made, which could eventually give
computers a million-fold speed boost”
https://newatlas.com/electronics/fastest-ever-logic-gates-computers-million-times-faster-petahertz/
May 11, 2022
“By zapping graphene and gold with
laser pulses, the new logic gates are a
million times faster than those in
existing computers, demonstrating the
viability of “lightwave electronics.”

Current computers use electronic currents for logic gates that
produce delays in processing that amount to the order of
nanoseconds, light-based logic gates could reduce processing delays
down to femtoseconds. Which would move processing speed
possibilities from Gigahertz (GHz) all the way to Petahertz (PHz).
= 0.000000000000001 Seconds
Femtoseconds
= 0.000000001 Seconds
Nanoseconds
May 11, 2022
Once Again, Barriers Are Broken,
The Impossible Becoming Possible

July 30th, 2021
https://www.cnbc.com/2021/07/30/elon-musks-neuralink-backed-by-google-ventures-peter-thiel-sam-altman.html
Elon Musk’s Brain Computer Startup Raises
$205 Million from Google Ventures & Others
Neuralink is trying to develop
high-bandwidth brain implants
that can communicate with
phones and computers.
Total investment in the company
now stands at $363 million.

April 9th, 2022
https://www.cnbc.com/2022/04/08/elon-musk-humans-could-eventually-download-their-brains-into-robots.html
Elon Musk says humans could eventually
download their brains into robots — and
Grimes thinks Jeff Bezos would do it
“ElonMusksays a lot of seeminglyfantastical
things.Forexample: The billionaireTesla and
SpaceX CEO seemsto believethathumanswill
eventually be able to
by downloading their brains into robots”
LIVE FOREVER,

August 31, 2022
“… the device is implanted near the area of
the brain that controls movement.”
“Signals captured by a receiver in the chest
are sent wirelessly to a device that decodes
thoughts into commands for a digital
device.”
https://www.cbsnews.com/news/can-we-reset-our-biological-clocks/

https://www.wsj.com/articles/how-brain-computer-interfaces-could-restore-speech-and-help-fight-depression-11662129229
Brain-Computer Interface Published Research Doubled in 5Years
| Sept. 2, 2022
Fueling some of this activity are the availability of
more powerful computers, improvements in
artificial intelligence, and the further miniaturization
of devices that can be implanted into the brain…”
“The amount of research in brain-computer
interfaces has been growing steadily in recent
years…In 2021, there were almost 600 studies,
compared to roughly 340 in 2016.
Dr. Chang shows a brain-computer interface.
He paired the technology with AI to help
paralyzed patients communicate.

► Co-founder of medical device maker Boston
Scientific Corp. Tens of thousands of employees.
►Dead at age 80 from cancer.
► Boston Scientific: “a pioneer who helped shape the
field of minimally invasive surgery.”
► He focused much of his philanthropy on education and
marine causes.
Who missed the longevity boat?
Peter Michael Nicholas
(1941 – 2022)
Expiration date: May 14, 2022
Net Worth > $4 billion https://www.bloomberg.com/news/articles/2022-05-16/peter-nicholas-co-founder-of-boston-scientific-dies-at-80

► Canadian businessman, philanthropist, and owner of
the National Hockey League Ottawa Senators.
► Founder of one of Canada's largest publicly traded
pharmaceutical companies.
► One of the richest residents of Barbados.
Eugene Melnyk (1959 – 2022)
Net Worth > $1.2 billion https://www.forbes.com/sites/carolschram/2022/03/29/ottawa-senators-owner-eugene-melnyk-dies-at-age-62/
►Died at age 62… Five years after a liver transplant.

Who Missed the Longevity Boat
https://www.forbes.com/profile/edward-johnson-iii/
EdwardJohnsonIII(1930-2022)
Net worth > $11.5 billion
Expiration date: Mar. 23, 2022
► Edward “Ned” Johnson III, former CEO of Fidelity Investments.
► When he took over in 1977, Fidelity had $3.9 billion in
assets under management.
► The firm now holds more than $11 trillion in assets.
► Johnson donated his wealth mostly anonymously, some
named places include the Museum of Fine Arts in Boston &
the Peabody Essex Museum in Massachusetts.

