stem cells and its applicable techniques in egypt

1. Under Supervision:
Dr: Tahsin Shoala
Sahar Tarek Hadeer Saleh
Nourhan Fadel
Haidy Abd Elmonem
Eman Mohamed

2. DEFINITION
A cell that has the ability to continuously divide
and differentiate (develop) into various other kind(s)
of cells/tissues (Tuch, 2006).

3. CHARACTERISTICS
 Blank cells (unspecialized)
 Capable of dividing and renewing themselves
for long periods of time (proliferation and
renewal)
 Have the potential to give rise to specialized cell
types (differentiation).
-some organs, such as the gut and bone marrow,
stem cells divide to repair and replace worn out or
damaged tissues. In other organs, such as the
pancreas and the heart, stem cells only divide
under special conditions.

4. DIFFERENTIATION POTENCY

5. SOURCES OF STEM CELLS
1-Embryonic stem cells (ESCs)blastocyst
A- fetal (abortion)
B- post natal
• umbilical cord
• placenta
• Amniotic fluid (AF)
4- Adult stem cell
• Adipose tissue
• Bone marrow (BM)
• Dental bulb(teeth)
• Menstrual blood

6. MESENCHYMAL VS HEMATOPOIETIC STEM
CELLS
There are 2 sources where we can find both
mesenchymal and hemtopoietic stem cells:
1-Umbilical cord
2-Bone marrow

7. MAPCs: Multipotent adult progenitor cells;
HSCs: Hematopoietic stem cells; EPCs: Endothelial progenitor cells

8. POTENTIAL USES

9. SUCCESS RATES
A survey was conducted by Asia Stem Cell
Association (ASCA) in January 2013

10. PROMISE OF STEM CELL RESEARCH

11. TECHNIQUESRELEVANT
1- Cord blood- derived multi potent stem cell banking
 treating hematological diseases

12. 2- Bone marrow-derived multi potent stem
cell transplantation
 treating hematological diseases : leukemia &
Thalassemia

13. AVAILABILITY IN EGYPT
1- Bone marrow transplantation units(BMT).
• BMT - - Children's Cancer Hospital Egypt (CCHE
57357)
• BMT unit at the Nasser Institute.
• BMT unit at national cancer institute(NCI), Cairo
university

14. 2- CORD BLOOD BANKING
1- Cell Safe, Alexandria
2- Smart Cells, Cairo
3- Baby Cell Egypt
4- Cells4Life, Cairo
5- Cryo-Save, Cairo

15. ADVANTAGE
 provides medical benefits in therapeutic
cloning and regenerative medicine.
 discovering treatments of diseases including
Parkinson's disease and cancer
Limbs and organs could be grown in a lab from
stem cells
help scientists to learn about human growth
and cell development.

16.  Scientists will be able to test millions of
potential drugs and medicine, without the use
of animals or human testers.
 Stem cell research benefits the study of
development stages that cannot be studied
directly in a human embryo, which sometimes
are linked with major clinical consequences
such as birth defects, pregnancy-loss, and
infertility
CONT.

17. DISADVANTAGE
 using of embryonic stem cells involves the
destruction of blastocysts formed from
laboratory-fertilized human eggs, the blastocyst
is a human life and to destroy it is immoral and
unacceptable (Ethical Issues).
 unknown long-term effects of such an
interference with nature could materialize.
 Carcinogenicity, (cause teratoma)
 Immunorejection .

18. Using stem cells is a power for science but
ethical issues of embryonic stem cells leads
to many restrictions of using it ..
Adult stem cells are widely used today
instead of embryonic and achieve great
success in the world of cell therapy. Such as:
Garvit Goel (2 year- old boy) was one of the
unlucky children diagnosed with Thalassemia
Major. He did successful stem cell
transplantation from adult Indian donor.
CONCLUSION