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Bill Faloon 2019 RAADfest keynote presentation

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Bill Faloon presents updates on human age-reversal research, including his announcement of two human trials testing potential age-reversal interventions in humans.

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Bill Faloon 2019 RAADfest keynote presentation

  1. 1. Age Reversal Update October 3rd 2019 RAADfest Las Vegas, Nevada William Faloon
  2. 2. Unparalleled Track Record of Biomedical Innovation Established 1977
  3. 3. Manhattan Beach Summit Attendees November 2009
  4. 4. Identify one intervention to reverse one aging mechanism Manhattan Beach Longevity Summit – 2009 Where were we 10 years ago? Objective:
  5. 5. November 2009 Find one age-reversal intervention Goal:
  6. 6. November, 2009 Our Dilemma 10 Years Ago Life Extension® ($60,000)
  7. 7. November, 2009 No Human Age-Reversal Intervention Identified Outcome of 3-Day Conference
  8. 8. 10 Years Ago: Desperation No Validated Method to Reverse Aging in People Manhattan Beach Summit November 2009
  9. 9. April 27, 2019 https://www.newscientist.com/issue/3227/
  10. 10. “The Science of Living Longer” “No longer is it (aging) being treated as a dreadful inevitability but instead as a puzzle that can be solved---as a disease with a cure.” TIME-Special Edition - Fall 2019
  11. 11. 2009-2019 Senolytics NAD+ Sirtuins mTOR-inhibition AMPK Activation Umbilical Cord Plasma/Blood Exosomes from Young Cells Mesenchymal Stem Cells Immune Restoration Mitochondria Restoration Today: Multiple Interventions
  12. 12. “Can we live forever?” January 28, 2019 Harvard Medical School geneticist Vadim Gladyshev: “His research on 31 species has identified around 1000 genes… whose levels define how long an organism will live for.2 1. https://www.chemistryworld.com/features/can-we-live-forever/3009999.article 2. Aging Cell, 2015, 14, 352 (DOI: 10.1111/acel.12283)
  13. 13. Can human mortality be hacked? March 24, 2019 https://theweek.com/articles/830455/human-mortality-hacked “...a growing number of ‘transhumanists’ are convinced that, in time, human beings can be transformed through bioengineering, and that aging will be curable just like any other malady.” “A fringe group of scientists and tech moguls think they're closing in on the fountain of youth…”
  14. 14. “The Ever-Growing Reality That We Might Be Able To Live Forever” What once was science fiction now looks more like our near future. Jan 2, 2019 Would you like to live forever? “ ”“ https://melmagazine.com/en-us/story/the-ever-growing-reality-that-we-might-be-able-to-live-forever
  15. 15. CAN WE CHEAT AGING Dec. 13, 2018 All around the world, scientists are trying to beat the most debilitating condition known to humans: ageing http://www.bbc.com/future/story/20181211-how-science-and-medicine-could-cure-ageing
  16. 16. Huge Advances in Only 10 Years No Way to Reverse Aging Manhattan Beach Summit Attendees November 2009 Many Potential Methods 2009 2019
  17. 17. http://analytics.dkv.global/data/pdf/Longevity-Conferences/longevity-conferences-summary.pdf
  18. 18. http://analytics.dkv.global/data/pdf/Longevity-Conferences/longevity-conferences-summary.pdf
  19. 19. https://www.longevity.vc/ Investing in Human Longevity Laura Deming is a venture capitalist with $37 Million under management, investing in breakthrough longevity companies.
  20. 20. Life Biosciences raised more than $75 million to research treatments for age-related decline. March 4, 2019 https://www.fastcompany.com/90314848/pepsicos-top-scientist-is-joining-the-fight-to-help-you-live-forever https://www.bloomberg.com/news/articles/2019-03-04/departing-pepsico-scientist-to-become-ceo-of-anti-aging-startup Mehmood Khan, vice chairman and chief scientific officer of PepsiCo, announced he’s joining Life Biosciences, a startup dedicated to “age-reversal.”
  21. 21. Insilico Medicine Secures $37M in Series B Funding Alexander Zhavoronkov, Ph.D., is the Chief Executive Officer of Insilico Medicine, Inc, a company applying advances in artificial intelligence to drug discovery, biomarker development and aging research. Landmark AI paper resulted in a $37 million round of additional funding from venture capitalists. Total dedication to finding an aging cure. https://insilico.com Life Extension contributed $140K start-up funding for Insilico.
