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CURRENT STATUS OF IODINE
DEFICIENCY IN NORTHEAST
INDIA
Longvah T., Naidu N., Rao P.A.,
Das H.K.*, Prasanna T.P.
National Institute of Nutrition
Indian Council of Medical Research
Jamai-Osmania PO
Hyderabad - 500 007
* Regional Medical Research Centre
Indian Council of Medical Research
Dibrugarh - 786 001
BANGLADESH
TRIPURA
CHINA
MYANMAR
ASSAM
MEGHALAYA
BHUTAN
NAGALAND
MANIPUR
MIZORAM
SIKKIM
ARUNACHAL
PRADESH
1.To assess the iodine nutiture of the population
2.To evaluate the implementation and impact of
salt iodization
programme in the region
OBJECTIVES
Methodology
Selection of villages/towns was carried out by the thirty cluster
sampling method (PPS) as recommended by WHO/UNICEF/ICCIDD
(1992).
In each cluster 100 households were covered for KAP studies.
Clinical examination of goiter was carried out as per the WHO
criteria (0,I,II).
Urine and salt sampling was carried out from every tenth
household. Iodine in urine samples was estimated by the wet
digestion method as described by Dunn, J. T. et al (1993). Iodine
in common salt was estimated by standard titration method.
Breast milk sampling was carried out from lactating mothers
encountered during the survey. Iodine content of breast milk was
estimated by the method of Gokmen, I.G. & Dagh, G. (1995).
Age groups (years)%State Sex n
0-5 yrs 6-12 yrs 12-18 yrs >18 yrs
Male 7167 16.3 25.1 12.6 46.0
Female 8546 13.0 21.9 12.9 52.2Sikkim
Total 15713 14.5 23.4 12.7 49.4
Male 6311 28.2 26.5 11.7 33.6
Female 8032 22.5 22.3 12.4 42.8Meghalaya
Total 14343 25.0 24.2 12.1 38.7
Male 6026 18.4 28.7 17.1 35.7
Female 6672 14.7 25.1 17.5 42.7Arunachal
Pradesh
Total 12698 16.5 26.8 17.3 39.4
Population distribution by age groups
State Sikkim Meghalaya Arunachal
Pradesh
Goiter
awareness %
Yes
No
52.7
47.3
37.6
62.4
67.0
33.0
Goiter
prevention %
Using iodized salt
Consulting doctor
Not aware
18.9
5.4
75.7
11.3
1.4
87.3
33.7
0.3
66.0
Point of salt
purchase %
Village itself
Nearby town
49.1
50.9
74.5
25.5
90.5
9.5
Frequency of
purchase %
Fortnightly
Monthly
Others
33.3
49.9
16.8
8.5
88.0
3.5
23.5
68.5
8.0
Salt Type % Powder
Crystalline
62.5
37.5
62.8
37.2
83.6
16.4
Package % Plastic bag
Loose*
Gunny bag
51.7
24.4
23.9
64.5
16.3
19.2
85.8
11.7
2.6
Storage % Plastic/bottle jars
Bamboo jars
Others*
85.9
14.0
0.1
74.8
9.0
-
55.8
41.4
2.8
Container % Closed
Open
60.9
38.7
66.3
33.7
73.5
26.5
KAP GOITER & SALT
State N Iodine
content
µg/L
Range
µg/L
Sikkim 218 2.0 ±1.7 0 – 7.76
Meghalaya 202 4.6 ±2.2 0.2 – 9.8
Arunachal
Pradesh
201 0.5 ±1.4 0 – 14.6
Iodine content of drinking water
State Salt type n Iodine content
µg/L
Mean ±S.D
Range
Sikkim
Crystalline
Powder
Total
109
115
224
24.1±11.3
36.6±9.9
30.7±10.8
4.2 – 52.9
10.6 – 67.6
4.2 – 67.7
Meghalaya