►Billionaire Ray-Ban owner and one of Italy’s
wealthiest business figures.
►Went from childhood in orphanage to amass a
fortune…one of most famous rags-to-riches
stories in Italy’s post-war recovery.
►Died at age 87.
https://www.forbes.com/sites/carolschram/2022/03/29/ottawa-senators-owner-eugene-melnyk-dies-at-age-62/
Leonardo Del Vecchio
(1935 – 2022)
Expirationdate:June18,2022
Net Worth > $25.7 billion

Chuck Bundrant
(1942 - 2021)
Expiration date: Oct 17, 2021
net worth > $1.3 billion
https://www.kdlg.org/post/trident-founder-chuck-bundrant-remembered-industry-
risk-taker-who-emphasized-personal#stream/0
Founded Trident seafood company
Boosted Alaskan pollock fish sales
40 times in U.S.
Died at age 79 from Parkinson’s

Walter Scott
(1921 - 2021)
Expiration date: Sep, 25, 2021
net worth > $6 billion https://www.3newsnow.com/news/local-news/former-kiewit-ceo-walter-scott-jr-dead-at-90
Omaha businessman and philanthropist.
Past top executive of Peter Kiewit Sons
Inc. construction firm.
Helped oversee Warren Buffett’s
Berkshire Hathaway.
Died of undisclosed causes at age 90.

Frank Hasenfratz (1935-2022)
Expiration date: Jan. 8, 2022
Net worth ~ $1 billion https://www.wsj.com/articles/hungarian-refugee-founded-car-parts-maker-linamar-in-canada-11643122802
Frank fled communist Hungary, arriving in
Canada at age 22, as a penniless refugee.
He founded what became Linamar at age 29.
Linamar is now Canada's second largest auto
parts manufacturer, with 26,000 employees
in 17 countries at the time of his death.
Died at age 86 from cancer.

John Arrillaga Sr. (1937-2022)
Expiration date: Jan. 24, 2022
Net worth ~ $2.5 billion https://www.wsj.com/articles/real-estate-developer-made-early-bets-on-silicon-valley-11643382026
John began buying land and developing office
buildings in the 1960s in an area south of San
Francisco that became known as Silicon Valley.
He cofounded the commercial real-estate
firm Peery Arrillaga, which eventually
attained more than 20 million square feet of
holdings as the valley boomed.
Died of undisclosed causes at age 84.

Fayez Sarofim (1929-2022)
Net worth ~ $1.6 billion https://www.forbes.com/profile/fayez-sarofim/




►Founded investment management firm,
largest shareholder of Kinder Morgan, part
owner of the Houston Texans NFL team.
►Supported medical innovation and donated
Baylor College of Medicine, Texas Heart
Institute, MD Anderson and more.
►Dead at the age of 93.

Robert Brockman, founded Universal
Computer Systems which merged with
Reynolds and Reynolds, providing computer
systems to nearly all car dealerships and other
services to healthcare/insurance companies.
Dead at Age 81.
nypost.com/2022/08/06/software-developer-robert-brockman-dies-amid-tax-evasion-case/
RobertBrockman(1941-2022)
Expiration date: Aug. 5, 2022

Herbert Kohler Jr. was an American billionaire businessman, a
member of the Kohler family, the former CEO & the executive
chairman of the Kohler Company, which is best known for its
plumbing products, golf courses and resorts, with the latter two
fields of business directly entered into under his chairmanship.
https://www.cnn.com/2022/09/06/business/kohler-death-wisconsin/index.html
HerbertKohlerJr.(1939-2022)
Expiration date: Sep. 3, 2022 Dead at Age 83.

