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Working principle of compression machine
- 1. WORKING PRINCIPLE OF COMPRESSIONMACHINE Presented By Prashik Humane Department of Pharmaceutical Sciences, RTMNU, Nagpur 1
- 2. CONTENTS Introduction Compressionfacilities Different parts of compression machine Mechanism of compression cycle Additional machine line Critical process parameter In-process testing 2
- 3. INTRODUCTION Compression- Compression isa process of applying pressure to the powder material for the reduction of bulk volume to give a solid matrix. It is a process by which granules are compressed into the core tablet form. The manufacturing of solid dossage form such as a complex multistage process under which the starting material change there physical characteristics a number of time before the final dossage form is produced. Need of Compression- To form the unit dossage form For better stability as compare to other dossage form Cost effective Patient compliance 3
- 4. COMPRESSION FACILITY • CTXCad-mach 26 • Sejong 36 • Cad-mach 36 Single rotary • Sejong 39 • Cad-mach 45 • Cad-mach 75 • BOSCH Manestry 49 • BOSCH Manestry 61 Double rotary 4
- 5. DIFFERENT CHANGE PARTS Hopper Upper and lover cam tracks Dies and punches Feeders Tail over die and scraper blade Pressure role Take off plate filling cam and ejection cam Dust cap 5
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- 7. COMMON STAGES OCCURRINGDURING COMPRESSION Stage 1 • Fill the die Stage 2 • Weight Adjustment Stage 3 • Compress the powder Stage 4 • Ejection of tablet Stage 5 • Return to stage One 7
- 8. IN-PROCESS TESTING Weightvariation test Thickness Hardness diameter/ length/ width Disintegration test Friability 8
- 9. ADDITIONAL MACHINE LINE De-duster Machine Metal Detector 9
- 10. CRITICAL PROCESS PARAMETER Filling depth Punch separation Pre-compression force Main compression force Turret RPM Tablet per minutes 10
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