  22. 22. According to Juvenescence’s Greg Bailey “We won’t be aging as fast or poorly as our parents” “I think the world is going to be shocked” Juvenescence has now raised $165 million to fund longevity projects with the goal of extending human lifespans to 150 years. “Science fiction has become science” ‘Extraordinary’ Breakthroughs In Anti-Aging Research ‘Will Happen Faster Than People Think’ https://www.forbes.com/sites/robinseatonjefferson/2019/08/26/how-extraordinary-breakthroughs-in-anti-aging-research-will-happen-faster-than-people-think
  23. 23. https://www.wsj.com/articles/the-advantagesand-limitationsof-living-to-100-11558361828 Since 1995 the prevalence of Americans living to age 100 has doubled. By year 2030, the number of Americans living to 100 years and older will increase almost 5-fold compared to 1980. “Do you want to live to be 100?” May 20, 2019 |
  24. 24. https://www.wsj.com/articles/the-advantagesand-limitationsof-living-to-100-11558361828May 20, 2019 | 2.5-Fold increase from 1980 to 2017 Source: US Census Bureau
  25. 25. https://www.wsj.com/articles/the-advantagesand-limitationsof-living-to-100-11558361828May 20, 2019 | Source: US Census Bureau Nearly 5-Fold increase in Centenarians by 2030 Note: 2020-2030 Totals are Estimates
  26. 26. https://www.wsj.com/articles/the-advantagesand-limitationsof-living-to-100-11558361828 Relative Change in Centenarian Rate per 10,000 Americans May 20, 2019 | 1980 – 1990: +5.3% 1990 – 2000: +16.2% 2000 – 2010: -3.4% Obesity Epidemic May Be Stifling Improvements
  27. 27. Age-adjusted Prevalence of Obesity and Diagnosed Diabetes Among US Adults Diabetes No Data < 14.0% 14.0%–17.9% 18.0%–21.9% 22.0%–25.9% > 26.0% No Data < 4.5% 4.5%–5.9% 6.0%–7.4% 7.5%–8.9% > 9.0% Age-Adjusted Prevalence of Obesity and Diagnosed Diabetes Among US Adults CDC’s Division of Diabetes Translation. United States Diabetes Surveillance System available at http://www.cdc.gov/diabetes/data 1994 2000 2015 Diabetes1994 20152000 Obesity
  28. 28. New Genetic Test Measures Lifelong Body Weight Reveals Startling Link between Obesity and Cancer It Is Worse Than Previously Thought!  59% higher risk of kidney cancer (revised up from 30%)  106% higher risk of endometrial cancer (revised up from 50%)  13% higher risk of ovarian cancer (revised up from 6%)  110% higher risk of esophageal cancer (revised up from 48%)  47% higher risk of pancreatic cancer (revised up from 10%)  44% higher risk of colorectal cancer (revised up from 5%) What can Mendelian randomization tell us about causes of cancer? International Journal of Epidemiology. 2019; 48(3): 816-821https://academic.oup.com/ije/article-abstract/48/3/816/5539268?redirectedFrom=fulltext. July 25, 2019
  29. 29. People with high BMI and central obesity have 3.5 times increased dementia risk. Central Obesity (belly fat) Increases Dementia Risk Central obesity and increased risk of dementia more than three decades later (PDF). Neurology 2008: 71, 1057-1064
  30. 30. RapamycinClinicalTrial Dose: 5 mg/week of sirolimus (rapamycin) Recruitment: Age Reversal Network volunteers Subjects: 20 overweight individuals initiated and 14 concluded Side effects: 10% had minor canker sores that usually resolved (No one stopped because of side effects)
  31. 31. California wildfires caused some to drop out and high stress levels in those who continued. Major Impediment
  32. 32. More data on this study will be sent soon to RAADfest participants via email Rapamycin Study Partial Results Significant reductions in visceral adipose tissue. Non-smoke affected subjects showed indicatorsofage-reversal Reduction
  33. 33. Reduced Rapamycin (5 mg) once weekly well tolerated Initial Interpretations High stress offsets beneficial effects of this regenerative technique. More data on this study will be sent soon to RAADfest participants via email
  34. 34. Interventions that may improve your odds of living to year 2030
  35. 35. “Measuring population ageing: an analysis of the Global Burden of Disease Study 2017.” Lancet Public Health. 2019 Mar;4(3):e159-e167. “At what age do you feel 65?” In a startling revelation, 76-year-old people in Japan and 46-year-old people in Papua New Guinea have the same level of age-related health problems as an average 65-year-old. Available at: https://medicalxpress.com/news/2019-03-age.html. Accessed April 2, 2019. March 8, 2019
  36. 36. “Measuring population ageing: an analysis of the Global Burden of Disease Study 2017.” Lancet Public Health. 2019 Mar;4(3):e159-e167. Level of Age-Related Health Problems Available at: https://medicalxpress.com/news/2019-03-age.html. Accessed April 2, 2019. March 8, 2019 New Guinea: 46 year old = 65 year old Japan: 76 year old = 65 year old
  37. 37. “Measuring population ageing: an analysis of the Global Burden of Disease Study 2017.” Lancet Public Health. 2019 Mar;4(3):e159-e167. You Control Disease Risk and How Old You Feel! Available at: https://medicalxpress.com/news/2019-03-age.html. Accessed April 2, 2019. March 8, 2019 The Lancet Public Health showing marked differences in the “age-related disease burden” between countries...The United States ranked 54th on this list, between Algeria and Iran.
  38. 38. https://www.cdc.gov/dhdsp/maps/national_maps/stroke65_all.htm Huge Variances in Stroke Incidence
  39. 39. https://www.wsj.com/articles/the-advantagesand-limitationsof-living-to-100-11558361828May 20, 2019 | Compared to 1980, by 2030 there will be almost 5-times more centenarians. Surging numbers of Americans living to age 100 and older
  40. 40. May 8, 2019 One of the biggest investment opportunities over the next decade will be in companies working to delay human death, a market expected to be worth at least $600 billion by 2025, according to Bank of America analysts. https://www.cnbc.com/2019/05/08/techs-next-big-disruption-could-be-delaying-death.html Human life expectancy could pass 100 years
  41. 41. May 9, 2019 https://www.dailymail.co.uk/sciencetech/article-7009493/Human-life-expectancy-pass- 100-years-thanks-tech-developments-worth-600-billion-2025.html Human life expectancy could pass 100 years AI, gene editing and death delaying technologies will be one of the biggest investment areas. Life expectancy of more than 100 years will soon become commonplace as advances in technology tackle the problem of aging.
