The document summarizes various technologies for wound healing, including X-Stat, a syringe-like device that injects expandable sponges to stop arterial bleeding. It also discusses a self-healing nanogel that can accelerate burn wound healing by acting as a scaffold for skin cell growth. Additionally, it covers Vetigel, a plant-derived gel that claims to quickly stop bleeding in external and internal wounds. Digital bandages are described that can monitor vital signs like heart rate from a wearable adhesive patch. Smart bandages incorporating sensors to monitor wound status and deliver medicine are also presented.

1. Guided By:
Dr.(Mrs.) A. M. AVACHAT
Presented By:
RESHMA UKALE
ANIKET VAIDHYA
M. Pharm, Sem- II
(Pharmaceutics)
Roll.no:521 & 522
Sinhgad College of Pharmacy Vadgaon Bk, Pune (41)
Seminar on
1
(2016)
16/ 03 /2016
WOUND HEALING TECHNOLOGY

2. WOUND
 It is a injury caused by external force and it can
involve any tissue or organ

3.  A wound is a break in the integrity of the skin or tissues
often which may be associated with disruption of the structure
and function.
 A cut or break in the continuity of any tissue, caused by
injury or operation.

4. CLASSIFICATION OF WOUND:
1. Clean Wound
2. Colonized Wound
3. Contaminated Wound
4. Infected Wound

5. HEALING
 Healing is the body’s response to injury in an attempt to
restore normal structure and function
 Response of an organism to a physical disruption of a
tissue/organ with an aim to repair or reconstitute the
defect and to re-establish homeostasis.
 During healing, a complex cascade of cellular events
occur to achieve resurfacing, reconstitution and
restoration of tensile strength of injured tissue.

6. The progress of healing involves two
distinct processes:
 REGENERATION
 REPAIR

7. 1. Inflammatory phase: It can be broken down
into further
a) Clot formation
b) Early inflammation
c) Late inflammation
2.Proliferative phase
3.Maturation phase
PHASES OF WOUND HEALING:

8. PHASES OF WOUND HEALING:

9. a) Clot formation:
 Blood vessel contraction initiated by platelet
degranulation of serotonin, which acts on endothelial
cell and increases the permeability of the vessel,
allowing a protein rich exudate to enter the wound site
 A platelet plug formation
 Activation of extrinsic and intrinsic clotting mechanism
INFLAMMATORY PHASE

10.  Characterized by formation of granulation tissue in
the wound.
 2 key cell types are present in this phase:
a) fibroblasts
b) endothelial cells
PROLIFERATIVE PHASE:

11.  Begins 5 to 7 days after injury.
 There is conversion of granulation tissue to fibrous
connective tissue and decrease parallelism of collagen to the
plane of the wound.
 Maturation of the epithelial layer quickly follows
formation of the epithelial seal.
MATURATION PHASE:

12. WOUND HEALING TECHNOLOGY
1. X Stat
2. Self Healing Nanogel
3. Vetigel
4. Digital Bandage

13. X STAT
 XStat® is applied into the wound
cavity using a lightweight applicator
 The applicator is available in a
30mm diameter size.
 XStat® is not indicated for use in
other parts of the body such as the
thorax, pleural cavity, abdomen or
retroperitoneal space

14.  Is a syringe-like device that injects small, expandable,
haemostatic sponges designed to stop high-flow arterial
bleeding from non-compressible junctional wounds
 The sponges are coated with a haemostatic agent and
have a radiopaque marker attached to aid removal later using
X-ray imaging.
The sponges which are containing a cellulose that have an
absorbent coating

15. X STAT MECHANISM

16. SELF HEALING NANOGEL:
 Nanotechnology have developed a nanogel that can
accelerate the healing of burn wounds to minimize the risk of
infection and scaring
 The peptide hydrogels can promote skin regeneration by
acting as a scaffold for skin cells to grow
 When water is added, the peptide self assembled into
nanofibers that entrap water to form fibrous gel which
resembles the extracellular matrix

