Prevalence and Predictors of Malaria Among HIV Infected Subjects Attending an Antiretroviral Therapy (ART) Clinic in a Tertiary Healthcare Facility in Central Nigeria
Malaria is still considered globally as a leading cause of morbidity with Nigeria carrying the highest burden of 19%. Coinfection of malaria and Human Immunodeficiency Virus (HIV) accelerate disease progression of HIV/AIDS subjects. This study investigated the prevalence and predictors of malaria among HIV infected subjects attending the antiretroviral therapy Clinic at Federal the Medical Centre, Keffi, Nigeria. After ethical clearance, 200 whole blood specimens were collected from patients who gave informed consent and completed a self-structured questionnaire. The specimens were examined for malarial parasite using rapid kits and microscopy. The overall prevalence of the infection was 78/200 (39.0%). The prevalence was higher in male (44.7%) than female (34.0%) subjects. Those subjects aged < 20 years (54.5), male gender (44.7%), non-formal education holders (61.5%), farmers (62.5%), stream water users (48.1%), those that lives in rural setting (43.6%), those that do not use Insecticides Treated Nets (ITNs) (39.4%) and swampy environment dwellers (41.7%) were identified predictors for malaria infection in the area. All the predictors studied did not show any statistically significant difference with the infection but some arithmetic difference exists (P > 0.05). The 39.0% prevalence of malaria in HIV infected subjects is a public health concern. Therefore, Public health surveillance and health education among HIV population should be advocated to help eradicate malaria comes 2030. Further study that will characterize the genes of the parasite should be carried out.
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
Washington Global Health Alliance Discovery Series
Supamit Chinsuttiwat
May 22, 2008
'Response to Avian Influenza and Preparedness for Pandemic Influenza: Thailand's Experience'
This was a prospective cross sectional hospital based study included 117 patients with a definitive history of snake bite and clinical features consistent with the pres¬ence of fang marks at the emergency department, Gadarif Hospital, Eastern Sudan from 1st January 2015 to 1st January 2016 to identify the epidemiological factors of snake bite. The majority of these 117 patients were adult (86.3%) and male gender constituted 85.4%. Most of the patients were of rural residence (65.8%) and were involved in farming related activities (68.3%). A relatively high proportion of snake bite episodes happened in the afternoon times (53.9%) and half of the cases were reported during August (18%) and November. (12.8%). Lower limbs were involved in maximum number of the cases (83.7%). The reported systemic reaction included: swelling (100%), sweating (100%), hypotension (54.7%), nausea (51.%), vomiting (47.8%), local bleeding (13.6%), hymoptysis (1.7%) and neurotoxic symptoms (0.8%). In this study, there were ten (8.5%) deaths; 7 had grade 3 and the other three patients had grade 4 envenomation. In conclusion Snake bites is a real medical threat in Eastern Sudan; thus, it is very important to educate the native people to increase awareness about the risk of snake bites in particular among male, farmers and during the period from August to November.
emerging and re-emerging vector borne diseasesAnil kumar
this presentation in about emerging and re-emerging vector borne diseases and their spatial spread with reference to time, surveillance, monitoring and management program and other difficulties and suggestions for program
The International Journal of Engineering & Science is aimed at providing a platform for researchers, engineers, scientists, or educators to publish their original research results, to exchange new ideas, to disseminate information in innovative designs, engineering experiences and technological skills. It is also the Journal's objective to promote engineering and technology education. All papers submitted to the Journal will be blind peer-reviewed. Only original articles will be published.
The papers for publication in The International Journal of Engineering& Science are selected through rigorous peer reviews to ensure originality, timeliness, relevance, and readability.
Washington Global Health Alliance Discovery Series
Supamit Chinsuttiwat
May 22, 2008
'Response to Avian Influenza and Preparedness for Pandemic Influenza: Thailand's Experience'
This was a prospective cross sectional hospital based study included 117 patients with a definitive history of snake bite and clinical features consistent with the pres¬ence of fang marks at the emergency department, Gadarif Hospital, Eastern Sudan from 1st January 2015 to 1st January 2016 to identify the epidemiological factors of snake bite. The majority of these 117 patients were adult (86.3%) and male gender constituted 85.4%. Most of the patients were of rural residence (65.8%) and were involved in farming related activities (68.3%). A relatively high proportion of snake bite episodes happened in the afternoon times (53.9%) and half of the cases were reported during August (18%) and November. (12.8%). Lower limbs were involved in maximum number of the cases (83.7%). The reported systemic reaction included: swelling (100%), sweating (100%), hypotension (54.7%), nausea (51.%), vomiting (47.8%), local bleeding (13.6%), hymoptysis (1.7%) and neurotoxic symptoms (0.8%). In this study, there were ten (8.5%) deaths; 7 had grade 3 and the other three patients had grade 4 envenomation. In conclusion Snake bites is a real medical threat in Eastern Sudan; thus, it is very important to educate the native people to increase awareness about the risk of snake bites in particular among male, farmers and during the period from August to November.
emerging and re-emerging vector borne diseasesAnil kumar
this presentation in about emerging and re-emerging vector borne diseases and their spatial spread with reference to time, surveillance, monitoring and management program and other difficulties and suggestions for program
The prevalence of tuberculosis and Rifampicin-resistant tuberculosis (RMP-TB) among patients showing symptoms of tuberculosis that visited Federal Medical Centre, Yenagoa, Bayelsa state, Nigeria was determined from June 2015 to December 2015. A total of 456 patients comprising 218(47.8%) males and 238(52.2%) females were examined using their sputum and gastric lavage samples. GeneXpert System was used to determine the TB and RMF-TB. Results showed that out of the 456 patients, overall tuberculosis prevalence was 88(19.3%), males recorded 48(10.5%) while females had 40(8.8%). The highest tuberculosis prevalence was recorded amongst 21-30 years and 31-40 years age groups (5.5%). Out of the 456 patients, total prevalence for Rifampicin resistance was 11(2.4%). Of these, females and male prevalence was 6(1.3%) and 5(1.1%) respectively. There was no significant difference (P>0.05) in prevalence between age and gender. The treatment and follow-up of existing cases is a key to preventing the spread of multi drug-resistant tuberculosis.
Module 1.1 An overview of emerging and re emerging infectious diseasesAdaora Anyichie - Odis
This module helps to understand the global trends of emerging & re-emerging infections and chronic diseases, identify the threats of diseases and develop desirable attitude and skill in planning to go for new treatment regimens and public health programs that substantially reduce and even prevent the spread of infections and promotion of public health
Malaria parasitaemia and socioeconomic status of selected residents of Emohua...IOSRJPBS
In Nigeria, malaria consistently ranks among the five most common cause of death in children. This study investigated the prevalence of malaria and socioeconomic status of someresidents of Emohua Community, Rivers State, Nigeria.Following ethical clearance which was obtained from the University of Port Harcourt and the parents of the subjects who gave their written consents, blood samples were collected through vein puncture from 200 subjects within the age 0-17years, from July 2014-February 2015. Structured questionnaire were administered to the subjects and parents provided answers for younger children.Thick and Thin films were examined microscopically using oil immersion objective following the standardparasitological method. The thin films were fixed with methanol and all films were stained with 10% Giemsa stain diluted with 7.2 buffer water for 10 minutes. The demographic characteristics of 200 subjects examined in Emohua showed that 120(60%) were females and 60(40%) were males. Sex related prevalence showed that more females were infected with 66(62.3%) and had higher parasite density of 144720/ul than males with 40 (37.7%) and parasite density of 106160/ul though the difference was not significant (P>0.05). Out of the 200 subjects examined, 106(53.0%) were positive for Plasmodium falciparum. Age related prevalence showed that subjects within the age 0-3years and 4-6years had higher prevalence of 62 (31%) followed by those within the age 7-9years with 31(15.5%) and the least with zero prevalence was within the age 16-18 years. Those within the age of 4-6years had higher parasite density of 71680/ul followed by 0-3years of age with parasite density of 63360/ul while those within the age 16-18yrs had none (0). The difference in prevalence of malaria in relation to age was significant (P<0.05).>0.05). Subjects that used treated net were more with 117(58.5%), followed by those that do not use net at all with 54(27%) and those whose nets were untreated with 28(14%). Only 1(0.5%) person believed in the potency of prayer as a preventive measure against malaria while none trusted environmental sanitation. Subjects that are non- net users had higher prevalence of 46(85.2%) and more parasite density of 98080/ul followed by the untreated net users with 22(78.6%) and parasite density of 77280/ul while the least prevalence was recorded among the treated net users with 38(32.5%) and parasite density of 75520/ul. The differences in prevalence of infection in relation to preventive measures was significant (P<0.05).more><0.05).There is need to improve socio-economic status and awareness for total compliance to preventive measures among the subjects so as to reduce the malaria prevalence rate to the desired zero level
Malaria Control Strategies among Rural Dwellers in a Typical Nigerian Settingasclepiuspdfs
Malaria is a major public health problem in sub-Saharan African, including Nigeria, causing 63% of total outpatient attendance in health facilities, 30% under-five mortality, and 11% of maternal mortality. Malaria control practices remain a major strategy in the combat of this menace. Therefore, the aim of this study is to determine the malaria control strategies utilized among rural dwellers in the Ezza North local government area (LGA) of Ebonyi state.