  42. 42. “There is now compelling evidence that the ageing process is plastic and that it is possible to revive aged cells and tissues” “Turning back time with emerging rejuvenation strategies” Jan. 2019 Nature Cell Biology Volume 21, Pages 32-43 (January, 2019)
  43. 43. “Strategies to delay and potentially even reverse the aging process have recently been developed” Jan. 2019
  44. 44. A piece of non-coding DNA may hold the key to how humans could regenerate body parts. Some animals can achieve extraordinary feats of repair, such as salamanders which grow back legs, or geckos. Scientists at Harvard University uncovered the DNA switch that controls genes for whole-body regeneration. Humans may soon have the ability to regrow limbs. Mar. 17, 2019 Harvard University uncovers DNA switch that controls genes for whole-body regeneration https://www.telegraph.co.uk/science/2019/03/14/harvard-university-uncovers-dna-switch-controls-genes-whole/
  45. 45. A new CRISPR/Cas9 therapy can suppress aging, enhance health and extend life span in mice, opening door for better understanding of aging in humans Salk Institute researchers have developed a new gene therapy to help decelerate the aging process. From left: (front) Reyna Hernandez-Benitez, Hsin- Kai Liao; (back) Pradeep Reddy, Mako Yamamoto, Juan Carlos Izpisua Belmonte Feb.2019PUTTING THE BRAKES ON AGING https://www.salk.edu/news-release/putting-the-brakes-on-aging/
  46. 46. “Has this scientist finally found the fountain of youth?” August 2019 Juan Carlos Izpisúa Belmonte, Gene Expression Laboratory at San Diego’s Salk Institute for Biological Studies “It completely rejuvenates…If you look inside, obviously, all the organs, all the cells are younger.” Salk Institute uses gene editing “age-reversal mixture” to rejuvenate progeroid mice on verge of death.
  47. 47. CRISPR-cas9 therapy delays aging partially by removing Senescent Cells Feb. 18, 2018 Overall, the treated progeria mice had activity levels similar to normal mice, and their life span increased by roughly 25 percent Two months after delivery of the (CRISPR) therapy, the mice were stronger and more active, with improved cardiovascular health. They showed decreased degeneration of a major arterial blood vessel and delayed onset of bradycardia - two issues commonly observed in progeria and old age. https://www.nature.com/articles/s41591-019-0343-4#article-info These two mice are the same age
  48. 48. This is why we need to start treating aging as a disease By David A. Sinclair and Nir Barzilai The next medical frontier is extending the human lifespan. But changing the definition of aging is still a huge obstacle Nir Barzilai, Ph.D. Albert Einstein College of Medicine Metformin Advocate David Sinclair, Ph.D. Harvard Medical School NAD+ Advocate December 31, 2018
  49. 49. Life Extension recommended metformin 24 years ago… the FDA went berserk! March 1995
  50. 50. https://www.pressreader.com/usa/popular-science/20180505/281672550562011 “Bill Faloon has pursued immortality for decades. Now he’s got lots of company. What does science have to say?” “The FOREVER Man” May 5, 2018
  51. 51. A Conversation with ‘Forever Man’ Bill Faloon About Fending Off Aging https://www.noozhawk.com/article/tam_hunt_conversation_about_aging_with_forever_man_bill_faloon_20181108 Bill Faloon is a man with a mission: to fend off aging. As long as possible, and maybe even forever. A recent Popular Science story called him “the forever man.” This is both because Faloon wants to figure out how we can live forever and because he has been working to resolve this problem for what can seem like forever — or at least since the 1970s, which seems to most of us to be pretty much forever. I met Faloon at this year’s RAADfest conference in San Diego, where he was omnipresent. When he wasn’t on stage giving a talk or appearing on a panel, he was mingling with attendees answering questions and generally offering wisdom where he could. He talks a mile a minute with a soft intensity and keen intelligence.
  52. 52. https://www.technologyreview.com/magazine/2019/09 September 2019 “Later this year, at a conference of longevity enthusiasts called RAADfest, to be held in Las Vegas, Faloon plans to take the strategy one step further with what he has been calling the “Perpetual Clinical Trial.” “OLD AGE IS OVER!”
  53. 53. “…If You Want It” https://www.technologyreview.com/magazine/2019/09 September 2019 It’s so named because “there is no upper limit as to how long we will attempt to enable study participants to live.”
  54. 54. Still Shot from European Special on the “Forever Man” December 2018
  55. 55. Rejuvenating Aging Brains
  56. 56. 1) Preserve general health of neurons. 2) Brain’s primary immune cells. 3) Clean-up toxins around neurons. https://www.nature.com/articles/d41586-018-04930-7 What are Microglial Cells?
  57. 57. “Young bone marrow transplantation preserves learning and memory in old mice”, Communications Biology (2019). DOI: 10.1038/s42003-019-0298-5 “Young bone marrow rejuvenates aging mouse brains, study finds” Transplanting the of young laboratory mice into old mice prevented cognitive decline in the old mice. Available at:https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html. February 20, 2019
  58. 58. Information from one neuron flows to another neuron across a synapse Neurons communicate with one another at synaptic junctions Synapses: The point of connection between brain cells
  59. 59. “Young bone marrow rejuvenates aging mouse brains, study finds” Microglia in brains of old mice have fewer/shorter branches than young mice Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html. Feb. 20, 2019 Synaptic branches of microglia of old mice who received bone marrow transplants from young mice resembled those of young mice
  60. 60. Young Bone marrow transplants restore exploratory activity in old mice Feb. 20, 2019 “Remarkably, young bone marrow recipients, but not old bone marrow recipients, were more active than old control mice.” https://www.nature.com/articles/s42003-019-0298-5/figures/1
  61. 61. “Young bone marrow rejuvenates aging mouse brains, study finds” Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html. Feb. 20, 2019 Young bone marrow restores aged mouse brains!
  62. 62. PHILADELPHIA (CBS) — Could the secret to eternal youth be found in blood transfusions from young people? Some claim that transfusions with “young blood” from teenagers can reverse the aging process. Dec. 20, 2018 Controversial Treatment Transfuses Patients With ‘Young Blood’From Teenagers To Reverse Aging Process
  63. 63. Transfer Research goes Mainstream Johnson and Johnson signs $50 million deal with Stanford University researchers to identify blood factors responsible for age reversal in parabiosis studies: "…it could mean new therapeutic approaches for treating numerous diseases associated with aging, including neural dysfunction and dementias such as Alzheimer's disease.” March 4, 2015
  64. 64. Stanford University scientists previously showed that transfused serum from 12-to-15-month age mice into old mice reverses some signs of brain aging. Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019). DOI: 10.1073/pnas.1902672116 JUNE 3, 2019
  65. 65. Researchers find synapse-boosting factors in young blood Available at: https://medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019. June 4, 2019 Stanford University researchers used serum from 15-day old (very young) mice and discovered: “ ”
  66. 66. https://medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html 15-Day old Mouse (left) compared to 15-Month Old Mouse (right)
  67. 67. Very Young Blood (serum) Regenerates Synapses, Dendrites, Neurotransmitters Available at: medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019. June 4, 2019 “When two proteins (thrombospondin-4 and SPARC-like protein-1) richer in younger serum were applied to older serum…some of the same rejuvenating effects took place.”