Crystalline
Powder
Total
96
106
202
17.3±10.3
33.7±10.4
25.9±13.2
3.2 – 50.8
6.3 – 66.7
3.2 – 66.7
Arunachal
Pradesh
Crystalline
Powder
Total
138
56
194
26.6±11.5
38.8±13.9
30.1±13.4
3.0 – 76.2
13.8 – 71.9
3.0 – 76.2
Iodine content of common salt
0
5
10
15
20
25
30
0-5 5-10 10-15 15-20 20-25 25-30 30-35 35-40 40-45 45-50 50+
Salt Iodine Content (ppm)
%Samples
Sikkim
Meghalaya
Arunachal Pradesh
Salt Iodine Distribution
Frequency distribution of goiter
by age (%)
State Sex TGR Range
by
cluster 0-5
yrs
6-12
yrs
13-18
yrs
>18
yrs
Male 0.9 0.2 0.3 0.7 1.5
Female 4.1 0.1 0.6 3.7 6.6Sikkim
Total 2.6 (0.4-5.9) 0.1 0.5 2.4 4.4
Male 1.71 0.5 0.9 2.6 3.0
Female 4.0 0.1 1.2 4.6 7.2Meghalaya
Total 3.0 (0.2-9.0) 0.2 1.1 3.8 5.6
Male 0.9 0.1 0.1 0.8 2.1
Female 2.7 0.1 0.2 1.5 5.5Arunachal
Pradesh Total 1.9 (0.2-7.7) 0.1 0.1 1.2 4.0
Total goiter Rate (TGR)
State N Iodine content µg/L
Mean ±S.D
Range µg/L
Sikkim 86 74.5 ± 8.8 3 – 480
Meghalaya 274 71.0 ± 8.2 2 – 479.0
Arunachal
Pradesh
375 34 ± 12.5 20 – 88.8
Iodine content of Breast Milk
Urinary Iodine Excretion µg/L
Frequency distribution of urinary iodine excretion
(%)
State Sex n Median
µg/L
0-20 20-50 50-100 100-200 >200
Male 1076 80.4 13.6 18.9 22.8 26.4 16.8
Female 1172 75.8 14.3 19.7 25.7 25.1 14.6
Sikkim
Total 2248 80.0 14.0 19.3 24.3 25.8 15.7
Male 1075 119 2.6 12.8 25.9 40.4 15.2
Female 1303 112 3.1 12.8 27.9 39.3 18.0
Meghalaya
Total 2378 114 2.9 12.8 27.0 39.9 16.5
Male 1158 86 6.7 19.9 31.3 37.8 4.2
Female 1372 78 4.5 15.9 34.1 33.4 3.9
Arunachal
Pradesh
Total 2533 81.3 8.8 20.7 31.0 35.5 4.1
0
5
10
15
20
25
30
35
40
45
0-20 20-50 50-100 100-200 200+
Iodine (µg/L)
%Samples
Sikkim
Meghalaya
Arunachal Pradesh
Urinary Iodine Distribution
CONCLUSIONS
•Household salt iodine content shows that the universal salt
iodization programmme has been effectively implemented in
the states studied
•Iodine nutrition has improved markedly in Sikkim but UIE
shows that iodine deficiency still exist.
•Arunachal Pradesh is in a transition phase from iodine
deficient to iodine sufficient nutrition while Meghalaya is on
the verge of eradicating IDD
• The region being environmentally deficient in iodine
continuous monitoring of the salt iodization programme is
warranted for eradication of IDD.
The authors gratefully acknowledge:
The Indian Council of Medical Research, New Delhi, for the
Financial grant to carry out the study
Dr M.Mohan Ram, Former Director, National Institute of
nutrition, Hyderabad for initiating me into this project.
The respective state governments of Sikkim, Meghalaya and
Arunachal Pradesh for providing local help and support during
the survey
Dr Kamala Krishnaswamy, Former Director, National Institute
of Nutrition, Hyderabad, for the guidance and support provided
during the study.