This study evaluated the prevalence of malaria parasite among pregnant and non pregnant women attending Federal Medical Centre (FMC) Owerri Imo State Nigeria within the age range of 21-50 years. The molecular identification and speciation of the malaria parasites were carried out using different diagnostic techniques. The blood samples were analyzed using microscopy, Rapid Diagnostic Test (RDT) and Polymerase Chain Reaction (PCR). Results using the microscopy for pregnant women was 181(90.5%) and for non pregnant women, it was 185(92.5%) within the age range of under 21, 41 and above. The result of RDT for pregnant women was 58(32.0%) and for non pregnant women were 46(24.9%). However, the age group of pregnant women that had the highest occurrence of malaria using microscopy was (21-25yrs) with 100% of persons tested positive and (41-45yrs) with 78.8% had the lowest occurrence. For non pregnant women, the age group that had the highest occurrence of malaria parasite was (31-35yrs) with 95.3%of persons reporting tested reporting positive while, (21-25yrs) with 84.6% had the lowest occurrence. Polymerase Chain Reaction (PCR) was used for the speciation of the parasites and the result revealed that Plasmodium falciparum in pregnant women within the ages of 46-50yrs had the highest (96.0%) prevalent followed by Plasmodium vivax for women within the ages of 21-25yrs had the highest (13.6%) occurrence, Plasmodium malariae for women within the ages 21-25yrs and had the highest (9.4%) occurrence. In this study, Polymerase Chain Reaction was very sensitive, takes more large samples at a time and specific for both P. falciparum and non falciparum Plasmodium infections and has many diagnostic advantages over microscopy. Out of 400 venous blood samples collected from both pregnant and non-pregnant women, 27 blood samples had mixed malaria parasite infections. Therefore, following this study, it will be recommended that we urge the pharmaceutical companies to improve on the manufacturing of broad-spectrum antimalarial drugs to cover all species of Plasmodium as it’s done with antimicrobials not only concentrating on the drugs for the treatment of P. falciparum alone.
Evaluation of the factors that contribute to high prevalence of malaria in HI...PUBLISHERJOURNAL
Evaluation of the factors that contribute to high prevalence of malaria in HIV Patients in Bushenyi District, Uganda
Kakuru James
Faculty of Nursing Sciences Kampala International University, Uganda.
________________________________________
ABSTRACT
Malaria remains the single main cause of ill health and death among HIV/AIDS patients in resource-poor countries worldwide. Malaria still remains a challenging infection affecting the lives of several HIV-infected persons in Uganda. Statistics from the Ministry of Health show that malaria is still the leading cause of death in Uganda, accounting for over 27% of deaths. Malaria prevalence in HIV-positive patients in Kyamuhunga Health Centre III is thought to be at 7.8% of the HIV-positive patients attending the clinic on a daily basis. This study therefore aimed at assessing the factors contributing to the high prevalence of malaria among HIV-positive patients attending the HIV Clinic at Kyamuhunga Health Centre III in Bushenyi District. The study covered a sample of eighty (80) respondents to gather primary data. A simple random sampling method was used to gather responses from patients. Questionnaires and an interview guide were used as data collection tools. Results indicated that the majority of the participants were female patients and malaria was dominant among HIV-positive patients aged 38-47 years. It was noted that the odds of having malaria also increased among patients with lower levels of education. It was also noted that more odds of having malaria were found among the majority of patients who were farmers and unemployed participants. Malaria infection was acquired with repeated exposure to malaria parasites especially for patients who did not use insecticide treated mosquito nets. It is noted that HIV-positive patients with malaria greatly acquired unbalanced immunity with relatively low CD4+ cell count and unbalanced hemoglobin levels, greatly affected by body pain and weakness, fever, headache, and variety issues of vomiting. Paracetamol, use of treated mosquito nets, clinical examination, and patient follow-up was shown to provide a beneficial effect in preventing malaria infection among HIV-positive patients. In conclusion, malaria infection is acquired from repeated exposure to malaria parasites especially for patients who did not use Treated mosquito nets which increased the susceptibility to new malaria infections among HIV-positive patients. The researcher, therefore, recommends that comprehensive health education, antiretroviral therapy, and malaria preventive materials such as insecticide-treated bed nets should be provided to reduce the prevalence of malaria among HIV-positive patients.
Keywords: Malaria, HIV patients, Treated mosquito nets, Antiretroviral therapy.
The prevalence of tuberculosis and Rifampicin-resistant tuberculosis (RMP-TB) among patients showing symptoms of tuberculosis that visited Federal Medical Centre, Yenagoa, Bayelsa state, Nigeria was determined from June 2015 to December 2015. A total of 456 patients comprising 218(47.8%) males and 238(52.2%) females were examined using their sputum and gastric lavage samples. GeneXpert System was used to determine the TB and RMF-TB. Results showed that out of the 456 patients, overall tuberculosis prevalence was 88(19.3%), males recorded 48(10.5%) while females had 40(8.8%). The highest tuberculosis prevalence was recorded amongst 21-30 years and 31-40 years age groups (5.5%). Out of the 456 patients, total prevalence for Rifampicin resistance was 11(2.4%). Of these, females and male prevalence was 6(1.3%) and 5(1.1%) respectively. There was no significant difference (P>0.05) in prevalence between age and gender. The treatment and follow-up of existing cases is a key to preventing the spread of multi drug-resistant tuberculosis.
Module 1.1 An overview of emerging and re emerging infectious diseasesAdaora Anyichie - Odis
This module helps to understand the global trends of emerging & re-emerging infections and chronic diseases, identify the threats of diseases and develop desirable attitude and skill in planning to go for new treatment regimens and public health programs that substantially reduce and even prevent the spread of infections and promotion of public health
Respiratory virus shedding in exhaled breath and efficacy of face masks
Similar to Prevalence and Predictors of Malaria Among HIV Infected Subjects Attending an Antiretroviral Therapy (ART) Clinic in a Tertiary Healthcare Facility in Central Nigeria
Malaria parasitaemia and socioeconomic status of selected residents of Emohua...IOSRJPBS
In Nigeria, malaria consistently ranks among the five most common cause of death in children. This study investigated the prevalence of malaria and socioeconomic status of someresidents of Emohua Community, Rivers State, Nigeria.Following ethical clearance which was obtained from the University of Port Harcourt and the parents of the subjects who gave their written consents, blood samples were collected through vein puncture from 200 subjects within the age 0-17years, from July 2014-February 2015. Structured questionnaire were administered to the subjects and parents provided answers for younger children.Thick and Thin films were examined microscopically using oil immersion objective following the standardparasitological method. The thin films were fixed with methanol and all films were stained with 10% Giemsa stain diluted with 7.2 buffer water for 10 minutes. The demographic characteristics of 200 subjects examined in Emohua showed that 120(60%) were females and 60(40%) were males. Sex related prevalence showed that more females were infected with 66(62.3%) and had higher parasite density of 144720/ul than males with 40 (37.7%) and parasite density of 106160/ul though the difference was not significant (P>0.05). Out of the 200 subjects examined, 106(53.0%) were positive for Plasmodium falciparum. Age related prevalence showed that subjects within the age 0-3years and 4-6years had higher prevalence of 62 (31%) followed by those within the age 7-9years with 31(15.5%) and the least with zero prevalence was within the age 16-18 years. Those within the age of 4-6years had higher parasite density of 71680/ul followed by 0-3years of age with parasite density of 63360/ul while those within the age 16-18yrs had none (0). The difference in prevalence of malaria in relation to age was significant (P<0.05).>0.05). Subjects that used treated net were more with 117(58.5%), followed by those that do not use net at all with 54(27%) and those whose nets were untreated with 28(14%). Only 1(0.5%) person believed in the potency of prayer as a preventive measure against malaria while none trusted environmental sanitation. Subjects that are non- net users had higher prevalence of 46(85.2%) and more parasite density of 98080/ul followed by the untreated net users with 22(78.6%) and parasite density of 77280/ul while the least prevalence was recorded among the treated net users with 38(32.5%) and parasite density of 75520/ul. The differences in prevalence of infection in relation to preventive measures was significant (P<0.05).more><0.05).There is need to improve socio-economic status and awareness for total compliance to preventive measures among the subjects so as to reduce the malaria prevalence rate to the desired zero level
Malaria Control Strategies among Rural Dwellers in a Typical Nigerian Settingasclepiuspdfs
Malaria is a major public health problem in sub-Saharan African, including Nigeria, causing 63% of total outpatient attendance in health facilities, 30% under-five mortality, and 11% of maternal mortality. Malaria control practices remain a major strategy in the combat of this menace. Therefore, the aim of this study is to determine the malaria control strategies utilized among rural dwellers in the Ezza North local government area (LGA) of Ebonyi state.