  68. 68. “Strikingly, recombinant THBS4 and SPARCL1… may represent rejuvenation factors that enhance synaptic connectivity by increasing dendritic arborization, synapse formation, and synaptic transmission.” Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019). DOI: 10.1073/pnas.1902672116 JUNE 3, 2019 Human equivalent of a 15-day old mouse may be approximately one to two years.
  69. 69. https://www.reuters.com/article/us-health-elderly-falls/more-elderly-americans-dying-from-falls-idUSKCN1T5213 Hip Fractures in the Elderly Are Often a Death Sentence http://theconversation.com/why-hip-fractures-in-the-elderly-are-often-a-death-sentence-95784
  70. 70. “Some reports show that up to 50% of patients with hip fracture die within six months and many of those who survive do not recover their baseline independence and function.” Negrete-Corona, J., J. C. Alvarado-Soriano, and L. A. Reyes-Santiago. "Hip fracture as risk factor for mortality in patients over 65 years of age. Case-control study." Acta ortopedica mexicana 28, no. 6 (2014): 352-362. https://www.ncbi.nlm.nih.gov/pubmed/26016287 “Hip Fracture Among Older Patients Is A Devastating Injury”
  71. 71. https://medicalxpress.com/news/2018-12-scientists-youth-factor-blood-cells.html “Scientists identify ‘youth factor’ in blood cells that speeds fracture repair” Medical press Dec. 5, 2018 Duke Health researchers showed introducing bone marrow stem cells to a bone injury can expedite healing. New study by same Duke-led team has pinpointed “youth factor” inside bone marrow stem cells that can have a rejuvenating effect on tissue.
  72. 72. Stem Cells Bone Marrow Progenitor Cells Functional Cells Healthy Tissues Where Do Progenitor Cells Come From?
  73. 73. Progenitor Cell Self-Renewal and Differentiation
  74. 74. Adult stem cells lose ability to repopulate tissues with functional cells Systemic deterioration occurs as functional cells degenerate/die Khorraminejad-Shirazi M et al., Aging and stem cell therapy: AMPK as an applicable pharmacological target for rejuvenation of aged stem cells and achieving higher efficacy in stem cell therapy. Hematol Oncol Stem Cell Ther (2017)  Boost cellular AMPK  Suppress excess mTORC1  Replenish NAD+ cell levels  Activate sirtuin proteins How your stem cells may be renewed:
  75. 75. Interventions that may improve your odds of living to year 2030
  76. 76. More than 90% of people over 65 years of age have at least one chronic disease Harsh Reality: Goldman, Dana P., et al. "Substantial health and economic returns from delayed aging may warrant a new focus for medical research." Health affairs 32, no. 10 (2013): 1698-1705.
  77. 77. Level 1 Level 2 The House of Optimal Health
  78. 78. Optimal Health Level 2 Level 1 Before we can utilize the latest technologies… We must address the first level foundation toward optimal health - Hormones - Kidney function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Triglycerides
  79. 79. House of Optimal Health - Hormones - Kidney function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Triglycerides Level 2 Level 1 - Senolytics - NAD+ Restoration - mTOR-inhibition - Umbilical Cord Blood/Plasma - Umbilical Exosomes - Mesenchymal Stem Cells - Mitochondria Restoration - Very Young Plasma Overlooking the Basics Circumvents Rejuvenation
  80. 80. Interventions that may improve your odds of living to year 2030
  81. 81. HowtoActivate AMPK Calorie restriction or intermittent fasting with emphasis on reducing sugar & starch. Drugs: metformin Nutrients: curcumin, green tea, gynostemma pentaphyllum, hesperidin Aerobic exercise (less effective in persons over 65 years)
  82. 82. Senolytics are compounds that selectively destroy senescent cells.
  83. 83. Senescent cells accumulate with normal aging and: Removing Senescent Cells Confers Healthy Longevity
  84. 84. Normal Aged Mouse Senolytic Treated Mouse
  85. 85. Anti-Cancer Properties of Senolytics May. 17, 2019 https://science.sciencemag.org/content/364/6441/636.full “Indeed, elimination of senescent cells with aging attenuates tumor formation in mice, raising the possibility that senolysis might be an effective strategy to treat cancer.”
  86. 86. 8 Million Americans Suffer Chronic Heart Failure Clinical trial urgently needed! Pharmacologic and genetic removal of p16-positive (senescent) cells in mice appears to ameliorate (or improve) the level of age-induced fibrosis and hypertrophy in senescent cardiac muscle cells, and may support regeneration of cardiomyocytes… What we learned from 2019 studies:
  87. 87. Senolytics May Reverse Heart Failure Clinical trial urgently needed! What We Learned in 2019: “Pharmacological clearance of senescent cells improves survival and recovery in aged mice following acute myocardial infarction”1 1. https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.12945
  88. 88. Stem Cells Bone Marrow Progenitor Cells Functional Cells Healthy Heart Where Do Progenitor Cells Come From?
  89. 89. “Aged‐senescent cells contribute to impaired heart regeneration.” Aging Cell; June 2019 Senescent Cells Damage Aging Hearts “Aging leads to increased cellular senescence and is associated with decreased potency of tissue‐specific stem/progenitor cells.” “In aged subjects (>70 years old), over half of cardiac progenitor cells are senescent…” “Therapeutic approaches that eliminate senescent cells may alleviate cardiac deterioration with aging and restore the regenerative capacity of the heart.”
