1. William Faloon
DaVinci 50 Mastermind Conference
Key Largo, Florida
April 29th, 2021
Stroke Risk Reduction
Optimizing Blood Pressure

2. Heart attack &
stroke deaths
increase relative
to cancer in
elderly persons.
Reference: Heron, M. Deaths: Leading Causes for 2017.
National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6.
https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf
Heart Disease Still #1 Killer

3. Leading cause of long-term
disability in the United States.
Stroke

4. Epidemic of Ischemic Strokes
More than 2,000 Americans suffer a stroke each day.
As neurons die from oxygen starvation the result is:
1)Paralysis
2)Blindness
3)Cognitive impairment
4)Death

5. Three Outcomes After Stroke
Quick or Modest Recovery Permanent Paralysis Death

6. Hypertension and Aging
Majority of adults are hypertensive.
Hypertension increases with age.
Most of you have higher-than-
optimal blood pressure.

7. Severity of the Epidemic
Persons defined as hypertensive by CDC:
Men 65-74 years 63.4%
75 years and over 72.3%
Women 65-74 years 64.3%
75 years and over 79.9%
http://www.cdc.gov/nchs/fastats/older-american-health.htm. Accessed August 23, 2016

8. Hypertensive Diseases
• Stroke
• Congestive heart failure
• Alzheimer’s and other dementias
• Kidney failure
• Coronary artery occlusion
• Retinopathy and other eye disorders
These are leading causes of disability and death!

9. What is Hypertension?
Dictionary definition:
“abnormally high
blood pressure”

10. Hypertension is “normal”
• One of every three adults in the United States
has blood pressure readings over 139/89 mmHg.
• Two of every three adults over 65 have
hypertension.
• Hypertension is not abnormal.

11. What is Hypertension?
Medical definition:
“blood pressure high enough
that it may eventually cause
health problems…”

12. How Doctors Got it Wrong?
Since it is not abnormal for older
adults to have higher-than-optimal
blood pressure, many physicians
fail to recognize and adequately
treat hypertension.

13. Hypertension Debate
 Conventional medicine said high blood pressure
begins at 140/90 mmHg.
 Life Extension® always said blood pressure
should be under 120/80 mmHg.

14. Deadly Impact of Systolic
Blood Pressure 120-139
Year 2013 analysis of 18 prior studies showed correlation in
those with systolic blood pressure between 120-139 and an
associated:
• 50% increased risk of coronary heart
disease
• 71% increased risk of stroke
“Prehypertension and incidence of cardiovascular disease: a meta-analysis.” BioMed Central
(BMC Med) 2013;11:177

16. So what is optimal systolic blood pressure?
<140 or <120
???

17. Benefits of Lower Blood Pressure
Confirmed in 2015
Compared to people with a target systolic blood pressure below
140, subjects with target systolic blood pressure below 120 had:
• 38% lower risk of heart failure
• 43% lower risk of cardiovascular death
• 27% lower overall mortality
New England Journal of Medicine 2015,373(22):2103-16

18. American Heart Association
November 13, 2017
• The term “prehypertension” is abolished.
• New guideline for optimal systolic blood pressure:
“Under 120 mmHg”
American Heart Association Annual Conference-Anaheim, California/Nov 13 2017

19. Telmisartan
Ideal Anti-Hypertensive Drug?
• Majority of adults have blood pressure
high enough to cause disease.
• Blood pressure target for most people
should be below 120 mmHg.
• To review best drug choice for most
people to lower blood pressure go to:
LifeExtension.com/Hypertension

20. Stroke Risk Factors
Blood tests can identify correctable causes of ischemic stroke:
• C-reactive protein (inflammation)
• Homocysteine
• Fibrinogen
• LDL cholesterol
• Glucose/Insulin

21. Ischemic Stroke = No Blood Flow

22. Acute Paralysis is Reversible
Yet Doctors Give up Too Soon

23. Most Stroke Victims Did Not
Receive Optimal Treatment
A 2011 study found only 1 to 3% of ischemic
stroke patients in community settings
receive clot-dissolving therapy.
Tissue plasminogen activator and stroke: review of the literature for the clinician. Journal of
Emergency Med. 2012 Dec;43(6):1149-54.