This study evaluated the prevalence of malaria parasite among pregnant and non pregnant women attending Federal Medical Centre (FMC) Owerri Imo State Nigeria within the age range of 21-50 years. The molecular identification and speciation of the malaria parasites were carried out using different diagnostic techniques. The blood samples were analyzed using microscopy, Rapid Diagnostic Test (RDT) and Polymerase Chain Reaction (PCR). Results using the microscopy for pregnant women was 181(90.5%) and for non pregnant women, it was 185(92.5%) within the age range of under 21, 41 and above. The result of RDT for pregnant women was 58(32.0%) and for non pregnant women were 46(24.9%). However, the age group of pregnant women that had the highest occurrence of malaria using microscopy was (21-25yrs) with 100% of persons tested positive and (41-45yrs) with 78.8% had the lowest occurrence. For non pregnant women, the age group that had the highest occurrence of malaria parasite was (31-35yrs) with 95.3%of persons reporting tested reporting positive while, (21-25yrs) with 84.6% had the lowest occurrence. Polymerase Chain Reaction (PCR) was used for the speciation of the parasites and the result revealed that Plasmodium falciparum in pregnant women within the ages of 46-50yrs had the highest (96.0%) prevalent followed by Plasmodium vivax for women within the ages of 21-25yrs had the highest (13.6%) occurrence, Plasmodium malariae for women within the ages 21-25yrs and had the highest (9.4%) occurrence. In this study, Polymerase Chain Reaction was very sensitive, takes more large samples at a time and specific for both P. falciparum and non falciparum Plasmodium infections and has many diagnostic advantages over microscopy. Out of 400 venous blood samples collected from both pregnant and non-pregnant women, 27 blood samples had mixed malaria parasite infections. Therefore, following this study, it will be recommended that we urge the pharmaceutical companies to improve on the manufacturing of broad-spectrum antimalarial drugs to cover all species of Plasmodium as it’s done with antimicrobials not only concentrating on the drugs for the treatment of P. falciparum alone.
Evaluation of the factors that contribute to high prevalence of malaria in HI...PUBLISHERJOURNAL
Evaluation of the factors that contribute to high prevalence of malaria in HIV Patients in Bushenyi District, Uganda
Kakuru James
Faculty of Nursing Sciences Kampala International University, Uganda.
________________________________________
ABSTRACT
Malaria remains the single main cause of ill health and death among HIV/AIDS patients in resource-poor countries worldwide. Malaria still remains a challenging infection affecting the lives of several HIV-infected persons in Uganda. Statistics from the Ministry of Health show that malaria is still the leading cause of death in Uganda, accounting for over 27% of deaths. Malaria prevalence in HIV-positive patients in Kyamuhunga Health Centre III is thought to be at 7.8% of the HIV-positive patients attending the clinic on a daily basis. This study therefore aimed at assessing the factors contributing to the high prevalence of malaria among HIV-positive patients attending the HIV Clinic at Kyamuhunga Health Centre III in Bushenyi District. The study covered a sample of eighty (80) respondents to gather primary data. A simple random sampling method was used to gather responses from patients. Questionnaires and an interview guide were used as data collection tools. Results indicated that the majority of the participants were female patients and malaria was dominant among HIV-positive patients aged 38-47 years. It was noted that the odds of having malaria also increased among patients with lower levels of education. It was also noted that more odds of having malaria were found among the majority of patients who were farmers and unemployed participants. Malaria infection was acquired with repeated exposure to malaria parasites especially for patients who did not use insecticide treated mosquito nets. It is noted that HIV-positive patients with malaria greatly acquired unbalanced immunity with relatively low CD4+ cell count and unbalanced hemoglobin levels, greatly affected by body pain and weakness, fever, headache, and variety issues of vomiting. Paracetamol, use of treated mosquito nets, clinical examination, and patient follow-up was shown to provide a beneficial effect in preventing malaria infection among HIV-positive patients. In conclusion, malaria infection is acquired from repeated exposure to malaria parasites especially for patients who did not use Treated mosquito nets which increased the susceptibility to new malaria infections among HIV-positive patients. The researcher, therefore, recommends that comprehensive health education, antiretroviral therapy, and malaria preventive materials such as insecticide-treated bed nets should be provided to reduce the prevalence of malaria among HIV-positive patients.
Keywords: Malaria, HIV patients, Treated mosquito nets, Antiretroviral therapy.
Modeling the Consequence of Multi Intervention Campaigns for the Spread of Ma...ijtsrd
This paper proposes and analyses a basic deterministic mathematical model to investigate Simulation for controlling malaria Diseases Transmission dynamics. The model has nine non linear differential equations which describe the control of malaria with two state variables for mosquitoes populations and five state variables for humans population and to introduce the new SPITR model for the transmission dynamics of malaria with four time dependent control measures in Ethiopia Insecticide treated bed nets ITNS , Treatments, Indoor Residual Spray IRs and Intermittent preventive treatment of malaria in pregnancy IPTP . The models are analyzed qualitatively to determine criteria for control of a malaria transmission dynamics, and are used to calculate the basic reproductionR 0. The equilibria of malaria models are determined. In addition to having a disease free equilibrium, which is globally asymptotically stable when the R 0 1, the basic malaria model manifest ones possession of a quality of the phenomenon of backward bifurcation where a stable disease free equilibrium co exists at the same time with a stable endemic equilibrium for a certain range of associated reproduction number less than one. The results also designing the effects of some model parameters, the infection rate and biting rate. The numerical analysis and numerical simulation results of the model suggested that the most effective strategies for controlling or eradicating the spread of malaria were suggest using insecticide treated bed nets, indoor residual spraying, prompt effective diagnosis and treatment of infected individuals with vaccination is more effective for children. Fekadu Tadege Kobe | Tigabu Abera Nune | Nuriye Hakima Kadiso "Modeling the Consequence of Multi-Intervention Campaigns for the Spread of Malaria" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd33048.pdf Paper Url :https://www.ijtsrd.com/mathemetics/applied-mathamatics/33048/modeling-the-consequence-of-multiintervention-campaigns-for-the-spread-of-malaria/fekadu-tadege-kobe
Genotypes and Associated Risk Levels of Human Papilloma Virus among Female Pa...IIJSRJournal
Background: Human papillomavirus is the main factor in the etiology of cervical cancer, with over 99.7% of cases being associated with high-risk human papillomavirus infection. Although the majority of HPV infections are asymptomatic and self-limiting, persistent HPV infection can result in genital warts, oropharyngeal cancer, and cervical cancer in women, in addition to various anogenital malignancies and other genital warts in both men and women.
Method: This was a cross-sectional descriptive study which employed a convenience sampling technique where both qualitative and quantitative methods were used for data collection. A total of 374 participants were enrolled in the study and a semi structured questionnaire was administered to collect socio-demographic, reproductive and sexual history data. Laboratory analysis involved detection of HPV DNA hybrids with a chemiluminescent substrate, Digene Hybrid Capture 2 technology. Descriptive and inferential (logistic regression) analyses at level of significant (α=0.05) were used to summarize the data, and results illustrated using charts and tables.
Results: The study findings reported a significant risk level of human papillomavirus among female of age group 40-49 years (AOR; 0.15, 95% CI: 0.03-0.79; p = 0.026). Furthermore, in bivariate logistic regression the circulating HPV genotypes among the respondents was significantly characterized among women of the same age group (95% CI; 0.09-0.7; p = 0.008) as well as in the multivariate regression (AOR = 0.13; 95% CI: 0.02-0.72; p = 0.019).
Conclusion: The study thus concluded that there is 23/94 (25.67%) risk of developing cervical cancer due to high risk level HPV (with the presence of low risk level HPV 71/94 (74.33%) known for causing various forms of warts. Therefore, there is need for combined efforts from the Ministry of health and stakeholders to avail and train health care workers on the usage of HPV DNA kits to ensure timely detection of low and high-risk levels HPV. This will ensure timely identification of women at increased risk for the development of cervical cancer, thereby reducing mortality rate.
