KEY TAKEAWAYS: 1. ABOUT COVID-19 Biology of the COVID-19, virulence, diagnosis and treatment 2. PREVENTION MEASURES How can one stay unaffected from the current and future outbreaks 3. STATS ABOUT COVID-19 Patterns of this infection worldwide

1. COVID-19
Know the Coronaviruses, It’s not only
WEBINAR TOPIC

2. ISHITA MEHTA
— Business Development Executive,
XLPAT Labs
MODERATOR

3. 01.
ABOUT COVID-19
Biology of the COVID-19, virulence,
diagnosis and treatment
PREVENTION MEASURES
How can one stay unaffected from
the current and future outbreaks
STATS ABOUT COVID-19
Patterns of this infection
worldwide
CONCLUSION
03.
02.
04.
KEY TAKEAWAYS

4. KEYNOTE SPEAKERS
Pranav Sharma
Head – Business Development
XLPAT Labs – TT Consultants
GOURAV DHIMAN
Manager– Business
Development,
XLPAT Labs – TT Consultants
DR. SHABBIR
SYED ABDUL
Associate Professor, MD, MSc, PhD
Taipei Medical University
Taipei City, Taiwan

5. CoVs are divided into
four genera: α-, β-, γ-,
and δ-coronavirus.
WHAT ARE
CORONAVIRUSES
Reference: David J Cennimo et al., Coronavirus Disease 2019
(COVID-19).

6. SARS-CoV-2 (COVID-19) is the seventh member of the
family of coronaviruses that infects humans.
SARS-CoV-2 (COVID-19) likely originated in bats, based on
the similarity of its genetic sequence to that of other
coronaviruses. The intermediate animal host of SARS-CoV-
2 between a probable bat reservoir and humans is still
unknown.
WHAT ARE
CORONAVIRUSES

7. INFECTION
PATTERN
All you need to know!
01.

8. Human coronavirus (CoV) infections have traditionally
caused a low percentage of annual respiratory
infections.
Severe acute respiratory syndrome CoV (SARS-CoV)
and Middle East respiratory syndrome CoV (MERS-
CoV), have emerged and cause severe human
diseases
INFECTION
PATTERN

9. TRANSMISSION
Entry into Host Cell
02.

10. TRANSMISSION
Entry into Host Cell - Explained
Reference: Muhammad Adnan Shereen, Suliman Khan, Abeer Kazmi, Nadia Bashir, Rabeea Siddique. COVID-19 infection:
origin, transmission, and characteristics of human coronaviruses. Journal of Advanced Research.

11. CLINICAL
FEATURES
Indications
03.

12. The spectrum of clinical presentations
of COVID-19 have been reported
ranging from asymptomatic infection
to severe respiratory failure
CLINICAL FEATURES - Indications
CASESINFECTION
A large case study indicated that
the case-fatality rate was elevated
among those patients with
coexisting medical conditions

13. HIGH FEVER
TIREDNESS &
MYALGIA
DYSPNEA - DIFFICULTY
BREATHING
DRY COUGH
The body temperature can
exceed 37.3 Celsius degrees
The body feels completely
tired, without energy
Breathing actually feels
more difficult
Constant coughing without
expelling any mucus
CLINICAL FEATURES – Main Symptoms

14. CLINICAL
FEATURES
Immunology
04.

15. Changes of several cytokines (plasma IL1B, IL1RA, IL7,
IL8, IL9, IL10, basic FGF, GCSF, GMCSF, IFNγ, IP10, MCP1,
MIP1A, MIP1B, PDGF, TNFα, and VEGF) in serum in the
COVID-19 patients
Initiation of the immune response result in the
production of chemokines and cytokines, which damage
normal host lung.
CLINICAL FEATURES
Immunology

16. CLINICAL
FEATURES
Diagnosis
05.

17. RT-PCR is routinely used to detect causative viruses from
respiratory secretions
CLINICAL
FEATURES
Diagnosis

18. CLINICAL
FEATURES
Treatment
06.

19. The main treatment of COVID-19 is symptomatic treatment.
The antiviral drugs, including oseltamivir, ribavirin, ganciclovir,
lopinavir, and ritonavir have been used for treatment.
Remdesivir was reported in the treatment of a patient with
COVID-19 in the United States and got an effective result.
CLINICAL FEATURES
Treatment

20. Current evidence in patients with SARS and MERS suggests that
receiving corticosteroids (immunosuppressant) did not have a
survival benefit, but rather delayed viral clearance
Therefore, routine corticosteroids (immunosuppressant) should be
avoided unless they are indicated for other reason.
CLINICAL FEATURES
Treatment

21. THERE IS NO
VACCINE AND
SPECIFIC
TREATMENT FOR
COVID-19
At the moment

22. The best strategy to deal with
SARS-CoV-2 epidemic includes
controlling the sources of infection,
protecting the susceptible people,
and cutting off the transmission.
At the moment

23. VIRULENCE OF
COVID-19
AND
TAIWAN’S RESPONSE

24. Viral Strain -
Route of Infection -
Dose of Virus -
Fatality -
FACTORS INFLUENCING VIRULENCE
HOST FACTORSVIRAL FACTORS
- Species
- Age
- Susceptibility

25. Why outbreaks like
coronavirus
spread exponentially,
and how to “flatten the curve”

26. This so-called exponential curve has experts worried. If the number of cases were to continue
to double every three days, there would be about a hundred million cases in the United
States by May.