► Rakesh Jhunjhunwala began his career with the equivalent
of about $420 to invest in 1985.
► His long-term investments in well-managed companies
earned him unofficial title of India’s Warren Buffett.
► Forbes recently estimated his net worth at $5.8 billion.
RakeshJhunjhunwala1960-2022
Expiration date: Aug. 14, 2022
Net Worth > $5.8 billion https://www.wsj.com/articles/rakesh-jhunjhunwala-known-as-indias-warren-buffett-has-died-at-age-62-11660918869
Dead at age 62 of a Heart Attack

Fasting Glucose: 80 to 86 mg/dL
Fasting Insulin: <5.0 to 7.0 ulU/ml
Hemoglobin A1C: 5.0 to 5.4%
Know Your Glycemic Blood Markers
Target Interventions to Achieve:

Heart attack, stroke,
cancer, dementia
associated with
BIOLOGICAL AGE
Reference: Heron, M. Deaths: Leading Causes for 2017.
National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6.
https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf
Aging: Our #1 Risk Factor

Blood Tests at RAADcity
Reference: "An epigenetic biomarker of aging for lifespan and healthspan", Aging (Albany NY) 10(4) 573-591 (2018 Apr 18).
CBC/Chemistry + C-reactive protein
provides surrogate measure of your
BIOLOGICAL AGE

Levine-Horvath Phenotypic Age Model
No Cost to RAADfest Attendees
►‘Phenotypic Age’ estimate based on clinical measures of
9,926 adults with complete biomarker (blood test) data
►Analyzed data from over 23 years of mortality follow-up
►Advanced computational/statistical methods used to identify 9
phenotypic blood test markers to predict morbidity/mortality risk
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111

• Physiological Age
• Functional Age
• Biological Age
http://www.longlonglife.org/en/transhumanism-longevity/aging/measure-of-aging/measuring-aging-physiological-age/
Phenotypic Age helps predict future morbidity-mortality
It is also described as:

Bill’s calculated phenotypic (biological) age
11.12 younger than chron age
and difference
Albumin 4.5 g/dL
Creatinine 0.93 mg/dL
Glucose 95 mg/dL
CRP 0.27 mg/L
Lymphocytes 29%
MCV 93 fL
RDW 12.7%
Alka phosphatase 40 u/L
White Blood Cells 3.8
WBC 3.8
=
11.12-year younger
phenotypic age
compared to
chronological age
“An epigenetic biomarker of aging for lifespan and healthspan”- www.ncbi.nlm.nih.gov/pmc/articles/PMC5940111
Blood result calculate implied phenotypic
(biological) age of Bill Faloon as shown below:

Commercial Lab: $572
LifeExtension®: $77
+ Phenotypic Age at no cost
Blood Tests
to Calculate Phenotypic Age:
A1C + Lipids + Fasting Insulin
Complete Blood Count-Chemistry
and C-reactive protein
Added tests:

Target Fasting Blood Glucose
80 mg/dL to 86 mg/dL
What are Optimal Blood Sugar Levels?
And target…
Hemoglobin A1C: 5.0-5.4%
Fasting Insulin: <5.0-7.0 uIU/ml

Vincent Stona
1955-2022
A Needless Death
Urgent Need for
Patient Empowerment
Dedicated RAADfest
& Longevity Supporter

SGLT2 Inhibitors
Potential Anti-Aging Strategy
SGLT2 = Sodium-Glucose Cotransporter2
These drugs inhibit SGLT2 in kidneys to
flush away excess glucose:

Sodium-Glucose in
Sodium-Glucose out
Normal
or
SGLT2 Inhibitor
More Sodium-Glucose
removed in Urine
Kidneys return about 100% of Glucose to Circulation
SGLT2 inhibitors redirects Sodium-Glucose to Urine

Prescription Drug Lets You Urinate
Away Excess Salt and Sugar
Sodium-Glucose Cotransporter-2 (SGLT2)
inhibitors approved to treat type II diabetes.
SGLT2 inhibitors block a kidney
receptor that recovers glucose and
sodium from filtered blood. Enables
some sodium-glucose to urinate out.