  90. 90. Senolytic Update age-reversal.net
  91. 91. “Just a year ago I felt immortal, wearing my age with pride, even joking about it.” https://www.nytimes.com/2019/09/11/business/boone-pickens-dead.html Who missed the longevity boat? T. Boone Pickens (1928-2018) Expiration date: Sept. 11, 2019 Net worth > $950 million In 2016 T. Boone Pickens wrote: One year later suffered series of strokes and a fall. Dead at age 91.
  92. 92. You Can READ About a Breakthrough
  93. 93. Or You Can Be There
  94. 94. At Kitty Hawk
  95. 95. On Dec 17th 1903
  96. 96. When The World Changed Forever
  97. 97. How to do a $50 million/5-Year Clinical trial in 1 Year for $530,000 (Many of us can't wait 5 years and we don't have $50 million)
  98. 98. Solution is Two Studies: 1) Vitality in Aging Longitudinal Study 2) Vitality in Aging Interventions Trial
  99. 99. age-reversal.net This entire presentation available at:
  100. 100. Step 1: Join the Vitality in Aging Longitudinal Study (Sign up in RAADcity)
  101. 101. Open to Everyone! Modeled on Framingham Heart Study  Long term and ongoing  No upper age threshold  No preset termination date
  102. 102. Began in 1948 with 5,209 adults from Framingham, Massachusetts PriortoFraminghamlittlewas knownabout hypertension/cardiovascularrisks Doctors backthen didnotknow how toprevent heartattacks Atherosclerosiswasthoughtanunavoidableaspectofnormalaging Framingham Heart Study Millions of Lives Saved
  103. 103. 3,000 medical papers published using Framingham…now in its third generation FraminghamHeartStudyissourceoftheterm“riskfactor” Framingham Heart Study Millions of Lives Saved Framingham findings revealed role of diet and other artery-clogging factors
  104. 104. Vitality in Aging Longitudinal Study Become part of a team effort to defeat aging! Identify “risk factors” causing you to age Access biomarker tests at subsidized prices Access interventions at discount prices Test safety & efficacy of self-experimentation Accelerate science of human age reversal
  105. 105. Long Term Funding Sources Will Be Needed Human Age Reversal Project Bill Faloon Donations of Physicians’ Time Funding Need: > $800,000 Donations Received to Date: $395,000 SOURCES OF FUNDING:
  106. 106. New charity to fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  107. 107. I Refunded >$ 1 Million to Age Reversal Investors 100% of these monies refunded to investors Initial attempts to raise $10-$25 Million for age-reversal research raised over $1,000,000 This amount insufficient to fund viable commercial entity
  108. 108. Some tests only available to VIA Study Subjects! Results help identify factors associated with rapid aging, age-delay, or age-reversal…analogous to Framingham. Longitudinal Study includes biomarkers (such as NAD+) visceral fat measure, cognitive testing, comprehensive blood test, medical evaluation Vitality in Aging Longitudinal Study Commercial Prices Longitudinal Study >$4,000 $595 Age Management Diagnostics Panels
  109. 109. Omega-3 IndexLiver-Kidney Function Cardiovascular Inflammatory Hormones Lipids (full-spectrum) NAD+ Glycemic Markers Blood Cell Counts Vitamin D Insulin Resistance Growth Factors
  110. 110. Wrist Band Measures 1.Sleepquality&quantity 2.Heartratevariability 3.Physicalactivitylevel Morpheuswristbandswillbeusedin theLongitudinalStudytomeasure:
  111. 111. Heart rate variability predicted first cardiovascular event in populations without known cardiovascular disease Low heart rate variability is associated with approximately 40% increased risk of a first cardiovascular event in populations without known cardiovascular disease. Heart rate variability and first cardiovascular event in populations without known cardiovascular disease: meta-analysis and dose–response meta-regression. EP Europace, Volume 15, Issue 5, May 2013, Pages 742–749,https://doi.org/10.1093/europace/eus341 Published: 30 January 2013
  112. 112. LowHeartRateVariabilityAssociatedwithHigherRiskofStroke Decreased Nighttime Heart Rate Variability Is Associated With Increased Stroke Risk Originally published 15 Sep 2011 https://doi.org/10.1161/STROKEAHA.110.607697 Stroke. 2011;42:3196–3201 Low HeartRateVariabilityassociated with33%increasedstrokerisk. Lower half of nighttime Heart Rate Variability interval analysis associated with 331% increased stroke risk.
  113. 113. Heart rate variability as predictive factor for sudden cardiac death. Aging (Albany NY). 2018 Feb 23;10(2):166-177. https://www.ncbi.nlm.nih.gov/pubmed/29476045 Heart RateVariabilityCan PredictSudden Cardiac Death Sudden cardiac death represents about 25% of deaths in clinical cardiology. Low heart rate variability has been shown to be independently predictive of increased mortality in post-myocardial infarction (heart attack) patients and heart failure patients. The cost/benefit relationship between heart rate variability and sudden cardiac death in general population groups is currently considered only modest by mainstream medicine. Heart rate variability measures important for aging population groups
  114. 114. HEART RATE VARIABILITY “Heart rate variability is simply a measure of the variation in time between each heartbeat.” https://www.health.harvard.edu/blog/heart-rate-variability-new-way-track-well-2017112212789 “This variation is controlled by a primitive part of the nervous system called the autonomic nervous system.” ANewWaytoTrackWellBeing Nov 22, 2017
  115. 115. Wrist Band Measures 1.Sleepquality&quantity 2.Heartratevariability 3.Physicalactivitylevel Morpheuswristbandswillbeusedin theLongitudinalStudytomeasure:
  116. 116. Vitality in Aging Longitudinal Study  Morpheus wrist band  Standard clinical tests  Age Management Blood Test Panel  NAD+ and Omega-3 Index  Bioimpedance measure of visceral fat  Cognitive tests  Initial medical exam Commercial cost: >$4,000 RAADfest attendee: $595 More tests if funding is secured.