Mrs K.L. Rao, Mr K. Mangthya, Mr Leelakanta Gogoi and Mr
Rajib Gogoi for tirelessly carrying out the analysis.
ACKNOWLEDGEMENTS
Current status of iodine deficiency in northeast india

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Current status of iodine deficiency in northeast india

  • 1. CURRENT STATUS OF IODINE DEFICIENCY IN NORTHEAST INDIA Longvah T., Naidu N., Rao P.A., Das H.K.*, Prasanna T.P. National Institute of Nutrition Indian Council of Medical Research Jamai-Osmania PO Hyderabad - 500 007 * Regional Medical Research Centre Indian Council of Medical Research Dibrugarh - 786 001
  • 3. 1.To assess the iodine nutiture of the population 2.To evaluate the implementation and impact of salt iodization programme in the region OBJECTIVES
  • 4. Methodology Selection of villages/towns was carried out by the thirty cluster sampling method (PPS) as recommended by WHO/UNICEF/ICCIDD (1992). In each cluster 100 households were covered for KAP studies. Clinical examination of goiter was carried out as per the WHO criteria (0,I,II). Urine and salt sampling was carried out from every tenth household. Iodine in urine samples was estimated by the wet digestion method as described by Dunn, J. T. et al (1993). Iodine in common salt was estimated by standard titration method. Breast milk sampling was carried out from lactating mothers encountered during the survey. Iodine content of breast milk was estimated by the method of Gokmen, I.G. & Dagh, G. (1995).
  • 5. Age groups (years)%State Sex n 0-5 yrs 6-12 yrs 12-18 yrs >18 yrs Male 7167 16.3 25.1 12.6 46.0 Female 8546 13.0 21.9 12.9 52.2Sikkim Total 15713 14.5 23.4 12.7 49.4 Male 6311 28.2 26.5 11.7 33.6 Female 8032 22.5 22.3 12.4 42.8Meghalaya Total 14343 25.0 24.2 12.1 38.7 Male 6026 18.4 28.7 17.1 35.7 Female 6672 14.7 25.1 17.5 42.7Arunachal Pradesh Total 12698 16.5 26.8 17.3 39.4 Population distribution by age groups
  • 6. State Sikkim Meghalaya Arunachal Pradesh Goiter awareness % Yes No 52.7 47.3 37.6 62.4 67.0 33.0 Goiter prevention % Using iodized salt Consulting doctor Not aware 18.9 5.4 75.7 11.3 1.4 87.3 33.7 0.3 66.0 Point of salt purchase % Village itself Nearby town 49.1 50.9 74.5 25.5 90.5 9.5 Frequency of purchase % Fortnightly Monthly Others 33.3 49.9 16.8 8.5 88.0 3.5 23.5 68.5 8.0 Salt Type % Powder Crystalline 62.5 37.5 62.8 37.2 83.6 16.4 Package % Plastic bag Loose* Gunny bag 51.7 24.4 23.9 64.5 16.3 19.2 85.8 11.7 2.6 Storage % Plastic/bottle jars Bamboo jars Others* 85.9 14.0 0.1 74.8 9.0 - 55.8 41.4 2.8 Container % Closed Open 60.9 38.7 66.3 33.7 73.5 26.5 KAP GOITER & SALT
  • 7. State N Iodine content µg/L Range µg/L Sikkim 218 2.0 ±1.7 0 – 7.76 Meghalaya 202 4.6 ±2.2 0.2 – 9.8 Arunachal Pradesh 201 0.5 ±1.4 0 – 14.6 Iodine content of drinking water