PERSISTENTLY ELEVATED GLUCOSE
Glycation of
Proteins
High Blood Glucose Contributes to Glycation

https://news.cornell.edu/stories/2021/03/excess-blood-sugar-promotes-clogging-arteries-study
“Excess sugar in the blood, the
central feature of diabetes, can
react with immune proteins to
cause myriad changes in the
immune system, including
inflammatory changes that
promote atherosclerosis.”
March 23rd, 2021

Some of the Many Dangers of High Glucose:
 Atherosclerosiswhichcausesreducedbloodflow,arterial
blockages and contributes to high blood pressure.1
 Endothelial dysfunction which can damage every organ.
Most visibly eyes, kidneys, heart, brain & peripheral nerves.4,5
 Oxidative stress and inflammation
which increases risk of cancer.2,3
 Reduced insulin sensitivity and metabolic dysfunction
which cause increased body fat and high cholesterol.6
https://pubmed.ncbi.nlm.nih.gov/32155866/ https://pubmed.ncbi.nlm.nih.gov/31757028/
https://pubmed.ncbi.nlm.nih.gov/31242027/ https://pubmed.ncbi.nlm.nih.gov/25126408/ https://pubmed.ncbi.nlm.nih.gov/26566492/
2.
1.
4. 5. 6.
3.

SGLT2 Inhibitors reduce
GLUCOSE
and more to delay aging!

https://onlinelibrary.wiley.com/doi/10.1002/0471266949.bmc277
SGLT2 inhibitors show potentialto
protectagainstdiabetic nephropathy:
1) Improved glycemic control and
lower blood pressure.
2) Reducedglomerular hyperfiltration
3) Decreased inflammation-fibrosis of
proximal tubular cells in response to
hyperglycemia, and albuminuria.
SGLT2 Inhibitors Benefit the Kidneys

Aug. 17, 2017
Ten Thousand Patient NEJM Study Finds
Multiple Major Benefits of SGLT-2 Inhibitors
https://www.nejm.org/doi/10.1056/NEJMoa1611925
ThosetakingaSGLT2inhibitorwere27%lesslikelytoprogress
toalbuminuria(proteininurine)comparedtoplacebo.
Regression of albuminuria occurred 70% more frequently
in the SGLT2 inhibitor group, indicating an improvement
in advanced stage chronic kidney failure patients.
Among type II diabetic patients taking a SGLT2 inhibitor,
there were 40% fewer instances of a massive drop in
eGFR, a need for kidney dialysis or transplant, or death
from kidney causes compared to the placebo arm.

Pathophysiologyofdiabetickidneydisease:impactofSGLT2inhibitors
Known Kidney Benefits as of 2021:

https://link.springer.com/article/10.1007/s00125-021-05424-4
SGLT2 inhibitor associatedwith50% reducedincidenceofKidney Stones

https://www.nature.com/articles/s41591-021-01536-x
SGLT2 inhibitors Benefit the Heart
⬇ Microvascular Dysfunction
⬇ Inflammation & Oxidative Stress
⬆ Myocardial Energy Production
⬆ Systemic Endothelial Function
⬆ Fatty Acid Oxidation (heart muscle)
⬆ Insulin Sensitivity (heart muscle)

The Danger of High Sodium Intake
The main danger of salt can concisely be understood as:
higher salt = higher blood pressure.
Salt’s overall effect on the vasculature similar to
sugar, but in a reversed order:
• High glucose damages the arteries which
leads to high blood pressure.
• High sodium directly causes high blood
pressure, which leads to damaged arteries.
Deadly synergy from high glucose + high sodium.
Combination danger exceeds the sum of the two.

