This document summarizes a study that examined the oral microbial pathogens isolated in newly diagnosed HIV positive patients in Dakar, Senegal. 57 newly diagnosed HIV patients were included in the study. Their CD4 counts, viral loads, and oral examinations were performed. Samples found the most common microbial pathogens were Pseudomonas, Klebsiella, and Proteus. An inverse correlation was found between CD4 count and viral load. The frequency of oral lesions and microbial isolates increased with higher viral loads. 70% of patients had CD4 counts below 500. The study concludes maintaining a low oral microbial load is important for preventing opportunistic infections in HIV patients.
Malaria is still considered globally as a leading cause of morbidity with Nigeria carrying the highest burden of 19%. Coinfection of malaria and Human Immunodeficiency Virus (HIV) accelerate disease progression of HIV/AIDS subjects. This study investigated the prevalence and predictors of malaria among HIV infected subjects attending the antiretroviral therapy Clinic at Federal the Medical Centre, Keffi, Nigeria. After ethical clearance, 200 whole blood specimens were collected from patients who gave informed consent and completed a self-structured questionnaire. The specimens were examined for malarial parasite using rapid kits and microscopy. The overall prevalence of the infection was 78/200 (39.0%). The prevalence was higher in male (44.7%) than female (34.0%) subjects. Those subjects aged < 20 years (54.5), male gender (44.7%), non-formal education holders (61.5%), farmers (62.5%), stream water users (48.1%), those that lives in rural setting (43.6%), those that do not use Insecticides Treated Nets (ITNs) (39.4%) and swampy environment dwellers (41.7%) were identified predictors for malaria infection in the area. All the predictors studied did not show any statistically significant difference with the infection but some arithmetic difference exists (P > 0.05). The 39.0% prevalence of malaria in HIV infected subjects is a public health concern. Therefore, Public health surveillance and health education among HIV population should be advocated to help eradicate malaria comes 2030. Further study that will characterize the genes of the parasite should be carried out.
Brucellosis is an infectious debilitating, acute or sub-acute febrile illness usually marked by an intermittent or remittent fever accompanied by malaise, anorexia and prostration, and which, in the absence of specific treatment, may persist for weeks or months. The aim of this study was to determine the relationship between Socio-Demography Characteristics and prevalence of brucellosis among community members in Kenya. A case of Mandera East Sub-county, Mandera County, Kenya. The study was descriptive cross sectional study which collected both qualitative and quantitative data from where a sample of 420 respondents was systematically selected from heads of 2,617 households form Mandera East Sub-county. The study instruments included questionnaire, Focus Group Discussion guide and Interview Guide. Blood samples were screened for brucellosis using Rose Bengal Plate Test (RBPT) and the positive sera were subjected through Serum Slow Agglutination Test (SSAT) which acted as a confirmatory test. Data was analyzed using SPSS Version 20 and results of the study presented in frequencies and percentages in Tables and Figures. Ethical issues were observed and consent sought from the respondents. Rose Bengal Plate Test (RBPT) indicated a prevalence of 24.8% (95% CI: 20.0–29.6) and Serum Slow Agglutination Test (SSAT) indicated that the prevalence was at 14.3% (95% CI: 8.7–19.9) among the respondents. The study showed that the seroprevalence was higher among the male respondents (98%; n=103) as detected through RBPT and (98%; n=57) confirmed through SSAT. There was significant relationship between the gender and seroprevalence as tested through RBPT (P<0.001).
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
Malaria is still considered globally as a leading cause of morbidity with Nigeria carrying the highest burden of 19%. Coinfection of malaria and Human Immunodeficiency Virus (HIV) accelerate disease progression of HIV/AIDS subjects. This study investigated the prevalence and predictors of malaria among HIV infected subjects attending the antiretroviral therapy Clinic at Federal the Medical Centre, Keffi, Nigeria. After ethical clearance, 200 whole blood specimens were collected from patients who gave informed consent and completed a self-structured questionnaire. The specimens were examined for malarial parasite using rapid kits and microscopy. The overall prevalence of the infection was 78/200 (39.0%). The prevalence was higher in male (44.7%) than female (34.0%) subjects. Those subjects aged < 20 years (54.5), male gender (44.7%), non-formal education holders (61.5%), farmers (62.5%), stream water users (48.1%), those that lives in rural setting (43.6%), those that do not use Insecticides Treated Nets (ITNs) (39.4%) and swampy environment dwellers (41.7%) were identified predictors for malaria infection in the area. All the predictors studied did not show any statistically significant difference with the infection but some arithmetic difference exists (P > 0.05). The 39.0% prevalence of malaria in HIV infected subjects is a public health concern. Therefore, Public health surveillance and health education among HIV population should be advocated to help eradicate malaria comes 2030. Further study that will characterize the genes of the parasite should be carried out.
Brucellosis is an infectious debilitating, acute or sub-acute febrile illness usually marked by an intermittent or remittent fever accompanied by malaise, anorexia and prostration, and which, in the absence of specific treatment, may persist for weeks or months. The aim of this study was to determine the relationship between Socio-Demography Characteristics and prevalence of brucellosis among community members in Kenya. A case of Mandera East Sub-county, Mandera County, Kenya. The study was descriptive cross sectional study which collected both qualitative and quantitative data from where a sample of 420 respondents was systematically selected from heads of 2,617 households form Mandera East Sub-county. The study instruments included questionnaire, Focus Group Discussion guide and Interview Guide. Blood samples were screened for brucellosis using Rose Bengal Plate Test (RBPT) and the positive sera were subjected through Serum Slow Agglutination Test (SSAT) which acted as a confirmatory test. Data was analyzed using SPSS Version 20 and results of the study presented in frequencies and percentages in Tables and Figures. Ethical issues were observed and consent sought from the respondents. Rose Bengal Plate Test (RBPT) indicated a prevalence of 24.8% (95% CI: 20.0–29.6) and Serum Slow Agglutination Test (SSAT) indicated that the prevalence was at 14.3% (95% CI: 8.7–19.9) among the respondents. The study showed that the seroprevalence was higher among the male respondents (98%; n=103) as detected through RBPT and (98%; n=57) confirmed through SSAT. There was significant relationship between the gender and seroprevalence as tested through RBPT (P<0.001).