Tarannum Yasmin1*, Krishan Nandan2
1Associate Professor, Department of Microbiology, Katihar Medical College Katihar, Bihar, India
2Assistant Professor, Department of Microbiology, Katihar Medical College Katihar, Bihar, India
*Address for Correspondence: Dr Tarannum Yasmin, Associate Professor, Department of Microbiology, Katihar
Medical College, Katihar, Bihar, India
Received: 15 September 2016/Revised: 03 October 2016/Accepted: 22 October 2016
ABSTRACT- INTRODUCTION- HIV/AIDS pandemic is responsible for the resurgence of Tuberculosis worldwide,
resulting in increased morbidity and mortality. Co-infection with HIV infection leads to difficulty in both the diagnosis
and treatment of Tuberculosis, increased risk of death, treatment failure and relapse.
OBJECTIVE- The present study highlights the correlation of Pulmonary Tuberculosis in HIV positive cases and its
association with CD4 count.
MATERIAL & METHODS- A total of 72 known case of HIV were screened for tuberculosis infection by clinical
examination, radiology & ZN staining.
RESULTS AND CONCLUSIONS- From our study 60 (83.33%) were diagnosed as tuberculosis and 12 (16.67%) were
negative. More common HIV infection in case of male 48 (66.67%). Out of 60 tuberculosis infection 53 (88.33%) were
diagnosed as Pulmonary Tuberculosis and 7 (11.67%) were diagnosed as Extrapulmonary Tuberculosis. The result of
study emphasizes that co-infection of tuberculosis in HIV/AIDS patient is a concern. There is direct correlation between
CD4 counts depletion and Pulmonary Tuberculosis in HIV/AIDS patients.
Key-words- Pulmonary Tuberculosis, HIV, AIDS, CD4 count
Malaria infection during pregnancy is a major public health problem- especially in tropical and sub-tropical regions; with substantial risks for the mother, her foetus and the new-born, Pregnant women are particularly susceptible to malaria, and in low transmission settings they have a greater risk of severe Plasmodium falciparum malaria. This study aimed at investigating the rate of parasitaemia amongst pregnant and none pregnant women was conducted among people attending clinics at the University of Calabar Teaching Hospital, Mambo hospital, Nosam medical laboratory services in Calabar Cross River state. They fall within the age group 18 to 60 years. They were pregnant women who came for Antenatal clinic, controls were sampled from patients who came to request for medical examination and blood donors. Thick and thin blood smears were made from finger prick samples of 400 candidates attending Antenatal clinics 200 of them were from established pregnant women and the other 200 were from non-pregnant women to serve as control. The blood films were dried and fixed in absolute methanol dried and stained with 2% Giemsa stain for 30 min. it was then rinse in clean water and allowed to dry in a draining rack. Dried slides were viewed using x100 oil immersion objective. Result revealed a parasitic rate of 132 (55.9 %) among pregnant women and104 (44.1%) parasitaemia among none pregnant women. The difference between pregnant women and none pegnant women were significantly different at p < 0.05. Similarly, the mean parasite density of the pregnant women was higher 28.9 against 14.2 of control none pregnant women. In conclusion there was a significant density of malaria parasitaemia amongst pregnant women in this study.
Knowledge of the Implementation of the Malaria Control Program in Four Health...YogeshIJTSRD
Malaria is one of the oldest diseases of mankind and has been the greatest scourge and killer of all times. Djam Chefor Alain | Ndale Wozerou Nghonjuyi | Njem Peter Kindong "Knowledge of the Implementation of the Malaria Control Program in Four Health Districts in Yaounde, Cameroon" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-3 , April 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38668.pdf Paper URL: https://www.ijtsrd.com/medicine/other/38668/knowledge-of-the-implementation-of-the-malaria-control-program-in-four-health-districts-in-yaounde-cameroon/djam-chefor-alain
The Prevalence of Cytomegalovirus among Eligible Blood Donors in Keffi, NigeriaConferenceproceedings
8th International Scientific Conference on Applied
Sciences and Engineering
2-3 April, 2016
Hotel Istana Kuala Lumpur City Centre, Kuala Lumpur, Malaysia
33.Vohra P, Jamatia K, Subhada B, Tiwari RVC, Althaf MN, Jain C. Correlation of CD4 counts with oral and systemic manifestations in HIV patients. J Family Med Prim Care. 2019 Oct;8(10):3247-3252. doi: 10.4103/jfmpc.jfmpc_767_19. eCollection 2019 Oct. PubMed PMID: 31742150; PubMed Central PMCID: PMC6857402.
Similar to Prevalence and Predictors of Malaria Among HIV Infected Subjects Attending an Antiretroviral Therapy (ART) Clinic in a Tertiary Healthcare Facility in Central Nigeria (20)
Carbon monoxide (CO) poisoning is a major public health issue in the United States that accounts for approximately 50% of poisoning cases in the nation each year and around 50,000 emergency room visits. In most instances of CO poisoning, the culprit is a malfunctioning or poorly tended heating system within the home or, occasionally, commercial building, which causes the system to leak this hazardous gas. One of the more insidious aspects of CO poisoning is that the gas is odorless and colorless, and victims of CO poisoning often do not realize that there is a problem until they begin to experience the effects of poisoning and have no choice but to seek medical attention. Unfortunately, many victims of CO poisoning die before they are able to seek treatment. This paper makes use of a qualitative, systematic literature review to examine the four major parts of the brain that are most severely affected by CO poisoning. Overall, the literature review showed that the white matter, globus pallidus, basal ganglia, and cortex are the parts of the brain most severely impacted by CO poisoning. While many CO poisoning victims do make it to the hospital on time and are treated, they may nonetheless suffer long-term neurological consequences as a result of their exposure. As such, CO poisoning is a major public health issue.
Drug abuse has now become a major public health problem in Nigeria requiring urgent attention. Although drug abuse cut across all age groups, the youths are however the most affected. This study aimed at assessing Community Pharmacists involvement in the rehabilitation of drug abuse victims. The study was carried out in Abuja Municipal Area Council, questionnaires were administered to Community Pharmacists practicing within the Area Council. A total of 176 Community Pharmacists participated in the study, and slightly above a quarter (27.43%) of them had post-graduate degrees. More than three-quarters (79.5%) of the study participants had received training on drug abuse. A total of 89.2% of the study participants had come across persons suspected to be abusing prescription medicines. Almost all (96.6%) of the study participants indicated that they are willing to advise persons suspected to be abusing drugs on the dangers of drug abuse, and 88.1% of the study participants had spoken to clients concerning abuse of prescription medicines. Also, more than three-quarters (80.1%) of the study participants indicated that pharmacists’ role in the prevention of drug abuse is very important. The study has revealed that Community Pharmacists can play an invaluable role in the rehabilitation of drug abuse victims in Nigeria.
Background; Social Class has shown relation with admissions at Emergency Departments. To assess whether there is a relationship between the level of triage and the social class of patients who attend the emergency department and whether there are other variables that can modulate this association. Methods Observational study with 1000 patients was carried out between May and July 2018 in the Emergency Department of the University Hospital Arnau de Vilanova in Lleida. Sociodemographic variables such as age, gender, country of origin and marital status were analyzed. The triage level and the main explanatory variable was social class. Social class was calculated based on the CSO-SEE 2012 scale. Results 49.4% were male and the average age was 51.7 years. Most of the patients (66.6%) attended the emergency department under their own volition and the most common triage levels were level III or Emergency (45%). There is a significant relationship between age and triage level. The younger patients had a lower triage level (p <0.001). The percentage of patients with lower social class who attended the emergency department for minor reasons was 42% higher compared to the rest of the patients (RR = 1.42; 1.21-1.67 95% CI, p <0.001). Conclusions; Patients with a lower socioeconomic class go to the Emergency Department for less serious pathologies.
This paper will explore child health care and treatment seeking behavior of villagers and presents factors that discourage them from using public health facilities. The perspective of human health is not only stay behind in the contact between the disease and the human body and the extermination of the demon by providing few medicines rather it is a complex web where multiple factors are affecting human to live a sound life. The environment has a diverse effect on human life: some indulge humans with it extravaganza while some impose serious theaters but one thing in common, every environment shares basic problems of acquiring and allocating space, food, energy and resources for health. Haor people have endless problems to meet, starting from food to basic human rights. Maintaining a healthy life does end up with some formality of going to some popular and folk treatment though going to professionals is rare. Government and non-Governmental organizations have a variety of scope to improve the situation by providing health infrastructure, awareness building measures, eradicating superstition and including health education in the school curriculum.
Objective: The purpose of this paper is to review literature on music and biomarkers of stress in order to (1) Identify music interventions and (2) Detail the biomarkers of stress associated with music. Methods: PRISMA guidelines were followed in performing this systematic review. Studies published from January 1995 to January 2020 that pertain to biomarkers of stress and music were identified through the use of the PubMed database, using the keywords: ‘music’ AND ‘biomarker’ OR ‘marker’ OR ‘hormone’. Two authors independently conducted a focused analysis and reached a final consensus on 16 studies that met the specific selection criteria and passed the study quality checks. Results: The reviewed studies were all randomized controlled trials. Reviewed music interventions included Music Listening (ML), Meditational Music (MM), ‘Guided Imagery and Music’ (GIM), and Singing. The studies showed that music is associated with a decreasing trend in cortisol, salivary α-amylase, heart rate, and blood pressure, as well as an increasing trend in Immunoglobulin A (IgA), oxytocin, and EEG theta wave, while testosterone was associated with sex-related differences. Conclusion: Music is associated with significant changes in biomarkers of stress, suggesting that it could be utilized for the development of stress reduction tools.
