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International Journal of Scientific Research and E
ISSN: 2581-7175 ©IJSRED: All Rights are Reserved
The Carriage Rate of Neisseria Meningitides in Children 1
Years of Age, Khartoum State, Sudan, 2017
First Author:
Second
Abstract:
Background:
In the African meningitis belt devastating
Meningococcalepidemicsare important public
health problems. Sudan as one of the 26 countries
of the belt is not an exception, Neisseria
meningitides(Nm)is hosted only by humans and
transmission of the disease occurs usually through
close contact or by air-borne large respiratory
droplets from asymptomatic human carriers,
Thusstudying meningococcal carriage and human
to-human transmission is a key to contr
epidemic.
Objectives: To study the frequency of
colonization of Neisseria meningitidesisolated from
Healthy children of 1 to 15 years of age, in
Khartoum State, 2017.
Materials and Methods: This is a Cross
sectional community based study in Khartoum
Sudan. A total 824 of pharyngeal swabs were taken
from enrolled children using multi stage cluster
sampling technique during the non-seasonal period.
Laboratory tests were done using conventional PCR
to measure the overall carriage of Nm.
Results: The overall prevalence of Nm was
18.1 %,in 1to less than 5 years the prevalence was
18.2%, whileit was 23.5. %among 5
children.
RESEARCH ARTICLE
nal of Scientific Research and Engineering Development-– Volume 2 Issue 1, Jan
Available at
©IJSRED: All Rights are Reserved
The Carriage Rate of Neisseria Meningitides in Children 1
Years of Age, Khartoum State, Sudan, 2017
First Author: Mawahib S J Rashid,
Email : talentsforall@yahoo.com
Second Author: Abdelgader A Basheir
Email: abedelgadir50@yahoo.com
In the African meningitis belt devastating
Meningococcalepidemicsare important public
health problems. Sudan as one of the 26 countries
of the belt is not an exception, Neisseria
is hosted only by humans and
transmission of the disease occurs usually through
borne large respiratory
droplets from asymptomatic human carriers,
Thusstudying meningococcal carriage and human-
human transmission is a key to control the
To study the frequency of
colonization of Neisseria meningitidesisolated from
Healthy children of 1 to 15 years of age, in
This is a Cross-
sectional community based study in Khartoum state,
Sudan. A total 824 of pharyngeal swabs were taken
from enrolled children using multi stage cluster
seasonal period.
Laboratory tests were done using conventional PCR
The overall prevalence of Nm was
18.1 %,in 1to less than 5 years the prevalence was
18.2%, whileit was 23.5. %among 5-15 years
The PCR testing result for Nm carriage rate
among1-15, Khartoum state 2017
Conclusions: This was a high carriage rate fo
non-seasonal time, children aged 5 to 15 years
had a higher rate compared to less than 5 years
old.
Keywords: Neisseria meningitides,
Acknowledgment:
Great thanks to Dr Nada Gaffar Osman
Directorof Maternal and child health (MCH)
FMoH/ Sudan, andMrsEkhlasElgiely
Mohammed the Head of Planning and policy
Unit in National Expanded Program on
Volume 2 Issue 1, Jan-Feb 2019
Available at www.ijsred.com
Page 51
The Carriage Rate of Neisseria Meningitides in Children 1- 15
Years of Age, Khartoum State, Sudan, 2017
The PCR testing result for Nm carriage rate
15, Khartoum state 2017.
This was a high carriage rate for
seasonal time, children aged 5 to 15 years
ared to less than 5 years
Neisseria meningitides,carriage rate.
Great thanks to Dr Nada Gaffar Osman
Directorof Maternal and child health (MCH)
Sudan, andMrsEkhlasElgiely
Mohammed the Head of Planning and policy
Unit in National Expanded Program on
OPEN ACCESS
International Journal of Scientific Research and Engineering Development-– Volume 2 Issue 1, Jan-Feb 2019
Available at www.ijsred.com
ISSN: 2581-7175 ©IJSRED: All Rights are Reserved Page 52
Immunization (EPI) FMoH, Sudan for
supporting this study financially.
References:
1. World Health Organization. Control of
epidemic meningococcal disease: WHO
practical guidelines.