  117. 117. If future funding is raised from donations, investments and/or government grants…participants who join the Vitality in Aging Longitudinal Study now may receive no additional expenses for continued participation. Hidden Potential Benefit
  118. 118. This could translate into FREE long-term access to advanced diagnostics. As new interventions are discovered, new intervention studies will commence, ideally recruiting subjects from VIA Longitudinal Study participants. Hidden Potential Benefit
  119. 119. Blood Test Panel Only Option Age Management Blood Test Panel Omega-3 Index  Morpheus wrist band  Standard clinical tests  NAD+  Bioimpedance measure of visceral fat  Cognitive tests  Initial medical evaluation Commercial cost: >$3,000 RAADfest attendee: $395
  120. 120. Open to Everyone! Step 1 - Enroll in VIA Longitudinal Study at RAADcity Step 2 - Baseline Blood/Diagnostic Panels at RAADcity Step 3 - Use test results to adjust your longevity program Step 4 - Retest to measure age reversal efficacy Step 5 - Adjust interventions based on retest results Modeled after Framingham Heart Study, i.e. long term and ongoing…
  121. 121. Participants selected from Longitudinal Study Vitality in Aging Interventions Trial Step 2:
  122. 122. Statistically Significant + Meaningful Age Reversal in 12 Months Outcome Objectives: $530,000 + donated/discounted services Human Age Reversal Project Vitality in Aging Interventions Trial Study Cost: Major Funding Provided by:
  123. 123. Step #1: VIA Longitudinal Study Results will help determine if you qualify for: Step #2: VIA Interventions Trial HowtoParticipate in TheseClinicalTrials:
  124. 124. VIA Interventions Trial Price per Study Subject: ZERO Estimated Value per Study Subject: >$10,000
  125. 125. Step #1: VIA Longitudinal Study Step #2: VIA Interventions Trial You pay (at deep-discounted prices) for lab tests and interventions. (Everyone should enroll in this study) Human Age Reversal Project pays for lab tests and medical interventions. (30-50 people selected for this study)
  126. 126. Age Reversal Interventions Target 5 calorie restriction pathways Reduce/resolve inflammation Telomere lengthening Selective removal of senescent cells Restore youthful methylation
  127. 127. Age Reversal Interventions Autophagy Resolve inflammation Remove senescent cells Restore youthful methylation Lengthen telomeres AMPK/ mTOR Sirtuins - NAD+ Exosomes
  128. 128. Trial Parameters > Open label (no placebo group) > 50 healthy people aged 50-75 years Initial Phase Recruitment/Baseline Testing: October 3rd 2019 – December 15th 2019 Vitality in Aging Intervention Trial
  129. 129. Vitality in Aging Interventions Trial Timeline
  130. 130. Vitality in Aging Interventions Trial Intervention #1 Calorie Restriction Mimetics
  131. 131. 12% Calorie Reduction Improves Biological Age Scores by 1.5 Years 2018 Published Human study measures 8 Aging Biomarkers Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis, J Gerontol A Biol Sci Med Sci. 2018 Jan; 73(1): 4-10.
  132. 132. Intervention:1 Targeting Calorie Restriction Pathways Metformin, glucosamine Salicylate, metformin Rapamycin, metformin Pterostilbene, nicotinamide Nicotinamide riboside Rapamycin, glucosamine Beta-lapachone ↓Insulin/IGF-1 ↑AMPK ↓mTOR ↑Sirtuins ↑ NAD+ ↑Autophagy ↑NAD/NADH ratio
  133. 133. VIA Interventions Trial Increase AMPK Autophagy Sirtuins/NAD+ Decrease mTOR Insulin IGF-1 signals Targets Calorie Restriction Pathways
  134. 134. Downregulate Insulin/IGF-1 Pathway Approved for Human Use Reduce Insulin/IGF-1with: HasBeenShowntoReduceAll-causeMortalityinHumans
  135. 135. Boosting AMPK activity with: Metformin has been shown to reduce all-cause mortality in humans. Salicylate (this is not aspirin) can potently boosts AMPK. 1) Indirectly with metformin 2) Directly with salicylate
  136. 136. Inhibit mTOR Rapamycin inhibits mTOR and has been shown to increase lifespan in animals. Rapamycin reduces cancer risk by 40% in human kidney transplant patients. New research finds rapamycin reduces visceral fat in non-transplant patients. Turn back mTOR Turn back the clock
  137. 137. July 9, 2018 NAD+ Restores Cellular DNA Repair ►NAD+ depletion turns off DNA repair enzymes. ►Increase NAD+ with nicotinamide riboside. Boost NAD+ Blood Levels
  138. 138. July 9, 2018 Increase NAD+ / Reduce NADH ►Aging results in reduced NAD+ and higher relative levels of NADH, which creates cellular imbalances. ►The NAD+/NADH ratio will be tested after using beta-lapachone. Restore NAD+/NADH Ratio
  139. 139. Autophagy is another mechanism by which caloric restriction has been shown to extend mean and maximal lifespan in model organisms (yeast, fruit flies, nematodes, mice, rats, and large animals). Several CR mimetics induce autophagy, including glucosamine, metformin, and rapamycin. Autophagy triggers “self cleaning” programs in the body that selectively remove old mitochondria (mitophagy), damaged proteins, oxidized lipids, and even damaged cells.
