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Bill Faloon at DaVinci 50 about stroke risk and blood pressure

In this presentation on Thursday April 29th, 2021 at the DaVinci 50 Mastermind Conference in Key Largo, Florida, Bill Faloon discusses how to optimize blood pressure to reduce stroke risk.

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Bill Faloon at DaVinci 50 about stroke risk and blood pressure

  1. 1. William Faloon DaVinci 50 Mastermind Conference Key Largo, Florida April 29th, 2021 Stroke Risk Reduction Optimizing Blood Pressure
  2. 2. Heart attack & stroke deaths increase relative to cancer in elderly persons. Reference: Heron, M. Deaths: Leading Causes for 2017. National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6. https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf Heart Disease Still #1 Killer
  3. 3. Leading cause of long-term disability in the United States. Stroke
  4. 4. Epidemic of Ischemic Strokes More than 2,000 Americans suffer a stroke each day. As neurons die from oxygen starvation the result is: 1)Paralysis 2)Blindness 3)Cognitive impairment 4)Death
  5. 5. Three Outcomes After Stroke Quick or Modest Recovery Permanent Paralysis Death
  6. 6. Hypertension and Aging Majority of adults are hypertensive. Hypertension increases with age. Most of you have higher-than- optimal blood pressure.
  7. 7. Severity of the Epidemic Persons defined as hypertensive by CDC: Men 65-74 years 63.4% 75 years and over 72.3% Women 65-74 years 64.3% 75 years and over 79.9% http://www.cdc.gov/nchs/fastats/older-american-health.htm. Accessed August 23, 2016
  8. 8. Hypertensive Diseases • Stroke • Congestive heart failure • Alzheimer’s and other dementias • Kidney failure • Coronary artery occlusion • Retinopathy and other eye disorders These are leading causes of disability and death!
  9. 9. What is Hypertension? Dictionary definition: “abnormally high blood pressure”
  10. 10. Hypertension is “normal” • One of every three adults in the United States has blood pressure readings over 139/89 mmHg. • Two of every three adults over 65 have hypertension. • Hypertension is not abnormal.
  11. 11. What is Hypertension? Medical definition: “blood pressure high enough that it may eventually cause health problems…”
  12. 12. How Doctors Got it Wrong? Since it is not abnormal for older adults to have higher-than-optimal blood pressure, many physicians fail to recognize and adequately treat hypertension.
  13. 13. Hypertension Debate  Conventional medicine said high blood pressure begins at 140/90 mmHg.  Life Extension® always said blood pressure should be under 120/80 mmHg.
  14. 14. Deadly Impact of Systolic Blood Pressure 120-139 Year 2013 analysis of 18 prior studies showed correlation in those with systolic blood pressure between 120-139 and an associated: • 50% increased risk of coronary heart disease • 71% increased risk of stroke “Prehypertension and incidence of cardiovascular disease: a meta-analysis.” BioMed Central (BMC Med) 2013;11:177
  15. 15. So what is optimal systolic blood pressure? <140 or <120 ???
  16. 16. Benefits of Lower Blood Pressure Confirmed in 2015 Compared to people with a target systolic blood pressure below 140, subjects with target systolic blood pressure below 120 had: • 38% lower risk of heart failure • 43% lower risk of cardiovascular death • 27% lower overall mortality New England Journal of Medicine 2015,373(22):2103-16
  17. 17. American Heart Association November 13, 2017 • The term “prehypertension” is abolished. • New guideline for optimal systolic blood pressure: “Under 120 mmHg” American Heart Association Annual Conference-Anaheim, California/Nov 13 2017
  18. 18. Telmisartan Ideal Anti-Hypertensive Drug? • Majority of adults have blood pressure high enough to cause disease. • Blood pressure target for most people should be below 120 mmHg. • To review best drug choice for most people to lower blood pressure go to: LifeExtension.com/Hypertension
  19. 19. Stroke Risk Factors Blood tests can identify correctable causes of ischemic stroke: • C-reactive protein (inflammation) • Homocysteine • Fibrinogen • LDL cholesterol • Glucose/Insulin
  20. 20. Ischemic Stroke = No Blood Flow
  21. 21. Acute Paralysis is Reversible Yet Doctors Give up Too Soon
  22. 22. Most Stroke Victims Did Not Receive Optimal Treatment A 2011 study found only 1 to 3% of ischemic stroke patients in community settings receive clot-dissolving therapy. Tissue plasminogen activator and stroke: review of the literature for the clinician. Journal of Emergency Med. 2012 Dec;43(6):1149-54.