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
Prevalence of Cryptosporidiosis Among Selected Group of Sudanese Patients by Mosab Nouraldein Mohammed Hamad in Advancements in Bioequivalence & Bioavailability
Clinical Epidemiological Study of Secondary Syphilis - Current Scenarioiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Bacteria Isolated From the Cerebrio-Spinal Fluid (Csf) of Suspected Cases of ...iosrjce
IOSR Journal of Nursing and health Science is ambitious to disseminate information and experience in education, practice and investigation between medicine, nursing and all the sciences involved in health care. Nursing & Health Sciences focuses on the international exchange of knowledge in nursing and health sciences. The journal publishes peer-reviewed papers on original research, education and clinical practice.
By encouraging scholars from around the world to share their knowledge and expertise, the journal aims to provide the reader with a deeper understanding of the lived experience of nursing and health sciences and the opportunity to enrich their own area of practice. The journal publishes original papers, reviews, special and general articles, case management etc.
Malaria parasitaemia and socioeconomic status of selected residents of Emohua...IOSRJPBS
In Nigeria, malaria consistently ranks among the five most common cause of death in children. This study investigated the prevalence of malaria and socioeconomic status of someresidents of Emohua Community, Rivers State, Nigeria.Following ethical clearance which was obtained from the University of Port Harcourt and the parents of the subjects who gave their written consents, blood samples were collected through vein puncture from 200 subjects within the age 0-17years, from July 2014-February 2015. Structured questionnaire were administered to the subjects and parents provided answers for younger children.Thick and Thin films were examined microscopically using oil immersion objective following the standardparasitological method. The thin films were fixed with methanol and all films were stained with 10% Giemsa stain diluted with 7.2 buffer water for 10 minutes. The demographic characteristics of 200 subjects examined in Emohua showed that 120(60%) were females and 60(40%) were males. Sex related prevalence showed that more females were infected with 66(62.3%) and had higher parasite density of 144720/ul than males with 40 (37.7%) and parasite density of 106160/ul though the difference was not significant (P>0.05). Out of the 200 subjects examined, 106(53.0%) were positive for Plasmodium falciparum. Age related prevalence showed that subjects within the age 0-3years and 4-6years had higher prevalence of 62 (31%) followed by those within the age 7-9years with 31(15.5%) and the least with zero prevalence was within the age 16-18 years. Those within the age of 4-6years had higher parasite density of 71680/ul followed by 0-3years of age with parasite density of 63360/ul while those within the age 16-18yrs had none (0). The difference in prevalence of malaria in relation to age was significant (P<0.05).>0.05). Subjects that used treated net were more with 117(58.5%), followed by those that do not use net at all with 54(27%) and those whose nets were untreated with 28(14%). Only 1(0.5%) person believed in the potency of prayer as a preventive measure against malaria while none trusted environmental sanitation. Subjects that are non- net users had higher prevalence of 46(85.2%) and more parasite density of 98080/ul followed by the untreated net users with 22(78.6%) and parasite density of 77280/ul while the least prevalence was recorded among the treated net users with 38(32.5%) and parasite density of 75520/ul. The differences in prevalence of infection in relation to preventive measures was significant (P<0.05).more><0.05).There is need to improve socio-economic status and awareness for total compliance to preventive measures among the subjects so as to reduce the malaria prevalence rate to the desired zero level
Prevalence of Cryptosporidiosis Among Selected Group of Sudanese Patients by Mosab Nouraldein Mohammed Hamad in Advancements in Bioequivalence & Bioavailability
Clinical Epidemiological Study of Secondary Syphilis - Current Scenarioiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Bacteria Isolated From the Cerebrio-Spinal Fluid (Csf) of Suspected Cases of ...iosrjce
IOSR Journal of Nursing and health Science is ambitious to disseminate information and experience in education, practice and investigation between medicine, nursing and all the sciences involved in health care. Nursing & Health Sciences focuses on the international exchange of knowledge in nursing and health sciences. The journal publishes peer-reviewed papers on original research, education and clinical practice.
By encouraging scholars from around the world to share their knowledge and expertise, the journal aims to provide the reader with a deeper understanding of the lived experience of nursing and health sciences and the opportunity to enrich their own area of practice. The journal publishes original papers, reviews, special and general articles, case management etc.
Malaria parasitaemia and socioeconomic status of selected residents of Emohua...IOSRJPBS
In Nigeria, malaria consistently ranks among the five most common cause of death in children. This study investigated the prevalence of malaria and socioeconomic status of someresidents of Emohua Community, Rivers State, Nigeria.Following ethical clearance which was obtained from the University of Port Harcourt and the parents of the subjects who gave their written consents, blood samples were collected through vein puncture from 200 subjects within the age 0-17years, from July 2014-February 2015. Structured questionnaire were administered to the subjects and parents provided answers for younger children.Thick and Thin films were examined microscopically using oil immersion objective following the standardparasitological method. The thin films were fixed with methanol and all films were stained with 10% Giemsa stain diluted with 7.2 buffer water for 10 minutes. The demographic characteristics of 200 subjects examined in Emohua showed that 120(60%) were females and 60(40%) were males. Sex related prevalence showed that more females were infected with 66(62.3%) and had higher parasite density of 144720/ul than males with 40 (37.7%) and parasite density of 106160/ul though the difference was not significant (P>0.05). Out of the 200 subjects examined, 106(53.0%) were positive for Plasmodium falciparum. Age related prevalence showed that subjects within the age 0-3years and 4-6years had higher prevalence of 62 (31%) followed by those within the age 7-9years with 31(15.5%) and the least with zero prevalence was within the age 16-18 years. Those within the age of 4-6years had higher parasite density of 71680/ul followed by 0-3years of age with parasite density of 63360/ul while those within the age 16-18yrs had none (0). The difference in prevalence of malaria in relation to age was significant (P<0.05).>0.05). Subjects that used treated net were more with 117(58.5%), followed by those that do not use net at all with 54(27%) and those whose nets were untreated with 28(14%). Only 1(0.5%) person believed in the potency of prayer as a preventive measure against malaria while none trusted environmental sanitation. Subjects that are non- net users had higher prevalence of 46(85.2%) and more parasite density of 98080/ul followed by the untreated net users with 22(78.6%) and parasite density of 77280/ul while the least prevalence was recorded among the treated net users with 38(32.5%) and parasite density of 75520/ul. The differences in prevalence of infection in relation to preventive measures was significant (P<0.05).more><0.05).There is need to improve socio-economic status and awareness for total compliance to preventive measures among the subjects so as to reduce the malaria prevalence rate to the desired zero level
Bovine tuberculosis: Occupational hazard in Abattoir workersiosrjce
IOSR Journal of Dental and Medical Sciences is one of the speciality Journal in Dental Science and Medical Science published by International Organization of Scientific Research (IOSR). The Journal publishes papers of the highest scientific merit and widest possible scope work in all areas related to medical and dental science. The Journal welcome review articles, leading medical and clinical research articles, technical notes, case reports and others.
