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Age Reversal Update
Confidential Cures Summit
Palm Beach, Florida
December 8 2019
William Faloon
age-reversal.net
This entire presentation and info
about our research available at:
The New Paradigm
Human Age Reversal
A BIOMEDICAL RENAISSANCE!
Human Age Reversal
Prospect of
turns real year 2015
Feb 23 /March 2, 2015
TIME magazine
underestimates
the science.
Early Year 2015:
April 27, 2019
https://www.newscientist.com/issue/3227/
“The Science of Living Longer”
“No longer is it (aging)
being treated as a
dreadful inevitability but
instead as a puzzle that
can be solved---as a
disease with a cure.”
TIME-Special Edition - Fall 2019
https://www.technologyreview.com/magazine/2019/09 September
2019
“Later this year, at a conference
of longevity enthusiasts called
RAADfest, to be held in Las
Vegas, Faloon plans to take the
strategy one step further with
what he has been calling the
“Perpetual Clinical Trial.”
“OLD AGE IS OVER!”
Human Age Reversal
turns real year 2015
April 4 2015
“Harness advanced technologies…use that
knowledge to devise interventions that enable people
to lead longer and healthier lives.”
Mark Zuckerberg
pledges 99% of his
Facebook shares to
curing diseases
–CNBC, April 27, 2016
“We have a real shot at preventing, curing or
managing (most or all diseases) in the next 100
Zuckerberg said.
14
“IS JEFF BEZOS LOOKING FOR
THE FOUNTAIN OF YOUTH”
OCTOBER 27, 2016
Jeff Bezos, Billionaire founder of
Amazon and Mayo Clinic are
investors in a startup that’s received
$116 million to develop anti-aging
therapies.
http://www.geekwire.com/2016/forever-young-amazon-founder-jeff-bezos-backs-biotech-startup-developing-anti-
aging-therapies/
According to Juvenescence’s Greg Bailey
“We won’t be aging as fast or
poorly as our parents”
“I think the world is going to be shocked”
Juvenescence has now raised $165 million
to fund longevity projects with the goal of
extending human lifespans to 150 years.
“Science fiction has become science”
‘Extraordinary’ Breakthroughs In Anti-Aging
Research ‘Will Happen Faster Than People Think’
https://www.forbes.com/sites/robinseatonjefferson/2019/08/26/how-extraordinary-breakthroughs-in-anti-aging-research-will-happen-faster-than-people-think
December 2, 2015
George Church, Ph.D.
A Cure for Aging by Year 2030?
https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process/
AUGUST 25, 2018
https://www.newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body/
“George Church: The
maverick geneticist now
wants to reverse aging”
“He stirred controversy with his plans to bring back the
woolly mammoth. But first he's working on editing sperm –
and trying out his aging reversal techniques on dogs.”
December 4 2015
“By splicing animals
together, scientists have
shown that young blood
rejuvenates old tissues.
Now, they are testing
whether it works for
humans.”
January 21, 2015
January 21, 2015
University of Cambridge and Harvard researchers
show that young blood promotes repair of damaged spinal
cords in older mice.1
Harvard neuroscientist finds that young blood sparks the
formation of new neurons in the brain and olfactory system.2
Brigham and Women's Hospital in Boston, Massachusetts
— cardiologists find that young blood reverses age-related
thickening of the walls of the heart.3
1)Ruckh, J. M. et al. Cell Stem Cell, 10, 96–103 (2012).
2)Katsimpardi, L. et al. Science, 344, 630–634 (2014).
3) Loffredo, F. S. et al. Cell, 153, 828–839 (2013).
Young Blood Transfer
Research goes Mainstream
Johnson and Johnson signs $50 million deal with Stanford
University researchers to identify blood factors responsible for
age reversal in parabiosis studies:
"…it could mean new therapeutic approaches
for treating numerous diseases associated with
aging, including neural dysfunction and
dementias such as Alzheimer's disease.”
March 4, 2015
Scientists have rejuvenated old mice
with the blood of human teenagers
The fountain of youth is real, and it's creepy.
PETER DOCKRILL 16 NOV 2016
Nov 16 2016
•Improved cognition
•Decreased inflammation
•New brain cell formation
•Old animals acted young
Society of Neuroscience annual meeting-San Diego- Nov 2016
Small amounts of young human
plasma injected into old mice:
24
“The new blood made the
old mice act young again,
with the treated animals
running around in open
spaces much like their
younger controls.”
Nov 16 2016
March 22, 2017
Mice treated with young human
plasma appeared to have created
more new cells in their brain.
“Young human plasma
treatment can increase
neurogenesis.”
Growing New Brain Cells
Parabiosis Extends Longevity
• University of California researchers
studied the life spans of old–young rat
pairs in 1972.
• Old rats receiving young circulating
blood lived the human equivalent of
10-12 years longer.
Source: New York Academy of Sciences, (1972 Nov) Vol. 34, No. 7, pp. 582-7.
“Young bone marrow transplantation preserves learning and memory in old mice”, Communications Biology (2019). DOI: 10.1038/s42003-019-0298-5
“Young bone marrow rejuvenates
aging mouse brains, study finds”
Transplanting the
of young mice
into old mice prevented
cognitive decline in the
old mice.
Available at:https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
February 20, 2019
“Young bone marrow rejuvenates
aging mouse brains, study finds”
Microglia in brains of old mice have fewer/shorter branches than young mice
Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
Feb. 20, 2019
Synaptic branches of microglia of old mice who received bone marrow
transplants from young mice resembled those of young mice
Young Bone marrow transplants
restore exploratory activity in old mice
Feb. 20, 2019
“Remarkably, young
bone marrow
recipients, but not
old bone marrow
recipients, were
more active than
old control mice.”
https://www.nature.com/articles/s42003-019-0298-5/figures/1
“Young bone marrow rejuvenates
aging mouse brains, study finds”
Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html.
Feb. 20, 2019
Young bone marrow
restores aged mouse brains!
PHILADELPHIA (CBS) — Could the secret to eternal youth be found in blood transfusions from young people?
Some claim that transfusions with “young blood” from teenagers can reverse the aging process.
Dec. 20, 2018
Controversial Treatment Transfuses Patients With
‘Young Blood’From Teenagers To Reverse Aging Process
Stanford University scientists
previously showed that transfused
serum from 12-to-15-month age
mice into old mice reverses some
signs of brain aging.
Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse
formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019).
DOI: 10.1073/pnas.1902672116
JUNE 3, 2019
Researchers find synapse-boosting factors in young blood
Available at: https://medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019.
June 4, 2019
Stanford University researchers used serum from
15-day old (very young) mice and discovered:
“ ”
https://medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html
15-Day old Mouse (left) compared to 15-Month Old Mouse (right)
Very Young Blood (serum) Regenerates
Synapses, Dendrites, Neurotransmitters
Available at: medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019.
June 4, 2019
“When two proteins (thrombospondin-4 and
SPARC-like protein-1) richer in younger
serum were applied to older serum…some of
the same rejuvenating effects took place.”
“Strikingly, recombinant THBS4 and
SPARCL1… may represent rejuvenation
factors that enhance synaptic connectivity
by increasing dendritic arborization, synapse
formation, and synaptic transmission.”
Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse
formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019).
DOI: 10.1073/pnas.1902672116
JUNE 3, 2019
Human equivalent of a 15-day old mouse may be approximately one to two years.
“A triple drug
combination has been
used to extend the
lifespan of fruit flies by
48% in a new study.”
https://www.nextbigfuture.com/2019/10/rapamycin-and-two-other-drugs-extends-lifespan-twice-as-much-as-any-other-drug-combo.html
Rapamycin and Two Other Drugs Extends Lifespan
Twice As Much As Any Other Drug Combo
“Previousstudiesinfruitflieshave
achievedlifespan extensions ofabout
5-20%
…sowefounditwasquiteremarkable
thatthisdrugcombinationenabled
themtolive
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne
Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination
targeting components of the nutrient-sensing network maximizes longevity."
Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
September 30, 2019
Combined Interventions More Effective than SingleAgent Therapy
PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019
https://doi.org/10.1073/pnas.1913212116
Rapamycin Lithium Dasatinib-like Drug+ +
Fruit Fly Lifespan Extension by 48%
=
“…a combination of drugs already approved for
human use is a viable strategy to maximize animal
longevity…”
This recent study supports the stairstep approach advocated to enable us to live significantly longer
September 30, 2019
Fruit flies received drugs separately and/or in combination.
 Each drug individually extended lifespan by 11%
 Pairing two drugs extended lifespan roughly 30%
 Three drugs combined extended lifespan by 48%
Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana
Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network
maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819.
Combination Treatments are Essential
September 30, 2019
Senolytics NAD+ Sirtuins mTOR-inhibition
AMPK
Activation
Umbilical Cord
Plasma/Blood
Exosomes from
Young Cells
Mesenchymal
Stem Cells
Immune
Restoration
Mitochondria
Restoration
Today’s Age Reversal Interventions
…they are optimistic that a
person’s biological age can
be reversed.”
Age markers reversed by 2.5 years!
“ScientistsatInterveneImmuneandStanford
MedicalCenterhaveproventhat‘epigenetic
agingcanbereversedinhumans’...
Cocktail Of Drugs Gives First Hope
That ‘Biological Age’ Can Be Reversed
https://forbes.com/sites/robinseatonjefferson/2019/09/09/cocktail-of-drugs-gives-first-hope-that-biological-age-can-be-reversed/
“Reversal of epigenetic aging and immunosenescent trends in humans.” Aging Cell; Sept 2019
Combination Therapy also Effective in Humans
1) Human growth hormone
2) DHEA
3) Metformin
Study conducted by Dr. Greg Fahy in collaboration
with researchers from Stanford University and
UCLA consisted of individualized doses of:
Study subjects also provided with daily
vitamin D3 and zinc.
https://www.dailymail.co.uk/health/article-7435427/Aging-
REVERSED-small-group-men-study-reveals.htmll
Oct.22,2019Turning Back Time!
“Aging is REVERSED in
men using a cocktail of
growth hormones and
diabetes drugs in study
that saw test group shed
2.5 biological years.”
George C. Kohn, Encyclopedia of Plague and Pestilence: From Ancient Times to the Present; Infobase Publishing, 2007
We Don’t Have Time for
Delayed Age Reversal
Example of Lethal Delay
https://www.longevity.technology/worlds-first-anti-aging-trial-gets-green-light/
Sept 4, 2019
1958 - Metformin approved as anti-diabetic drug in England
1995 - Life Extension® lists metformin as anti-aging drug
2015 - FDA approves first anti-aging study of a drug (metformin)
2019 - Metformin study receives $75 million funding
($40 million from anonymous donor)
Type II diabetics taking metformin:
United Kingdom Diabetes Study
►32% reduced risk of diabetic complications
►42% reduced risk for diabetes-related death
►36% reduced all-cause mortality risk
Study results published January 1995
British Medical Journal; Jan 14, 1995;” United Kingdom Prospective Diabetes Study (UKPDS)
Life Extension recommended
metformin 24 years ago…
the FDA went berserk!
March 1995
Study Results Found on March 21st 2017
Journal of the American Medical Association
JAMA. Published online March 21, 2017. doi:10.1001/jama.2016.17844
Metformin studied in prediabetic patients. Compared
to placebo 850 mg of metformin two times a day:
Reduced type II diabetes risk 31%
In patients under age 60: metformin reduced diabetic risk by 58%.
“Metformin can cause weight loss…”Quote:
Decades of
research reveal
demonstrate
disease-fighting
impact of
metformin.
November 2010
Sept. 2017
Metformin Demonstrates Therapeutic
Effects Against Colon Cancer
Am J Med Sci. 2017 Sep;354(3):246-251. doi: 10.1016/j.amjms.2017.05.006. Epub 2017 May 19.
Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer.
Colon Cancer Metformin Patients Non-Metformin Patients
Recurrences 4% 19%
Metastases 23% 46%
5-Year Survival 57% 37%
Deaths 48% 76%
(Metformin boosts AMPK activity and indirectly inhibits mTOR)
Conclusion: “Metformin therapy is associated with significantly better prognosis in patients with colon cancer”
Caveat: Some diabetics in control group treated with insulin or sulfonylurea drugs that promote tumor cell propagation.
Diabetics on metformin showed these benefits compared to diabetics not prescribed metformin:
Diabetics taking metformin
have lower cancer rates
Metformin Prevents Cancer
MD Anderson Cancer Center found
risk of pancreatic cancer was 62%
lower in diabetics using metformin.
Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL. Antidiabetic therapies
affect risk of pancreatic cancer. Gastroenterology. 2009 Aug;137(2):482-8.
Nov 29. 2015
April 24, 2016
Catastrophic Loss of Life
A 2019 study tabulated reductions in cardiovascular mortality in
type II diabetics using metformin.1
Life Extension® calculated how many cardiovascular deaths may
have occurred in response to metformin’s 37-year delay.
This exceeds the death toll of all wars America has ever fought.
1. Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular
Events Among Patients With Diabetes and Reduced Kidney Function. JAMA. 2019 September 19:1-11.
Almost 4 million American diabetics may have died because of
the delay in this one drug (metformin) becoming available.
We Don’t Have Time for
Delayed Age Reversal
Statistically Significant + Meaningful
Age Reversal in 12 Months
Outcome Objectives:
$550,000 + donated/discounted services
Human Age Reversal Project
Vitality in Aging Interventions Trial
Study Cost:
Major Funding Provided by:
Long Term Funding Sources Will Be Needed
Human Age Reversal Project
Bill Faloon
Donations of Physicians’ Time
Funding Need: > $550,000
Donations Received to Date: >$627,000
Vitality In Aging Interventions Trial
SOURCES OF FUNDING:
Fund research with tax deductible donations:
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
Age Reversal Interventions
1)Target 5 calorie restriction pathways
2) Reduce/resolve inflammation
3) Telomere lengthening
4) Selective remove senescent cells
5) Restore youthful methylation
age-reversal.net
Age Reversal
Interventions
Autophagy Resolve inflammation
Remove
senescent cells
Restore
youthful methylation
Lengthen
telomeres
AMPK/
mTOR
Sirtuins -
NAD+
Exosomes
Trial Parameters
> Open label (no placebo group)
> 50 healthy people aged 50-75 years
Initial Phase
Recruitment/Baseline Testing:
October 3rd 2019 – December 15th 2019
Vitality in Aging Interventions Trial
Vitality in Aging Interventions Trial
Timeline
Vitality in Aging Interventions Trial
Intervention #1
Calorie Restriction Mimetics
12% Calorie Reduction Improves Biological Age Scores by 1.5 Years
2018 Published Human study measures 8 Aging Biomarkers
Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis, J Gerontol A Biol Sci Med Sci. 2018 Jan; 73(1): 4-10.