Managing Cardiovascular & Kidney Disease
https://www.nejm.org/doi/full/10.1056/NEJMra2115011
May 26th, 2022
“SGLT2 inhibitors are responsible for major paradigm
shifts in the care of patients with or at high risk for heart
failure, progression of chronic kidney disease, or both.
Theseagentsalsoreducetheriskofend-stagekidneydisease
inpatientswithtype2diabetesandchronic kidneydisease.”
SGLT2 inhibition improves cardiovascular outcomes
in patients with heart failure …regardless of whether
the patients have type 2 diabetes…

Meta-analysis of 57 Clinical Trials Finds:
Clinical Cardiovascular Benefits of SGLT2 Inhibitors
37%reduceddeathfromcardiovasculardisease
56% reduced all-cause mortality and 49% reduced
risk of cardiovascular disease compared to insulin
39%reducedriskofheartfailurehospitalization
37k Patient Swedish Study Finds:
309k Patient Study Finds:

1. https://pubmed.ncbi.nlm.nih.gov/32854852/
SGLT2 inhibitors Benefit the Brain
“Our findings revealed a previously unobserved
association between ≥3 years SGLT2 inhibitor use
and improved cognitive scores globally and in
language domain and executive function.”
2. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad215678
Type 2 diabetes increases Alzheimer’s risk.
SGLT2 inhibitors being studied to prevent or
reduce progress of Alzheimer's pathology.1
Results from separate clinical study:2

The Clinical Effects of SGLT2
Inhibitors on Cancer Development
SGLT2 Inhibitors are fairly novel drugs, being first
approved by the FDA for use in 2013, long term clinical
studies still don’t exist and early studies found little
correlation between its use and overall cancer risk.
2022 meta-analysis of 20 Clinical Trials Finds:
SGLT2 inhibitors linked to 65% reduction
in cancer risk in hyperglycemic patients.
Note:

https://pubmed.ncbi.nlm.nih.gov/28763435/ |https://pubmed.ncbi.nlm.nih.gov/29205334/
SGLT2 inhibitor-therapy induces AMPK-mediated cell cycle
arrest and apoptosis in breast and thyroid cancer cells.
SGLT2 Inhibitors Slow Cancer Growth
https://pubmed.ncbi.nlm.nih.gov/33068934/ |https://pubmed.ncbi.nlm.nih.gov/35148777/
Canagliflozin(SGLT2inhibitor)blocksComplex-Iincellularrespiration,
limiting cellular proliferation of prostate & lung cancer cells.
Dapagliflozin (SGLT2 inhibitor) regulates the cell cycle, apoptosis &
reduces glucose uptake in renal cell carcinoma and canagliflozin
doesthesameinhepatocellularcarcinomaandwasshowntoreduce
tumor growth & angiogenesis in a tumor graft model in mice.
SGLT2inhibitorsslow cancer by reducingglucosesystemically
& directly- many cancers expressSGLT2tohelp uptakeglucose

Placebo
(n=995)
JARDIANCE 10 mg
(n=999)
JARDIANCE 25 mg
(n=977)
Urinary tract infection 7.6% 9.3% 7.6%
UTIs*: Males 3.2% 3.6% 4.1%
UTIs*: Females 16.6% 18.4% 17.0%
Female genital mycotic infections 1.5% 5.4% 6.4%
Upper respiratory tract infection 3.8% 3.1% 4.0%
Increased urination 1.0% 3.4% 3.2%
Dyslipidemia 3.4% 3.9% 2.9%
Arthralgia 2.2% 2.4% 2.3%
Male genital mycotic infections 0.4% 3.1% 1.6%
Nausea 1.4% 2.3% 1.1%
https://pro.boehringer-ingelheim.com/us/products/jardiance/t2d/safety
Side Effects of Jardiance® (SGLT2 inhibitor) in Diabetics

SGLT2 inhibitor drug Risks versus Benefits
Risks
Increased incidence:
 Urinary tract infections
 Increased urination
 Fungal Infections
 Thirst/constipation
 Bone loss?
Benefits
 Heart disease
 Cancer
 Kidney disease
 Cognitive decline
 Cardiovascular death
 Inflammation
 Hypertension
 Severe type II diabetes
 Kidney stones
 All-cause mortality
versus
Decreased incidence:
Bone loss may be mitigated by vitamin D or
prescription drug activated vitamin D (calcitriol)