  23. 23. Grandfather 2 Months Before Needless Paralyzing Stroke
  24. 24. 3 Years in Nursing Home Prior to Death
  25. 25. Blood Clot Removal Pioneered Long Ago Endovascular Thrombectomy But Technology was Underutilized
  26. 26. Sept 2015 Effective Stroke Treatments Were Delayed for Decades
  27. 27. Snail’s Pace Advance in Reversing Acute Ischemic Stroke  February 1987- Larry King saved by experimental clot-dissolving therapy (tPA)  FDA refused to approve tPA to reverse acute coronary artery blockages https://www.lifeextension.com/magazine/2015/9/reversing-acute-ischemic-stroke  Life Extension®, Wall Street Journal, Larry King attack FDA over the delay  November 1987- FDA approves tPA to treat ischemic heart attack  Early 1996- FDA approves tPA for acute ischemic stroke (a 9-year delay)
  28. 28. New England Journal of Medicine January 1, 2015 “Is there any doubt left, or should thrombectomy now become the new standard treatment for severe stroke…up to six hours after stroke onset.”
  29. 29. 73% lower risk of treated patients winding up in nursing home. 48% of thrombectomy-treated patients live normal after 90 days. 13% in standard therapy group return to normal after 90 days. May 15th, 2017 Breakthrough in Reversing Acute Stroke “This is the largest treatment effect we have seen (in stroke).” Findings presented at European Stroke Conference-Prague; May 15, 2017---Tudor G. Jovin, University of Pittsburgh Medical Center Stroke Institute 24 hours after severe stroke…thrombectomy effective!
  30. 30. Evolution of Comprehensive Stroke Centers Performing Endovascular Thrombectomy • Year 2014---Only a few hospitals performed routine • thrombectomy to reverse ischemic stroke. • Year 2017---Many local hospitals start to offer thrombectomy. • You may still need to demand thrombectomy be tried up to 24 hours after stroke symptoms manifest. Endovascular thrombectomy represents major medical advance delayed for many years while stroke victims suffered and died.
  31. 31. Where is Your Nearest Comprehensive Stroke Center? • Thrombectomy now standard of care in patients with large vessel anterior circulation occlusion. • Many hospitals now offer thrombectomy, but you may need to ask. • Find out ahead of time your nearest Comprehensive Stroke Center using endovascular thrombectomy to treat acute stroke. “An historical and contemporary review of endovascular therapy for acute ischemic stroke. “ Neurovascular Imaging, March 1, 2017
  32. 32. Rapidly Changing Window of Time to Reverse Acute Ischemic Stroke ►3-5 hours using clot-dissolving drug therapy (1996-2012) ►4-8 hours using endovascular thrombectomy (2006-2016) ► 24 hours with more aggressive thrombectomy (2017) Large numbers of stroke victims forever paralyzed. Even More People Needlessly Aging to Death Today!
  33. 33. Level 1 is essential to progress to Level 2. Optimal Health Level 2 Level 1 - Hormones - Renal function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Correct Your Underlying Disease Risk Factors Age Reversal Interventions
  34. 34. Level 1 essential to sustain life Optimal Health Level 2 Level 1 - Hormones - Renal function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Failure To Correct Proven Risk Factors Death Harsh Reality!