Intervention:1 Targeting Calorie Restriction Pathways
Metformin
Metformin
Rapamycin, metformin
Pterostilbene, nicotinamide
Nicotinamide riboside
Rapamycin, glucosamine
Beta-lapachone
↓Insulin/IGF-1
↑AMPK
↓mTOR
↑Sirtuins
↑ NAD+
↑Autophagy
↑NAD/NADH ratio
VIA Interventions Trial
Increase
AMPK
Autophagy
Sirtuins/NAD+
Decrease
mTOR
Insulin
IGF-1 signals
Targets Calorie Restriction Pathways
Vitality in Aging Interventions Trial
Senolytics
Selective removal of senescent cells
Intervention #2
July 9, 2018
Magazine
“It’slooking like veryoldmice are able to substantially improve their health
span, reduce or delay age-related diseases and increase their survival.”
They calculated that if only one in 7,000 to 15,000 cells is senescent, then age-related
problems in physical function started to appear in the mice.
Like a contagion, senescent cells seem to pass on their accelerated aging abilities to healthy
cells by releasing a number of factors that can cause tissues like muscle to deteriorate.
Mice given senescent cells and the senolytic compounds lived 36% longer than animals
with senescent cell transplants who were not given the drugs.
How Scientists Are Testing
Cancer Drugs to Slow Down Aging
Drug to clear 'zombie cells' from body could be first
anti-aging treatment after ‘impressive’ human trial
https://www.telegraph.co.uk/science/2019/01/08/drug-clear-zombie-cells-body-could-first-anti-ageing-treatment/
Jan. 8, 2019
“A drug to fight aging may finally
be on the horizon after the
first trial in humans showed
‘impressive’ results.”
“The treatment clears out dead
cells even when the immune
system no longer can.”
“Senescent cells – also known as
zombie cells – form in the heart during
aging and lead to heart failure.”
“Newcastle scientists, in collaboration
with researchers in the Mayo Clinic…
not only discovered how this process
takes place in the heart but also how
it can be reversed or treated.”
Newcastle University scientists
are killing zombie cells to reverse
age-related damage in the heart
Feb.8,2019British Heart
Foundation
https://www.bhf.org.uk/what-we-do/news-from-the-bhf/news-archive/2019/february/newcastle-university-scientists-are-killing-zombie-cells-to-reverse-age-related-damage-in-the-heart
This drug cocktail reduced signs of age-related
diseases and extended life in mice and human cells
Senolytic Delay May = Death
“Group led by Mayo Clinic anti-aging researcher James Kirkland not only offers a clear look at
the power of senescent cells to drive the aging process, but also a pharmaceutical cocktail that,
in mice at least, can slow and even reverse it.
Compared to mice who aged normally, those who started getting the dasatinib-quercetin cocktail at
an age equivalent to 75 to 90 years in humans ended up living roughly 36% longer, and with better
physical function.
In human cells in a test tube and in mice bearing human senescent cells, the dasatinib-quercetin
cocktail showed equally promising results, targeting senescent cells while leaving other cells intact.
Aging…is beginning to look more and more like a disease — and a treatable one at that.
ScientistsAre Testing
CancerDrugstoSlowDownAging July 10, 2019
SEPTEMBER 17, 2018
Scientific Discovery and the Future of Medicine
Journal of the American Medical Association
“…many human pathologic conditions are associated with the presence of
senescent cells.”
“Interventions aimed at eliminating those senescent cells, commonly called
senolytic, have also been shown to improve health and extend life in various
mouse disease models.
“If senolytics are shown to be safe and effective in humans, they could transform
care of older adults and patients with multiple chronic diseases.”
Reference: “Aging, Cell Senescence, and Chronic Disease:Emerging Therapeutic Strategies.”;
Journal of the American Medical Association (JAMA) September 17th 2018.
“Moreover, tremendous advances are being made in our
understanding of the science of aging, yielding exciting potential
treatments that may alter the course of this inevitable process.5 One
aspect of this work relates to “senolytics,” the study of ways to
either eliminate senescent cells that may have deleterious effects or
slow or reverse the aging process by restoring cells’ lost function.
“Enabling Healthful Aging for All —
The National Academy of Medicine Grand Challenge in Healthy Longevity”
https://www.nejm.org/doi/full/10.1056/NEJMp1912298?query=TOC
October 31, 2019
“Enabling Healthful Aging for All”…
Selective removal of senescent cells - Age-related accumulation
of senescent cells contributes to atherosclerosis, aging of the
eye (cataracts, AMD), osteoporosis, skin and brain aging,
Kirkland and colleagues at Mayo Clinic show that senescent cells
are selectively eliminated by “senolytic” drugs.
Senolytic Cocktail of:
Senolytics
1) Dasatinib
2) Quercetin
3) Fisetin
1) Fish oil: Boost omega-3 index > 10%
Reduce and Resolve Chronic Inflammation
2) Resolvins: Return tissues to health
Intervention #3:
Telomere
Elongation
Intervention #4:
Telomere Lengthening
1) Exercise
2) Stress Control
3) Healthy Diet
4) Omega-3 fatty acids
“Telomeres, lifestyle, cancer, and aging.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370421/
Restoring
Youthful
Methylation
Intervention #5
“TheroleofDNA methylationin epigeneticsofaging”
 Epigenetics, especially DNA methylation,
plays a mechanistic role in aging.
 Epigenetic clocks are best biomarkers for
predicting human mortality.
 DNAmethylationinfluencedbymetformin,caloric
restriction and rapamycin treatment in mice.
 This may reverse/prevent 20% to 40% of the
age-related changes in DNA methylation.
Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001
Methods of Balancing Methylation
Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001
Metformin
CalorieRestrictionMimetics
Rapamycin
Nov. 17, 2019
NIH Funds $23 Million
Dog Study that includes
RAPAMYCIN
Daniel Promislow
principal investigator of the Dog Aging Project
“Old dogs, new tricks:
10,000 pets needed for
aging study”
https://www.heraldnet.com/northwest/old-dogs-new-tricks-10000-pets-needed-for-study/
Age Reversal
Interventions
Autophagy Resolve inflammation
Remove
senescent cells
Restore
youthful methylation
Lengthen
telomeres
AMPK/
mTOR
Sirtuins -
NAD+
Exosomes
LS/tandemmassspectrometrybasedtesting
Quantitativeb-galactosidasestaining,p16INK4a,etc)
Neurovision – Mayo Clinic CD38
Johns Hopkins
Aging Biomarker Tests
Vitality in Aging Interventions Trial
More Accurate FlowFISH-
Based Telomere Length Tests
Newer DNA
Methylation Age Tests
NAD+, NAD/NADH ratio,
and NAD+ metabolite tests
Cell Senescence Tests
Univ of British Columbia/UCLA Galactosidasestaining,p16INK4a,skinpunch
NanoSomiX
Exosome tests for predicting
Alzheimer’s disease 10 years
prior to onset of memory loss
Age Management Panel
Comprehensive blood
biomarkers with Levine
Biological Age Calculator
Long Term Funding Sources Will Be Needed
Human Age Reversal Project
Bill Faloon
Donations of Physicians’ Time
Funding Need: > $550,000
Donations Received to Date: >$627,000
Vitality In Aging Interventions Trial
SOURCES OF FUNDING:
New charity to fund research with tax deductible donations:
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
December 2, 2015
o 1497: Citrus shown to cure scurvy
o 1747: James Lind proves citrus cures scurvy
o 1870: Flawed study discredits “citrus cure”
o 1911: Dr. Robert Scott loses crew to scurvy
o 1932: Vitamin C proven to cure scurvy
Thousands of Deaths After Cure Discovered
We Don’t Have Time for
Delayed Age Reversal
Hotel magnate Barron Hilton died
of natural causes at the age of 91.
He left about 97% of his estate to
Conrad N. Hilton Foundation, which
expects to grow its endowment
from $2.9 billion to $6.3 billion
www.foxbusiness.com/business-leaders/barron-hilton-fortune-estate-foundation
Who missed the longevity boat?
Barron Hilton (1927-2019)
Expiration date: Sept. 19, 2019
Net worth > $2.9 billion
Paris Hilton Barron Hilton
Too Wealthy to Die at Age 65
Paul Allen, Chairman of the Seattle
Seahawks co-founded Microsoft in 1975.
Diagnosed and treated for non-Hodgkin
lymphoma in 2009. Cancer returned in
2018. He died from septic shock.
Paul Allen was philanthropist and
donated to medical research…
but did NOT make it his priority!
https://www.nytimes.com/2018/10/15/obituaries/paul-allen-dead.html
Paul Allen (1953-2018)
Net worth > $26.1 billion
Expiration date: Oct. 15, 2018
Too Wealthy to Die at Age 58
Blake Nordstrom, company co-president,
dies unexpectedly at 58 from lymphoma.
At the time, he described his
condition as "treatable" and said he
planned to "continue to work
throughout this process as normal."
https://www.cnn.com/2019/01/02/business/blake-nordstrom-obit/
Blake Nordstrom(1961-2019)
Net worth > $1.5 billion
Expiration date: Jan. 2, 2019
Who Missed the Longevity Boat
Robert "Bob" McNair, billionaire
founder and owner of the
Houston Texans died at age 81.
He battled squamous cell
skin cancer and then
leukemia for about 20 years.
https://www.forbes.com/profile/robert-mcnair/#130c78d9251a
RobertMcNair (1937-2018)
Net worth ~ $3.8 billion
Expiration date: Nov. 23, 2018
Wealthy And Famous
That Expired In 2018
Who Missed the Longevity Boat
Herb Kelleher, the eccentric
founder of Southwest Airlines
who helped revolutionize
low-cost air travel in 1971.
Died at age 87.
https://www.cnn.com/2019/01/03/business/southwest-airlines-founder-herb-kelleher-obit
Herb Kelleher(1931-2019)
Net worth ~ $2.5 billion
Expiration date: Jan. 3, 2019
Wealthy And Famous
That Expired In 2019
“Just a year ago I felt
immortal, wearing my
age with pride, even
joking about it.”
https://www.nytimes.com/2019/09/11/business/boone-pickens-dead.html
Who missed the longevity boat?
T. Boone Pickens (1928-2018)
Expiration date: Sept. 11, 2019
Net worth > $950 million
In 2016 T. Boone Pickens wrote:
One year later suffered series of
strokes and a fall. Dead at age 91.
T. Boone Pickens Largely Funded $260 Million
Oklahoma State University Stadium
(He made many other charitable donations to biomedical research)
http://med.miami.edu/news/interdisciplinary-stem-cell-institute-at-the-university-of-miami-receives-2
Interdisciplinary Stem Cell Institute
at the University of Miami Receives $25 Million Donation
“The Interdisciplinary Stem Cell Institute at
the University of Miami Miller School of
Medicine has received a $25 million donation
from the Soffer Family Foundation.”
“The funding will allow the institute to continue
its groundbreaking stem cell research… in
fields of cardiology, sports medicine, and
aging-related conditions.”
October 8th 2019
Fund research with tax deductible donations:
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
We Were Doomed 10 Years Ago
No Validated Method to
Reverse Aging in People
Manhattan Beach Summit
November 2009
Huge Advances in Only 10 Years
No Way to Reverse Aging
Manhattan Beach Summit Attendees
November 2009
Many Potential Methods
2009 2019
2009-2019
Senolytics NAD+ Sirtuins mTOR-inhibition
AMPK
Activation
Umbilical Cord
Plasma/Blood
Exosomes from
Young Cells
Mesenchymal
Stem Cells
Immune
Restoration
Mitochondria
Restoration
Multiple Regenerative Interventions
“Why the line between
life and death is now
more blurred than
ever…life's end is less
final than we thought.”
November 20, 2019
The Growing Rebellion
against Aging and Death
"...without daring innovators, disruptive
thinkers, and voluntary patients, little
medical progress could be made"
"Getting Comfortable with Risk."
New England Journal of Medicine
(381;17) October 24, 2019
October 24, 2019
age-reversal.net
To enroll in upcoming clinical trials:
We Don’t Have Time for
Delayed Age Reversal
How Humans Died Last Century
Average life expectancy in the U.S. in 1900 was 47.3 years.
It has since increased to about 79 years.
SOURCE: ODC, National Center for Health Statistics.
LethalDelays
•Antibiotic properties of penicillin discovered:1928
•Alexander Fleming findings published: 1929
•Penicillin not widely available until 1946
Millions of needless deaths!
Penicillin Availability
1928 1946
Age Reversal
?
Delay of 16 Years
Millions of Needless Deaths
2015
How many millions
will needlessly perish?
Penicillin andAge
Reversal
Human Age Reversal
A BIOMEDICAL RENAISSANCE!
Begins in Year 2015
Feb 23 /March 2, 2015
Living over 100
years no longer
limited to babies
Exponential Scientific Advances!
Fund research with tax deductible donations:
Human Age Reversal Project
Make checks payable to:
Human Age Reversal Project
300 NE 20th St. #409
Boca Raton, FL 33431
Or donate online:
age-reversal.net/donate
age-reversal.net
To enroll in upcoming clinical trials:
Unparalleled Track Record
of Biomedical Innovation
First Established 1977
age-reversal.net
This entire presentation and info
about our research available at:

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2019.12.08 Bill Faloon at Confidential Cures Summit Dec 8 2019.

  • 1. Age Reversal Update Confidential Cures Summit Palm Beach, Florida December 8 2019 William Faloon
  • 2. age-reversal.net This entire presentation and info about our research available at:
  • 3. The New Paradigm Human Age Reversal A BIOMEDICAL RENAISSANCE!