24. Grandfather 2 Months Before
Needless Paralyzing Stroke

25. 3 Years in Nursing Home Prior to Death

27. Blood Clot Removal Pioneered Long Ago
Endovascular Thrombectomy
But Technology was Underutilized

28. Sept 2015
Effective Stroke
Treatments Were
Delayed for
Decades

29. Snail’s Pace Advance in Reversing Acute Ischemic Stroke
 February 1987- Larry King saved by experimental clot-dissolving therapy (tPA)
 FDA refused to approve tPA to reverse acute coronary artery blockages
https://www.lifeextension.com/magazine/2015/9/reversing-acute-ischemic-stroke
 Life Extension®, Wall Street Journal, Larry King attack FDA over the delay
 November 1987- FDA approves tPA to treat ischemic heart attack
 Early 1996- FDA approves tPA for acute ischemic stroke (a 9-year delay)

30. New England Journal of Medicine
January 1, 2015
“Is there any doubt left, or should
thrombectomy now become the new
standard treatment for severe
stroke…up to six hours after stroke
onset.”

31. 73% lower risk of treated patients winding up in nursing home.
48% of thrombectomy-treated patients live normal after 90 days.
13% in standard therapy group return to normal after 90 days.
May 15th, 2017
Breakthrough in Reversing Acute Stroke
“This is the largest treatment effect we have seen (in stroke).”
Findings presented at European Stroke Conference-Prague; May 15, 2017---Tudor G. Jovin, University of Pittsburgh Medical Center Stroke Institute
24 hours after severe stroke…thrombectomy effective!

32. Evolution of Comprehensive Stroke Centers
Performing Endovascular Thrombectomy
• Year 2014---Only a few hospitals performed routine
• thrombectomy to reverse ischemic stroke.
• Year 2017---Many local hospitals start to offer thrombectomy.
• You may still need to demand thrombectomy be tried up to
24 hours after stroke symptoms manifest.
Endovascular thrombectomy represents major medical advance
delayed for many years while stroke victims suffered and died.

33. Where is Your Nearest
Comprehensive Stroke Center?
• Thrombectomy now standard of care in patients with large vessel
anterior circulation occlusion.
• Many hospitals now offer thrombectomy, but you may need to ask.
• Find out ahead of time your nearest Comprehensive Stroke Center
using endovascular thrombectomy to treat acute stroke.
“An historical and contemporary review of endovascular therapy for acute ischemic stroke. “
Neurovascular Imaging, March 1, 2017

34. Rapidly Changing Window of Time
to Reverse Acute Ischemic Stroke
►3-5 hours using clot-dissolving drug therapy (1996-2012)
►4-8 hours using endovascular thrombectomy (2006-2016)
► 24 hours with more aggressive thrombectomy (2017)
Large numbers of stroke victims forever paralyzed.
Even More People Needlessly
Aging to Death Today!

35. Level 1 is essential to
progress to Level 2.
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Correct Your Underlying
Disease Risk Factors
Age Reversal Interventions

36. Level 1 essential
to sustain life
Optimal Health
Level 2
Level 1
- Hormones - Renal function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Failure To Correct
Proven Risk Factors
Death
Harsh Reality!

37. House of
Optimal Health
- Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Level 2
Level 1
- Senolytics
- NAD+ Restoration
- mTOR-inhibition
- Exosomes
- Mesenchymal Stem Cells - Mitochondria Transfer
- Young Plasma
Failure to optimize
Level 1, preclude
benefits of Level 2.
Age Reversal Interventions
Healthy Aging
- Perinatal tissues

38. Heart attack &
stroke deaths
increase relative
to cancer in
elderly persons.
Reference: Heron, M. Deaths: Leading Causes for 2017.
National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6.
https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf
Heart Disease Still #1 Killer

39. Baron Benjamin de Rothschild, heir
to a French banking fortune, died of
a heart attack at age 57 on January
15, 2021.
He oversaw the Edmond de Rothschild empire, which
has stakes in banks in France and Switzerland, owns
restaurants and hotels vineyards in Argentina, New
Zealand, South Africa, Spain and France.
Who missed the longevity boat?
Baron Benjamin de Rothschild
(1963 - 2021)
Expiration date: Jan. 15, 2021
net worth > $1.5 billion https://www.forbes.com/profile/benjamin-de-rothschild/?sh=401323666454