Background: Nurse practitioners play a vital role in wound care and management because of the prevalence of wounds in the community and hospital setting. Aims and objectives: The purpose was to identify current knowledge and practices of nurses with respect to wound management. Method: A qualitative descriptive research was designed, nineteen nurses in wound care wards in Bingham University teaching hospital were recruited into this study. This was achieved with the aid of a self-administered questionnaire for a two-week period. Results: Three groups of nurses responded to this survey (73.7% males; 31.6% aged 31-40 years). Registered nurses dominated (68.4%), majority of them worked in male ward (36.8%) and private ward (36.8%). Almost on full-time (94.7%), more than half were diploma holders (57.9%) with 1 to 5 years of experience (47.4%). Majority (84.2%) were involved in wound treatment and management, there were significant association between years of experience and wound classification, wound treatment, treatment failure and treatment failure factors. Conclusion: Wound care practices require accurate knowledge and assessment skills, a better understanding of wound management provides comprehensible, rapid patient wound care and minimizes patient mortality as well as reduces health services financial costs.
Background: Job satisfaction is a significant indicator of the way nurses feel about their profession, the efforts to perform their professional duties, or otherwise abandons it willingly. Method: cross-sectional research design approach was used to assess the job satisfaction and the associated factors among 300 hundred nurses. Data was analyzed using descriptive statistics and kruskal wallis test for association between the socio-demographic variables and job satisfaction at significance level of 0.05 Result: About 1/3 of the respondents (31%) reported gross dissatisfaction with their job, 0% reported being well satisfaction while (68.7%) respondents reported moderate satisfaction with their job. Across items on the scale, gross dissatisfaction was noted on key managerial factors and the salary of the workers. Job satisfaction was associated with specialty (p<0.018), gender (P<0.002) and age (P<0.000) of Nurses. Conclusion: majority of the respondents were moderately satisfied with their job but grossly dissatisfied with salary and administrative roles like communication flow.
Viral infections have always been of major concern in communities, health care settings and medical fields including radiotherapy and Radiology. Recently corona virus infection has attained global attention in the wake of covid-19 outbreak and consequently highlighted importance of viral prevention, diagnostic and therapeutic strategies to control and treat viral disease. In view of the recent events, the author reviewed the current and past literature to discuss contagious versus infectious viral transmission, as well as simple and effective ways of preventing the spread of viral diseases in community and health care setting so that this information can be used for preventing viral transmission at all levels. The article is written for a wide variety of audiences i.e. scientific and medical communities policy makers and general public.
The Coronavirus Disease – 2019 (COVID-19) is officially now a pandemic and not just a public health emergency of international concern as previously labelled. Worldwide, the new coronavirus has infected more than 4.9 million people and leaving more than 300,000 people dead in 188 countries. As countries of the world get locked down in an effort to contain the widespread of the virus, experts are concern about the global impacts of the pandemic on individuals, countries and the world at large. Millions of people are currently under quarantine across the globe. Many countries have responded by proclaiming a public health emergency, closed their borders and restrict incoming flights from high risk countries. This has grossly affected the travel plan of many. Several international programs, conferences, workshops and sporting activities are either postponed or cancelled. As the number of confirmed cases continues to escalate across the globe, hospitals seems to be running out of medical supplies, hospital spaces and personnel. Health workers are being overwhelmed by the numbers of people requesting for testing and treatment. Many of such health workers have been infected with the coronavirus and even lost their lives since the fight against COVID-19 started. Public health experts are also concerned about the huge medical wastes coming from the hospitals at this time and the adverse effects associated with improper management of such medical wastes, both at the hospital and community levels. The pandemic has also impacted negatively on the global economy. There have been serious crises in the stock market, with gross fall in the price of crude oil resulting in inflation and economic hardship among the populace. Many are currently out of job and as a result, the level of crime, protest and violence have continued to escalate in different parts of the world. The deaths of loved ones due to the coronavirus has left many emotionally traumatized. Nigeria, like other African countries is not spared of the ravaging effects of the pandemic, even as the government take strict measures to contain the virus. No doubt, this is very challenging, but the country is capable of surmounting the virus with the needed help from her international partners and cooperation from the citizenry. But if we as a people, remain complacent and continue with business as usual, without taking measures to flatten the curve, the disease will escalate too quickly beyond our capacity to handle and our health system will be overwhelmed and may collapse eventually. We cannot therefore afford to be complacent in our response to containing the pandemic.
Purpose: To investigate the effect of sulfur dioxide on the lung microbiota of healthy rats. Methods Fifteen male rats were randomly divided into high dose and low dose exposure group and control group. After 7 days of SO2 exposure, the lung tissues were obtained and the lung microbiota was identified by Illumina high-throughput sequencing. Results The microbial community of lung microbiota was significantly alternated in the exposure group and the dominant phylum changed from Firmicutes to Proteobacteria. In addition, the SO2 exposure caused the bronchial wall thickening and a large number of inflammatory cell infiltration in the lungs of rats in exposure groups. Conclusions The results suggest that SO2 can significantly alter the lung microbiota and pathological structure of the lungs.
A mathematical model to eliminate malaria by breaking the life cycle of anopheles mosquito using copepods at larva stage and tadpoles at pupa stage was derived aimed at eradicating anopheles pupa mosquito by introduction of natural enemies “copepods and tadpoles” (an organism that eats up mosquito at larva and pupa stage respectively). The model equations were derived using the model parameters and variables. The stability analysis of the free equilibrium states was analyzed using equilibrium points of Beltrami and Diekmann’s conditions for stability analysis of steady state. We observed that the model free equilibrium state is stable which implies that the equilibrium point or steady state is stable and the stability of the model means, there will not be anopheles adult mosquito in our society for malaria transmission. The ideas of Beltrami’s and Diekmann conditions revealed that the determinant and trace of the Jacobian matrix were greater than zero and less than zero respectively implying that the model disease free equilibrium state is stable. Hence, the number of larva that transforms to pupa is almost zero while the pupa that develop to adult is zero meaning the life-cycle is broken at the larva and pupa stages with the introduction of natural enemy. Maple was used for the symbolic and numerical solutions.
Spindle cell neoplasms usually occur in head, neck, orbit, soft tissues of scalp and along the upper aerodigestive tract. They are relatively uncommon in lower gastrointestinal tract and represent a distinct clinical entity. Increased awareness is required among colorectal surgeons and pathologists due to their benign nature & uncertain etiology, to avoid misdiagnosis of rectal cancer. Definitive diagnosis necessitates immunohistochemical analysis. We present an unusual case of spindle cell neoplasm of rectum in an asymptomatic elderly gentleman, detected on screening colonoscopy. Following thorough evaluation with MRI pelvis, CT scan thorax, abdomen, pelvis with contrast and multidisciplinary meeting discussion (MDT) at our institution, he was successfully treated with a specialized minimally invasive approach (TAMIS). Histopathology with immunohistochemistry confirmed the diagnosis of spindle cell neoplasm. As they are uncommon in colorectum & non-invasive, management and long-term follow-up is still under study. These lesions should be differentiated from other stromal tumours in GIT.
Brucellosis is an infectious debilitating, acute or sub-acute febrile illness usually marked by an intermittent or remittent fever accompanied by malaise, anorexia and prostration, and which, in the absence of specific treatment, may persist for weeks or months. The aim of this study was to determine the relationship between Socio-Demography Characteristics and prevalence of brucellosis among community members in Kenya. A case of Mandera East Sub-county, Mandera County, Kenya. The study was descriptive cross sectional study which collected both qualitative and quantitative data from where a sample of 420 respondents was systematically selected from heads of 2,617 households form Mandera East Sub-county. The study instruments included questionnaire, Focus Group Discussion guide and Interview Guide. Blood samples were screened for brucellosis using Rose Bengal Plate Test (RBPT) and the positive sera were subjected through Serum Slow Agglutination Test (SSAT) which acted as a confirmatory test. Data was analyzed using SPSS Version 20 and results of the study presented in frequencies and percentages in Tables and Figures. Ethical issues were observed and consent sought from the respondents. Rose Bengal Plate Test (RBPT) indicated a prevalence of 24.8% (95% CI: 20.0–29.6) and Serum Slow Agglutination Test (SSAT) indicated that the prevalence was at 14.3% (95% CI: 8.7–19.9) among the respondents. The study showed that the seroprevalence was higher among the male respondents (98%; n=103) as detected through RBPT and (98%; n=57) confirmed through SSAT. There was significant relationship between the gender and seroprevalence as tested through RBPT (P<0.001).