27. NORMAL
SCENARIOS

29. FORCED
QUARANTINE

30. Quarantines are effective because
they limit the number of people
exposed to a disease.
This scenario shows what happens
if a quarantine is established quickly
after the first few cases are
discovered.
QUARANTINES

33. SOCIAL
DISTANCING

35. MORE
SOCIAL
DISTANCING

38. 1. Border Control, Travel Restrictions and Case Finding Dec 31
2. Taiwan CDC notified if passenger from Wuhan has fever and/or URTI Jan 5
3. Entry permits canceled for 459 tourists from Wuhan set to arrive later in January
22
4. Foreign nationals with travel to China, Hong Kong, or Macau in the past 14-days are
banned Feb 7
5. Foreigners must see an immigration officer and cannot use e-Gate (quick entry)
Feb 7
6. Couple fined NT$300,000 (USD $10,000) for breaking 14-day home quarantine rule
Feb 7
7. 128 passengers on SuperStar Aquarius cruise ship tested within one day and all
were negative for the coronavirus Feb 8
8. Foreigners on cruise ship MS Westerdam are not allowed to enter or transfer in
Taiwan Feb 13
9. Japan and South Korea: Level 2 travel alert Feb 22
10. Italy and Iran: Level 1 travel alert Feb 23
11. Healthcare professionals banned from overseas travel Feb 23
Actions taken by Taiwanese Government

39. 1. Government allocates masks to retailers and sets price limit of 50 masks at NT$300
(USD $10) Jan 22
2. Testing of COVID-19 to take place at Taiwan CDC or eight designated hospitals Jan
24
3. Export ban on disposable surgical masks until Feb 23 Jan 24
4. Outbound travelers can only take up to 250 masks Jan 24
5. Mask prices drop to NT$6 a piece (USD $0.20)
6. Government announced the spread of fake news on epidemic can be fined up to
NT$3 million (USD $100,000)
7. Ministry of Education guidelines for suspension of classes due to confirmed
coronavirus cases
8. Ministry of Labor to provide financial assistance to workers furloughed due to
COVID-19 and receive up to NT$18,960 a month (USD $630) in subsidies.
Actions taken by Taiwanese Government

40. BUSINESS
IMPACT
How work culture and businesses have
been affected
07.

41. Covid-19 has turned
around the way of doing
business
BUSINESS IMPACT

42. BUSINESS IMPACT ON THE RISE
• Global shares take a hit
• A global slowdown
• A pandemic-driven
recession
• Small and mid-size
companies more acutely
• Shutdown –
Factories/Manufacturing

43. Remote working is set to
gain pace and will see
popularity in the times to
come.
Conference will be replaced by
teleconferences.
Virtual rooms will form the new age
seminars.
REMOTE WORKING ON THE RISE

44. BUSINESS ETHICS
Priority
• Integrity with the team
• Empathy towards everyone
• Strong Leadership
• Honesty & Trust
Social distancing and Isolation are
the new work ethics.

45. • Business travel will be impacted globally
• Many of the IMP conferences have been already called off
• Relatively slow deal-making environment for the first half of the year.
COVID-19
Fallout of
Licensing Departments

46. • Cloud Meet = Personal Meet
• Online Deal = In-person Deal
• Local partners - Development
CHANGE
in Mindset is required

47. • Financial Burden
• Pressure building from Investors
• Patent Sell off
• Intels, Googles, Apples will be the potential buyers
SMALL &
MID SIZE
Companies…

48. Spike in Business:
The cloud industry will witness more innovations.
E-commerce is already on the rise these days however new
innovations are expected in these areas.
Drone delivery wars between Amazon and Walmart is a testimony
to the same
SOCIAL
DISTANCING
is here to stay for a little longer

49. WHAT’S IN STORE
FOR FUTURE?
How the things will take place exactly towards the
end of all this is still yet to unfold.

50. REFERENCES
• Chris Tikellis and M. C. Thomas. Angiotensin-Converting Enzyme 2 (ACE2) Is a Key
Modulator of the Renin Angiotensin System in Health and Disease. International Journal
of Peptides. Volume 2012, Article ID 256294, 8 pages.
• Muhammad Adnan Shereen, Suliman Khan, Abeer Kazmi, Nadia Bashir, Rabeea Siddique.
COVID-19 infection: origin, transmission, and characteristics of human coronaviruses.
Journal of Advanced Research.
• Feng He, Yu Deng, Weina Li. Coronavirus Disease 2019 (COVID-19): What we know?. J
Med Virol.
• Junwen Luan, Yue Lu, Xiaolu Jin , Leiliang Zhang. Spike protein recognition of mammalian
ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection.
Biochemical and Biophysical Research Communications.
• Hossam M. Ashour, Walid F. Elkhatib, Md. Masudur Rahman and Hatem A. Elshabrawy.
Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human
Coronavirus Outbreaks. Pathogens 2020, 9, 186

51. REFERENCES
• Alimuddin Zumla, Jasper F. W. Chan, Esam I. Azhar, David S. C. Hui and Kwok-Yung Yuen.
Coronaviruses - drug discovery and therapeutic options. Reviews.
• Didier Raoult, Alimuddin Zumla, Franco Locatelli, Giuseppe Ippolito and Guido Kroemer.
Coronavirus infections: Epidemiological, clinical and immunological features and
hypotheses. Cell Stress.

52. THANKS!
Do you have any
questions?
contact@xlpat.com
1-(202)-370-6471
www.xlpat.com