  140. 140. Intervention:1 Targeting Calorie Restriction Pathways Metformin, glucosamine Salicylate, metformin Rapamycin, metformin Pterostilbene, nicotinamide Nicotinamide riboside Rapamycin, glucosamine Beta-lapachone ↓Insulin/IGF-1 ↑AMPK ↓mTOR ↑Sirtuins ↑ NAD+ ↑Autophagy ↑NAD/NADH ratio
  141. 141. Vitality in Aging Interventions Trial Senolytics Selective removal of senescent cells Intervention #2
  142. 142. Selective removal of senescent cells - Age-related accumulation of senescent cells contributes to atherosclerosis, aging of the eye (cataracts, AMD), osteoporosis, skin and brain aging, Kirkland and colleagues at Mayo Clinic show that senescent cells are selectively eliminated by “senolytic” drugs. Senolytic Cocktail of: Senolytics 1) Dasatinib 2) Quercetin 3) Fisetin
  143. 143. Suppress Chronic Inflammation Intervention #3:
  144. 144. 1) Fish oil: Boost omega-3 index > 10% Reduce and Resolve Chronic Inflammation 2) Resolvins: Return tissues to health Inflammaging major cause of aging and contributes to the global loss of Sirt1 function. We intend to use omega-3 fatty acids and other fatty acids to increase resolvins, protectins, and maresins with a target of a minimum of 10% omega-3 index.
  145. 145. Telomere Elongation Intervention #4:
  146. 146. Telomereshortening normally occurs atarateof0.9%/year. Telomere Lengthening 1) Exercise 2) Stress Control 3) Healthy Diet 4) Omega-3 fatty acids Onesmallprospectivecontrolledstudyinolder menshowedthattelomerescouldbelengthened by2%peryearwithacombinationof:
  147. 147. Restoring Youthful Methylation Intervention #5
  148. 148. “TheroleofDNA methylationin epigeneticsofaging”  Epigenetics, especially DNA methylation, plays a mechanistic role in aging.  Epigenetic clocks are best biomarkers for predicting human mortality.  DNAmethylationinfluencedbymetformin,caloric restriction and rapamycin treatment in mice.  This may reverse/prevent 20% to 40% of the age-related changes in DNA methylation. Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001
  149. 149. Methods of Balancing Methylation Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001 Metformin CalorieRestrictionMimetics Rapamycin
  150. 150. LS/tandemmassspectrometrybasedtesting Quantitativeb-galactosidasestaining,p16INK4a,etc) Neurovision – Mayo Clinic CD38 Johns Hopkins Aging Biomarker Tests Vitality in Aging Interventions Trial More Accurate FlowFISH- Based Telomere Length Tests Newer DNA Methylation Age Tests NAD+, NAD/NADH ratio, and NAD+ metabolite tests Cell Senescence Tests Univ of British Columbia/UCLA Galactosidasestaining,p16INK4a,skinpunch NanoSomiX Exosome tests for predicting Alzheimer’s disease 10 years prior to onset of memory loss Age Management Panel Comprehensive blood biomarkers with Levine Biological Age Calculator
  151. 151. VIA Interventions Trial Price per Study Subject: ZERO Estimated Value per Study Subject: >$10,000
  152. 152. Healthy Subjects in order to Measure Meaningful Age Reversal in 12 Months Strict Inclusion Criteria for Study Subjects Vitality in Aging Interventions Trial Exercise (10,000 step equivalent each day) Healthy diet patterns (no junk foods) Restful sleep patterns (no benzodiazepines) Body Mass Index: 18-24 (no significant central fat mass) No serious preexisting disorders No prescription narcotics or recreational drugs Target LDL below 80 mg/dl Omega-3 Index > 8% (achievablewithhighdosefishoil)
  153. 153. (Need website for donations) Human Age Reversal Project $395,000 Donated Funds Allocated for the VIA Intervention Trial: Goal: Statistically Significant + Meaningful Age Reversal $??? age-reversal.net/donate
  154. 154. Procrastination Our greatest enemy:
  155. 155. (Sign up in RAADclinic) Vitality in Aging Longitudinal Study Step 1: Join
  156. 156. Long Term Funding Sources Will Be Needed Human Age Reversal Project Bill Faloon Donations of Physicians’ Time Funding Need: > $800,000 Donations Received to Date: $395,000 SOURCES OF FUNDING:
  157. 157. New charity to fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  158. 158. Some tests only available to VIA Study Subjects! Results help identify factors associated with rapid aging, age-delay, or age-reversal…analogous to Framingham. Longitudinal Study includes biomarkers (such as NAD+) visceral fat measure, cognitive testing, comprehensive blood test, medical evaluation Vitality in Aging Longitudinal Study Commercial Prices Longitudinal Study >$4,000 $595 Age Management Diagnostics Panels
  159. 159. Omega-3 IndexLiver-Kidney Function Cardiovascular Inflammatory Hormones Lipids (full-spectrum) NAD+ Glycemic Markers Blood Cell Counts Vitamin D Insulin Resistance Growth Factors
  160. 160. Wrist Band Measures 1.Sleepquality&quantity 2.Heartratevariability 3.Physicalactivitylevel Morpheuswristbandswillbeusedin theLongitudinalStudytomeasure:
  161. 161. Oxygen MeasuresRed Blood Cells A1C Glucose HDL Triglycerides LDL Liver-Kidney Function Homocysteine Cholesterol Immune cells Platelets
  162. 162. Interleukin-6 (IL-6)2NMR – Lipoprofile1 DHEA-S Free T44 TSH5 Ferritin PSA6 Total Testosterone Free Testosterone Estradiol7 Apolipoprotein B3 Free T34 1: Measures Atherosclerosis Risk 2: Longevity Measure 3: Atherosclerosis Measure 4: TSH Measure 5: Thyroid Stimulating Hormone 6: or Progesterone (gender based) 7: Atherosclerosis Measure
  163. 163. Omega-6: Omega-3 RatioOmega-3 Percent IGF-11 C-Reactive Protein IGFBP-32 Full Fatty Acid Profile Trans Fat Index Vitamin D3 AA:EPA Ratio Insulin NAD+ NADH 1: Insulin Growth Factor-1 (Growth Hormone) 2: Insulin Growth Factor Binding Protein 3 3: 25, Hydroxyvitamin D