  35. 35. House of Optimal Health - Hormones - Kidney function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Level 2 Level 1 - Senolytics - NAD+ Restoration - mTOR-inhibition - Exosomes - Mesenchymal Stem Cells - Mitochondria Transfer - Young Plasma Failure to optimize Level 1, preclude benefits of Level 2. Age Reversal Interventions Healthy Aging - Perinatal tissues
  36. 36. Heart attack & stroke deaths increase relative to cancer in elderly persons. Reference: Heron, M. Deaths: Leading Causes for 2017. National Vital Statistics Reports. June 24, 2019; Volume 68, Number 6. https://www.cdc.gov/nchs/data/nvsr/nvsr68/nvsr68_06-508.pdf Heart Disease Still #1 Killer
  37. 37. Baron Benjamin de Rothschild, heir to a French banking fortune, died of a heart attack at age 57 on January 15, 2021. He oversaw the Edmond de Rothschild empire, which has stakes in banks in France and Switzerland, owns restaurants and hotels vineyards in Argentina, New Zealand, South Africa, Spain and France. Who missed the longevity boat? Baron Benjamin de Rothschild (1963 - 2021) Expiration date: Jan. 15, 2021 net worth > $1.5 billion https://www.forbes.com/profile/benjamin-de-rothschild/?sh=401323666454
  38. 38. Level 1 is essential to progress to Level 2. Optimal Health Level 2 Level 1 - Hormones - Kidney function - LDL/HDL - Vitamin D - Blood Pressure - Glucose - C-reactive protein - Homocysteine - Insulin - Coagulation Correct Your Underlying Disease Risk Factors Age Reversal Interventions
  39. 39. “In the multi-variable model, high adherence to the Mediterranean diet was associated with 25% lower risk of death as compared with the lowest category.” https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/mediterranean-diet-and-mortality-in- the-elderly-a-prospective-cohort-study-and-a-metaanalysis/F2D6B083AA187849477112DB77820521 “Mediterranean diet and mortality in the elderly: a prospective cohort study and a meta-analysis” Published online by Cambridge University Press: 30 August 2018
  40. 40. Mediterranean diet and longevity A. Trichopoulou* and E. Vasilopoulou University of Athens Medical School, Department of Hygiene and Epidemiology, Mikras Asias 75, 115 27 Athens, Greece British Journal of Nutrition (2000), 84, Suppl. 2, S205±S209 The conclusion of these studies is that a diet that adheres to the principles of the traditional Mediterranean one is associated with longer survival. The Greek version of the Mediterranean diet is dominated by the consumption of olive oil and by high consumption of vegetables and fruits. Antioxidants represent a common element in these foods and an antioxidant action provides a plausible explanation for the apparent benefits. Wild edible greens frequently eaten in rural Greece in the form of salads and pies contain very high quantities of flavonoids considerably higher than those found in red wine or black tea. While there is no direct evidence that these antioxidants are central to the benefits of the Mediterranean Diet, indirect evidence from epidemiological data and the increasing understanding of their mechanisms of action suggest that antioxidants may play a major role. https://www.researchgate.net/profile/Effie_Vasilopoulou/publication/12090631_Mediterranean_diet_and_longevity/links/00b4951e39aed3d079000000.pdf
  41. 41. May 2008 Sept 2016 April 2015 Longevity Benefits of Mediterranean Diet
  42. 42. https://www.mayoclinic.org/healthy-lifestyle/nutrition-and-healthy-eating/in-depth/mediterranean-diet/art-20047801 Mediterranean Diet Healthy Foods More fruits, vegetables, and whole grains, and less dairy & meat than typical Western diet.
  43. 43. Foods to Reduce/Avoid on Mediterranean Diet Re  Red meat  Overcooked meats  Processed red meat (hot dogs, bacon)  Butter  Cured ham (nitrite/nitrite preserved meats)  Most frozen meals  Soda, desserts, candy  Most processed foods  Sugars  Refined grains (white bread/white grain pasta)  Excess salt https://www.foodnetwork.com/healthy/articles/what-foods-are-not-allowed-on-mediterranean-diet
  44. 44. New evidence links ultra-processed foods with a range of health risks May 29, 2019 Two large European studies find positive associations between consumption of highly processed ('ultra- processed') foods and risk of cardiovascular disease and death. https://www.sciencedaily.com/releases/2019/05/190529221040.htm
  45. 45. https://www.health.harvard.edu/staying-healthy/eating-more-ultra-processed-foods-may-shorten-life-span May 2019 After nine years, the researchers found a direct statistical connection between higher intake of ultra-processed food and a higher risk of early death from all causes, especially cancers and cardiovascular disease. Eating more ultra-processed foods may shorten life span