The Matrix metalloproteinase-9 is involved in several pathologies. Its strong presence in ocular pathologies explains our interest for its genetic variation in cataract, glaucoma and retinoblastoma in Senegal. MMP9 is highly polymorphic with cataract and glaucoma. 77 mutations were noted with 21 haplotypes for the entire population. The haplotype diversity Hd is 0.831 and the nucleotide diversity Pi is 0.016; k = 17.395. The polymorphism of the Matrix metalloproteinase-9 gene is associated with all three diseases and SNP 3918249 is found in both cataract and glaucoma.
This paper proposes the development of a software that performs the pre-diagnosis of malignant melanoma, spincellular carcinoma and basal-cell carcinoma. The software is divided into five modules, these being: digital imaging, analysis and processing, storage, feature extraction and classification by means of an Artificial Neural Network (ANN). The results shown the performance of the software for two different combination of activation functions in the network. With the use of spectroscopic techniques for the acquisition of images and the combination of non-linear and linear activation functions in the ANN, the software shows an effectiveness greater than 80%, concluding that it can be an effective tool as an aid in the diagnosis of cancer of skin.
Background: Tuberculous meningitis is defined as an inflammatory response to mycobacterial bacterial infection of the pia, arachnoid and CSF of the subarachnoid space. It is a dangerous form of extrapulmonary tuberculosis because it can cause permanent neurological disabilities and even death. Stroke is a devastating complication which further increase the morbidity and mortality in the disease. Matrix metalloproteinases are endopeptidases which degrade all the components of the extracellular matrix and thus have potential to disrupt blood brain barrier and cause CNS damage. Matrix metalloproteinases have been associated with pathophysiology of ischemic stroke. MMP levels in serum and CSF have also been seen to rise with advancing stage of TBM. So it is postulated that MMP may have role in the pathophysiology of stroke in TBM and may serve as a biomarker to predict stroke in TBM. Aims: To compare Serum Matrix metalloproteinase-9 in patients with Tuberculous Meningitis with and without Stroke and correlate it with various clinical, biochemical and radiological features of TBM. Methods: 40 Patients of probable or definite TBM and 40 age and sex matched patients of TBM with clinical stroke were enrolled in the study and formed two groups i.e. cases and controls. The two groups were compared for various clinical parameters, biochemical parameters (CSF cytology, glucose and protein), neuroimaging parameters and serum MMP-9 levels. Serum MMP-9 was estimated by ELISA method. Results: Serum MMP-9 levels were (224 ± 261.627 ng/ml) in cases and (157.23 ± 197.155 ng/ml) controls, which though higher in cases but no difference was statistically significant (p value 0.157) between two groups. Also there was no correlation between the serum MMP-9 levels and various clinical features (duration of illness, fever, headache, vomiting, weight loss, seizure, hemiparesis), CSF characteristics (protein, sugar and cytology) and radiological findings (tuberculoma, and hydrocephalus). Conclusion: we conclude that MMP-9 levels is not correlated with occurrence of stroke in TBM. MMP-9 levels were not increased with severity of disease, complications and outcomes.
Background: Maternal health remains today, one of the major public health concerns in developing countries. Maternal deaths and newborn deaths usually occur within 48 hours of delivery. In Cameroon, despite all the initiatives set up by the Ministry of Public Health to reduce the mortality rate, the situation remains alarming in terms of postnatal consultation; this is much more felt in the West region of Cameroon, which is one of the most affected regions because 43.1% of women who give birth in hospitals do not return to postnatal consultation and this rate is higher than the national average with a value of 21.5%. Objective:This work aims to determine the factors influencing postnatal follow-up in the Bafang Health District. Methodology: This is a cross-sectional descriptive study for analytical purposes, carried out in the Bafang Health District between January 1 to November 30, 2017. Our study population consisted of all women of childbearing age living in the Bafang Health District during the study period. The variables studied were sociodemographic characteristics, socio-cultural characteristics and the provision of care. Results: Analysis carried out during this study, it appears that, the person who informs the women on the dates of rendez-vous during the CPoN (OR = 2.92; [95%CI = 1.16-7,]; p-value = 0.02), women who think the appropriate period of postnatal follow-up is 6 weeks postpartum (OR = 4.27, [95%CI = 1.47-12.39], p-value = 0.00 ) and those who massage the abdomen after childbirth (OR = 2.62, [95%CI = 1.34 - 5.12], p-value = 0.00) are more likely to have knowledge about follow-up postnatal. While women who have no knowledge of postnatal follow-up (OR = 0.18, 95%CI = 0.07-0.45, p-value = 0.00) are less likely to have more knowledge. Conclusion: Lack of knowledge of the existence and importance of postnatal consultation (CPoN), traditional practices are the factors that influence postnatal follow-up in the Bafang Health District. A good and effective care for women after childbirth requires increased awareness campaigns at the hospital level as well as in community settings.
Aim: To highlight the challenge in the management of Arginosuccinic acidemia as well as demonstrate the importance of newborn screening for inborn errors of metabolism. Method: Report of two cases of neonatal onset ASA with encephalopathy and review of relevant literature. Conclusion: Early diagnosis and institution of appropriate intervention can significantly improve outcome. Routine newborn metabolic screening should not only be implemented universally, the result should be available promptly.
To form the basis of a respiratory disease model in rats by investigating the microbial distribution and composition in the lower respiratory tracts of normal rats. Methods: DNA was extracted from the intestine, trachea, bronchus and lung samples collected from healthy rats under sterile conditions. The 16S rDNA V4-V5 region was sequenced using Illumina high-throughput technology. Results: The sequencing results showed that there was no significant difference in abundance and species diversity of microbiota between the lower respiratory and the intestine. The microbiota structure analysis showed samples from lungs and intestinal shared similarity. However, the dominant species at the levels of phylum, family, and genus diverged. The similarity analysis showed that the lung microbiota were different from the intestines. The linear discriminant analysis showed significantly different species in different tissues; function prediction also showed different microbiota function in different tissues. Conclusions: These results suggest that bacterial colonization depends on the sample’s anatomical location. The human pathogen Acinetobacter lwoffii was also detected in the rat lower respiratory tract samples.
In article the natural technology of improvement of qualities, normalization of a state and increase in activity of the person is considered. The spectral analysis of biofield, correction of a biofield by analog reconstructive optical method of tomography and healthy lifestyle are fundamentals of natural technology. According to the spectral analysis of a biofield the card of step-by-step correction is formed. According to the card of step-by-step correction stage-by-stage impact by the light, acoustic and power field on a biofield of the person is programmed. Process of correction of biofield is carried out under control of the expert in real time by means of a spectroscope. Process of correction comes to an end with normalization of biofield. After normalization of biofield, people passes to healthy activity.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
Struggling with intense fears that disrupt your life? At Renew Life Hypnosis, we offer specialized hypnosis to overcome fear. Phobias are exaggerated fears, often stemming from past traumas or learned behaviors. Hypnotherapy addresses these deep-seated fears by accessing the subconscious mind, helping you change your reactions to phobic triggers. Our expert therapists guide you into a state of deep relaxation, allowing you to transform your responses and reduce anxiety. Experience increased confidence and freedom from phobias with our personalized approach. Ready to live a fear-free life? Visit us at Renew Life Hypnosis..
We understand the unique challenges pickleball players face and are committed to helping you stay healthy and active. In this presentation, we’ll explore the three most common pickleball injuries and provide strategies for prevention and treatment.
Navigating Challenges: Mental Health, Legislation, and the Prison System in B...Guillermo Rivera
This conference will delve into the intricate intersections between mental health, legal frameworks, and the prison system in Bolivia. It aims to provide a comprehensive overview of the current challenges faced by mental health professionals working within the legislative and correctional landscapes. Topics of discussion will include the prevalence and impact of mental health issues among the incarcerated population, the effectiveness of existing mental health policies and legislation, and potential reforms to enhance the mental health support system within prisons.
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
Navigating the Health Insurance Market_ Understanding Trends and Options.pdfEnterprise Wired
From navigating policy options to staying informed about industry trends, this comprehensive guide explores everything you need to know about the health insurance market.
Defecation
Normal defecation begins with movement in the left colon, moving stool toward the anus. When stool reaches the rectum, the distention causes relaxation of the internal sphincter and an awareness of the need to defecate. At the time of defecation, the external sphincter relaxes, and abdominal muscles contract, increasing intrarectal pressure and forcing the stool out
The Valsalva maneuver exerts pressure to expel faeces through a voluntary contraction of the abdominal muscles while maintaining forced expiration against a closed airway. Patients with cardiovascular disease, glaucoma, increased intracranial pressure, or a new surgical wound are at greater risk for cardiac dysrhythmias and elevated blood pressure with the Valsalva maneuver and need to avoid straining to pass the stool.
