Here you can get general concept of wound healing including various stages and complication on it.

1. Prabesh paudel
Wound Healing

2. Types of wound
• Surgical wound
• Contaminated wound or open wound

3. Types of wound healing
• Healing by primary intention
An example of wound healing by primary intention is a surgical
incision.
• Healing by secondary intention
Repair time is longer and scarring is greater
• Facture healing
it deal with bone healing n bit differ from tissue healing.

4. Stages of wound healing
• Hematoma formation
This mean blood clot formation or formation of platelet. This is
the first response shown by the injured site.
• Inflammation
This mean swelling, this occur when the neutrophils enters into
the cell which lead in release of cytokines then other WBC like
monocytes , lymphocytes inters into the tissue. The monocytes
then called the macrophages which eat bacteria and other
pathogens present in injured area and protect from infection.
so inflammation occor

5. Granulation tissue formation
Granulation tissue is new microscopic blood
vessels (angiogenesis) and fibroblast cell. The
new vessels help in conduction of blood
(arterial n venous) at the injured area and
fibroblast start formation of collagen III.

6. Maturation and remodeling
• When the levels of collagen production and degradation
equalize, the maturation phase of tissue repair is said to have
begun. During maturation, type III collagen, which is prevalent
during proliferation, is replaced by type I collagen. The
maturation phase can last for a year or longer depend upon
wound. Since activity at the wound site is reduced, the scar
loses its red appearance as blood vessels that are no longer
needed are removed by apoptosis.
•

7. Factor affecting wound healing
• Local factor
Moisture
Mechanical factors
Edema
Foreign bodies
Ischemia
Necrosis
Low oxygen tension

8. • Systemic factors
Inflammation
Diabetes
Nutrients
Metabolic diseases
Immunosuppression
Smoking
Age
Alcohol

9. Complication in wound healing
• inadequate scar formation – leading to wound
dehiscence
• excessive scar formation – either hypertrophic
or ‘keloid’ scarring
• contracture formation – an exaggeration of
normal wound edge contraction forming
deformities