  • 4. Human Age Reversal Prospect of turns real year 2015
  • 5. Feb 23 /March 2, 2015 TIME magazine underestimates the science. Early Year 2015:
  • 7. “The Science of Living Longer” “No longer is it (aging) being treated as a dreadful inevitability but instead as a puzzle that can be solved---as a disease with a cure.” TIME-Special Edition - Fall 2019
  • 8. https://www.technologyreview.com/magazine/2019/09 September 2019 “Later this year, at a conference of longevity enthusiasts called RAADfest, to be held in Las Vegas, Faloon plans to take the strategy one step further with what he has been calling the “Perpetual Clinical Trial.” “OLD AGE IS OVER!”
  • 9. Human Age Reversal turns real year 2015
  • 11. “Harness advanced technologies…use that knowledge to devise interventions that enable people to lead longer and healthier lives.”
  • 12.
  • 13. Mark Zuckerberg pledges 99% of his Facebook shares to curing diseases –CNBC, April 27, 2016 “We have a real shot at preventing, curing or managing (most or all diseases) in the next 100 Zuckerberg said.
  • 14. 14 “IS JEFF BEZOS LOOKING FOR THE FOUNTAIN OF YOUTH” OCTOBER 27, 2016 Jeff Bezos, Billionaire founder of Amazon and Mayo Clinic are investors in a startup that’s received $116 million to develop anti-aging therapies. http://www.geekwire.com/2016/forever-young-amazon-founder-jeff-bezos-backs-biotech-startup-developing-anti- aging-therapies/
  • 15. According to Juvenescence’s Greg Bailey “We won’t be aging as fast or poorly as our parents” “I think the world is going to be shocked” Juvenescence has now raised $165 million to fund longevity projects with the goal of extending human lifespans to 150 years. “Science fiction has become science” ‘Extraordinary’ Breakthroughs In Anti-Aging Research ‘Will Happen Faster Than People Think’ https://www.forbes.com/sites/robinseatonjefferson/2019/08/26/how-extraordinary-breakthroughs-in-anti-aging-research-will-happen-faster-than-people-think
  • 16. December 2, 2015 George Church, Ph.D. A Cure for Aging by Year 2030? https://www.washingtonpost.com/news/achenblog/wp/2015/12/02/professor-george-church-says-he-can-reverse-the-aging-process/
  • 17. AUGUST 25, 2018 https://www.newscientist.com/article/mg23931920-600-how-a-positive-mind-really-can-create-a-healthier-body/ “George Church: The maverick geneticist now wants to reverse aging” “He stirred controversy with his plans to bring back the woolly mammoth. But first he's working on editing sperm – and trying out his aging reversal techniques on dogs.”
  • 19. “By splicing animals together, scientists have shown that young blood rejuvenates old tissues. Now, they are testing whether it works for humans.” January 21, 2015 January 21, 2015
  • 20. University of Cambridge and Harvard researchers show that young blood promotes repair of damaged spinal cords in older mice.1 Harvard neuroscientist finds that young blood sparks the formation of new neurons in the brain and olfactory system.2 Brigham and Women's Hospital in Boston, Massachusetts — cardiologists find that young blood reverses age-related thickening of the walls of the heart.3 1)Ruckh, J. M. et al. Cell Stem Cell, 10, 96–103 (2012). 2)Katsimpardi, L. et al. Science, 344, 630–634 (2014). 3) Loffredo, F. S. et al. Cell, 153, 828–839 (2013).
  • 21. Young Blood Transfer Research goes Mainstream Johnson and Johnson signs $50 million deal with Stanford University researchers to identify blood factors responsible for age reversal in parabiosis studies: "…it could mean new therapeutic approaches for treating numerous diseases associated with aging, including neural dysfunction and dementias such as Alzheimer's disease.” March 4, 2015
  • 22. Scientists have rejuvenated old mice with the blood of human teenagers The fountain of youth is real, and it's creepy. PETER DOCKRILL 16 NOV 2016 Nov 16 2016
  • 23. •Improved cognition •Decreased inflammation •New brain cell formation •Old animals acted young Society of Neuroscience annual meeting-San Diego- Nov 2016 Small amounts of young human plasma injected into old mice:
  • 24. 24 “The new blood made the old mice act young again, with the treated animals running around in open spaces much like their younger controls.” Nov 16 2016
  • 25. March 22, 2017 Mice treated with young human plasma appeared to have created more new cells in their brain. “Young human plasma treatment can increase neurogenesis.” Growing New Brain Cells
  • 26. Parabiosis Extends Longevity • University of California researchers studied the life spans of old–young rat pairs in 1972. • Old rats receiving young circulating blood lived the human equivalent of 10-12 years longer. Source: New York Academy of Sciences, (1972 Nov) Vol. 34, No. 7, pp. 582-7.
  • 27. “Young bone marrow transplantation preserves learning and memory in old mice”, Communications Biology (2019). DOI: 10.1038/s42003-019-0298-5 “Young bone marrow rejuvenates aging mouse brains, study finds” Transplanting the of young mice into old mice prevented cognitive decline in the old mice. Available at:https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html. February 20, 2019
  • 28. “Young bone marrow rejuvenates aging mouse brains, study finds” Microglia in brains of old mice have fewer/shorter branches than young mice Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html. Feb. 20, 2019 Synaptic branches of microglia of old mice who received bone marrow transplants from young mice resembled those of young mice
  • 29. Young Bone marrow transplants restore exploratory activity in old mice Feb. 20, 2019 “Remarkably, young bone marrow recipients, but not old bone marrow recipients, were more active than old control mice.” https://www.nature.com/articles/s42003-019-0298-5/figures/1
  • 30. “Young bone marrow rejuvenates aging mouse brains, study finds” Available at: https://medicalxpress.com/news/2019-02-young-bone-marrow-rejuvenates-aging.html. Feb. 20, 2019 Young bone marrow restores aged mouse brains!
  • 31. PHILADELPHIA (CBS) — Could the secret to eternal youth be found in blood transfusions from young people? Some claim that transfusions with “young blood” from teenagers can reverse the aging process. Dec. 20, 2018 Controversial Treatment Transfuses Patients With ‘Young Blood’From Teenagers To Reverse Aging Process
  • 32. Stanford University scientists previously showed that transfused serum from 12-to-15-month age mice into old mice reverses some signs of brain aging. Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019). DOI: 10.1073/pnas.1902672116 JUNE 3, 2019
  • 33. Researchers find synapse-boosting factors in young blood Available at: https://medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019. June 4, 2019 Stanford University researchers used serum from 15-day old (very young) mice and discovered: “ ”
  • 35. Very Young Blood (serum) Regenerates Synapses, Dendrites, Neurotransmitters Available at: medicalxpress.com/news/2019-06-synapse-boosting-factors-young-blood.html. Accessed June 4, 2019. June 4, 2019 “When two proteins (thrombospondin-4 and SPARC-like protein-1) richer in younger serum were applied to older serum…some of the same rejuvenating effects took place.”