  46. 46. https://www.health.harvard.edu/staying-healthy/eating-more-ultra-processed-foods-may-shorten-life-span May 2019  Ready-to-eat foods  Microwaveable foods  Bread, breakfast cereals  Instant noodles  Chicken or fish nuggets  Chocolate bars, candies, chips  Artificially sweetened beverages Ultra-processed foods defined as:
  47. 47. Foods like instant noodles and soups, breakfast cereals and chicken nuggets were associated with an earlier death. Feb. 29, 2019 The authors suggest that high- temperature processing may form contaminants, that additives may be carcinogenic, and that the packaging of prepared foods can lead to contamination. https://www.nytimes.com/2019/02/12/well/eat/eating-processed-foods-longevity-death-mortality.html Avoid High Temperature Cooked Foods
  48. 48. Small Increases in Ultra-processed Food Intake Increases Incidence of Stroke and Heart Attack May 29, 2019 Results showed that an absolute 10% increase in the proportion of ultra- processed food in the diet was associated with significantly higher rates of overall cardiovascular disease, coronary heart disease, and cerebrovascular disease (increase of 12%, 13%, and 11% respectively). https://www.sciencedaily.com/releases/2019/05/190529221040.htm
  49. 49. LowerDiseaseRiskWithUnprocessed Or Minimally Processed Foods May 29, 2019 Researchersfound a significantassociation betweenunprocessedor minimallyprocessedfoods and lowerrisksof all reporteddiseases. https://www.sciencedaily.com/releases/2019/05/190529221040.htm
  50. 50. "Ultra-processed" foods linked to heart disease, early death May 30, 2019 In the second study — of nearly 20,000 Spanish adults — ultra-processed foods were linked to a shorter life span: Those with the highest intake were 62% more likely to die over two decades, compared to those with the lowest intake. https://www.cbsnews.com/news/ultra-processed-foods-linked-to-heart-disease-early-death/
  51. 51. January 7, 2021 Adherence to the Mediterranean diet and grade group progression in localized prostate cancer: An active surveillance cohort https://acsjournals.onlinelibrary.wiley.com/doi/10.1002/cncr.33182 Each one-unit improved adherence to the Mediterranean diet was associated with a 12% lower trend of aggressive (high Gleason score) prostate cancer detrimental progression. A four-unit improved Mediterranean diet score would equate to a 48% associated lower trend of prostate cancer progression.
  52. 52. Reverse Aging with Combined Interventions Senolytics NAD+ Sirtuins mTOR AMPK Young Plasma Factors Stem Cells Restore Immune Function Mitochondria Exosomes
  53. 53. Adult stem cells lose ability to repopulate tissues with functional cells Systemic deterioration occurs as functional cells degenerate/die Khorraminejad-Shirazi M et al., Aging and stem cell therapy: AMPK as an applicable pharmacological target for rejuvenation of aged stem cells and achieving higher efficacy in stem cell therapy. Hematol Oncol Stem Cell Ther (2017)  Boost cellular AMPK  Suppress excess mTORC1  Replenish NAD+ cell levels  Activate sirtuin proteins  Remove senescent cells How your stem cells may be renewed:
  54. 54. Sheldon G. Adelson, a cabdriver’s son who built the world’s largest empire of casinos and resort hotels in Las Vegas, Macau, Singapore and other gambling meccas. The cause was complications of non-Hodgkin’s lymphoma. Donated to many charities including some that supported medical research. Who missed the longevity boat? Sheldon Adelson (1933 - 2021) Expiration date: Jan. 11, 2021 net worth > $35.8 billion https://www.palmerfuneralhomes.com/obituary/Arthur-Decio
  55. 55. Human Age-Reversal Research Projects • Repair cellular DNA with NAD+ infusions • Systemic regeneration using young plasma • Stem cell-mobilized young plasma infusions • Thymic regeneration to reverse immune senescence • GDF11 restoration to help mimic parabiosis • Purge senescent cells with dasatinib/quercetin • Remove cellular debris with rapamycin • Mesenchymal stem cells for autoimmune conditions • Hematopoietic stem cells for autoimmunity and cancer These technologies are ready now for large clinical trials. No new drug development is required.
  56. 56. NAD+ Thymic regeneration Young plasma infusion GDF11 Senolytics Rapamycin Hematopoietic stem cells Mesenchymal stem cells Urgent Goal: Combine Age-Reversal Therapies
  57. 57. FDA Surrenders in 1996 By February 1996, Federal Judge Daniel Hurley dismissed all 56 criminal charges against Saul Kent and William Faloon. This was the first time the FDA has been forced to give up on a criminal prosecution. This victory goes beyond winning in court. The FDA's defeat is a victory for everyone who cherishes freedom in healthcare. https://www.lifeextension.com/magazine/1996/9/freedom
  58. 58. William Faloon DaVinci 50 Mastermind Conference Key Largo, Florida April 29th, 2021 Stroke Risk Reduction Optimizing Blood Pressure

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