Normal defecation is painless, resulting in passage of soft, formed stool
CONSTIPATION
Constipation is a symptom, not a disease. Improper diet, reduced fluid intake, lack of exercise, and certain medications can cause constipation. For example, patients receiving opiates for pain after surgery often require a stool softener or laxative to prevent constipation. The signs of constipation include infrequent bowel movements (less than every 3 days), difficulty passing stools, excessive straining, inability to defecate at will, and hard feaces
IMPACTION
Fecal impaction results from unrelieved constipation. It is a collection of hardened feces wedged in the rectum that a person cannot expel. In cases of severe impaction the mass extends up into the sigmoid colon.
DIARRHEA
Diarrhea is an increase in the number of stools and the passage of liquid, unformed feces. It is associated with disorders affecting digestion, absorption, and secretion in the GI tract. Intestinal contents pass through the small and large intestine too quickly to allow for the usual absorption of fluid and nutrients. Irritation within the colon results in increased mucus secretion. As a result, feces become watery, and the patient is unable to control the urge to defecate. Normally an anal bag is safe and effective in long-term treatment of patients with fecal incontinence at home, in hospice, or in the hospital. Fecal incontinence is expensive and a potentially dangerous condition in terms of contamination and risk of skin ulceration
HEMORRHOIDS
Hemorrhoids are dilated, engorged veins in the lining of the rectum. They are either external or internal.
FLATULENCE
As gas accumulates in the lumen of the intestines, the bowel wall stretches and distends (flatulence). It is a common cause of abdominal fullness, pain, and cramping. Normally intestinal gas escapes through the mouth (belching) or the anus (passing of flatus)
FECAL INCONTINENCE
Fecal incontinence is the inability to control passage of feces and gas from the anus. Incontinence harms a patient’s body image
PREPARATION AND GIVING OF LAXATIVESACCORDING TO POTTER AND PERRY,
An enema is the instillation of a solution into the rectum and sig
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Prevalence and Predictors of Malaria Among HIV Infected Subjects Attending an Antiretroviral Therapy (ART) Clinic in a Tertiary Healthcare Facility in Central Nigeria
1. International Journal of Healthcare and Medical Sciences
ISSN(e): 2414-2999, ISSN(p): 2415-5233
Vol. 6, Issue. 2, pp: 15-20, 2020
URL: https://arpgweb.com/journal/journal/13
DOI: https://doi.org/10.32861/ijhms.62.15.20
Academic Research Publishing
Group
*Corresponding Author
15
Original Research Open Access
Prevalence and Predictors of Malaria Among HIV Infected Subjects Attending
an Antiretroviral Therapy (ART) Clinic in a Tertiary Healthcare Facility in
Central Nigeria
I. Yahaya
Department of Microbiology, Nasarawa State University Keffi, Nasarawa State, Nigeria
V. B. Oti*
Department of Microbiology, Nasarawa State University Keffi, Nasarawa State, Nigeria
J. Y. Dahiru
Department of Biological Sciences, Federal University Kashere, Gombe State, Nigeria
Abstract
Malaria is still considered globally as a leading cause of morbidity with Nigeria carrying the highest burden of 19%.
Coinfection of malaria and Human Immunodeficiency Virus (HIV) accelerate disease progression of HIV/AIDS
subjects. This study investigated the prevalence and predictors of malaria among HIV infected subjects attending the
antiretroviral therapy Clinic at Federal the Medical Centre, Keffi, Nigeria. After ethical clearance, 200 whole blood
specimens were collected from patients who gave informed consent and completed a self-structured questionnaire.
The specimens were examined for malarial parasite using rapid kits and microscopy. The overall prevalence of the
infection was 78/200 (39.0%). The prevalence was higher in male (44.7%) than female (34.0%) subjects. Those
subjects aged < 20 years (54.5), male gender (44.7%), non-formal education holders (61.5%), farmers (62.5%),
stream water users (48.1%), those that lives in rural setting (43.6%), those that do not use Insecticides Treated Nets
(ITNs) (39.4%) and swampy environment dwellers (41.7%) were identified predictors for malaria infection in the
area. All the predictors studied did not show any statistically significant difference with the infection but some
arithmetic difference exists (P > 0.05). The 39.0% prevalence of malaria in HIV infected subjects is a public health
concern. Therefore, Public health surveillance and health education among HIV population should be advocated to
help eradicate malaria comes 2030. Further study that will characterize the genes of the parasite should be carried
out.
Keywords: Malaria; Plasmodium species; HIV; Prevalence; Subjects; Central Nigeria.
CC BY: Creative Commons Attribution License 4.0
1. Introduction
Malarial and Human Immunodeficiency Virus (HIV) infections are public health issues facing Africa in recent
years and coinfection of these two infections has scantly been studied [1-3]. Our current understanding of human
immune response to malaria and HIV leads us to expect of the other [4]. Many other types of infections have been
documented to cause at least a transient increase in HIV viral load [5, 6]. There were 435, 000 deaths from malaria
globally in 2017 compared with 451, 000 estimated deaths in 2016 [7], 88% of such deaths occurring in WHO
African region [7]. Currently, there are almost 37.9 million people living with HIV, and tens of millions mortality
have been reported due to AIDS-related causes since the beginning of the epidemic [8]. Those who are at high risk
are young children, pregnant women and immunocompromised people (PLWHIV) [7, 9].
In Nigeria, where the malaria situation has improved, almost 60 million people (about 50% of the population)
experience one episode of malaria or the other during the year and the disease causes death of over 200,000 people
annually [10, 11]. Hence, it is logical to expect malaria to do the same; and thus accelerate HIV disease progression.
Malaria is a mosquito-borne infectious disease of humans and other animals caused by Plasmodium species [11].
The disease arises from the division of Plasmodium parasites in the red blood cells, causing symptoms which
headache and fever, in severe cases progressing to coma and/or death. It is widespread in tropical and subtropical
regions, including much of Sub-Saharan Africa, Asia, and the Americas [11-13]. Five species of malarial parasite
causes infection in humans exists [14]. Severe disease is largely caused by Plasmodium falciparum while the disease
caused by Plasmodium vivax, Plasmodium ovale and Plasmodium malariae is generally mild and seldom fatal [14,
15]. This infection still remains a life threatening vector borne concern and has a significant role on the economic
development of most endemic countries [13, 16, 17].
Malaria transmission can be mitigated by preventing mosquito bites by distribution of insecticidal treated net
(ITN) insect repellants, or by mosquito-control measures such as spraying insecticides and draining stagnant water
[5]. There is no vaccine that offers a high level of protection in existence but efforts in developing such are ongoing.
Although number of medications are available as prophylaxis especially among travelers to malaria-endemic regions
[3].
2. International Journal of Healthcare and Medical Sciences
16
Co-infection of malaria with HIV is very common in Sub-Saharan Africa [1, 5, 6, 10, 14, 18-20]. The
overlapping features of malaria and HIV/AIDS has established the fact that people living with HIV/AIDS are at high
risk of clinical malaria and HIV infection can reduce the protection offered by anti-malarial drugs [4, 21]. Malaria
contributes to a temporary increase in viral load among HIV- infected people which may lead to increased clinical
disease and enhances mother to child transmission [22, 23]. This study examined the prevalence and predictors of
malaria among HIV infected subjects attending ART clinic in a tertiary healthcare facility in Central Nigeria.
2. Materials and Methods
2.1. Study Area
This study was carried out in Keffi. Keffi is 68 Km from Abuja, the Federal Capital Territory and 128 Km from
Lafia, Nasarawa State. It lies in latitude eight 5’N of the equator and longitude seven 8’E, it also situates on altitude
of 850 M above sea level [24]. The average annual rainfall in Keffi is ±2,000 millimeters (79 in), and is often heavier
during the rainy months having its peak around July through September [25]. Most of the people living here are
dominantly traders, farmers, civil servants, and students.
2.2. Study Population
A prospective cross sectional study was carried out among 200 HIV infected subjects attending the facility who
agreed to participate in the study from a period of June through August, 2018. Structured questionnaire was
administered to the parents/guardians of the children; information on age, gender and risk factors such as; source of
drinking water and use of insecticidal treated nets was obtained from each participant. Participants who could not
read or write in the English Language were interviewed orally in Hausa. Representative sample size was determined
using the formula propounded by Swinscow and Campbell [26].