Evaluation factors contributing to the treatment default by tuberculosis pati...PUBLISHERJOURNAL
Tuberculosis (TB) is one of the biggest public health problem and now ranks alongside Human Immunodeficiency Virus (HIV) as the world’s leading infectious cause of death. Globally, patient compliance with anti-TB therapy estimated as low as 40% in developing countries, remains the principle cause of treatment failure. The aim of this study was to establish the factors contributing to treatment default by Tuberculosis patients at ART clinic in Ishaka Adventist Hospital, Bushenyi District. A cross-sectional and descriptive study which employed both qualitative and quantitative approach of data collection were used. The study was conducted in ART clinic at Ishaka Adventist Hospital, Bushenyi District and it took a period of four weeks. A purposive sampling technique was used to select the study participants. Results showed that out of 38 study participants, majority 26 (68%) were of age 30 years and above. A large proportion 24 (63%) of the participants were unemployed compared to the least 14 (37%) who were employed. Majority 21 (55%) travel at a distance of 10km and above to get TB treatment. Out of 38 participants, majority 26 (68%) did not informed the family or friends when they were on TB treatment. Of 26 participants 16 (61.5%) had fear of being isolated and 2 (7.7%) were other reason of no support. A large proportion of participants rated the attitude of staff who attended to them at the health facility to be unfriendly with 21 (55%) while very few 6 (16%) were rude. The ministry should ensure availability of and access to resources for strengthening systems for delivery of quality tuberculosis treatment, prevention and control.
Keywords: treatment, default, tuberculosis, ART, Uganda
Evaluation factors contributing to the treatment default by tuberculosis pati...PUBLISHERJOURNAL
Tuberculosis (TB) is one of the biggest public health problem and now ranks alongside Human Immunodeficiency Virus (HIV) as the world’s leading infectious cause of death. Globally, patient compliance with anti-TB therapy estimated as low as 40% in developing countries, remains the principle cause of treatment failure. The aim of this study was to establish the factors contributing to treatment default by Tuberculosis patients at ART clinic in Ishaka Adventist Hospital, Bushenyi District. A cross-sectional and descriptive study which employed both qualitative and quantitative approach of data collection were used. The study was conducted in ART clinic at Ishaka Adventist Hospital, Bushenyi District and it took a period of four weeks. A purposive sampling technique was used to select the study participants. Results showed that out of 38 study participants, majority 26 (68%) were of age 30 years and above. A large proportion 24 (63%) of the participants were unemployed compared to the least 14 (37%) who were employed. Majority 21 (55%) travel at a distance of 10km and above to get TB treatment. Out of 38 participants, majority 26 (68%) did not informed the family or friends when they were on TB treatment. Of 26 participants 16 (61.5%) had fear of being isolated and 2 (7.7%) were other reason of no support. A large proportion of participants rated the attitude of staff who attended to them at the health facility to be unfriendly with 21 (55%) while very few 6 (16%) were rude. The ministry should ensure availability of and access to resources for strengthening systems for delivery of quality tuberculosis treatment, prevention and control.
Keywords: treatment, default, tuberculosis, ART, Uganda
Prevalence of Intestinal Parasitic Infections among Patients Attended to Alri...CrimsonpublishersCJMI
Prevalence of Intestinal Parasitic Infections among Patients Attended to Alribat University hospital, Khartoum State, Sudan, 2017 by Mohammed HMN in Cohesive Journal of Microbiology & Infectious Disease
A Serological Survey of Human Parainfluenza Viruses (HPIVs) among Children in...iosrjce
This study was done to carry out a survey of Human Parainfluenza Virus in children aged 1-12years
in Kaduna Metropolis, Nigeria using the Enzyme Linked Immunosorbent Assay Diagnostic kits. Of the 376
samples tested for IgG antibody of HPIV 1, 2 and 3, 288 were seropositive (76.6%). Risk and demographic
factors such as age of the children parental occupation, parental educational status, vitamin A deficiency,
frequency of eating, household size, duration of breastfeeding, environmental smoke, respiratory symptoms,
fever, sickle cell and underlying diseases were analysed. Age (χ2=17.408, p=0.001), parental occupation
(χ2=10.116, p=0.039), duration of breastfeeding (χ2=8.439, p=0.015), presence of respiratory symptoms
(χ2=5.116, p=0.024) were significantly associated with the infection. Observation from the study showed the
importance of Human Parainfluenza Virus as an agent of respiratory tract infection in children. As antiviral
drugs are not readily available, preventive measures should be adhered to in the control of the infection.
33.Vohra P, Jamatia K, Subhada B, Tiwari RVC, Althaf MN, Jain C. Correlation of CD4 counts with oral and systemic manifestations in HIV patients. J Family Med Prim Care. 2019 Oct;8(10):3247-3252. doi: 10.4103/jfmpc.jfmpc_767_19. eCollection 2019 Oct. PubMed PMID: 31742150; PubMed Central PMCID: PMC6857402.
Vohra P, Jamatia K, Subhada B, Tiwari RV, Althaf MS, Jain C. Correlation of CD4 counts with oral and systemic manifestations in HIV patients. J Family Med Prim Care 2019;8:3247-52.