40. Level 1 is essential to
progress to Level 2.
Optimal Health
Level 2
Level 1
- Hormones - Kidney function
- LDL/HDL - Vitamin D
- Blood Pressure - Glucose
- C-reactive protein - Homocysteine
- Insulin - Coagulation
Correct Your Underlying
Disease Risk Factors
Age Reversal Interventions

41. “In the multi-variable model,
high adherence to the
Mediterranean diet was
associated with 25% lower
risk of death as compared
with the lowest category.”
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/mediterranean-diet-and-mortality-in-
the-elderly-a-prospective-cohort-study-and-a-metaanalysis/F2D6B083AA187849477112DB77820521
“Mediterranean diet and mortality
in the elderly: a prospective cohort
study and a meta-analysis”
Published online by Cambridge University Press: 30 August 2018

42. Mediterranean diet and longevity
A. Trichopoulou* and E. Vasilopoulou
University of Athens Medical School, Department of Hygiene and Epidemiology, Mikras Asias 75, 115 27 Athens, Greece
British Journal of Nutrition (2000), 84, Suppl. 2, S205±S209
The conclusion of these studies is that a diet that adheres to the principles of the
traditional Mediterranean one is associated with longer survival. The Greek
version of the Mediterranean diet is dominated by the consumption of olive oil
and by high consumption of vegetables and fruits. Antioxidants represent a
common element in these foods and an antioxidant action provides a plausible
explanation for the apparent benefits. Wild edible greens frequently eaten in rural
Greece in the form of salads and pies contain very high quantities of flavonoids
considerably higher than those found in red wine or black tea. While there is no
direct evidence that these antioxidants are central to the benefits of the
Mediterranean Diet, indirect evidence from epidemiological data and the
increasing understanding of their mechanisms of action suggest that antioxidants
may play a major role.
https://www.researchgate.net/profile/Effie_Vasilopoulou/publication/12090631_Mediterranean_diet_and_longevity/links/00b4951e39aed3d079000000.pdf

43. May 2008 Sept 2016
April 2015
Longevity Benefits of Mediterranean Diet

44. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/mediterranean-diet/art-20047801
Mediterranean Diet Healthy Foods
More fruits, vegetables, and whole grains, and less dairy & meat than typical Western diet.

45. Foods to Reduce/Avoid on Mediterranean Diet
Re
 Red meat
 Overcooked meats
 Processed red meat (hot dogs, bacon)
 Butter
 Cured ham (nitrite/nitrite preserved meats)
 Most frozen meals
 Soda, desserts, candy
 Most processed foods
 Sugars
 Refined grains (white bread/white grain pasta)
 Excess salt
https://www.foodnetwork.com/healthy/articles/what-foods-are-not-allowed-on-mediterranean-diet

46. New evidence links ultra-processed
foods with a range of health risks May 29, 2019
Two large European studies
find positive associations
between consumption of
highly processed ('ultra-
processed') foods and risk
of cardiovascular disease
and death.
https://www.sciencedaily.com/releases/2019/05/190529221040.htm

47. https://www.health.harvard.edu/staying-healthy/eating-more-ultra-processed-foods-may-shorten-life-span
May 2019
After nine years, the researchers found a
direct statistical connection between higher
intake of ultra-processed food and a higher
risk of early death from all causes, especially
cancers and cardiovascular disease.
Eating more ultra-processed foods may shorten life span

48. https://www.health.harvard.edu/staying-healthy/eating-more-ultra-processed-foods-may-shorten-life-span
May 2019
 Ready-to-eat foods
 Microwaveable foods
 Bread, breakfast cereals
 Instant noodles
 Chicken or fish nuggets
 Chocolate bars, candies, chips
 Artificially sweetened beverages
Ultra-processed foods defined as:

49. Foods like instant noodles and soups, breakfast cereals and
chicken nuggets were associated with an earlier death.
Feb. 29, 2019
The authors suggest that high-
temperature processing may form
contaminants, that additives may
be carcinogenic, and that the
packaging of prepared foods can
lead to contamination.
https://www.nytimes.com/2019/02/12/well/eat/eating-processed-foods-longevity-death-mortality.html
Avoid High Temperature Cooked Foods