2.3. Sample Collection
Blood sample was collected from each participant by venipuncture. A tourniquet was used to tie in the upper
region of the arm for the veins to be visible and also increase the pressure of blood into the veins. The area in which
needle was inserted was cleaned with a spirit cotton wool after which the needle was introduced into the vein, and
5ml of blood was collected. The tourniquet was loosed before the needle was pulled out from the vein and the blood
transferred to an EDTA (Ethylenediamine Tetra Acetic Acid) container after which it was labeled accordingly using
unique identifier codes to ensure confidentiality of participants [13].
2.4. Laboratory Analysis
2.4.1. Rapid Diagnosis of Malaria Parasite
All the subjects were screened for malarial parasite using the Care Start TM
malaria HRP2 (Pf) rapid test for
Plasmodium falciparum malaria ML no: 338 (Orchid Biomedical System, India) following the manufacturer’s
specifications prior to microscopy.
2.4.2. Microscopic Examination of the Malaria Parasite
Thin and thick smears were prepared to determine the malaria parasitemia in the target population of HIV
subjects. The both smears were stained using 3% Giemsa technique as described by Cheesbrough [27]. This is
considered as the gold standard and it was used to confirm the initial screening with the rapid kit.
2.5. Ethical Clearance
In line with the Helsinki Declaration which specifies the code of ethics for biomedical research involving human
samples, clearance for the study was obtained from the Ethical Committee on Health Research of Federal Medical
Centre, Keffi, Nigeria. Formal consents were retrieved from all participating subjects using a consent form.
2.6. Statistical Analysis
The information obtained were analyzed statistically using Smith’s Statistical Package (SSP version 2.80,
Claremont, California-USA). Chi-square statistical test was used to determine association and values obtained were
considered statistically significant at p ≤ 0.05.
3. Results and Discussion
Out of 200 HIV subjects examined for the parasitic infection, 78 (39.0%) were infected with malarial parasite.
Table 1 shows the prevalence of malaria among HIV infected subjects with respect to possible predictors. The
prevalence of malaria in this study was higher among those < 20 years of age (54.5%), male gender (44.7%), non-
formal education holders (61.5%), farmers (62.5%), stream water users (48.1%), those that lives in rural setting
(43.6%), those that do not use ITNs (39.4%) and swampy environment dwellers (41.7%). All of the studied
predictors showed no statistically significant association with malaria but some arithmetic differences were observed
(p > 0.05).
3. International Journal of Healthcare and Medical Sciences
17
Table-1. Prevalence of malaria among HIV infected subjects attending Federal Medical Centre Keffi, Nigeria with respect to possible predictors
Parameters No. Examined No. Positive Prevalence (%) ᵡ2
P
Age (Years)
< 20
21-30
31-40
>40
22
54
86
38
12
20
34
12
54.5
37.0
39.5
31.6
1.3334 0.7212
Gender
Male
Female
94
106
42
36
44.7
34.0 1.0525 0.3049
Educational Status
Non-formal education
Primary
Secondary
Tertiary
26
34
62
78
16
18
20
24
61.5
52.9
32.3
30.8
4.7868 0.1880
Occupation
Artisans
Students
Civil servants
Farmers
36
54
78
32
16
20
22
20
44.4
37.0
28.2
62.5
4.8347 0.1842
Locality
Rural
Urban
78
122
34
44
43.6
36.1
0.4914 0.4833
Sources of Drinking
Water
Tap
Well
Stream
84
62
54
24
28
26
28.6
45.2
48.1
3.0198 0.2208
Use of ITNs
Yes
No
134
66
52
26
38.8
39.4
0.0028 0.9577
Nature of Environment
Swampy
Dry
24
176
10
68
41.7
38.6 0.0352 0.8512
Human immunodeficiency virus infected individuals are at higher risk of malaria and other opportunistic
infections because of their compromised immune systems. Sub-Saharan Africa carries a high burden of coinfection
with malaria and HIV [2, 7, 16].
An overall prevalence rate of 39.0% was recorded among the HIV subjects attending the Federal Medical
Centre, Keffi, Nigeria in this study which is in agreement with the reports in other parts of the country. It was 65%
among people living with HIV/AIDS in Keffi Bello and Ishaleku [1], 56.8% among patients in Keffi Yohanna, et al.
[13], 24% among HIV patients in Jos Iroezindu, et al. [28], 14.2% among HIV patients in Uyo Amadi, et al. [29],
16.2% among HIV-infected individuals in North Central Nigeria Inyama, et al. [15], 59.2% among HIV patients in
Kaduna Abioye, et al. [5] and 18.5% among HIV positive individuals in Osogbo Olusola, et al. [3]. Findings from
other countries have been reported such as 14% among HIV seropositive patients in Cameroon Sandie, et al. [19],
61.7% among HIV patients in Mozambiqu Saracino, et al. [20], 36% in South Africa Cohen, et al. [18], 83.8%
among HIV infected and uninfected population in Uganda Katrak, et al. [6] and a high malaria parasite density
among HIV/AIDS subjects in Kenya Kirinyet [30]. Differences in sample size, study population, sensitivity and
specificity of tests used, weather and climate conditions may account for these differences in the prevalence rates.
In this study, there was no statistically significant association between the age groups and malaria (p > 0.05).
The infection was highest among subjects aged < 20 years (54.5%) and least prevalence among those aged greater
than 40 years old (31.6%). This correlates with the findings of Bello and Ishaleku [1] in Keffi, Amadi, et al. [29]
and Kirinyet [30] reported that age was not significant to malaria acquisition in their studies. The less than 20 years
subjects are active with developing immune system and have less knowledge on how to prevent the infection which
enhance their vulnerability to the infection.
With respect to gender, malaria was not associated with gender of the subjects (p > 0.05). The infection was
higher in male (44.7%) than the female (34.0%) counterparts. Similar studies in Nigeria and beyond also report same
outcome [9, 11, 30] but contradicts the reports of Sandie, et al. [19] in Cameroun, Bello and Ishaleku [1] in Keffi,
and Amadi, et al. [29] in Uyo, Nigeria. Male gender tends to have severe immunosuppression than the female
counterparts. This finding might be because males often stayed out lately at night most times and thus exposes
themselves to mosquito bites.
There was no statistically significant association between educational status and the prevalence of malaria (p >
0.05). Those subjects without any formal education reported the highest prevalence of 61.5% while those with a
tertiary education had the least prevalence of 30.8%. This outcome is obvious because education has long been
4. International Journal of Healthcare and Medical Sciences
18
embraced to be of great advantage in our society. Therefore, more improved preventive measures and prophylaxis is
intertwined with higher levels of education.
This study reports showed that the prevalence of malaria is highest among farmers (62.5%) and lowest among
the civil servants (28.2%). There was no statistical association between the parasitic infection and occupation of the
subjects in the area (P > 0.05). Malaria is understood to be both a disease of poverty and a cause of poverty [5]. The
high prevalence rate among farmers might be because of low income rate, lack of proper preventive means and
treatment and also lack of proper feeding which make their body system vulnerable to opportunistic infections
including malaria.
In this study, no significant association statistically was observed between malaria and the locality of the
subjects (p > 0.05). The prevalence of the infection was higher among subjects from the rural areas (43.6%) than
those in the urban settings (36.1%). This report is in consonance with Iroezindu, et al. [28] findings in Jos, Nigeria.
Rural dwellers are more likely to indulge in practices that create favorable breeding environment for the vector.
Furthermore, malaria prevention and control programs are less commonly done in rural settings in Nigeria.
In this study, no significant association statistically was observed among malaria and use of ITNs (p > 0.05).
The prevalence of the infection was higher among those subjects that do not use ITNs (39.4%) than those who use
ITNs (38.8%). Findings in this study was also recorded in related researches in Nigeria and other countries [13, 31-
33]. The protective effect of ITNs usage shown in this study adds to the body of evidence supporting the
effectiveness of ITNs for protection against malaria and other vector-borne diseases [7]. This finding is a wake-up
call to all healthcare providers to provide and continue distributing the long lasting ITNs to HIV population in
Nigeria
Source of drinking water and nature of environment are not statistically associated with malaria infection among
the population (P > 0.05). Amadi, et al. [29] and Iroezindu, et al. [28] reported similar findings in their studies.
Those that use stream water and live in swampy environment are at high risk of malaria from this study. This high
rate of stream water users and those in swampy environment is interrelated. HIV individuals living in riverine areas
are at high risk of malaria infection.
4. Conclusion
This study successfully revealed a high prevalence of malaria among HIV infected subjects in the area. None of
the predictors studied showed any statistically significant association with the infection (p > 0.05). This study has
contributed to the understanding of malaria among HIV subjects in Nigeria. Thus, continuous screening of malaria
parasites in HIV patients and public health awareness should be priorities in eliminating the infection in Nasarawa
State, Nigeria.
Acknowledgement
We thank the staff and study subjects of the facility for their support in making this study a success. This study
did not acquire any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. We
dedicate this study to the blessed memory of Patrick Baba Oti, PhD.
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