Incidence of Tuberculosis in HIV Sero-positive Patients at HIV Clinic at Kamp...PUBLISHERJOURNAL
Incidence of Tuberculosis in HIV Sero-positive Patients at HIV Clinic at Kampala International University Teaching Hospital, Bushenyi District
Okello, Andrew
School of Allied Health Sciences Kampala International University-Western Campus
________________________________________
ABSTRACT
This study on the prevalence of TB among HIV sero-positive was carried at the HIV CLINIC of Kampala International University Teaching Hospital (KIUTH), Ishaka Bushenyi district. A retrospective cross-sectional study design was used to conduct this research. The study targeted all patients attending KIUTH HIV/TB clinic. A standard structured and semi-structured questionnaires were designed and pre-tested for validity and reliability at Kampala International University Teaching Hospital HIV/Tuberculosis clinic before being used for data collection. Data collection started by recruitment of qualified research assistants, appropriate training and orientation of the interviewers before the survey for example when reading the questions. Quantitative methods of data analysis was used in which data was presented in form of bar charts, graphs and tables. The prevalence of TB among HIV sero-positive patients attending HIV clinic at KIUTH stands at 8.06 per 100 participants. The study found that generally, people are aware about the modes of transmission of TB but there is still need for more awareness. Many patients are still not certain whether TB is curable in HIV patients. As seen from the above study, most of the people are not yet aware whether HIV goes hand in hand with tuberculosis. The prevalence of TB in HIV sero-positive attending HIV clinic at KIUTH is high. Generally, TB is affecting patients of all ages and most patients are still not aware if TB in HIV is curable. Most patients have a perception that all TB patients have HIV. Health workers in HIV clinic of KIU-TH should teach patients the modes of transmission and prevention of TB. KIUTH also need to provide easy access to TB screening services to patients. There is need for financial support by the government to the unemployed patients and low-income earners in order to curb TB infections.
Keywords: Tuberculosis, HIV, Sero-positive, Bushenyi District
________________________________________
Tarannum Yasmin1*, Krishan Nandan2
1Associate Professor, Department of Microbiology, Katihar Medical College Katihar, Bihar, India
2Assistant Professor, Department of Microbiology, Katihar Medical College Katihar, Bihar, India
*Address for Correspondence: Dr Tarannum Yasmin, Associate Professor, Department of Microbiology, Katihar
Medical College, Katihar, Bihar, India
Received: 15 September 2016/Revised: 03 October 2016/Accepted: 22 October 2016
ABSTRACT- INTRODUCTION- HIV/AIDS pandemic is responsible for the resurgence of Tuberculosis worldwide,
resulting in increased morbidity and mortality. Co-infection with HIV infection leads to difficulty in both the diagnosis
and treatment of Tuberculosis, increased risk of death, treatment failure and relapse.
OBJECTIVE- The present study highlights the correlation of Pulmonary Tuberculosis in HIV positive cases and its
association with CD4 count.
MATERIAL & METHODS- A total of 72 known case of HIV were screened for tuberculosis infection by clinical
examination, radiology & ZN staining.
RESULTS AND CONCLUSIONS- From our study 60 (83.33%) were diagnosed as tuberculosis and 12 (16.67%) were
negative. More common HIV infection in case of male 48 (66.67%). Out of 60 tuberculosis infection 53 (88.33%) were
diagnosed as Pulmonary Tuberculosis and 7 (11.67%) were diagnosed as Extrapulmonary Tuberculosis. The result of
study emphasizes that co-infection of tuberculosis in HIV/AIDS patient is a concern. There is direct correlation between
CD4 counts depletion and Pulmonary Tuberculosis in HIV/AIDS patients.
Key-words- Pulmonary Tuberculosis, HIV, AIDS, CD4 count
Congenital Agenesis Of The Corpus Callosum With Intracerebral Lipoma And Fron...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
“Hemodynamic and recovery profile with Dexmedetomidine and Fentanyl in intrac...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Correlation of Estrogen and Progesterone Receptor expression in Breast Canceriosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Analytical Study of Urine Samples for Epidemiology of Urinary Tract Infection...iosrphr_editor
The current study was carried out in District Abbottabad aimed to determine the common urinary
tract infections in local community to determine the epidemiology of significant diseases in asymptomatic patients
of renal disorder. In this study a total of 1000 urine samples were examined during 3rd February to 1st April 2015
from patients attending Ayub Teaching Hospital Abbottabad by using dipstick and microscopic analysis of urine.
There were 638 females and 362 males patients examined during this period. The range of age groups is between
1.5 years to 80 years. Results of this study was reported as Pyuria 11%, Proteinuria 21.1%, Hematuria 10.4%,
Epithelial Cells 8.2%, pH 7.8 %, Granular casts 7.3%, Triple phosphate 6.6%, Calcium oxalate 6.4%, Glycosuria
6.3%, Bacteria 6.2% and mucous 4.1%. This study concludes that routing urinalysis should be performed for all
individuals to diagnose the asymptomatic diseases that will help in simple therapeutic measurements as urinalysis
is a simple step to determine the root of Urinary tract disorders.
Chest sonography images in neonatal r.d.s. And proposed gradingiosrphr_editor
BACKGROUND : Lung sonography has been used to monitor the patients of R.D.S. in
N.I.C.U. in recent times.
AIMS : To Describe and Grade the changes of R.D.S. by lung sonography.
SETTING & DESIGN : Tertiary care institutional set up in a rural medical college.
STUDY DURATION : September 2014 to May 2015. Follow-up variable, upto 2 weeks.
PROSPECTIVE, ANALYTICAL STUDY.
MATERIALS AND METHODS -This was a single institute study approved by the institutional ethics
committee. Prior informed consent was obtained from the parents. 100 consecutive patients admitted in
N.I.C.U. WITH gestational age < 36 weeks with respiratory complaints were enrolled. Chest x-ray was
obtained within few hours of admission and lung sonography was performed within 24 hours. Follow – up
sonography was performed as and when necessary. Sonography image was graded and correlated with chest
xray and clinical picture
The Comprehensive Review on Fat Soluble Vitaminsiosrphr_editor
This review article deals with brief description of fat soluble vitamins with figures and tables
showing statistical analytical data duly quoting the references wherever necessary. The word “soluble” actually
means “able to be dissolved.” Whether a vitamin is classified as 'fat-soluble' or 'water-soluble' has to do with
how the vitamin is absorbed, stored and removed from the body. Vitamins are tiny organic compounds with a
huge impact on the health and well-being of the body. The body needs a small amount of fat soluble vitamins in
order to stay in optimal health. Fat soluble vitamins play an important role in keeping the body healthy and
functioning from immune system and muscle and heart function, easy flow and clotting of blood as well as eye
health. They are critical to health and wellness–particularly reproductive health and wellness. Low-fat, no-fat
and vegan diets are woefully lacking in fat soluble vitamins. However a diet based on traditional foods can
naturally provide these vitamins. Science is still learning about many of the functions of vitamins. "Too much
vitamin A, D, or K can lead to increased levels that are unhealthy and can cause serious health consequences.