  • 36. “Strikingly, recombinant THBS4 and SPARCL1… may represent rejuvenation factors that enhance synaptic connectivity by increasing dendritic arborization, synapse formation, and synaptic transmission.” Kathlyn J. Gan et al. Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment, Proceedings of the National Academy of Sciences (2019). DOI: 10.1073/pnas.1902672116 JUNE 3, 2019 Human equivalent of a 15-day old mouse may be approximately one to two years.
  • 37. “A triple drug combination has been used to extend the lifespan of fruit flies by 48% in a new study.” https://www.nextbigfuture.com/2019/10/rapamycin-and-two-other-drugs-extends-lifespan-twice-as-much-as-any-other-drug-combo.html Rapamycin and Two Other Drugs Extends Lifespan Twice As Much As Any Other Drug Combo
  • 38. “Previousstudiesinfruitflieshave achievedlifespan extensions ofabout 5-20% …sowefounditwasquiteremarkable thatthisdrugcombinationenabled themtolive Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819. September 30, 2019 Combined Interventions More Effective than SingleAgent Therapy
  • 39. PNAS October 15, 2019 116 (42) 20817-20819; first published September 30, 2019 https://doi.org/10.1073/pnas.1913212116 Rapamycin Lithium Dasatinib-like Drug+ + Fruit Fly Lifespan Extension by 48% = “…a combination of drugs already approved for human use is a viable strategy to maximize animal longevity…” This recent study supports the stairstep approach advocated to enable us to live significantly longer September 30, 2019
  • 40. Fruit flies received drugs separately and/or in combination.  Each drug individually extended lifespan by 11%  Pairing two drugs extended lifespan roughly 30%  Three drugs combined extended lifespan by 48% Castillo-Quan, Jorge Iván, Luke S. Tain, Kerri J. Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T. Keith Blackwell, Ivana Bjedov, and Linda Partridge. "A triple drug combination targeting components of the nutrient-sensing network maximizes longevity." Proceedings of the National Academy of Sciences 116, no. 42 (2019): 20817-20819. Combination Treatments are Essential September 30, 2019
  • 41. Senolytics NAD+ Sirtuins mTOR-inhibition AMPK Activation Umbilical Cord Plasma/Blood Exosomes from Young Cells Mesenchymal Stem Cells Immune Restoration Mitochondria Restoration Today’s Age Reversal Interventions
  • 42.
  • 43. …they are optimistic that a person’s biological age can be reversed.” Age markers reversed by 2.5 years! “ScientistsatInterveneImmuneandStanford MedicalCenterhaveproventhat‘epigenetic agingcanbereversedinhumans’... Cocktail Of Drugs Gives First Hope That ‘Biological Age’ Can Be Reversed https://forbes.com/sites/robinseatonjefferson/2019/09/09/cocktail-of-drugs-gives-first-hope-that-biological-age-can-be-reversed/
  • 44. “Reversal of epigenetic aging and immunosenescent trends in humans.” Aging Cell; Sept 2019 Combination Therapy also Effective in Humans 1) Human growth hormone 2) DHEA 3) Metformin Study conducted by Dr. Greg Fahy in collaboration with researchers from Stanford University and UCLA consisted of individualized doses of: Study subjects also provided with daily vitamin D3 and zinc.
  • 45. https://www.dailymail.co.uk/health/article-7435427/Aging- REVERSED-small-group-men-study-reveals.htmll Oct.22,2019Turning Back Time! “Aging is REVERSED in men using a cocktail of growth hormones and diabetes drugs in study that saw test group shed 2.5 biological years.”
  • 46. George C. Kohn, Encyclopedia of Plague and Pestilence: From Ancient Times to the Present; Infobase Publishing, 2007
  • 47. We Don’t Have Time for Delayed Age Reversal
  • 48. Example of Lethal Delay https://www.longevity.technology/worlds-first-anti-aging-trial-gets-green-light/ Sept 4, 2019 1958 - Metformin approved as anti-diabetic drug in England 1995 - Life Extension® lists metformin as anti-aging drug 2015 - FDA approves first anti-aging study of a drug (metformin) 2019 - Metformin study receives $75 million funding ($40 million from anonymous donor)
  • 49. Type II diabetics taking metformin: United Kingdom Diabetes Study ►32% reduced risk of diabetic complications ►42% reduced risk for diabetes-related death ►36% reduced all-cause mortality risk Study results published January 1995 British Medical Journal; Jan 14, 1995;” United Kingdom Prospective Diabetes Study (UKPDS)
  • 50. Life Extension recommended metformin 24 years ago… the FDA went berserk! March 1995
  • 51. Study Results Found on March 21st 2017 Journal of the American Medical Association JAMA. Published online March 21, 2017. doi:10.1001/jama.2016.17844 Metformin studied in prediabetic patients. Compared to placebo 850 mg of metformin two times a day: Reduced type II diabetes risk 31% In patients under age 60: metformin reduced diabetic risk by 58%. “Metformin can cause weight loss…”Quote:
  • 53. Sept. 2017 Metformin Demonstrates Therapeutic Effects Against Colon Cancer Am J Med Sci. 2017 Sep;354(3):246-251. doi: 10.1016/j.amjms.2017.05.006. Epub 2017 May 19. Metformin Has Positive Therapeutic Effects in Colon Cancer and Lung Cancer. Colon Cancer Metformin Patients Non-Metformin Patients Recurrences 4% 19% Metastases 23% 46% 5-Year Survival 57% 37% Deaths 48% 76% (Metformin boosts AMPK activity and indirectly inhibits mTOR) Conclusion: “Metformin therapy is associated with significantly better prognosis in patients with colon cancer” Caveat: Some diabetics in control group treated with insulin or sulfonylurea drugs that promote tumor cell propagation. Diabetics on metformin showed these benefits compared to diabetics not prescribed metformin:
  • 54. Diabetics taking metformin have lower cancer rates Metformin Prevents Cancer MD Anderson Cancer Center found risk of pancreatic cancer was 62% lower in diabetics using metformin. Li D, Yeung SC, Hassan MM, Konopleva M, Abbruzzese JL. Antidiabetic therapies affect risk of pancreatic cancer. Gastroenterology. 2009 Aug;137(2):482-8.
  • 57. Catastrophic Loss of Life A 2019 study tabulated reductions in cardiovascular mortality in type II diabetics using metformin.1 Life Extension® calculated how many cardiovascular deaths may have occurred in response to metformin’s 37-year delay. This exceeds the death toll of all wars America has ever fought. 1. Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular Events Among Patients With Diabetes and Reduced Kidney Function. JAMA. 2019 September 19:1-11. Almost 4 million American diabetics may have died because of the delay in this one drug (metformin) becoming available.
  • 58. We Don’t Have Time for Delayed Age Reversal
  • 59.