50. Small Increases in Ultra-processed Food Intake
Increases Incidence of Stroke and Heart Attack
May 29, 2019
Results showed that an absolute 10%
increase in the proportion of ultra-
processed food in the diet was
associated with significantly higher
rates of overall cardiovascular
disease, coronary heart disease, and
cerebrovascular disease (increase of
12%, 13%, and 11% respectively).
https://www.sciencedaily.com/releases/2019/05/190529221040.htm

51. LowerDiseaseRiskWithUnprocessed
Or Minimally Processed Foods
May 29, 2019
Researchersfound a
significantassociation
betweenunprocessedor
minimallyprocessedfoods
and lowerrisksof all
reporteddiseases.
https://www.sciencedaily.com/releases/2019/05/190529221040.htm

52. "Ultra-processed" foods linked to
heart disease, early death
May 30, 2019
In the second study — of nearly 20,000 Spanish
adults — ultra-processed foods were linked to a
shorter life span:
Those with the highest intake were 62% more likely
to die over two decades, compared to those with the
lowest intake.
https://www.cbsnews.com/news/ultra-processed-foods-linked-to-heart-disease-early-death/

53. January 7, 2021
Adherence to the Mediterranean diet and grade group
progression in localized prostate cancer: An active
surveillance cohort
https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33182
Each one-unit improved adherence to the Mediterranean diet was
associated with a 12% lower trend of aggressive (high Gleason score)
prostate cancer detrimental progression.
A four-unit improved Mediterranean diet score would equate to a 48%
associated lower trend of prostate cancer progression.

54. Reverse Aging with Combined Interventions
Senolytics NAD+ Sirtuins mTOR
AMPK
Young
Plasma
Factors
Stem Cells
Restore
Immune
Function
Mitochondria
Exosomes

55. Adult stem cells lose ability to repopulate tissues with functional cells
Systemic deterioration occurs as functional cells degenerate/die
Khorraminejad-Shirazi M et al., Aging and stem cell therapy: AMPK as an applicable pharmacological target for
rejuvenation of aged stem cells and achieving higher efficacy in stem cell therapy. Hematol Oncol Stem Cell Ther (2017)
 Boost cellular AMPK
 Suppress excess mTORC1
 Replenish NAD+ cell levels
 Activate sirtuin proteins
 Remove senescent cells
How your stem cells may be renewed:

56. Sheldon G. Adelson, a cabdriver’s son who built
the world’s largest empire of casinos and resort
hotels in Las Vegas, Macau, Singapore and other
gambling meccas.
The cause was complications of non-Hodgkin’s
lymphoma.
Donated to many charities including some that
supported medical research.
Who missed the longevity boat?
Sheldon Adelson
(1933 - 2021)
Expiration date: Jan. 11, 2021
net worth > $35.8 billion https://www.palmerfuneralhomes.com/obituary/Arthur-Decio

57. Human Age-Reversal Research Projects
• Repair cellular DNA with NAD+ infusions
• Systemic regeneration using young plasma
• Stem cell-mobilized young plasma infusions
• Thymic regeneration to reverse immune senescence
• GDF11 restoration to help mimic parabiosis
• Purge senescent cells with dasatinib/quercetin
• Remove cellular debris with rapamycin
• Mesenchymal stem cells for autoimmune conditions
• Hematopoietic stem cells for autoimmunity and cancer
These technologies are ready now for large clinical trials.
No new drug development is required.

58. NAD+
Thymic
regeneration
Young plasma
infusion
GDF11
Senolytics
Rapamycin
Hematopoietic
stem cells
Mesenchymal
stem cells
Urgent Goal: Combine Age-Reversal Therapies

61. FDA Surrenders in 1996
By February 1996, Federal Judge Daniel
Hurley dismissed all 56 criminal charges
against Saul Kent and William Faloon.
This was the first time the FDA has been
forced to give up on a criminal prosecution.
This victory goes beyond winning in court.
The FDA's defeat is a victory for everyone
who cherishes freedom in healthcare.
https://www.lifeextension.com/magazine/1996/9/freedom

63. William Faloon
DaVinci 50 Mastermind Conference
Key Largo, Florida
April 29th, 2021
Stroke Risk Reduction
Optimizing Blood Pressure