There are two main types of wound healing: primary and secondary. Primary healing occurs when the wound edges are close together and heal within 2-3 weeks. Secondary healing occurs when the wound edges cannot be approximated, resulting in more extensive granulation tissue formation and wound contraction over a longer period. The healing process involves hemostasis, inflammation, granulation, and remodeling phases across inflammation, proliferation, and maturation stages. Factors like infection, foreign bodies, nutrition, age, and diseases can impact wound healing.
aetiology of inflammation; types of inflammation; how inflammation occur; cells involve in inflammation; role of wbc in inflammation; outcome of inflammation; how inflammation associated with immunity, clotting system, complementary system kinin system, how inflammation is associated with oral cavity; disease associated with inflammatory system
aetiology of inflammation; types of inflammation; how inflammation occur; cells involve in inflammation; role of wbc in inflammation; outcome of inflammation; how inflammation associated with immunity, clotting system, complementary system kinin system, how inflammation is associated with oral cavity; disease associated with inflammatory system
Bandaging and Splinting & Slings; Techniques and Types (Health Subject)Jewel Jem
A short report about bandaging, types of bandages, bandaging techniques and even Splinting & Slings, types of splinting & slings, splinting & Splints techniques
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Wound healing is a complex, but well-coordinated process, which attempts to restore the normal structure and function of the injured tissue/organ.
A wound is a disruption in the continuity and regulatory process of tissue cell
During healing, a complex cascade of cellular events occurs to achieve resurfacing, reconstitution, and restoration of tensile strength of injured tissue.
Dentist in pune.(BDS. MDS) - Dr. Amit T. Suryawanshi. Wound healing in Dentis...All Good Things
entist in pune. (BDS. MDS) - Dr. Amit T. Suryawanshi. Seminar- Wound healing in dentistry.
Email ID- amitsuryawanshi999@gmail.com
Contact -Ph no.-9405622455
Subscribe our channel on youtube - Copy and paste this URL. https://www.youtube.com/channel/UC_gylEXTrjmEbbOTSXjuZ4Q/videos?view_as=public
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
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Triangles of Neck and Clinical Correlation by Dr. RIG.pptx
Wound Healing
1.
2. WOUND
- is a type of physical trauma wherein the
skin is torn, cut or punctured (open
wound), or where blunt force trauma
causes a contusion (closed wound).
- a break in the continuity of any bodily
tissue due to violence is understood to
encompass any action of external
agency, including for example surgery.
3. HEALING
- act or process of curing or restoring the
wound.
- prevents the egress of irritants may
result in continued tissue disruption
and/or infection
4. WOUND HEALING
- comprises a fundamental biological
activity that involves both regenerative
and reparative activities.
- functions to restore the disrupted or
dead tissues to its normal state.
5. * An ideal repair can be achieved in
tissues undergoing constant renewal
but is least effective in nerve &
muscle tissue.
* Nerve undergo repair only when cell
bodies are intact.
* Muscle tissue is repaired by fibrous
connective (scar) tissue, with
permanent loss of function.
6. TYPES OF WOUND HEALING:
1. PRIMARY UNION
- healing by first intention
- there is narrow space between the
two cut surfaces of a wound
- healing is completed in 2-3 weeks
7. 2. SECONDARY UNION
- healing by second intention
- the two cut surfaces cannot be
appointed
- granulation tissue tend to heal the
wound from the base of wound
contraction.
8. 3. DELAYED UNION
- there is movement between the two
fractured surfaces
- infection
- poor blood supply
- pathogenic fractures
10. Factors Affecting Wound Healing:
1. Infection – promotes further
inflammation & tissue destruction.
2. Foreign Bodies – stimulates
inflammation, thereby impending
the process of healing.
11. 3. Old Age – due to nutritional &
vascular deficiencies and
deteriorating immune system.
4. Nutritional Status – Vitamin C
deficiency has been associated
with impaired healing
12. 5. Concurrent Disease:
a. Vascular Disease – any disturbance
to the blood supply of a tissue
will result in delayed or impaired
wound healing.
13. b. Diabetes Mellitus – impaired blood
supply, impaired PMN
leukocytes function &
increased susceptibility to
microbial agents.
14. c. Uremia – because of disturbance
in inflammation response.
d. Blood Disease – hemorrhage at
the site of tissue damage,
resulting in large hematomas
that predispose secondary
microbial infection.
15. PRIMARY
UNION
- Narrow space
between the 2 cut
surfaces.
- Undergoes
hemorrhage prior to
clotting.
SECONDARY
UNION
- Large gap between
the 2 cut surfaces
that cannot be
appointed.
- Initial degree of
hemorrhage followed
by blood clot
formation.
16. PRIMARY
UNION
- Margins of wound
subsequently
undergo mild
inflammatory
reactions releasing
plasma and
polymorphonuclear
leukocytes into
incised space.
SECONDARY
UNION
- Mild short-lived acute
inflammatory
reactions occur in the
wound margins at the
same time.
17. PRIMARY
UNION
- After approximately 24
hours, capillary blood
vessels from wound
margins begin to bud
into the wound space
& then are followed
by both macrophages
and fibroblasts.
SECONDARY
UNION
- Granulation tissue
subsequently begins
to move into the
wound base & sides.
(These tissue
comprising capillary
buds, fibroblasts,
macrophages,
plasma cells &
lymphocytes.
18. PRIMARY
UNION
- Macrophages are
primarily associated
with phagocytosis of
the wound debris &
haemosiderin from
hemoglobin
breakdown.
SECONDARY
UNION
- Component cells
ensure the removal
of tissue debris,
these cells include
macrophages,
fibroblasts &
polymorphonuclear
leukocytes.
19. PRIMARY
UNION
- Fibroblasts begin to
form ground
substances.
SECONDARY
UNION
- Fibrous tissue is laid
down in the deeper
layers of the wound.
Granulation tissue
tends to heal the
wound from the base.
20. PRIMARY
UNION
- At the same time or a
little earlier, epithelial
cells from wound
margins undergo
mitosis & migrate
toward center of
wound thereby
forming a complete
but thin epithelial
covering. (SCAB)
SECONDARY
UNION
- Wound undergoes
contraction, primarily
reflecting fibroblastic
activity. Thus edges
of the wound is
closed by granulation
tissue & wound
contraction thereby
facilitating epithelial
migration & mitosis.
(SCAB)
21. PRIMARY
UNION
- Epithelium undergoes
progressive
maturation to regain
its full thickness.
SECONDARY
UNION
- Excessive granulation
is formed so that
recently healed
wound may appear
proud of the adjacent
tissue usually
resolved in a few
weeks.
22. PRIMARY
UNION
- Healing is usually
complete by 2-3
weeks.
- A longer period may
be required before
there is complete
restoration of the
tissue architecture.
SECONDARY
UNION
- Complex interactions
occur between
epithelia &
connective tissues:
CT formation – initially is essential
for the restoration of normal
epithelial continuity.
ET – subsequently may be
responsible for the formation of
connective tissue scar growth.
23. Secondary Healing differs from Primary
Healing in several aspects:
1. Large tissue defects initially have
more fibrin & more necrotic debris &
exudates that must be removed.
Inflammation reaction is more
intense.
24. 2. Much larger amount of granulation
tissue is formed.
3. Phenomenon of wound contraction.
That is, the defect is markedly
reduced from its original size.