  • 60. Statistically Significant + Meaningful Age Reversal in 12 Months Outcome Objectives: $550,000 + donated/discounted services Human Age Reversal Project Vitality in Aging Interventions Trial Study Cost: Major Funding Provided by:
  • 61. Long Term Funding Sources Will Be Needed Human Age Reversal Project Bill Faloon Donations of Physicians’ Time Funding Need: > $550,000 Donations Received to Date: >$627,000 Vitality In Aging Interventions Trial SOURCES OF FUNDING:
  • 62. Fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  • 63. Age Reversal Interventions 1)Target 5 calorie restriction pathways 2) Reduce/resolve inflammation 3) Telomere lengthening 4) Selective remove senescent cells 5) Restore youthful methylation age-reversal.net
  • 64. Age Reversal Interventions Autophagy Resolve inflammation Remove senescent cells Restore youthful methylation Lengthen telomeres AMPK/ mTOR Sirtuins - NAD+ Exosomes
  • 65. Trial Parameters > Open label (no placebo group) > 50 healthy people aged 50-75 years Initial Phase Recruitment/Baseline Testing: October 3rd 2019 – December 15th 2019 Vitality in Aging Interventions Trial
  • 66. Vitality in Aging Interventions Trial Timeline
  • 67. Vitality in Aging Interventions Trial Intervention #1 Calorie Restriction Mimetics
  • 68. 12% Calorie Reduction Improves Biological Age Scores by 1.5 Years 2018 Published Human study measures 8 Aging Biomarkers Change in the Rate of Biological Aging in Response to Caloric Restriction: CALERIE Biobank Analysis, J Gerontol A Biol Sci Med Sci. 2018 Jan; 73(1): 4-10.
  • 69. Intervention:1 Targeting Calorie Restriction Pathways Metformin Metformin Rapamycin, metformin Pterostilbene, nicotinamide Nicotinamide riboside Rapamycin, glucosamine Beta-lapachone ↓Insulin/IGF-1 ↑AMPK ↓mTOR ↑Sirtuins ↑ NAD+ ↑Autophagy ↑NAD/NADH ratio
  • 71. Vitality in Aging Interventions Trial Senolytics Selective removal of senescent cells Intervention #2
  • 72. July 9, 2018 Magazine “It’slooking like veryoldmice are able to substantially improve their health span, reduce or delay age-related diseases and increase their survival.” They calculated that if only one in 7,000 to 15,000 cells is senescent, then age-related problems in physical function started to appear in the mice. Like a contagion, senescent cells seem to pass on their accelerated aging abilities to healthy cells by releasing a number of factors that can cause tissues like muscle to deteriorate. Mice given senescent cells and the senolytic compounds lived 36% longer than animals with senescent cell transplants who were not given the drugs. How Scientists Are Testing Cancer Drugs to Slow Down Aging
  • 73. Drug to clear 'zombie cells' from body could be first anti-aging treatment after ‘impressive’ human trial https://www.telegraph.co.uk/science/2019/01/08/drug-clear-zombie-cells-body-could-first-anti-ageing-treatment/ Jan. 8, 2019 “A drug to fight aging may finally be on the horizon after the first trial in humans showed ‘impressive’ results.” “The treatment clears out dead cells even when the immune system no longer can.”
  • 74. “Senescent cells – also known as zombie cells – form in the heart during aging and lead to heart failure.” “Newcastle scientists, in collaboration with researchers in the Mayo Clinic… not only discovered how this process takes place in the heart but also how it can be reversed or treated.” Newcastle University scientists are killing zombie cells to reverse age-related damage in the heart Feb.8,2019British Heart Foundation https://www.bhf.org.uk/what-we-do/news-from-the-bhf/news-archive/2019/february/newcastle-university-scientists-are-killing-zombie-cells-to-reverse-age-related-damage-in-the-heart
  • 75. This drug cocktail reduced signs of age-related diseases and extended life in mice and human cells Senolytic Delay May = Death “Group led by Mayo Clinic anti-aging researcher James Kirkland not only offers a clear look at the power of senescent cells to drive the aging process, but also a pharmaceutical cocktail that, in mice at least, can slow and even reverse it. Compared to mice who aged normally, those who started getting the dasatinib-quercetin cocktail at an age equivalent to 75 to 90 years in humans ended up living roughly 36% longer, and with better physical function. In human cells in a test tube and in mice bearing human senescent cells, the dasatinib-quercetin cocktail showed equally promising results, targeting senescent cells while leaving other cells intact. Aging…is beginning to look more and more like a disease — and a treatable one at that. ScientistsAre Testing CancerDrugstoSlowDownAging July 10, 2019
  • 76. SEPTEMBER 17, 2018 Scientific Discovery and the Future of Medicine Journal of the American Medical Association “…many human pathologic conditions are associated with the presence of senescent cells.” “Interventions aimed at eliminating those senescent cells, commonly called senolytic, have also been shown to improve health and extend life in various mouse disease models. “If senolytics are shown to be safe and effective in humans, they could transform care of older adults and patients with multiple chronic diseases.” Reference: “Aging, Cell Senescence, and Chronic Disease:Emerging Therapeutic Strategies.”; Journal of the American Medical Association (JAMA) September 17th 2018.
  • 77. “Moreover, tremendous advances are being made in our understanding of the science of aging, yielding exciting potential treatments that may alter the course of this inevitable process.5 One aspect of this work relates to “senolytics,” the study of ways to either eliminate senescent cells that may have deleterious effects or slow or reverse the aging process by restoring cells’ lost function. “Enabling Healthful Aging for All — The National Academy of Medicine Grand Challenge in Healthy Longevity” https://www.nejm.org/doi/full/10.1056/NEJMp1912298?query=TOC October 31, 2019 “Enabling Healthful Aging for All”…
  • 78. Selective removal of senescent cells - Age-related accumulation of senescent cells contributes to atherosclerosis, aging of the eye (cataracts, AMD), osteoporosis, skin and brain aging, Kirkland and colleagues at Mayo Clinic show that senescent cells are selectively eliminated by “senolytic” drugs. Senolytic Cocktail of: Senolytics 1) Dasatinib 2) Quercetin 3) Fisetin
  • 79. 1) Fish oil: Boost omega-3 index > 10% Reduce and Resolve Chronic Inflammation 2) Resolvins: Return tissues to health Intervention #3:
  • 81. Telomere Lengthening 1) Exercise 2) Stress Control 3) Healthy Diet 4) Omega-3 fatty acids “Telomeres, lifestyle, cancer, and aging.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370421/
  • 83. “TheroleofDNA methylationin epigeneticsofaging”  Epigenetics, especially DNA methylation, plays a mechanistic role in aging.  Epigenetic clocks are best biomarkers for predicting human mortality.  DNAmethylationinfluencedbymetformin,caloric restriction and rapamycin treatment in mice.  This may reverse/prevent 20% to 40% of the age-related changes in DNA methylation. Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001
  • 84. Methods of Balancing Methylation Pharmacol Ther. 2019 March; 195:172-185. doi:10.1016/j.pharmthera.2018.11.001 Metformin CalorieRestrictionMimetics Rapamycin
  • 85. Nov. 17, 2019 NIH Funds $23 Million Dog Study that includes RAPAMYCIN Daniel Promislow principal investigator of the Dog Aging Project “Old dogs, new tricks: 10,000 pets needed for aging study” https://www.heraldnet.com/northwest/old-dogs-new-tricks-10000-pets-needed-for-study/
  • 86. Age Reversal Interventions Autophagy Resolve inflammation Remove senescent cells Restore youthful methylation Lengthen telomeres AMPK/ mTOR Sirtuins - NAD+ Exosomes
  • 87. LS/tandemmassspectrometrybasedtesting Quantitativeb-galactosidasestaining,p16INK4a,etc) Neurovision – Mayo Clinic CD38 Johns Hopkins Aging Biomarker Tests Vitality in Aging Interventions Trial More Accurate FlowFISH- Based Telomere Length Tests Newer DNA Methylation Age Tests NAD+, NAD/NADH ratio, and NAD+ metabolite tests Cell Senescence Tests Univ of British Columbia/UCLA Galactosidasestaining,p16INK4a,skinpunch NanoSomiX Exosome tests for predicting Alzheimer’s disease 10 years prior to onset of memory loss Age Management Panel Comprehensive blood biomarkers with Levine Biological Age Calculator
  • 88. Long Term Funding Sources Will Be Needed Human Age Reversal Project Bill Faloon Donations of Physicians’ Time Funding Need: > $550,000 Donations Received to Date: >$627,000 Vitality In Aging Interventions Trial SOURCES OF FUNDING:
  • 89. New charity to fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  • 90.