  • 8. State Salt type n Iodine content µg/L Mean ±S.D Range Sikkim Crystalline Powder Total 109 115 224 24.1±11.3 36.6±9.9 30.7±10.8 4.2 – 52.9 10.6 – 67.6 4.2 – 67.7 Meghalaya Crystalline Powder Total 96 106 202 17.3±10.3 33.7±10.4 25.9±13.2 3.2 – 50.8 6.3 – 66.7 3.2 – 66.7 Arunachal Pradesh Crystalline Powder Total 138 56 194 26.6±11.5 38.8±13.9 30.1±13.4 3.0 – 76.2 13.8 – 71.9 3.0 – 76.2 Iodine content of common salt
  • 9. 0 5 10 15 20 25 30 0-5 5-10 10-15 15-20 20-25 25-30 30-35 35-40 40-45 45-50 50+ Salt Iodine Content (ppm) %Samples Sikkim Meghalaya Arunachal Pradesh Salt Iodine Distribution
  • 10. Frequency distribution of goiter by age (%) State Sex TGR Range by cluster 0-5 yrs 6-12 yrs 13-18 yrs >18 yrs Male 0.9 0.2 0.3 0.7 1.5 Female 4.1 0.1 0.6 3.7 6.6Sikkim Total 2.6 (0.4-5.9) 0.1 0.5 2.4 4.4 Male 1.71 0.5 0.9 2.6 3.0 Female 4.0 0.1 1.2 4.6 7.2Meghalaya Total 3.0 (0.2-9.0) 0.2 1.1 3.8 5.6 Male 0.9 0.1 0.1 0.8 2.1 Female 2.7 0.1 0.2 1.5 5.5Arunachal Pradesh Total 1.9 (0.2-7.7) 0.1 0.1 1.2 4.0 Total goiter Rate (TGR)
  • 11. State N Iodine content µg/L Mean ±S.D Range µg/L Sikkim 86 74.5 ± 8.8 3 – 480 Meghalaya 274 71.0 ± 8.2 2 – 479.0 Arunachal Pradesh 375 34 ± 12.5 20 – 88.8 Iodine content of Breast Milk
  • 12. Urinary Iodine Excretion µg/L Frequency distribution of urinary iodine excretion (%) State Sex n Median µg/L 0-20 20-50 50-100 100-200 >200 Male 1076 80.4 13.6 18.9 22.8 26.4 16.8 Female 1172 75.8 14.3 19.7 25.7 25.1 14.6 Sikkim Total 2248 80.0 14.0 19.3 24.3 25.8 15.7 Male 1075 119 2.6 12.8 25.9 40.4 15.2 Female 1303 112 3.1 12.8 27.9 39.3 18.0 Meghalaya Total 2378 114 2.9 12.8 27.0 39.9 16.5 Male 1158 86 6.7 19.9 31.3 37.8 4.2 Female 1372 78 4.5 15.9 34.1 33.4 3.9 Arunachal Pradesh Total 2533 81.3 8.8 20.7 31.0 35.5 4.1
  • 13. 0 5 10 15 20 25 30 35 40 45 0-20 20-50 50-100 100-200 200+ Iodine (µg/L) %Samples Sikkim Meghalaya Arunachal Pradesh Urinary Iodine Distribution
  • 14. CONCLUSIONS •Household salt iodine content shows that the universal salt iodization programmme has been effectively implemented in the states studied •Iodine nutrition has improved markedly in Sikkim but UIE shows that iodine deficiency still exist. •Arunachal Pradesh is in a transition phase from iodine deficient to iodine sufficient nutrition while Meghalaya is on the verge of eradicating IDD • The region being environmentally deficient in iodine continuous monitoring of the salt iodization programme is warranted for eradication of IDD.
  • 15. The authors gratefully acknowledge: The Indian Council of Medical Research, New Delhi, for the Financial grant to carry out the study Dr M.Mohan Ram, Former Director, National Institute of nutrition, Hyderabad for initiating me into this project. The respective state governments of Sikkim, Meghalaya and Arunachal Pradesh for providing local help and support during the survey Dr Kamala Krishnaswamy, Former Director, National Institute of Nutrition, Hyderabad, for the guidance and support provided during the study. Mrs K.L. Rao, Mr K. Mangthya, Mr Leelakanta Gogoi and Mr Rajib Gogoi for tirelessly carrying out the analysis. ACKNOWLEDGEMENTS