2. Borrow R. Advances with vaccination
against Neisseria meningitidis. Tropical
Medicine & International Health. 2012 Dec
1;17(12):1478-91.
3. Sow SO, Okoko BJ, Diallo A, Viviani S,
Borrow R, Carlone G, Tapia M, Akinsola
AK, Arduin P, Findlow H, Elie C.
Immunogenicity and safety of a
meningococcal A conjugate vaccine in
Africans. New England Journal of Medicine.
2011 Jun 16;364(24):2293-304.
4. Djingarey MH, Barry R, Bonkoungou M,
Tiendrebeogo S, Sebgo R, Kandolo D,
Lingani C, Preziosi MP, Zuber PL, Perea W,
Hugonnet S. Effectively introducing a new
meningococcal A conjugate vaccine in
Africa: the Burkina Faso experience.
Vaccine. 2012 May 30;30:B40-5.
5. Kristiansen PA, Diomandé F, Ba AK, Sanou
I, Ouédraogo AS, Ouédraogo R, Sangaré L,
Kandolo D, Aké F, Saga IM, Clark TA.
Impact of the serogroupA meningococcal
conjugate vaccine, MenAfriVac, on carriage
and herd immunity. Clinical infectious
diseases. 2012 Oct 19;56(3):354-63.
6. Massenet D, Vohod D, Hamadicko H,
Caugant DA. Epidemic meningococcal
meningitis, Cameroon. Emerging infectious
diseases. 2011 Nov;17(11):2070.
7. MenAfriCar Consortium. Meningococcal
carriage in the African meningitis belt.
Tropical medicine & international health:
TM & IH. 2013 Aug;18(8):968.
8. .MacNeil JR, Medah I, Koussoubé D,
Novak RT, Cohn AC, Diomandé FV,
Yelbeogo D, Kambou JL, Tarbangdo TF,
Ouédraogo-Traoré R, Sangaré L. Neisseria
meningitidisserogroup W, Burkina Faso,
2012. Emerging infectious diseases. 2014
Mar;20(3):394.
9. Kristiansen PA, Ba AK, Ouédraogo AS,
Sanou I, Ouédraogo R, Sangaré L, Diomandé F,
Kandolo D, Saga IM, Misegades L, Clark TA.
Persistent low carriage of serogroup A Neisseria
meningitidis two years after mass vaccination
with the meningococcal conjugate vaccine,
MenAfriVac. BMC infectious diseases. 2014
Dec 4;14(1):663.
10. Bårnes GK, Kristiansen PA, Beyene D,
Workalemahu B, Fissiha P, Merdekios B,
Bohlin J, Préziosi MP, Aseffa A, Caugant DA.
Prevalence and epidemiology of meningococcal
carriage in Southern Ethiopia prior to
implementation of MenAfriVac, a conjugate
vaccine. BMC infectious diseases. 2016 Nov
4;16(1):639.
11. Díaz J, Cárcamo M, Seoane M, Pidal P,
Cavada G, Puentes R, Terrazas S, Araya P,
Ibarz-Pavon AB, Manríquez M, Hormazábal JC.
Prevalence of meningococcal carriage in
children and adolescents aged 10–19 years in
Chile in 2013. Journal of infection and public
health. 2016 Aug 31;9(4):506-15.
12. Maïnassara HB, Paireau J, Idi I, Jusot JF,
Pelat JP, Oukem-Boyer OO, Fontanet A,
Mueller JE. Serogroup-Specific Characteristics
of Localized Meningococcal Meningitis
Epidemics in Niger 2002–2012 and 2015:
Analysis of Health Center Level Surveillance
Data. PloS one. 2016 Sep 22;11(9):e0163110.
13. Toneatto D, Pizza M, Masignani V,
Rappuoli R. Emerging experience with
International Journal of Scientific Research and Engineering Development-– Volume 2 Issue 1, Jan-Feb 2019
Available at www.ijsred.com
ISSN: 2581-7175 ©IJSRED: All Rights are Reserved Page 53
meningococcal serogroup B protein vaccines.
Expert Review of Vaccines. 2017 May
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14.Evans CM, Pratt CB, Matheson M, Vaughan
TE, Findlow J, Borrow R, Gorringe AR, Read
RC. Nasopharyngeal colonization by Neisseria
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against Neisseria meningitidis. Clinical
Infectious Diseases. 2011 Jan 1;52(1):70-7.