Diseased conditions leading to decreased fat absorption leads to decreased absorption of vitamins. The fatsoluble
vitamins work most safely and effectively when obtained them from natural foods within the context of a
diet rich in all their synergistic partners. If fat soluble vitamins are stored for lengthy time they generate threat
for toxicity than water soluble vitamins and such situation even aggravated, provided they are consumed in
excess. Vitamin products, above the legal limits are not considered food supplements and must be registered as
prescription or non-prescription (over-the-counter drugs) due to their potential side effects. Vitamin A and E
supplements do not provide health benefits for healthy individuals, instead they may enhance mortality, and it is
held proved that beta-carotene supplements can be harmful to smokers
Sulphasalazine Induced Toxic Epidermal Necrolysis A Case Reportiosrphr_editor
Toxic Epidermal Necrolysis (TEN) is a rare and life threatening mucocutaneous reaction
characterized by extensive necrosis and detachment of epidermis. The Worldwide incidence of TEN is 0.9 to 1.4
per million populations per year [1]. Here we have discussed a case of Toxic Epidermal Necrolysis secondary
to Sulfasalazine managed with fluid replacement, analgesics, anti-infective therapy aggressive nutritional
support and intravenous high dose steroid therapy.
Keywords- Toxic Epidermal Necrolysis, Sulfasalazine
Evaluation the efficacy of IVIgG in treatment of Hemolytic Disease of Newborniosrphr_editor
Hemolytic disease of newborn (HDN) is an important cause of hyperbilirubinemia in the
neonatal period,and delayed diagnosis and treatment may lead to permanent brain damage. Traditional
neonatal treatment of HDN is intensive phototherapy and exchange transfusion.Intravenous
immunoglobulin(IVIgG) has been introduced as an alternative therapy to exchange transfusion. This study was
conducted to assess the effect of IVIG in HDN .
FIBROLIPOMATOUS HAMARTOMA OF ULNAR NERVE: A RARE CASE REPORT.iosrphr_editor
Nervous fibrolipomatous hamartoma is said to be a rare tumor-like condition involving the peripheral
nerves,in which the epineurium and perineurium are enlarged and distorted by excess of fatty and fibrous tissue
s that infiltrate between and around nerve boundaries. The median nerve is more likely to develop a hamartoma
than other nerves with a predilection for the carpal tunnel.
A fibrolipomatous hamartoma – is a rare, benign, congenital lesion most commonly found in the median nerve,
usually at the level of the wrist or hand.
We report a case of this rare condition in ulnar nerve.
SELF MEDICATION PRACTICES FOR ORAL HEALTH PROBLEMS AMONG DENTAL PATIENTS IN B...iosrphr_editor
Introduction: Self‑ medication is commonly practiced all over the world. Self-medication is defined as the use
of medication by a patient on his own initiative or on the advice of a pharmacist or a lay person instead of
consulting a medical practitioner. The present study was aimed to estimate the prevalence of self-medication for
oral health problems among dental patients in Bengaluru city; to identify triggering factors that could influence
self-medication practices; to identify sources of medications used; to identify sources of information about
medications used; and to identify reasons for self-medication.Study Design: A Cross sectional Study.Methods:A
survey was conducted among 175 subjects among dental patients in Bengaluru city. Data were collected
through a specially designed proforma using a closed‑ ended, self‑ administered questionnaire containing 15
questions, in five sections.
Results: The prevalence of
Clinico-haematological Profile of Falciparum Malaria in a Rural Hospital of T...iosrphr_editor
Aim: To study the clinico-haematological profile malaria in a rural hospital of Tripura.
Material and methods: A cross-sectional hospital-based study was done from at Kulai District
Hospital,Tripura. This hospital based cross sectional study was done on 60 confirmed cases of falciparum
malaria (either by peripheral smear or rapid diagnostic test) admitted in Kulai District Hospital. A case sheet
proforma was prepared and data (demographic profile,clinical feature, investigation, treatment, and
complication) from all indoor patients was collected and analyzed.
Result: Out of 60 patients, 40(66.6%) were males and 20 (33.4%) were females. Most of the patients were
between the age group 21-40 years with the highest prevalence between the age group of 21-30. Fever was the
most common symptom. Anemia was present in 42(70%) patients, out of which 6(10%) patients had severe
anemia. Thrombocytopenia was present in 36(60%) patients.Abnormal liver function tests were observed in
26(43.3%) subjects while abnormal kidney function tests were observed in16(26.6%) patients. All the 60
patients received Artemisinin based antimalarial drugs.
Conclusion: Early detection, prompt management, and adequate supportive therapy may reduce mortality due
to falciparum cerebral malaria.
Indonesian Wild Ginger (Zingiber sp) Extract: Antibacterial Activity against ...iosrphr_editor
Lempuyang gajah (Zingiber zerumbet (L.) Smith), lempuyang pahit (Zingiber amaricans BL.), and
lempuyang wangi (Zingiber aromaticum Vahl.) are used as traditional medicine (jamu) in Indonesia. It is also
used for treatment of microbial infections, helps to increase appetite and stimulate digestion in chickens.
Information on their uses are available, but only limited in the scientific data on their bioactivity. The study was
conducted on the antibacterial effect of organic extracts of these plants with Mycoplasma gallisepticum as the
agent of chronic respiratory disease in chickens. Juice and extracts of fresh and dried rhizome are evaluated
through the disc diffusion assay and minimum inhibitory concentration. Oxytetracyclin (30 µg) are used as
standards. All extracts are individually exhibited as antibacterial activity against Mycoplasma gallisepticum (7
± 0.11 mm to 21 ± 0.86 mm). The minimum inhibitory concentration (MIC) determination of plants extracts are
ranged from 7.8 mg/ml to 31.2 mg/ml. The preliminary results suggested promising antibacterial properties of
wild ginger from Indonesia, and probably could be used in management of chronic respiratory disease in
chickens.