  164. 164. NicotinamideFull ADPR NAAD ADPR NAMN NAD + metabolites PADPH NAM MeNAM NADP+
  165. 165. Consumer value of participating in VIA Longitudinal Study: ~ $4,000 VIA Longitudinal Study also includes for $595: Morpheus Wrist Band: Heart Rate Variability, Sleep , Physical Activity Bioimpedance: Body Fat/Muscle Mass Scan Cognitive Testing Health Evaluations
  166. 166. Open to Everyone! Step 1 - Enroll in VIA Longitudinal Study at RAADfest Step 2 - Baseline Blood/Diagnostic Panels at RAADcity Step 3 - Use test results to adjust your longevity program Step 4 - Retest to measure age reversal efficacy Step 5 - Adjust interventions based on retest results Modeled after Framingham Heart Study, i.e. long term and ongoing…
  167. 167. Blood Test Panel Only Option Age Management Blood Test Panel Omega-3 Index  Morpheus wrist band  Standard clinical tests  NAD+  Bioimpedance measure of visceral fat  Cognitive tests  Initial medical evaluation Commercial cost: >$3,000 RAADfest attendee: $395
  168. 168. Initial Vitality in Aging (VIA) Study Sites JamesWatson,MD 351RollingOaksDrive,Suite203 ThousandOaks,California91361 (805)497-8411 RichardGaines,MD 3785N.FederalHighway,STE150 BocaRaton,Florida33431 (561)931-2430
  169. 169. Initial Vitality in Aging (VIA) Study Sites John Sturges,MD 2170WestIronwoodCenterDrive#A Coeur d’ Alene, Idaho 83814 (208)665-5596
  170. 170. Friday morning at 8 a.m. Saturday morning at 8 a.m. and (Sunday morning 8 a.m. if needed) To enroll in the VIA studies, you should attend the informed consent lecture at RAADcity: or or
  171. 171. age-reversal.net This entire presentation available at:
  172. 172. Interventions that may improve your odds of living to year 2030
  173. 173. 2009-2019 Senolytics NAD+ Sirtuins mTOR-inhibition AMPK Activation Umbilical Cord Plasma/Blood Exosomes from Young Cells Mesenchymal Stem Cells Immune Restoration Mitochondria Restoration Today: Multiple Interventions
  174. 174. Lifespans not limited by senescence Neocortex Connects- Converts to the Cloud Years 2030 2050 Stair Step Approach to Infinite Longevity Singularity + A.I. enables limitless self-improvement.
  175. 175. Hotel magnate Barron Hilton died of natural causes at the age of 91. He left about 97% of his estate to Conrad N. Hilton Foundation, which expects to grow its endowment from $2.9 billion to $6.3 billion www.foxbusiness.com/business-leaders/barron-hilton-fortune-estate-foundation Who missed the longevity boat? Barron Hilton (1927-2019) Expiration date: Sept. 19, 2019 Net worth > $2.9 billion Paris Hilton Barron Hilton
  176. 176. Too Wealthy to Die at Age 65 Paul Allen, Chairman of the Seattle Seahawks co-founded Microsoft in 1975. Diagnosed and treated for non-Hodgkin lymphoma in 2009. Cancer returned in 2018. He died from septic shock. Paul Allen was philanthropist and donated to medical research… but did NOT make it his priority! https://www.nytimes.com/2018/10/15/obituaries/paul-allen-dead.html Paul Allen (1953-2018) Net worth > $26.1 billion Expiration date: Oct. 15, 2018
  177. 177. Too Wealthy to Die at Age 58 Blake Nordstrom, company co-president, dies unexpectedly at 58 from lymphoma. At the time, he described his condition as "treatable" and said he planned to "continue to work throughout this process as normal." https://www.cnn.com/2019/01/02/business/blake-nordstrom-obit/ Blake Nordstrom(1961-2019) Net worth > $1.5 billion Expiration date: Jan. 2, 2019
  178. 178. Who Missed the Longevity Boat Robert "Bob" McNair, billionaire founder and owner of the Houston Texans died at age 81. He battled squamous cell skin cancer and then leukemia for about 20 years. https://www.forbes.com/profile/robert-mcnair/#130c78d9251a RobertMcNair (1937-2018) Net worth ~ $3.8 billion Expiration date: Nov. 23, 2018 Wealthy And Famous That Expired In 2018
  179. 179. Who Missed the Longevity Boat Herb Kelleher, the eccentric founder of Southwest Airlines who helped revolutionize low-cost air travel in 1971. Died at age 87. https://www.cnn.com/2019/01/03/business/southwest-airlines-founder-herb-kelleher-obit Herb Kelleher(1931-2019) Net worth ~ $2.5 billion Expiration date: Jan. 3, 2019 Wealthy And Famous That Expired In 2019
  180. 180. “Just a year ago I felt immortal, wearing my age with pride, even joking about it.” https://www.nytimes.com/2019/09/11/business/boone-pickens-dead.html Who missed the longevity boat? T. Boone Pickens (1928-2018) Expiration date: Sept. 11, 2019 Net worth > $950 million In 2016 T. Boone Pickens wrote: One year later suffered series of strokes and a fall. Dead at age 91.
  181. 181. T. Boone Pickens Largely Funded $260 Million Oklahoma State University Stadium (He made many other charitable donations to biomedical research)
  182. 182. Fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  183. 183. November,2009 No Human Age-Reversal Intervention Identified We Were Doomed 10 Years Ago
  184. 184. Huge Advances in Only 10 Years No Way to Reverse Aging Manhattan Beach Summit Attendees November 2009 Many Potential Methods 2009 2019
  185. 185. Enroll in Longitudinal Study at RAADcity
  186. 186. Fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  187. 187. William Faloon How Enrolling in Clinical Trials Can Save Your Life Friday, October 4rd 2019 RAADcity Stage 10:30 am
  188. 188. Unparalleled Track Record of Biomedical Innovation Established 1977

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