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IJSRED-V2I1P8

  • 1. International Journal of Scientific Research and E ISSN: 2581-7175 ©IJSRED: All Rights are Reserved The Carriage Rate of Neisseria Meningitides in Children 1 Years of Age, Khartoum State, Sudan, 2017 First Author: Second Abstract: Background: In the African meningitis belt devastating Meningococcalepidemicsare important public health problems. Sudan as one of the 26 countries of the belt is not an exception, Neisseria meningitides(Nm)is hosted only by humans and transmission of the disease occurs usually through close contact or by air-borne large respiratory droplets from asymptomatic human carriers, Thusstudying meningococcal carriage and human to-human transmission is a key to contr epidemic. Objectives: To study the frequency of colonization of Neisseria meningitidesisolated from Healthy children of 1 to 15 years of age, in Khartoum State, 2017. Materials and Methods: This is a Cross sectional community based study in Khartoum Sudan. A total 824 of pharyngeal swabs were taken from enrolled children using multi stage cluster sampling technique during the non-seasonal period. Laboratory tests were done using conventional PCR to measure the overall carriage of Nm. Results: The overall prevalence of Nm was 18.1 %,in 1to less than 5 years the prevalence was 18.2%, whileit was 23.5. %among 5 children. RESEARCH ARTICLE nal of Scientific Research and Engineering Development-– Volume 2 Issue 1, Jan Available at ©IJSRED: All Rights are Reserved The Carriage Rate of Neisseria Meningitides in Children 1 Years of Age, Khartoum State, Sudan, 2017 First Author: Mawahib S J Rashid, Email : talentsforall@yahoo.com Second Author: Abdelgader A Basheir Email: abedelgadir50@yahoo.com In the African meningitis belt devastating Meningococcalepidemicsare important public health problems. Sudan as one of the 26 countries of the belt is not an exception, Neisseria is hosted only by humans and transmission of the disease occurs usually through borne large respiratory droplets from asymptomatic human carriers, Thusstudying meningococcal carriage and human- human transmission is a key to control the To study the frequency of colonization of Neisseria meningitidesisolated from Healthy children of 1 to 15 years of age, in This is a Cross- sectional community based study in Khartoum state, Sudan. A total 824 of pharyngeal swabs were taken from enrolled children using multi stage cluster seasonal period. Laboratory tests were done using conventional PCR The overall prevalence of Nm was 18.1 %,in 1to less than 5 years the prevalence was 18.2%, whileit was 23.5. %among 5-15 years The PCR testing result for Nm carriage rate among1-15, Khartoum state 2017 Conclusions: This was a high carriage rate fo non-seasonal time, children aged 5 to 15 years had a higher rate compared to less than 5 years old. Keywords: Neisseria meningitides, Acknowledgment: Great thanks to Dr Nada Gaffar Osman Directorof Maternal and child health (MCH) FMoH/ Sudan, andMrsEkhlasElgiely Mohammed the Head of Planning and policy Unit in National Expanded Program on Volume 2 Issue 1, Jan-Feb 2019 Available at www.ijsred.com Page 51 The Carriage Rate of Neisseria Meningitides in Children 1- 15 Years of Age, Khartoum State, Sudan, 2017 The PCR testing result for Nm carriage rate 15, Khartoum state 2017. This was a high carriage rate for seasonal time, children aged 5 to 15 years ared to less than 5 years Neisseria meningitides,carriage rate. Great thanks to Dr Nada Gaffar Osman Directorof Maternal and child health (MCH) Sudan, andMrsEkhlasElgiely Mohammed the Head of Planning and policy Unit in National Expanded Program on OPEN ACCESS