  • 92. o 1497: Citrus shown to cure scurvy o 1747: James Lind proves citrus cures scurvy o 1870: Flawed study discredits “citrus cure” o 1911: Dr. Robert Scott loses crew to scurvy o 1932: Vitamin C proven to cure scurvy Thousands of Deaths After Cure Discovered
  • 93. We Don’t Have Time for Delayed Age Reversal
  • 94. Hotel magnate Barron Hilton died of natural causes at the age of 91. He left about 97% of his estate to Conrad N. Hilton Foundation, which expects to grow its endowment from $2.9 billion to $6.3 billion www.foxbusiness.com/business-leaders/barron-hilton-fortune-estate-foundation Who missed the longevity boat? Barron Hilton (1927-2019) Expiration date: Sept. 19, 2019 Net worth > $2.9 billion Paris Hilton Barron Hilton
  • 95. Too Wealthy to Die at Age 65 Paul Allen, Chairman of the Seattle Seahawks co-founded Microsoft in 1975. Diagnosed and treated for non-Hodgkin lymphoma in 2009. Cancer returned in 2018. He died from septic shock. Paul Allen was philanthropist and donated to medical research… but did NOT make it his priority! https://www.nytimes.com/2018/10/15/obituaries/paul-allen-dead.html Paul Allen (1953-2018) Net worth > $26.1 billion Expiration date: Oct. 15, 2018
  • 96. Too Wealthy to Die at Age 58 Blake Nordstrom, company co-president, dies unexpectedly at 58 from lymphoma. At the time, he described his condition as "treatable" and said he planned to "continue to work throughout this process as normal." https://www.cnn.com/2019/01/02/business/blake-nordstrom-obit/ Blake Nordstrom(1961-2019) Net worth > $1.5 billion Expiration date: Jan. 2, 2019
  • 97. Who Missed the Longevity Boat Robert "Bob" McNair, billionaire founder and owner of the Houston Texans died at age 81. He battled squamous cell skin cancer and then leukemia for about 20 years. https://www.forbes.com/profile/robert-mcnair/#130c78d9251a RobertMcNair (1937-2018) Net worth ~ $3.8 billion Expiration date: Nov. 23, 2018 Wealthy And Famous That Expired In 2018
  • 98. Who Missed the Longevity Boat Herb Kelleher, the eccentric founder of Southwest Airlines who helped revolutionize low-cost air travel in 1971. Died at age 87. https://www.cnn.com/2019/01/03/business/southwest-airlines-founder-herb-kelleher-obit Herb Kelleher(1931-2019) Net worth ~ $2.5 billion Expiration date: Jan. 3, 2019 Wealthy And Famous That Expired In 2019
  • 99. “Just a year ago I felt immortal, wearing my age with pride, even joking about it.” https://www.nytimes.com/2019/09/11/business/boone-pickens-dead.html Who missed the longevity boat? T. Boone Pickens (1928-2018) Expiration date: Sept. 11, 2019 Net worth > $950 million In 2016 T. Boone Pickens wrote: One year later suffered series of strokes and a fall. Dead at age 91.
  • 100. T. Boone Pickens Largely Funded $260 Million Oklahoma State University Stadium (He made many other charitable donations to biomedical research)
  • 101. http://med.miami.edu/news/interdisciplinary-stem-cell-institute-at-the-university-of-miami-receives-2 Interdisciplinary Stem Cell Institute at the University of Miami Receives $25 Million Donation “The Interdisciplinary Stem Cell Institute at the University of Miami Miller School of Medicine has received a $25 million donation from the Soffer Family Foundation.” “The funding will allow the institute to continue its groundbreaking stem cell research… in fields of cardiology, sports medicine, and aging-related conditions.” October 8th 2019
  • 102. Fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  • 103. We Were Doomed 10 Years Ago No Validated Method to Reverse Aging in People Manhattan Beach Summit November 2009
  • 104. Huge Advances in Only 10 Years No Way to Reverse Aging Manhattan Beach Summit Attendees November 2009 Many Potential Methods 2009 2019
  • 105. 2009-2019 Senolytics NAD+ Sirtuins mTOR-inhibition AMPK Activation Umbilical Cord Plasma/Blood Exosomes from Young Cells Mesenchymal Stem Cells Immune Restoration Mitochondria Restoration Multiple Regenerative Interventions
  • 106. “Why the line between life and death is now more blurred than ever…life's end is less final than we thought.” November 20, 2019 The Growing Rebellion against Aging and Death
  • 107. "...without daring innovators, disruptive thinkers, and voluntary patients, little medical progress could be made" "Getting Comfortable with Risk." New England Journal of Medicine (381;17) October 24, 2019 October 24, 2019
  • 108. age-reversal.net To enroll in upcoming clinical trials:
  • 109. We Don’t Have Time for Delayed Age Reversal
  • 110. How Humans Died Last Century Average life expectancy in the U.S. in 1900 was 47.3 years. It has since increased to about 79 years. SOURCE: ODC, National Center for Health Statistics.
  • 111. LethalDelays •Antibiotic properties of penicillin discovered:1928 •Alexander Fleming findings published: 1929 •Penicillin not widely available until 1946 Millions of needless deaths!
  • 112. Penicillin Availability 1928 1946 Age Reversal ? Delay of 16 Years Millions of Needless Deaths 2015 How many millions will needlessly perish? Penicillin andAge Reversal
  • 113. Human Age Reversal A BIOMEDICAL RENAISSANCE! Begins in Year 2015
  • 114. Feb 23 /March 2, 2015 Living over 100 years no longer limited to babies Exponential Scientific Advances!
  • 115. Fund research with tax deductible donations: Human Age Reversal Project Make checks payable to: Human Age Reversal Project 300 NE 20th St. #409 Boca Raton, FL 33431 Or donate online: age-reversal.net/donate
  • 116. age-reversal.net To enroll in upcoming clinical trials:
  • 117. Unparalleled Track Record of Biomedical Innovation First Established 1977
  • 118. age-reversal.net This entire presentation and info about our research available at:

Editor's Notes

  1. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  2. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  3. I changed order of paragraphs.
  4. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  5. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.
  6. In about 15 minutes, I am going to make an announcement that is unprecedented in the history of medical science. In fact what is being unveiled right here at RAADfest is unparalleled in the history of the human race.