A case of allergy and food sensitivity: the nasunin, natural color of eggplantiosrphr_editor
Abstract: Allergies and food sensitivities can both be considered as "adverse reactions individualistic" to food.
Are pathological and individual forms because they affect a few individuals in way rather serious; immediate
or delayed reactions occur instead with simple effects histamine, or, in severe cases with respiratory and
anaphylactic shock
The eggplant (Solanum melongena L.) is known to cause food allergies in some Asian countries, but detailed
studies on allergies caused by eggplant are lacking, however, it was highlighted the presence of allergens in
edible parts of eggplant with preponderance in the peel .
The purpose of this study was to propose an extraction method rapid, efficient and cost of natural dye from
waste products from the food industry, such as the peels of eggplant, from which it was extracted, isolated and
purified the nasunin,a colored molecule in red-fuchsia.
Nasusin was tested on 58 patients to evaluate the potential sensitizing effect on the skin. The results demonstrate
that allergenic effects are negligible and therefore the nasunin can be used as a colorant in various industrial
sectors with a certain safety margin
Complete NMR Assignment of MogrosidesII A2, II E andIII A1Isolated from Luo H...iosrphr_editor
NMR analysis allowed complete assignments of three known mogrol glycosides, Mogroside IIA2 (1),
II E (2)and IIIA1 (3), isolated from the extracts of Luo Han Guo. Herein, complete 1H and 13C NMR
assignmentsof all threemogrosidesare described based on NMR experiments (1H NMR, 13C NMR, COSY,
HSQC-DEPT, HMBC, NOESY and 1DTOCSY) and mass spectral data.
Nanoemulsion and Nanoemulgel as a Topical Formulationiosrphr_editor
: Nanoemulsion is referred type of emulsion with uniform and extremely small droplet size in the range
of 20-200 nm. Nanoemulsion provides numerous advantages over other carrier such as polymeric nanoparticle
and liposomes, including low cost preparation procedure, high hydrophilic and lipophilic drug loading system
to enhance the longer shelf live upon preserving the therapeutic agents. Incorporating the preparation of
nanoemulsion with hydrogel matrix to produce nanoemulgel exhibited by the two separate systems that forming
it. Nanoemulgel possesses the properties of thixotropic, non-greasy, effortlessly spreadable, easily be removed,
emollient, not staining, soluble in water, longer shelf life, bio-friendly, translucent and agreeable appearance.
Pharmacokinetics of High-Dose Methotrexate in Egyptian Children with Acute Ly...iosrphr_editor
Aim:Since several factors have been shown to influence the clearance of methotrexate, the purpose of this study
was to identify potential relationships between patient covariates and the methotrexate clearance estimates and
deduce a pharmacokinetic model for the estimation of methotrexate clearance in Egyptian pediatric ALL
patients that may help dosage adjustment and achieve target steady-state plasma concentrations in a similar
sittings.
Patients and methods: A total of 94 pediatric patients with B-cell ALL, of whom 70 were the studied population
and 24 were the test population, were treated with four courses of HDMTX doses 2.5 gm/m2
(low-risk arm) or 5
gm/m2
(standard-/high-risk arm) given every other week by intermittent intravenous infusions over 24 hours as
a part of their treatment protocol. Patients were monitored for the 24 hour MTX concentration and the systemic
methotrexate clearance was calculated for each methotrexate dose
Epidemiology of Tuberculosis (TB) in Albania 1998-2009iosrphr_editor
Abstract : In Albania, many people erroneously think that tuberculosis (TB) is a disease of the past-an illness
that no longer constitutes a public health threat. Surveillance is an integral part of tuberculosis (TB) control.
Albania has a highTB notification rate and there are doubts about underreporting. The evolution of the
incidence of tuberculosis is presented, together with more detailed figures over the period 1998-2009. These
figures were obtained by the monthly forms (called 14/Sh) compared with the individual notification data.
Objective: To examine the distribution and sources of increased tuberculosis (TB) morbidity and reporting
system deficiencies in the Albania from 1998 through 2009. Metodology: The study is descriptive one conductet
during the period 1998-2009. The statistical analysis is based on data reported from regional level (regional
epidemiological departments) to the central level (Public Health Institute). Results: The main findings were:
discordance between the collected data (individual form) and reported data (monthly form); tuberculosis
incidence rate shows little oscillations which ranges from 6.67 to 9.2 cases/100.000 population; 50% of the
regions show a lack of information on the confirmation of diagnosis and laboratory examination type used for
confirmation. Conclusion: TB disease in high-risk populations where it is difficult to detect, diagnose, and treat;
limitations of current control measures and the need for new tests and treatments, including an effective
vaccine; improving information system, regulation of individual form and personnel training.
Total Phenol and Antioxidant from Seed and Peel of Ripe and Unripe of Indones...iosrphr_editor
Study on total phenol and antioxidantactivity ofsugar apple fruits of various solvent, part of fruits, and level of ripening. Solvent extraction used were 80% (v/v) methanol, 50% (v/v) acetone, boiling water, and 50% (v/v) ethanol. Part of fruits thatbeen used for samples were seed and peel which are normally by products of sugar apple processing, level of ripening were unripe, and ripe sugar apple fruits. Total phenol was determined by Folin-ciocalteau method. Total antioxidant was quantified by 1,1-diphenyl-2-picrylhydrazyl(DPPH) method.Therewas a difference in type of solvent, part of fruits, and level of ripeningon total phenol and antioxidant concentration of sugar apple fruits. Seeds have higher total phenol concentration than peels of this fruits. Unripe sugar apple fruits have higher total phenol and antioxidant than ripe fruit. The best solvent for phenol extraction was ethanol 50%butthe best solvent for antioxidant extraction was acetone 50%.