  • 2. International Journal of Scientific Research and Engineering Development-– Volume 2 Issue 1, Jan-Feb 2019 Available at www.ijsred.com ISSN: 2581-7175 ©IJSRED: All Rights are Reserved Page 52 Immunization (EPI) FMoH, Sudan for supporting this study financially. References: 1. World Health Organization. Control of epidemic meningococcal disease: WHO practical guidelines. 2. Borrow R. Advances with vaccination against Neisseria meningitidis. Tropical Medicine & International Health. 2012 Dec 1;17(12):1478-91. 3. Sow SO, Okoko BJ, Diallo A, Viviani S, Borrow R, Carlone G, Tapia M, Akinsola AK, Arduin P, Findlow H, Elie C. Immunogenicity and safety of a meningococcal A conjugate vaccine in Africans. New England Journal of Medicine. 2011 Jun 16;364(24):2293-304. 4. Djingarey MH, Barry R, Bonkoungou M, Tiendrebeogo S, Sebgo R, Kandolo D, Lingani C, Preziosi MP, Zuber PL, Perea W, Hugonnet S. Effectively introducing a new meningococcal A conjugate vaccine in Africa: the Burkina Faso experience. Vaccine. 2012 May 30;30:B40-5. 5. Kristiansen PA, Diomandé F, Ba AK, Sanou I, Ouédraogo AS, Ouédraogo R, Sangaré L, Kandolo D, Aké F, Saga IM, Clark TA. Impact of the serogroupA meningococcal conjugate vaccine, MenAfriVac, on carriage and herd immunity. Clinical infectious diseases. 2012 Oct 19;56(3):354-63. 6. Massenet D, Vohod D, Hamadicko H, Caugant DA. Epidemic meningococcal meningitis, Cameroon. Emerging infectious diseases. 2011 Nov;17(11):2070. 7. MenAfriCar Consortium. Meningococcal carriage in the African meningitis belt. Tropical medicine & international health: TM & IH. 2013 Aug;18(8):968. 8. .MacNeil JR, Medah I, Koussoubé D, Novak RT, Cohn AC, Diomandé FV, Yelbeogo D, Kambou JL, Tarbangdo TF, Ouédraogo-Traoré R, Sangaré L. Neisseria meningitidisserogroup W, Burkina Faso, 2012. Emerging infectious diseases. 2014 Mar;20(3):394. 9. Kristiansen PA, Ba AK, Ouédraogo AS, Sanou I, Ouédraogo R, Sangaré L, Diomandé F, Kandolo D, Saga IM, Misegades L, Clark TA. Persistent low carriage of serogroup A Neisseria meningitidis two years after mass vaccination with the meningococcal conjugate vaccine, MenAfriVac. BMC infectious diseases. 2014 Dec 4;14(1):663. 10. Bårnes GK, Kristiansen PA, Beyene D, Workalemahu B, Fissiha P, Merdekios B, Bohlin J, Préziosi MP, Aseffa A, Caugant DA. Prevalence and epidemiology of meningococcal carriage in Southern Ethiopia prior to implementation of MenAfriVac, a conjugate vaccine. BMC infectious diseases. 2016 Nov 4;16(1):639. 11. Díaz J, Cárcamo M, Seoane M, Pidal P, Cavada G, Puentes R, Terrazas S, Araya P, Ibarz-Pavon AB, Manríquez M, Hormazábal JC. Prevalence of meningococcal carriage in children and adolescents aged 10–19 years in Chile in 2013. Journal of infection and public health. 2016 Aug 31;9(4):506-15. 12. Maïnassara HB, Paireau J, Idi I, Jusot JF, Pelat JP, Oukem-Boyer OO, Fontanet A, Mueller JE. Serogroup-Specific Characteristics of Localized Meningococcal Meningitis Epidemics in Niger 2002–2012 and 2015: Analysis of Health Center Level Surveillance Data. PloS one. 2016 Sep 22;11(9):e0163110. 13. Toneatto D, Pizza M, Masignani V, Rappuoli R. Emerging experience with
  • 3. International Journal of Scientific Research and Engineering Development-– Volume 2 Issue 1, Jan-Feb 2019 Available at www.ijsred.com ISSN: 2581-7175 ©IJSRED: All Rights are Reserved Page 53 meningococcal serogroup B protein vaccines. Expert Review of Vaccines. 2017 May 4;16(5):433-51. 14.Evans CM, Pratt CB, Matheson M, Vaughan TE, Findlow J, Borrow R, Gorringe AR, Read RC. Nasopharyngeal colonization by Neisseria lactamica and induction of protective immunity against Neisseria meningitidis. Clinical Infectious Diseases. 2011 Jan 1;52(1):70-7.