FDA Approved SGLT2 Inhibitor Drugs

How Effective are SGLT-2 Inhibitors in Non-Diabetics?
4
76
90
81
0
10
20
30
40
50
60
70
80
90
100
Placebo 10 25 100
4
31
49
56
62
79
0
10
20
30
40
50
60
70
80
90
0.5 2.5 10 25 50 100
Jardiance in Type II Diabetics Jardiance in “Healthy Patients”
Dose (mg) Dose (mg)
Urinary
Glucose
Grams/Day
Urinary
Glucose
Grams/Day
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927118

Target Fasting Blood Glucose
80 mg/dL to 86 mg/dL
And target…
Hemoglobin A1C: 5.0-5.4%
Fasting Insulin: <5.0-7.0 uIU/ml

“Want to Live Forever? There's No Theoretical
Limit to Human Lifespan, New Study Says”
“Humans can probably live to at least 130, and possibly well
beyond, though the chances of reaching such super old age remain
vanishingly small, according to new research.
The outer limit of the human lifespan has long been hotly debated,
with recent studies making the case we could live up to 150 years,
or arguing that there is no maximum theoretical age for humans.
The new research, published Wednesday in the Royal Society
Open Science journal, wades into the debate by analyzing new
data on supercentenarians – people aged 110 or more – and semi-
supercentenarians, aged 105 or more.”
https://www.sciencealert.com/study-suggests-that-theoretically-we-should-be-able-to-live-forever
https://royalsocietypublishing.org/doi/10.1098/rsos.202097
September 29th 2021

March 7, 2022
“Scientists Can Reverse the Aging
Process in Middle-Aged Mice”
https://www.earth.com/news/scientists-can-reverse-the-aging-process-in-middle-aged-mice/

More People Are Living Longer
increase in number of Americans
reaching since year
“Mortality Among Centenarians in the United States 2000-2014”
Centers for Disease Control and Prevention; January/July 2016
AGE 100
43%
2000

https://www.wsj.com/articles/can-you-fight-aging-scientists-are-testing-drugs-to-help-11641913275
Can You Fight Aging? Scientists Are Testing Drugs to Help
“Academic research centers and
biotechnology companies are piling
into the antiaging field in pursuit of
the longevity dream. They are
backed in part by a $3 billion
annual budget for the U.S.
National Institute of Aging as well
as some high-profile billionaires
and other venture capital investors.”
| Jan 11, 2022

Human Age Reversal Project
$1,080,300
Goal: Statistically Significant
Human Age Reversal
age-reversal.net/donate

Fund Research with Tax-Deductible Donations
Make checks payable to:
3600 West Commercial Blvd.
Ft. Lauderdale, FL 33309
Or donate online:
age-reversal.net/donate

8,000B.C.–1899A.D. 1900 –2022A.D.
Time in Perspective
(Recorded Human History)
More progress
has occurred
since 1900 than
in prior 8,000
years of recorded
human history.

“Tiny Swimming Robots Treat
Deadly Pneumonia in Mice”
Sep. 22, 2022
anoengineers at the University of California
San Diego have developed microscopic robots,
called microrobots, that can swim around in
the lungs, deliver medication and be used to clear
up life-threatening cases of bacterial pneumonia.
In mice, the microrobots safely eliminated
pneumonia-causing bacteria in the lungs and
resulted in 100% survival. By contrast, untreated
mice all died within three days after infection.
Published Sept. 22, 2022 in Nature Materials.
https://today.ucsd.edu/story/tiny-swimming-robots-treat-deadly-pneumonia-in-mice

2 0 2 2
1. Research findings since last year's RAADfest.
2. What is an “Optimized diet?”
3. New life extension drugs.
4. Key to super longevity!
5. Clinical trials targeting systemic regeneration.
6. “Live Forever” via transhumanism.
Advancing Towards Immortality
Regeneration
Targeted
Clinical
Trials
New
Anti
Aging
Drugs
Key to Super
Longevity

These slides available for review at: www.age-reversal.net
AgeReversalUpdate
William Faloon
October 6th 2022
RAADfest 2022

Bill Faloon's RAADfest 2022 Keynote Presentation slides about Age Reversal

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