A Review on Step-by-Step Analytical Method Validationiosrphr_editor
When analytical method is utilized to generate results about the characteristics of drug related samples it is essential that the results are trustworthy. They may be utilized as the basis for decisions relating to administering the drug to patients. Analytical method validation required during drug development and manufacturing and these analytical methods are fit for their intended purpose. To comply with the requirements of GMP pharmaceutical industries should have an overall validation policy which documents how validation will be performed. The purpose of this validation is to show that processes involved in the development and manufacture of drug, production and analytical testing can be performed in an effective and reproducible manner. This review article provides guidance on how to perform validation characteristics for the analytical method which are utilized in pharmaceutical analysis.
A Cross Sectional Study of Ethnic Differences in Occurrence and Severity of A...iosrphr_editor
Non-steroidal anti-inflammatory drugs are the most widely used "over the counter" medication all over the world despite their complications in different major organs. Present studies envisaged for knowing the occurrence and severity of adverse drug reactions from NSAIDs in different ethnic communities of Sikkim. A cross sectional study was undertaken in the medicine outpatients department of a secondary and tertiary care hospital. The patients belonging to Nepalese, Bhutias, Lepchas ethnic communities and others community (settlers from other parts of India) were included to analyzed the data based on the age and gender, ethnicity and ADRs, drugs and ADRs. Severity assessment was done using Hartwing and Siegel scale and causality assessment by Naranjo scale. Total 109 cases of ADRs, predominating in female were detected. Nepalese were the most affected and Gastrointestinal tract (GIT) being the most affected organ in them. Diclofenac showed maximum number of ADRs in all the communities. Maximum number of cases occurred on single day use (40.36%) of drugs. All the cases were belonging to the "possible category" and the maximum being the mild (72.48%) in nature. It is advisable to consider the ethnic/racial differences equally with other factors, to improve the safety and efficacy of a drug.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
1. IOSR Journal of Pharmacy
Vol. 2, Issue 3, May-June, 2012, PP.509-511
Oral microbial pathogens isolates in newly diagnosed HIV positive
patients. A baseline survey of the sociale institute of health
and hygiene of Dakar.
P.G.Sow¹-²*,K.Toure 3 -4,M. Coume3-6,A.T. Dia3-5P.D.Diallo1-3,I.Traore1-6
1
Social institute of Health and hygiene of Dakar 2University of Bambey 3Cheikh AntaDiop University of Dakar
4
Hospital center of Fann 5Health Institute and development
6
Aristide le Dantec Hospital of Dakar-Bacteriology laboratory
Correspondence: Dr Papa gallo sow BP : 5856 Dakar- Fann /Sénègal
ABSTRACT
The subjects were evaluated in correlation of the CD4 count, viral load and types of oral microbes isolated and the
fungal infections in newly diagnosed patients with HIV infection prior to commencement of the highly active anti-retroviral
therapy (HAART).
Fifty – seven newly diagnosed HIV positive patients were included in this on going study. The CD4 count, viral load were
obtained. Oral examination was carried out and Buccal swabs was taken for Microscopy, Culture and Sensitivity. Males
were 14(24.6%) and 43(75.4%) were females. About 39% of the patients are within 30-39 years.The pattern of microbial
pathogens isolated were: Pseudomonas spp 16.5% , Klebsiella spp. 15.3% , Proteus spp. 12.9% Staphylococcus aureus in
12.9% Escherichia coli 9.40%, Candida albican 7.1%, Streptococcus faecalis 2.4%, Non Haemolytic streptococcus 2.4%
and Staphylococcus albus 21.2%. Concomitant tuberculosis infection was found in 3 patients .An inverse correlation was
noted between the CD4 count and the viral load, which was statistically significant. The frequency of the oral lesions and the
microbial isolates increased with high viral load. Seventy percent of the newly diagnosed HIV patients had CD4 counts less
than 500 mm3.
The reduction of the oral microbial load may decrease the incidence of opportunistic infection. Unmet oral health needs of
people living with HIV/AIDS have been consistently documented and finding new strategies for meeting these needs is
urgent.
Keywords: Viral load, CD4 count, Oral, Microbial isolates. HIV infection.
INTRODUCTION
Human Immune Deficiency Virus (HIV) infection is one of the most devastating infections in modern times. An
estimated 40.3 million HIV infections and 10 million AIDS cases have been reported worldwide. The brunt of the disease is
largely borne by communities in the sub Saharan Africa where an estimated 28 million people are living with HIV/AIDS
(UNAIDS/WHO,2010). Oral manifestations of HIV occur in approximately 30-80% of all affected patients, and the factors
which predispose to the expression of these lesions include; CD4 count (<200 cells/mm), viral load, xerostomia, poor oral
hygiene and smoking (EEC,1993). Although the commonest oral lesion is the opportunistic fungal infection (candidiasis),
‘normal’ microbial flora or commensals of the oral mucosa which are locked in the saliva, dental plague, gingival crevice,
tonsils and pharynx may become invasive or virulent as a result of weakened immune defenses (Patton,1994). With reduced
CD4 count in HIV infection, granulocytopenia occurs. When the value of the granulocytes falls below 500 cells/ml, and in
the presence of an attendant anatomical barrier damage that follows the viral infection, invasion of the bloodstream by
microorganisms is facilitated with resultant sepsis and death (Greenspan,1997).The periodontal tissues in the mouth provide a
potentially weak barrier through which bacteria and their toxins can enter the connective tissues and systemic circulation.
Therefore maintaining a low microbial load within the mouth should be seen as an essential component of preventive
treatment regime in HIV positive patients.
The aim of the study
The aim of this study is to correlate the CD4 count, viral load and types of oral microbes isolated in newly
diagnosed patients with HIV infection prior to commencement of the highly active anti-retroviral therapy (HAART).
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2. IOSR Journal of Pharmacy
Vol. 2, Issue 3, May-June, 2012, PP.509-511
Patients and Method
Fifty – seven newly diagnosed HIV positive patients were consecutively included in this on going study. The CD4
count and viral load were obtained. Oral examination was carried out on each patient by the principal investigator (VNO)
using the standard ‘examination set’ under adequate lightening. Buccal swab was taken and cultured directly into 10% Blood
agar, Chocolate agar and Macconkey agar, these plates were taken to Medical Microbiology Department for incubation for
24hrs at 37° C under a septic procedures that conforms with standard universal precautions .