17.  Gel which is a porous and rich in moisture acts as a
scaffold to support the growth of skin cells, thereby promoting
skin regeneration
 Ultrashot peptide are nonimmunogenic and non toxic

18. Invented by Joe Landolina
Student of New York University
year 2015
Company U.S. firm Suneris.
Veti-gel is a veterinary product, a plant-derived gel that is claimed
to quickly stop traumatic bleeding on external and internal wounds.
waiting on FDA approval for human tests
VETIGEL:

19. they participate in the activation of muscle tissue, blood
vessels or even bone structures
Composition
The gel is made of plant-derived polymers.
VetiGel is an algae-based polymer in the form of a
gel & extracellular matrix or ECM.
ECM are usually proteins produced by cells and
they are used as supporting items – hence the name
matrix

20. VETIGEL:
Action of vetigel:
Once it hits the damaged tissue, whether its open skin or soft
organ like livers , kidneys, spleens.
Gel is instantly forms a mesh like structure
injected into wound site , the gel can form a clot within 12
sec and permanently heal the wound within min.

21.  Fibrin helps repair tissue over the long term
 Vetigel not only to work fast in sealing leaks, but to
actually heal the skin within few min of application
The gels contain algae based polymers that acts as sealent,
sealing the wound allows platelets to accumulate at the site of
injury to form a mesh
 Mesh acts as a scaffold to helps the body produce fibrin at
the wound surface

22. VETIGEL 100% bio-compatible and should not create
problems regarding our organism.
extracellular matrix (ECM) are already commonly used
in laboratories, to create synthetic tissues for instance,
and they are considered as relatively harmless.
CONT……

23. Digital Bandage:
 Wireless specialist has created a high tech bandage that can
be used for checkings a patient vital signs
 The device work by attaching it to a patients chest, enabling
it to take readings every two min
 Different factors the gadget can monitor include heart rate,
temperature and respiration
 Its like a adhesive patch
 The key advantage of the system is the frequency of the data
send automatically from the patch

25.  Electronic bandages that can speed up
healing
 They recruited 40 volunteers who had two
identical wounds created on their inner arms
using a punch biopsy
 One was allowed to heal naturally, while
the other was treated with electric current
delivered in pulses over a period of two
weeks
 Resulting increase in vascular growth
within a treated wound the grew smaller
faster than untreated one

26.  Now a days develop a bandage that has the capability to
monitor the status of a wound and administer medicine if
necessary
 In this type of bandages, incorporating in to the bandage
electronic sensors to monitor a wound status
 Researchers develop the combination of bandage and
medical device are called flexible bioelectronics
 Use of these smart bandage would be intended for serious
wound, such as a burn injuries or chronic wound such as a
diabetic foot ulcers

27. SMART BANDAGE
STREACHABLE HYDROGEABLE ELECTRONICS

28. CONCLUSION
Now a days The field of wound care is ever
expanding with advances in technology.
.
 Current wound healing products and
modalities increase the armamentarium of the
wound practitioner to address all aspects of
wound care.

29.  Joshua Crist, M.S.E. ,Xstat-FDA Overview, Biomedical engineer,
Centre for devices and radiological health, Hemostatic product workshop,
September 3,4 2014
 Xstat Hemostatic device for noncompressible junctional haemorrhage,
By Horizon scanning research and intelligence centre, June 2015
 Patrick S. Murphy and gregory R.D.Evans, aesthetic and plastic surgery
institute, Advances in wound healing: A Review of Current Wound
Healing Product
 Sara UD Din and Ardeshir Bayat, Electrical stimulation and cutaneous
wound healing: A Review of Clinical Evidence Healthcare ISSN 2227-
9032
 Asian Scientist Magazine, Self Assembling Peptide Nanogel for burns,
May 26,2014
REFERENCES

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