RESULTS
The data obtained was analyzed using the SPSS version 12. There were 24.6% males and 75.4% female patients in
all. 38.6% patients were traders, 29.8% were artisans, 10.5% were civil servants and 5.3% were house wives. 75.4% patients
(male and female) were married. The CD4 count was found to be < 200 in 24.6%, 200 – 499 in 43.9% and > 500 in 22.8%.
Only 43 of the cases had results of the viral load documented. An inverse correlation was noted between the CD4 count and
the viral load, which was statistically significant. The most common oral lesion was Psuedomembranous candidiasis in
47.6%, Xerostomia in 14.3 %., Gingivitis in 13% and melanotic hyperpigmentation in 11.9%. The pattern of microbial
pathogens isolated were: Pseudomonas spp 16.5% , Klebsiella spp. 15.3% , Proteus spp. 12.9% Staphylococcus aureus in
12.9% Escherichia coli 9.40%, Candida albican 7.1%, Streptococcus faecalis 2.4%, Non Haemolytic streptococcus 2.4%
and Staphylococcus albus 21.2% (doubtful pathogens). The overall growth pattern showed 20% triple isolates, 40% multiple
isolates, 30% showed mono isolates and 10% yielded no growth. The frequency of the oral lesions as well as the microbial
isolates was found to increase with high viral load . In this study the most common systemic disease associated with HIV
infection was pulmonary tuberculosis, which was found in 3 cases.
DISCUSSION
To date, 300 different species of micro organisms are known to be associated with the oral cavity but only half of
the bacteria can be cultured. In health, the normal oral ecosystem is relatively stable in spite of its complexity (Duerden et al.,
1995) but many endogenous and exogenous factors may affect the composition and metabolic activities of the oral
microflora. The CD4 counts and viral loads are standard tools for monitoring the response to treatment and they are markers
of disease severity and progression in patients with HIV infection and AIDs.The principal cellular target of HIV infection is
the CD4 T-helper cells and the depletion of these cells is a central factor in the progression of HIV infection to AIDS as a
disease. This cellular immune dysfunction results in the inability of monocytes and macrophages to kill intracellular
pathogens effectively (Amsterdam ,1998) so that various opportunistic pathogens can produce infection in such instances.In
Senegal, the CD4 cell count in healthy individuals has been found to range from 636/mm 3 to 977/mm3. However, in
developed countries, the mean value of CD4 cell count in normal individuals ranges from 1000/mm 3 to 1100/mm3. The
relatively lower values in Senegal and probably in other Africa countries may be due to the constant exposure of inhabitants
in these countries to a large number of pathogens. (Marsh et al.,1992) When the presumably ‘normal’ oral microorganism
become invasive, they can establish infections at other sites remote from the mouth (e.g. infective endocarditis) and they may
also spread directly along tissue planes (e.g. cerebral abscess). Therefore, the delicate balance between the resident
commensal or ‘normal’ oral flora and the host must be maintained in healthy humans. (Olaleye et al.,2006)
In this study, 70% of the newly diagnosed HIV patients had CD4 counts less than 500 mm3 and a statistically significant
inverse correlation was observed between the CD4 count and viral load. The isolation of invasive and pathogenic microbes
such as Pseudomonas, Escherichia Coli, Klebsiella spp, Streptococcus faecalis and Staphylococcus aureus ( some of which
are predominantly colonic commensals and transitional bacteria) from the oral cavity may suggest the presence of depressed
immune status. Moreover, some patients in the bid to get well, usually visit the herbalist and spiritual houses for various
concoctions which are usually prepared in unhygienic situations The growth pattern that showed triple and double isolate also
reinforced that the patients were immune depressed . In Senegal the CD4 cell count in healthy individuals has been found to
range from 636 to 977/mm3 (Senegal Epidemiological fact sheet , 2004). However, in developed countries, the mean value of
CD4 cell count in normal individuals range from 1000 to 1100/mm3. The relatively lower values in Nigeria and probably in
other African countries may be due to the constant exposure of inhabitants in these countries to a large number of pathogens.
(Olaleye et al., 2006)
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3. IOSR Journal of Pharmacy
Vol. 2, Issue 3, May-June, 2012, PP.509-511
CONCLUSION
Oral health needs of people living with HIV/AIDs have been consistently documented and finding new strategies for
meeting these needs is urgent. Therefore the desire for prophylactic oral hygiene measures to reduce and if possible eliminate
these invasive microbial isolates and the incorporation of such in the holistic management of the HIV infected patients cannot
be compromised.
REFERENCES
[1]. Amsterdam (1998), Infections associated with immunodeficiency and immunosuppression. Topley
&Wilson’s Microbiology and microbial infections Volume 3. pp 9 th edition.
[2]. Duerden BI, Wade WG et al (eds) (1995) Medical and Dental Aspects of Anaerobes Science Reviews,
Northwood, 1-85.
[3]. EEC- Clearinghouse on Oral problems in HIV infection and WHO collaborating Center on Oral
manifestations of the immunodeficiency virus: An update of the classification and diagnostic criteria of oral
lesions in HIV infections. J Oral Pathol Med. 1993; 22: 289-291.
[4]. Greenspan JS(1997) Sentinels and signposts: The epidemiology and significance of the oral manifestation of
HIV disease. Oral Dis. (Suppl 1): S13-S17.
[5]. Marsh PD, Martin MV, (1992) Oral microbiology, 3 rd edn Chapman and Hall. London
[6]. Olaleye D.O, Tekena O Harry, Georgina N Odiabo(2006).The Virology and dynamics of the epidemic AIDS
in Nigeria; A nation on the threshold, pp 46.
[7]. Oral Health Care for people with HIV infections. HIV Clinical Guidelines for the
Primary care practitioner; New York State Department of Health AIDS Institute. December 2001
[8]. Patton LL(1994) Sensitivity, specificity and predictive value of oral opportunistic
infection in adults with HIV-related disease as markers for immune suppression and AIDS. Oral Surg.
Oral Pathol. 77 (4): 344-349
[9]. Senegal Epidemiological fact sheet N° 11, September 2004 UNAIDS/WHO Report on the global AIDS
Epidemic, May 2010
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